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Articles 7081 - 7110 of 9765

Full-Text Articles in Medicine and Health Sciences

Cd21-Positive Follicular Dendritic Cells A Possible Source Of PrpSc In Lymph Node Macrophages Of Scrapie-Infected Sheep, Lynn M. Herrmann, William P. Cheevers, William C. Davis, Donald P. Knowles, Katherine I. O'Rourke Jan 2003

Cd21-Positive Follicular Dendritic Cells A Possible Source Of PrpSc In Lymph Node Macrophages Of Scrapie-Infected Sheep, Lynn M. Herrmann, William P. Cheevers, William C. Davis, Donald P. Knowles, Katherine I. O'Rourke

Zoonotics and Wildlife Disease: Publications

Natural sheep scrapie is a prion disease characterized by the accumulation of PrPSc in brain and lymphoid tissues. Previous studies suggested that lymph node macrophages and follicular dendritic cells (FDC) accumulate PrPSc. In this study, lymph nodes were analyzed for the presence of PrPSc and macrophage or FDC markers using dual immunohistochemistry. A monoclonal antibody (mAb) to the C-terminus of PrP reacted with CD172a+ macrophages and CD21+ FDC processes in secondary follicles. However, a PrP N-terminus- specific mAb reacted with CD21+ FDC processes but not CD172a+ macrophages in secondary follicles. Neither the PrP N-terminus nor C-terminus-specific …

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Immunohistochemical Detection And Distribution Of Prion Protein In A Goat With Natural Scrapie, Reginald A. Valdez, Matthew J. Rock, Anne K. Anderson, Katherine I. O'Rourke Jan 2003

Immunohistochemical Detection And Distribution Of Prion Protein In A Goat With Natural Scrapie, Reginald A. Valdez, Matthew J. Rock, Anne K. Anderson, Katherine I. O'Rourke

Zoonotics and Wildlife Disease: Publications

Formalin-fixed, paraffin-embedded tissue sections from a 3-year-old female Angora goat suffering from clinical scrapie were immunostained after hydrated autoclaving using a monoclonal antibody (mAb, F99/ 97.6.1; IgG1) specific for a conserved epitope on the prion protein. Widespread and prominent deposition of the scrapie isoform of the prion protein (PrPSc) was observed in the brain, brainstem, spinal cord, retina, postganglionic neurons associated with parasympathetic ganglia of myenteric and submucosal plexuses, Peyer’s patches, peripheral lymph nodes, and pharyngeal and palatine tonsils. The goat was homozygous for PrP alleles encoding 5 octapeptide repeat sequences in the N-terminal region of the prion …

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A Prion Protein Epitope Selective For The Pathologically Misfolded Conformation, Eustache Paramithiotis, Marc Pinard, Trebor Lawton, Sylvie Laboissiere, Valerie I. Leathers, Wen-Quan Zou, Lisa A. Estey, Julie Lamontagne, Marty T. Lehto, Leslie H. Kondejewski, Gregory P. Francoeur, Maria Papadopoulos, Ashkan Haghighat, Stephen J. Spatz, Mark Head, Robert Will, James Ironside, Katherine I. O'Rourke, Quentin Tonelli, Harry C. Ledebur, Avi Chakrabartty, Neil R. Cashman Jan 2003

A Prion Protein Epitope Selective For The Pathologically Misfolded Conformation, Eustache Paramithiotis, Marc Pinard, Trebor Lawton, Sylvie Laboissiere, Valerie I. Leathers, Wen-Quan Zou, Lisa A. Estey, Julie Lamontagne, Marty T. Lehto, Leslie H. Kondejewski, Gregory P. Francoeur, Maria Papadopoulos, Ashkan Haghighat, Stephen J. Spatz, Mark Head, Robert Will, James Ironside, Katherine I. O'Rourke, Quentin Tonelli, Harry C. Ledebur, Avi Chakrabartty, Neil R. Cashman

Zoonotics and Wildlife Disease: Publications

Conformational conversion of proteins in disease is likely to be accompanied by molecular surface exposure of previously sequestered amino-acid side chains. We found that induction of β-sheet structures in recombinant prion proteins is associated with increased solvent accessibility of tyrosine. Antibodies directed against the prion protein repeat motif, tyrosine-tyrosinearginine, recognize the pathological isoform of the prion protein but not the normal cellular isoform, as assessed by immunoprecipitation, plate capture immunoassay and flow cytometry. Antibody binding to the pathological epitope is saturable and specific, and can be created in vitro by partial denaturation of normal brain prion protein. Conformation-selective exposure of …

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Properties Of A Disease-Specific Prion Probe, Guy Gorochov, Jean-Phillippe Deslys, Eustache Paramithiotis, Marc Pinard, Trebor Lawton, Sylvie Laboissiere, Valerie L. Leathers, Wen-Quan Zou, Lisa A. Estey, Julie Lamontagne, Marty T. Lehto, Leslie H. Kondejewski, Gregory P. Francoeur, Maria Paoadopoulos, Ashkan Haghighat, Stephen J. Spatz, Mark Head, Robert Will, James Ironside, Katherine I. O'Rourke, Quentin Tonelli, Harry C. Ledebur, Avi Chakrabartty, Neil R. Cashman Jan 2003

Properties Of A Disease-Specific Prion Probe, Guy Gorochov, Jean-Phillippe Deslys, Eustache Paramithiotis, Marc Pinard, Trebor Lawton, Sylvie Laboissiere, Valerie L. Leathers, Wen-Quan Zou, Lisa A. Estey, Julie Lamontagne, Marty T. Lehto, Leslie H. Kondejewski, Gregory P. Francoeur, Maria Paoadopoulos, Ashkan Haghighat, Stephen J. Spatz, Mark Head, Robert Will, James Ironside, Katherine I. O'Rourke, Quentin Tonelli, Harry C. Ledebur, Avi Chakrabartty, Neil R. Cashman

Zoonotics and Wildlife Disease: Publications

In a recently published article, Paramithiotis et al. describe antibodies specific for the prion Tyr-Tyr-Arg (YYR) repeat motif. These antibodies interact with the pathological isoform of the prion protein (PrPSC), but not with the normal cellular isoform (PrpC). Because of this restricted specificity, they suggest that YYR-specific antibodies could be useful for the diagnosis and treatment of prion diseases (Fig. O. The monoclonal antibodies, all of the IgM isotype, were produced by immunizing mice with a synthetic peptide (CYYRRYYRYY). When coupled to magnetic beads, these YYR-specific antibodies immunoprecipitate Prpsc much more efficiently than PrpC …

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Monte Carlo Assessments Of Goodness-Of-Fit For Ecological Simulation Models, Lance A. Waller, David Smith, James E. Childs, Leslie A. Real Jan 2003

Monte Carlo Assessments Of Goodness-Of-Fit For Ecological Simulation Models, Lance A. Waller, David Smith, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

One often develops stochastic ecologic simulation models based on local interactions between individuals or groups and bases systemic conclusions on trends summarized over multiple data sets generated from the model. In many cases, such models generate data sets (“realizations”) each violating the usual assumptions associated with traditional statistical tests of goodness-of-fit, most notably that of independent observations. Monte Carlo hypothesis tests applied to multiple realizations from such models provide appropriate goodness-of-fit tests regardless of within-model peculiarities. The Monte Carlo tests address the question “Do the observed data appear consistent with the model?” in contrast to the usual question “Does the …

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Abundant PrpCwd In Tonsil From Mule Deer With Preclinical Chronic Wasting Disease, Katherine I. O'Rourke, Dongyue Zhuang, Amy Lyda, Gabriel Gomez, Elizabeth S. Williams, Wenbin Tuo, Michael W. Miller Jan 2003

Abundant PrpCwd In Tonsil From Mule Deer With Preclinical Chronic Wasting Disease, Katherine I. O'Rourke, Dongyue Zhuang, Amy Lyda, Gabriel Gomez, Elizabeth S. Williams, Wenbin Tuo, Michael W. Miller

Zoonotics and Wildlife Disease: Publications

A monoclonal antibody dot-blot assay was used to evaluate detergent lysates of tonsil tissue from mule deer to detect PrPCWD, the marker for the cervid transmissible spongiform encephalopathy chronic wasting disease (CWD). Samples of formalin-fixed brain and tonsil tissues from mule deer were examined for PrPCWD using immunohistochemistry (IHC) with Mab F99/97.6.1, the gold standard for diagnosis of preclinical CWD. The contralateral tonsil from each of the 143 deer was prepared for confirmatory IHC and as a 10% (wt/vol) detergent lysate without purification or enrichment steps for monoclonal antibody dot-blot assay. PrPCWD was detected by dot-blot …

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Genealogical Relationships Influence The Probability Of Infection With Bovine Tuberculosis And Microgeographic Genetic Structure In Free-Ranging White-Tailed Deer, Julie Anne Blanchong Jan 2003

Genealogical Relationships Influence The Probability Of Infection With Bovine Tuberculosis And Microgeographic Genetic Structure In Free-Ranging White-Tailed Deer, Julie Anne Blanchong

Michigan Bovine Tuberculosis Bibliography and Database

Zoonoses are of increasing importance to wildlife conservation and human health. It has become increasingly recognized that wildlife ecology plays a key role in disease transmission in wildlife populations. In domestic populations, contacts among individuals are controlled by humans and disease transmission is often density dependent. Unlike domestic animals, wildlife populations often have complex social systems in whch contacts among individuals are not solely density dependent, and can play an important role in the transmission and maintenance of disease.

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A Priori Prediction Of Disease Invasion Dynamics In A Novel Environment, Colin A. Russell, David L. Smith, Lance A. Waller, James E. Childs, Leslie A. Real Jan 2003

A Priori Prediction Of Disease Invasion Dynamics In A Novel Environment, Colin A. Russell, David L. Smith, Lance A. Waller, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

Directly transmitted infectious diseases spread through wildlife populations as travelling waves away from the sites of original introduction. These waves often become distorted through their interaction with environmental and population heterogeneities and by long-distance translocation of infected individuals. Accurate a priori predictions of travelling waves of infection depend upon understanding and quantifying these distorting factors. We assess the effects of anisotropies arising from the orientation of rivers in relation to the direction of disease-front propagation and the damming effect of mountains on disease movement in natural populations. The model successfully predicts the local and large-scale prevaccination spread of raccoon rabies …

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Department Of Veterinary And Biomedical Sciences: Vbms Annual Report 2003 Jan 2003

Department Of Veterinary And Biomedical Sciences: Vbms Annual Report 2003

School of Veterinary and Biomedical Sciences: Information and History

Foreword
VBMS Faculty
VBMS Faculty and Staff, by Function and Unit
Honors. Awards and Recognitions
VBMS Committee Assignments
Faculty Profiles
VBMS Research Associates Profiles
VBMS Teaching Program
Great Plains Veterinary Educational Center (GPVEC)
VBMS Research Program
International Activities
Veterinary Extension Program
Nebraska Veterinary Diagnostic Laboratory Systems (NVDLS)
Grants and Contracts Program
Patents by VBMS Faculty
Publications by VBMS Faculty
Presentations by VBMS Faculty
Articles Regarding the Department
Selected Committees. Editorial and Other Appointments
Departmental Budget Summaries
Nebraska Agricultural Statistics

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Bovine Tuberculosis In Michigan: Understanding Stakeholder Attitudes Toward The Disease And Eradication Efforts, Meegan Leah Dorn Jan 2003

Bovine Tuberculosis In Michigan: Understanding Stakeholder Attitudes Toward The Disease And Eradication Efforts, Meegan Leah Dorn

Michigan Bovine Tuberculosis Bibliography and Database

Bovine tuberculosis has been discovered at unprecedented levels in Michigan wildlife, especially white-tailed deer (Odocoileus virginianus). Human behaviors, particularly the use of bait and feed, have facilitated the spread of the disease into free-ranging white-tailed deer populations. Policies aimed at eradicating bovine tuberculosis in Michigan require public compliance and cooperation in order to be successful. Because of the human contribution to the spread of bovine tuberculosis in Michigan wildlife, and the social nature of subsequent bovine tuberculosis eradication policies, we conducted a survey of bovine TB issue stakeholder groups in northeast Michigan, including non-resident hunters, resident hunters, livestock …

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Bovine Tuberculosis In Elk (Cervus Elaphus Manitobensis) Near Riding Mountain National Park, Manitoba, From 1992 To 2002 Jan 2003

Bovine Tuberculosis In Elk (Cervus Elaphus Manitobensis) Near Riding Mountain National Park, Manitoba, From 1992 To 2002

Michigan Bovine Tuberculosis Bibliography and Database

From 1991 to April 2003, outbreaks of bovine tuberculosis (TB caused by Mycobacterium bovis) have been found in 11 cattle herds surrounding Riding Mountain National Park (RMNP). Located in southwestern Manitoba, RMNP and the surrounding area are home to a free-ranging herd of 2500 to 4000 elk that have been implicated as being a wildlife reservoir of M. bovis infection. Indirect contact between cattle and elk that feed during the winter on the same large, round hay bales is presumed to be the most likely mode of transmission between the species (1).

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Prevalence Of Chronic Wasting Disease And Bovine Tuberculosis In Free-Ranging Deer And Elk In South Dakota, Christopher N. Jacques, Jonathan A. Jenks, Allen L. Jenny, Steven L. Griffin Jan 2003

Prevalence Of Chronic Wasting Disease And Bovine Tuberculosis In Free-Ranging Deer And Elk In South Dakota, Christopher N. Jacques, Jonathan A. Jenks, Allen L. Jenny, Steven L. Griffin

Michigan Bovine Tuberculosis Bibliography and Database

Heads of hunter-harvested deer and elk were collected throughout South Dakota (USA) and within established chronic wasting disease (CWD) surveillance areas from 1997–2002 to determine infection with CWD and bovine tuberculosis (TB). We used immunohistochemistry to detect CWD-infected individuals among 1,672 deer and elk sampled via geographically targeted surveillance. A total of 537 elk (Cervus elaphus nelsoni), 813 white-tailed deer (Odocoileus virginianus), and 322 mule deer (O. hemionus) was sampled for CWD. Estimated overall prevalence and associated confidence intervals (95%) in white-tailed deer was 0.001% (0–0.007%). Similarly, estimated overall prevalence in elk and mule …

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Spatial And Temporal Spread Of Bovine Tuberculosis In Wild White-Tailed Deer In Michigan, Graham J. Hickling, Stephen M. Schmitt, Daniel J. O'Brien Jan 2003

Spatial And Temporal Spread Of Bovine Tuberculosis In Wild White-Tailed Deer In Michigan, Graham J. Hickling, Stephen M. Schmitt, Daniel J. O'Brien

Michigan Bovine Tuberculosis Bibliography and Database

In 1975, a wild white-tailed deer infected with bovine tuberculosis was shot in the northeastern Lower Peninsula, Michigan. The shooting of a second infected deer in the same area in 1994 triggered ongoing disease surveillance in the region. By 2002, bovine tuberculosis had been confirmed in 12 Michigan counties: from 449 deer; two elk; 41 non-cervid wildlife; one captive cervid facility and 28 cattle herds. We analyzed geographic spread of disease since the surveillance began and investigated factors influencing the prevalence of disease within the infected area. These analyses reveal that 78 percent of tuberculous deer came from within a …

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Mycobacterial Diseases In Wildlife, Gary Witmer, Thomas J. Deliberto, Kurt C. Vercauteren, Peter Butchko Jan 2003

Mycobacterial Diseases In Wildlife, Gary Witmer, Thomas J. Deliberto, Kurt C. Vercauteren, Peter Butchko

Michigan Bovine Tuberculosis Bibliography and Database

Mycobacterium infections occur in numerous wildlife species worldwide and this bacterial genus can also cause disease in humans and livestock. Two Mycobacterium species and one subspecies that infect wildlife are important from a wildlife damage management perspective. Mycobacterium avium, avian tuberculosis, is a ubiquitous and cosmopolitan disease of wild and domestic birds. Wild and domestic ruminants are host to M. avium paratuberculosis, also known as Johne’s disease. Finally, Mycobaterium bovis, bovine tuberculosis, is primarily associated with domestic and wild bovines and ungulates, but also infects many other species of mammals. Eradicating these diseases from wildlife populations is …

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Mycobacterial Diseases In Wildlife, Gary W. Witmer, Thomas J. Deliberto, Kurt C. Vercauteren, Peter Butchko Jan 2003

Mycobacterial Diseases In Wildlife, Gary W. Witmer, Thomas J. Deliberto, Kurt C. Vercauteren, Peter Butchko

Michigan Bovine Tuberculosis Bibliography and Database

Mycobacterium infections occur in numerous wildlife species worldwide and this bacterial genus can also cause disease in humans and livestock. Two Mycobacterium species and one subspecies that infect wildlife are important from a wildlife damage management perspective. Mycobacterium avium, avian tuberculosis, is a ubiquitous and cosmopolitan disease of wild and domestic birds. Wild and domestic ruminants are host to M. avium paratuberculosis, also known as Johne’s disease. Finally, Mycobaterium bovis, bovine tuberculosis, is primarily associated with domestic and wild bovines and ungulates, but also infects many other species of mammals. Eradicating these diseases from wildlife populations is …

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The Mare Reproductive Loss Syndrome And The Eastern Tent Caterpillar: A Toxicokinetic/Statistical Analysis With Clinical, Epidemiologic, And Mechanistic Implications, Manu Sebastian, Marie G. Gantz, Thomas Tobin, J. Daniel Harkins, Jeffrey M. Bosken, Charlie Hughes, Lenn R. Harrison, William V. Bernard, Dana L. Richter, Terrence D. Fitzgerald Jan 2003

The Mare Reproductive Loss Syndrome And The Eastern Tent Caterpillar: A Toxicokinetic/Statistical Analysis With Clinical, Epidemiologic, And Mechanistic Implications, Manu Sebastian, Marie G. Gantz, Thomas Tobin, J. Daniel Harkins, Jeffrey M. Bosken, Charlie Hughes, Lenn R. Harrison, William V. Bernard, Dana L. Richter, Terrence D. Fitzgerald

Maxwell H. Gluck Equine Research Center Faculty Publications

During 2001, central Kentucky experienced acute transient epidemics of early and late fetal losses, pericarditis, and unilateral endophthalmitis, collectively referred to as mare reproductive loss syndrome (MRLS). A toxicokinetic/statistical analysis of experimental and field MRLS data was conducted using accelerated failure time (AFT) analysis of abortions following administration of Eastern tent caterpillars (ETCs; 100 or 50 g/day or 100 g of irradiated caterpillars/day) to late-term pregnant mares. In addition, 2001 late-term fetal loss field data were used in the analysis. Experimental data were fitted by AFT analysis at a high (P < .0001) significance. Times to first abortion (“lag time”) and abortion rates were dose dependent. Lag times decreased and abortion rates increased exponentially with dose. Calculated dose × response data curves allow interpretation of abortion data in terms of “intubated ETC equivalents.” Analysis suggested that field exposure to ETCs in 2001 in central Kentucky commenced on approximately April 27, was initially equivalent to approximately 5 g of intubated ETCs/day, and increased to approximately 30 g/day at the outbreak peak. This analysis accounts for many aspects of the epidemiology, clinical presentations, and manifestations of MRLS. It allows quantitative interpretation of experimental and field MRLS data and has implications for the basic mechanisms underlying MRLS. The results support suggestions that MRLS is caused by exposure to or ingestion of ETCs. The results also show that high levels of ETC exposure produce intense, focused outbreaks of MRLS, closely linked in time and place to dispersing ETCs, as occurred in central Kentucky in 2001. With less intense exposure, lag time is longer and abortions tend to spread out over time and may occur out of phase with ETC exposure, obscuring both diagnosis of this syndrome and the role of the caterpillars.

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Isovolumetric Regulation In Mammal Cells: Role Of Taurine, B. Ordaz, R. Franco, National University Of Mexico Tuz Jan 2003

Isovolumetric Regulation In Mammal Cells: Role Of Taurine, B. Ordaz, R. Franco, National University Of Mexico Tuz

School of Veterinary and Biomedical Sciences: Faculty Publications

The ability to regulate cell volume is an ancient conserved trait present in essentially all species through evolution. The maintenance of a constant cell volume is a homeostatic imperative in animal cells. Changes in cell water content affecting the concentration of intracellular messenger molecules impair the complex signaling network, crucial for cell functioning and intercellular communication. Although the renal homeostatic mechanisms exert a precise control of extracellular fluid osmolarity, this is challenged in a variety of pathological situations. The intracellular volume constancy is continuously compromised by the generation of local and transient osmotic microgradients, associated with nutrients uptake, secretion, cytoskeleton …

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Elastomeric Hoof Boots, John Hanley Jan 2003

Elastomeric Hoof Boots, John Hanley

Masters

The design, manufacture and testing of a prototype elastomeric equine boot is described in this thesis. Thoroughbred horses may suffer from a number of serious hoof disorders. These include stone bruising, navicular syndrome and hoof wall separation. Excessive concussion in the equine hoof is a major contributory factor in most of the problems horses experience in their lower limbs. Bandaging of a horses foot after injury is time consuming as well as being labour intensive. The proposed boot serves a number of purposes; by replacing bandages during poulticing it plays a part in faster healing of foot ailments. It can …

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Michigan Bovine Tuberculosis Eradication Project: Activities Report 2003, Bridget Patrick Jan 2003

Michigan Bovine Tuberculosis Eradication Project: Activities Report 2003, Bridget Patrick

Michigan Bovine Tuberculosis Bibliography and Database

Bovine tuberculosis (TB) is an infectious bacterial disease and poses a risk to domestic livestock, wildlife and public health in the United States (U.S). In 1917, the U.S. government began a comprehensive national bovine TB eradication program. The disease has been nearly eradicated from livestock in the U.S., but areas of infection resurface periodically. Michigan was declared free of bovine TB in 1975 and received Disease Free status in 1979. In 1975 a free-ranging white-tailed deer in Alcona County was confirmed to be bovine TB positive. It was thought to be an anomaly, and no policy was adopted to look …

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The Risk Of Disease Transmission To Livestock Posed By Contamination Of Farm Stored Feed By Wildlife Excreta, M. J. Daniels, M. R. Hutchings, A. Greig Jan 2003

The Risk Of Disease Transmission To Livestock Posed By Contamination Of Farm Stored Feed By Wildlife Excreta, M. J. Daniels, M. R. Hutchings, A. Greig

Michigan Bovine Tuberculosis Bibliography and Database

Livestock feed is susceptible to contamination from wildlife excreta during on farm storage. Pathogens associated with diseases such as paratuberculosis, salmonella and cryptosporidiosis are present in wild rodent and bird excreta. Feed stores on four farms in the east of Scotland were monitored monthly over the winter of 1998/9 to quantify the levels of wildlife faecal contamination. A mean of 79.9 rodent (95% confidence interval: 37.5–165.9) and 24.9 (14.3–41.7) bird faeces were deposited per m2 of stored feed per month. It was estimated that individual cattle and sheep could encounter 1,626 and 814 wildlife faeces over the winter.

A …

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Are There “Hot Spots” Of Bovine Tuberculosis In The Free-Ranging White-Tailed Deer (Odocoileus Virginianus) Herd Of Northeastern Michigan?, Brandi Danielle Hughey Jan 2003

Are There “Hot Spots” Of Bovine Tuberculosis In The Free-Ranging White-Tailed Deer (Odocoileus Virginianus) Herd Of Northeastern Michigan?, Brandi Danielle Hughey

Michigan Bovine Tuberculosis Bibliography and Database

This project looks at whether high case frequency areas or “hot spots” of bovine tuberculosis (tb) exist in free ranging white-tailed deer in northeastern Michigan, and examines the factors associated with them. Michigan Department of Natural Resources researchers have been collecting deer heads annually since 1996 in the five county area of Alcona, Alpena, Montmorency, Oscoda, and Presque Isle as part of an effort to manage an outbreak of bovine tb in the wild white-tailed deer population. From these heads a database containing age, sex, and harvest or collection location information was constructed. The townships within these five counties were …

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Aerosol Exposure Of White-Tailed Deer (Odocoileus Virginianus) To Mycobacterium Bovis, Mitchell V. Palmer, W. Ray Waters, Diana L. Whipple Jan 2003

Aerosol Exposure Of White-Tailed Deer (Odocoileus Virginianus) To Mycobacterium Bovis, Mitchell V. Palmer, W. Ray Waters, Diana L. Whipple

Michigan Bovine Tuberculosis Bibliography and Database

Tuberculosis due to Mycobacterium bovis affects both captive and free-ranging Cervidae in the United States. Various animal models have been developed to study tuberculosis of both humans and animals. Generally, tuberculosis is transmitted by aerosol and oral routes. Models of aerosol exposure of large animals to M. bovis are uncommon. In order to develop a reliable method of aerosol exposure of white-tailed deer (Odocoileus virginianus) to M. bovis, 12 healthy white-tailed deer, aged 8–10 mo, were infected by aerosol exposure to 2x105 to 1x106 colony forming units (CFU) (high dose, n=4) of M. bovis or …

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Feral Swine - Are They A Disease Threat To Livestock In The United States?, Gary W. Witmer, Robert B. Sanders, Arnold C. Taft Jan 2003

Feral Swine - Are They A Disease Threat To Livestock In The United States?, Gary W. Witmer, Robert B. Sanders, Arnold C. Taft

Michigan Bovine Tuberculosis Bibliography and Database

Feral swine populations provide both benefits and liabilities to citizens of the United States. Their expanding range and increasing densities, however, have raised concern over the adverse environmental and agricultural effects and the increased risk of disease transmission between feral swine and livestock. We discuss the role of feral swine in the transmission of wildlife diseases and, in particular, in diseases of national significance to the livestock industry. We also discuss available management tools and strategies for reducing feral swine populations, minimizing damage or disease occurrences and eradicating populations when deemed appropriate. Finally, we note areas of research that may …

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Characterization Of Protein Secretion In Mycobacterium Leprae Using Phoa Fusions In Escherichia Coli And Mycobacterium Smegmatis, Marina Noemi Torrero Jan 2003

Characterization Of Protein Secretion In Mycobacterium Leprae Using Phoa Fusions In Escherichia Coli And Mycobacterium Smegmatis, Marina Noemi Torrero

LSU Doctoral Dissertations

Complete sequencing and annotation of the M. leprae genome has provided new information related to proteins constituting its hypothetical proteome. Since M. leprae can not be grown in vitro, novel approaches are needed to determine which proteins are expressed during infection and whether these proteins are related to pathogenesis. Secreted proteins represent a distinct group of protein with respect to their structure and function, contribution to virulence and are of particular importance for vaccine development because they are often immunogenic and have the potential to be recognized early in infection. The objectives of this study were: 1) to identify putatively …

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Role Of Endothelin-1 In The Gastrointestinal Tract Of Horses In Health And Disease, Ramaswamy Monickarasi Chidambaram Jan 2003

Role Of Endothelin-1 In The Gastrointestinal Tract Of Horses In Health And Disease, Ramaswamy Monickarasi Chidambaram

LSU Doctoral Dissertations

Gastrointestinal tract disease is the leading natural cause of death in horses and horses with ischemic intestinal disease have the greatest mortality. We hypothesized there is basal synthesis of endothelin-1 (ET-1) in the intestinal tract of healthy horses that is likely involved in regulating vasomotor tone, secretion and motility and that ET-1 synthesis increases with gastrointestinal tract disease, which may be involved in the pathophysiology of these disorders. Plasma ET-like immunoreactivity was increased in horses with naturally-acquired gastrointestinal disease, compared with normal horses; values were greatest in horses with large intestinal strangulation obstruction, enterocolitis and peritonitis. There was an association …

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Role Of Endothelin In The Pathogenesis Of Acute Laminitis In Horses, Ashley Michelle Stokes Jan 2003

Role Of Endothelin In The Pathogenesis Of Acute Laminitis In Horses, Ashley Michelle Stokes

LSU Doctoral Dissertations

Acute laminitis is a severely debilitating disease of the laminae of the equine digit; however, the mechanism(s) of pathogenesis have yet to be fully elucidated. In physiologic states, the endothelium synthesizes substances, such as nitric oxide (NO; vasodilator) and endothelin-1 (ET-1; profound vasoconstrictor), which play a crucial role in vasomotor regulation. The overall hypothesis is that the initiating factor in the onset of acute laminitis is a disruption in the balance between NO and ET-1, which leads to digital vasoconstriction and subsequent laminar ischemic necrosis. In vitro studies with digital vessels from healthy horses and horses with naturally-acquired laminitis determined …

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Equine Immunity To Cyathostome Infections, Marie Alexandra Baudena Jan 2003

Equine Immunity To Cyathostome Infections, Marie Alexandra Baudena

LSU Doctoral Dissertations

To study the protective responses of cyathostome-infected ponies, two challenges were performed employing animals with different histories of exposure to these parasites. The hypothesis developed and to be tested in these experiments was that ponies that had longer exposure to cyathostome contaminated pastures would express acquired resistance to infection. The assumption behind this hypothesis was that helminth-naïve ponies infected with cyathostomes would eliminate the infection using only innate immune responses. Whereas previously exposed ponies would eliminate the infection with acquired immune responses, and these would be more effective in ponies with longer exposure to cyathostomes. Thus, helminth-naïve animals would acquire …

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The Effects Of Baker's Yeast (Saccharomyces Cerevisiae) In Dairy Cow Diets On Milk Yield, Some Rumen Fluid Parameters And Blood Metabolites Of Dairy Cow Diets, Hüseyi̇n Nursoy, Erol Baytok Jan 2003

The Effects Of Baker's Yeast (Saccharomyces Cerevisiae) In Dairy Cow Diets On Milk Yield, Some Rumen Fluid Parameters And Blood Metabolites Of Dairy Cow Diets, Hüseyi̇n Nursoy, Erol Baytok

Turkish Journal of Veterinary & Animal Sciences

The objective of this study was to investigate the effects of baker's yeast as a protein source instead of soybean meal in dairy cow diets. Four dairy cows were utilized in a 4 x 4 Latin Square experiment. Diets included 0.0% (Control Diet), 6.6% (Diet 1), 13.2% (Diet 2), and 19.8% (Diet 3) baker's yeast containing 3.56 x 10^8 CFU/g. Forty percent of the dry matter intake of dairy cows was supplied from concentrate, and forage was offered ad libitum. The dry matter intake, milk yield, and composition of milk were similar. While the rumen NH_3-N level was significantly low …

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The Effects Of Some Silage Additives In Sorghum Silage On The Silage Quality And Ruminal Degradabilities Of Nutrients I. The Effects On Silage Quality, N. Tuğba Bi̇ngöl, Erol Baytok Jan 2003

The Effects Of Some Silage Additives In Sorghum Silage On The Silage Quality And Ruminal Degradabilities Of Nutrients I. The Effects On Silage Quality, N. Tuğba Bi̇ngöl, Erol Baytok

Turkish Journal of Veterinary & Animal Sciences

The aim of the study was to determine the effects of different silage additives on the silage quality of sorghum silage. Different sorghum silages were prepared from sorghum harvested at the milk or dough stage (287.40 and 304.80 g/kg DM) with or without SIL-ALL (enzyme-inoculant complex; EI), molasses (M), formic acid (FA), M + FA, EI + FA, EI + M and EI + FA + M additives in laboratory silos (glass jar 1 kg in volume) and incubated for two months. After incubation, the silos were opened and chemical and physical analyses were done. The dry matter contents of …

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The Effect Of Age On Spermatological Properties In Rainbow Trout (Oncorhynchus Mykiss W., 1792), Necmetti̇n Teki̇n, Selçuk Seçer, Ergun Akçay, Yusuf Bozkurt, Sezer Kayam Jan 2003

The Effect Of Age On Spermatological Properties In Rainbow Trout (Oncorhynchus Mykiss W., 1792), Necmetti̇n Teki̇n, Selçuk Seçer, Ergun Akçay, Yusuf Bozkurt, Sezer Kayam

Turkish Journal of Veterinary & Animal Sciences

At the end of the spawning season, semen was collected without anesthesia by abdominal massage from 37 rainbow trout according to different age groups. In collected semens, color, volume, motility, activity time (duration of motility), concentration, total spermatozoa and pH were recorded. Furthermore, body weight and body length were measured and correlations beetween spermatological properties and these parameters were assessed. In the 1-2 years age group, volume (ml), motility (%), activity time (s), concentration (x 10^9 sp/ml), total spermatozoa (per ejaculate) and pH were 9.7, 81.0, 79.0, 8.97, 87.0 and 7.20 respectively; in the 2-3 years age group, these values …

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