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Honors Theses

2012

Discipline
Institution
Keyword

Articles 61 - 63 of 63

Full-Text Articles in Medicine and Health Sciences

Medical Illustration, Dusty Barnette Jan 2012

Medical Illustration, Dusty Barnette

Honors Theses

"When people ask me what I do for a living I tell them, 'I am a medical illustrator'. This response often elicits a look of confusion, along with the question, 'You're a what?"" This is the response often received by medical illustrator Monique Guilderson, after being asked the standard "What do you do for a living?" question. I think this one statement does an excellent job of summarizing the general public perception of the field. In fact, I myself would have responded the same way just a few years ago, but since I first came to realize that this is …


Computational Docking Simulations Of Nitroanisole And Nitrophenol With Cyp2e1, Kasa B. Cooper, Martin "Marty" D. Perry Jr., Grover P. Miller Jan 2012

Computational Docking Simulations Of Nitroanisole And Nitrophenol With Cyp2e1, Kasa B. Cooper, Martin "Marty" D. Perry Jr., Grover P. Miller

Honors Theses

Studies have shown that CYP2E1, a cytochrome P450 enzyme containing two primary binding sites, plays a substantial role in the oxidative metabolism of many foreign substances, including the detoxification reaction of 4-nitroanisole to 4-nitrophenol. Through the advancements of the computational docking software Tripos Sybyl7.2, it has been possible to investigate the mechanism of oxidation of 4-nitroanisole. Docking modules of Sybyl7.2 software, including Surflext and molecular dynamics, have created the ability to ascertain the likely binding configurations of 4-nitranisole and its constitutional isomers in either the distal or proximal binding sites of CYP2E1. Knowing the relative binding relationships of 4-nitroanisole to …


Mechanism Of Action Of A Novel Antifungal Compound, Amber Ward Jan 2012

Mechanism Of Action Of A Novel Antifungal Compound, Amber Ward

Honors Theses

Opportunistic fungal infections have become problematic in recent years. There has been an emergence of new fungal pathogens, development of antifungal resistance, and increasing prevalence. In addition, toxicity, resistance, and lack of efficacy as a single agent limit the effectiveness of current antifungal drugs. Therefore, new drugs targeting new pathways are greatly needed. An analog derived from the marine natural product phloeodictine, analog PHL5-34A, was identified as having strong in vitro antifungal activity. In this study, its mechanism of action (MOA) was investigated in the model yeast, Saccharomyces cerevisiae. This study made use of a collection of 166 yeast mutants …