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Full-Text Articles in Medicine and Health Sciences
The Role Of Actin Polymerization In The Development Of The Fetal Vertebrate Heart During S-Looping, Kevan Benn
The Role Of Actin Polymerization In The Development Of The Fetal Vertebrate Heart During S-Looping, Kevan Benn
Honors Theses
Research on fetal cardiac looping is an important because cardiac looping is the first organ to undergo asymmetrical organogenesis. As well, birth defects occur due to errors in the development process, of which congenital heart defects are very common. Most heart defects begin in the looping process that preludes the shape of a mature heart. Therefore, research into heart looping can give light to how these defects develop. The looping process, which occurs between 30 and 56 hours post incubation (stage 10-16 in development), is divided into two processes. The first process, C-looping, is the process where the heart tube, …
Establishing A Mouse Model For The Study Of Podocyte Regeneration After Injury, John A. Gomez
Establishing A Mouse Model For The Study Of Podocyte Regeneration After Injury, John A. Gomez
Honors Theses
Podocytes are vital, specialized kidney cells that are post-mitotic and cannot proliferate. Nevertheless, regeneration of podocytes after low-level ablation from a presently unidentified stem cell pool has been observed. The objective of this study was to establish a mouse model for the study of this regeneration process. Two transgenic mice were developed, the first of which possessed a tomato-reporter transgene for the assessment of podocyte turnover. Adriamycin was used to induce podocyte damage in this mouse. The second transgenic mouse possessed the tomato-reporter transgene as well as transgene allowing for the diphtheria toxin inducible (iDTR) ablation of podocytes. Dosage tests …