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Full-Text Articles in Medicine and Health Sciences
The Effects Of Ajulemic Acid On The Metatastic Potential Of Ewing's Sarcoma, Nolan J. West
The Effects Of Ajulemic Acid On The Metatastic Potential Of Ewing's Sarcoma, Nolan J. West
Honors Theses
Ewing's Sarcoma belongs in the Ewing's Sarcoma Family of Tumors (EFST) which represents approximately 2% of all cancers found in children and young adults. These tumors are generally treated by chemotherapy along with either surgery or radiation therapy which can themselves have debilitating effects on the patients. Dr. Lori Hensley's research has shown that ajulemic acid (AJA), a synthetic cannabinoid compound, exhibits extraordinary anti-tumor effects. In addition, AJA has not expressed any psychotropic side effects typically seen with other cannabinoids. Furthermore, ajulemic acid has been shown to eliminate the tumors by apoptosis, the preferred method of cell death. The purpose …
Establishing A Mouse Model For The Study Of Podocyte Regeneration After Injury, John A. Gomez
Establishing A Mouse Model For The Study Of Podocyte Regeneration After Injury, John A. Gomez
Honors Theses
Podocytes are vital, specialized kidney cells that are post-mitotic and cannot proliferate. Nevertheless, regeneration of podocytes after low-level ablation from a presently unidentified stem cell pool has been observed. The objective of this study was to establish a mouse model for the study of this regeneration process. Two transgenic mice were developed, the first of which possessed a tomato-reporter transgene for the assessment of podocyte turnover. Adriamycin was used to induce podocyte damage in this mouse. The second transgenic mouse possessed the tomato-reporter transgene as well as transgene allowing for the diphtheria toxin inducible (iDTR) ablation of podocytes. Dosage tests …
Understanding The Hurting: A Look Into The Lives Of Families Battling Ewing's Sarcoma, Abigail Dekle
Understanding The Hurting: A Look Into The Lives Of Families Battling Ewing's Sarcoma, Abigail Dekle
Honors Theses
A look into the lives of families struggling with the effects of Ewing's Sarcoma.
Medical Illustration, Dusty Barnette
Medical Illustration, Dusty Barnette
Honors Theses
"When people ask me what I do for a living I tell them, 'I am a medical illustrator'. This response often elicits a look of confusion, along with the question, 'You're a what?"" This is the response often received by medical illustrator Monique Guilderson, after being asked the standard "What do you do for a living?" question. I think this one statement does an excellent job of summarizing the general public perception of the field. In fact, I myself would have responded the same way just a few years ago, but since I first came to realize that this is …
Computational Docking Simulations Of Nitroanisole And Nitrophenol With Cyp2e1, Kasa B. Cooper, Martin "Marty" D. Perry Jr., Grover P. Miller
Computational Docking Simulations Of Nitroanisole And Nitrophenol With Cyp2e1, Kasa B. Cooper, Martin "Marty" D. Perry Jr., Grover P. Miller
Honors Theses
Studies have shown that CYP2E1, a cytochrome P450 enzyme containing two primary binding sites, plays a substantial role in the oxidative metabolism of many foreign substances, including the detoxification reaction of 4-nitroanisole to 4-nitrophenol. Through the advancements of the computational docking software Tripos Sybyl7.2, it has been possible to investigate the mechanism of oxidation of 4-nitroanisole. Docking modules of Sybyl7.2 software, including Surflext and molecular dynamics, have created the ability to ascertain the likely binding configurations of 4-nitranisole and its constitutional isomers in either the distal or proximal binding sites of CYP2E1. Knowing the relative binding relationships of 4-nitroanisole to …