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Articles 721 - 750 of 3580

Full-Text Articles in Pharmacology

Anthraquinones Extracted From Rubia Cordifolia Linn As Potential Ligands To Treat Alzheimer’S Disease, Pottella Srinivasulu, Janga Ramesh Babu, T.N.V. Ganesh Kumar, Padarthi Pavan Kumar, S. Vidyadhara Jan 2021

Anthraquinones Extracted From Rubia Cordifolia Linn As Potential Ligands To Treat Alzheimer’S Disease, Pottella Srinivasulu, Janga Ramesh Babu, T.N.V. Ganesh Kumar, Padarthi Pavan Kumar, S. Vidyadhara

The Thai Journal of Pharmaceutical Sciences

Objective: The present investigation aims to predict the pharmacokinetic aspects and assessing the anti-Alzheimer’s activity using both molecular docking platform and ex vivo pharmacological studies on muscle contraction. Materials and Methods: 2-Methyl Anthraquinone (MAQ) and Quinizarine (QNZ) were isolated from Rubia cordifolia L., and evaluated for absorption, distribution, metabolism, excretion, and toxicity. Molecular docking was performed with the help of Mcule software on five drug targets acetylcholinesterase enzyme (AChE), cyclin-dependent kinase5 (CDK5), glycogen synthase kinase 3β (GSK3β), monoamine oxidase (MAO-B), and β-secretase enzyme (BACE). The pharmacological activity was screened by recording the muscle contractions of chick ileum. Results: The selected …

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Current Perspectives On The Therapeutic Potential Of Mitragyna Speciosa And Its Derivatives On Animal Model, Norsyifa Harun, Illa Syafiqah Johari, Rima Atria Japarin, Farah Wahida Suhaimi, Zurina Hassan, Mohammed Shoaib Jan 2021

Current Perspectives On The Therapeutic Potential Of Mitragyna Speciosa And Its Derivatives On Animal Model, Norsyifa Harun, Illa Syafiqah Johari, Rima Atria Japarin, Farah Wahida Suhaimi, Zurina Hassan, Mohammed Shoaib

The Thai Journal of Pharmaceutical Sciences

The plant Mitragyna speciosa Korth. is receiving increased attention as a therapeutic substitution for opioid use disorder (OUD). The active alkaloids constituents of the plant, particularly mitragynine and 7-hydroxymitragynine, have been shown to modulate opioid receptors, acting as agonists at mu-opioid receptors. Given this pharmacology, several studies have examined the abuse and dependence potential of M. speciosa and its alkaloids in various animal models of dependence. In addition to action on opioid receptors, the Mitragyna alkaloids also appear to exert diverse activities at other receptors in the central nervous system which may explain the complex pharmacological profile of these alkaloids. …

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Evidence For Intravenous Self-Administration Of Mitragynine In Fentanyl-Dependent Rats, Norsyifa Harun, Zurina Hassan, Surash Ramanathan, Mohammed Shoaib Jan 2021

Evidence For Intravenous Self-Administration Of Mitragynine In Fentanyl-Dependent Rats, Norsyifa Harun, Zurina Hassan, Surash Ramanathan, Mohammed Shoaib

The Thai Journal of Pharmaceutical Sciences

Introduction: Kratom (Mitragyna speciosa Korth) is currently used as an alternative for the self-treatment of pain and management of opioid dependence and withdrawal. Due to the opioid-like effect of the plant’s active alkaloid, mitragynine (MG), the evaluation of its ability to maintain self-administration in animal models of opioid dependence appears to be great significance. Objectives: Here, the ability of MG to cross-substitute to the reinforcing effects of the synthetic narcotic fentanyl is investigated. Methods: Rats with implanted catheters were allowed to self-administer fentanyl (2.0 μg/kg/infusion) on a fixed-ratio 1 of schedule of reinforcement. Results: A significant increase in lever pressing …

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Synthesis And Anti-Inflammatory Effects Evaluation Of 1,3 Substituted Isatin Derivatives, Farshid Hassanzadeh, Elham Jafari, Nahal Khayambashi, Valiollah Hajhashemi Jan 2021

Synthesis And Anti-Inflammatory Effects Evaluation Of 1,3 Substituted Isatin Derivatives, Farshid Hassanzadeh, Elham Jafari, Nahal Khayambashi, Valiollah Hajhashemi

The Thai Journal of Pharmaceutical Sciences

Objectives: Inflammation is a pathophysiological response of the body to a variety of agents including infections and physical injury leading to local accumulation of plasma fluid and blood cells. Isatin as a promising heterocyclic molecule has shown interesting biological profile. In this study, some derivatives of isatin containing both Schiff and mannich base fragments were synthesized in a three-step procedure. Methods: Benzohydrazide derivatives were prepared by reaction of benzoat derivatives with hydrazine hydrate. The Schiff bases were formed by treatment isatin with the benzo hydrazide derivatives. The corresponding mannich bases have been synthesized by the reaction of the Schiff bases …

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Present Clinical Trial Regulatory System And Strategies For Improvement In Thailand, Charunee Krisanaphan, Rungpetch Sakulbumrungsil Jan 2021

Present Clinical Trial Regulatory System And Strategies For Improvement In Thailand, Charunee Krisanaphan, Rungpetch Sakulbumrungsil

The Thai Journal of Pharmaceutical Sciences

The study aimed to identify gaps and to develop strategies for improving the clinical trial regulatory system in Thailand. Two-step cross-sectional survey was conducted. The first questionnaire addressed the present situation and the expected system sent by mail. The participants were from the lists of ethics committee (EC) members available online and others obtained from Food and Drug Administration (FDA). The second questionnaire determined the strategies and methods to improve the regulatory system. The participants were the attendees at the Thailand Toward Excellence in Clinical Trials meeting. The first questionnaire with response rate of 26.9% showed that the present situation …

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In Vitro Antioxidants And Anticancer Activity Of Crude Extract Isolates From Euphorbiaceae In Northern Thailand, Siwalee Rattanapunya, Wiriyaporn Sumsakul, Akharasit Bunsongthae, Samart Jaitia Jan 2021

In Vitro Antioxidants And Anticancer Activity Of Crude Extract Isolates From Euphorbiaceae In Northern Thailand, Siwalee Rattanapunya, Wiriyaporn Sumsakul, Akharasit Bunsongthae, Samart Jaitia

The Thai Journal of Pharmaceutical Sciences

The properties of Croton persimilis Müll.Arg. and Antidesma puncticulatum Miq.— interesting plant in the family Euphorbiaceae were investigated. The ethanol crude plant extracts were established for phytochemicals screening, antioxidants activities, anticancer in five important human cancer cell lines (MCF-7, MDA-MB-231, HeLa, HepG2, and NCI-H187), and cytotoxic activity in normal cell line (hTERT-HME1). The leaves extracts of C. persimilis Müll. Arg. contained flavonoids, saponins, terpenoids, and tannins. The total phenolic content properties were found in 43.40 ± 1.36 mg Gallic Acid Equivalents (GAE)/g crude extract. They also showed lowest antioxidant activity through 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay (IC50>1,000 μg/ml) and 2.4.2 …

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Incidence Of Pneumocystis Carinii Pneumonia In Treatment-Naïve Hiv-Infected Adult Patients Receiving Primary Pneumocystis Carinii Pneumonia Chemoprophylaxis With 48-Week Antiretroviral Initiation, Piroon Khamlee, Peerawong Werarak, Chankit Puttilerpong Jan 2021

Incidence Of Pneumocystis Carinii Pneumonia In Treatment-Naïve Hiv-Infected Adult Patients Receiving Primary Pneumocystis Carinii Pneumonia Chemoprophylaxis With 48-Week Antiretroviral Initiation, Piroon Khamlee, Peerawong Werarak, Chankit Puttilerpong

The Thai Journal of Pharmaceutical Sciences

Objective: The objective of the study was to determine the incidence of primary Pneumocystis carinii pneumonia (PCP) between patients who received and did not receive primary PCP chemoprophylaxis and investigate adverse drug reactions (ADRs) related to the chemoprophylaxis use. Method: A retrospective study was conducted in Siriraj Hospital, Thailand. Data were collected from HIV-infected adults, initiated with highly active antiretroviral therapy (HAART) with initial CD4+ <200 cells/mm3. Results: Overall, 217 patients had a median initial CD4+ of 83 cells/mm3 (interquartile range: 33.5–150.5) (range: 0–199), most of the initial HAART regimen was non-nucleoside reverse transcriptase inhibitors based containing tenofovir disoproxil fumarate (94.94%), and 104 patients (47.93%) received chemoprophylaxis. The incidence between patients who received and did not receive prophylaxis found no statistically significant difference (p = 0.133). Only one event was found in a severely immunocompromised patient who did not receive the prophylaxis. The absolute risk reduction of primary PCP incidence, and rate of ADRs was 0.89% (95% confidence interval, −0.84, 2.61) and 10.58% in patients who received the chemoprophylaxis, respectively. Conclusion: The initiation of HAART in HIV-infected patients who had the initial CD4+ cell count <200 cells/mm3 may impact on reducing the risk of developing primary PCP. Aside from the patients who received the prophylaxis, most of the adverse reactions were skin disorders.

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Synthesis, Docking, And Molecular Dynamic Study Of Hydrazones Compounds To Search Potential Inhibitor For Breast Cancer Mcf-7, Jasril, Yuana Nurulita, Nur Afriana, Ihsan Ikhtiarudin, Neni Frimayanti Jan 2021

Synthesis, Docking, And Molecular Dynamic Study Of Hydrazones Compounds To Search Potential Inhibitor For Breast Cancer Mcf-7, Jasril, Yuana Nurulita, Nur Afriana, Ihsan Ikhtiarudin, Neni Frimayanti

The Thai Journal of Pharmaceutical Sciences

Introduction: Hydrazones have been reported for various biological activities, such as anticancer. The presence of the azomethine group (-NHN=CH-) makes these compounds as one of the important classes in many synthetic products. Objective: The aim of this work is to explore the potential of halogenated hydrazones series as breast cancer inhibitors. Methods: In this study, some series of halogenated hydrazones have been synthesized through condensation reaction between halogenated benzaldehydes and phenylhydrazine under microwave irradiation. The structures of the halogenated hydrazoes were confirmed by ultraviolet, fourier-transform infrared, NMR, and gas chromatography-mass spectrometry spectroscopic data. The in silico studies i.e. docking and …

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Analysis Of Hba1c, Medication Compliance, Income Subsidies, And Comorbidity In Medicare Type 2 Diabetics, Robert E. Lazarchik Jan 2021

Analysis Of Hba1c, Medication Compliance, Income Subsidies, And Comorbidity In Medicare Type 2 Diabetics, Robert E. Lazarchik

Walden Dissertations and Doctoral Studies

Diabetes is one of America’s leading chronic diseases with comorbidities contributing to lower health statuses and increased health care costs. While it is known that lowering HbA1c reduces the deleterious effects of diabetes, the capability to identify people with diabetes at risk for uncontrolled HbA1c levels or developing comorbidities based on the compliance rates for different oral antihyperglycemic medication classes (OAMCs) and financial assistance programs does not yet exist. These quantitative longitudinal retrospective studies examined the association between medication compliance, using Proportion of Days Covered (PDC), by OAMC and Medicare financial aid programs, on predicting HbA1c levels and comorbidities in …

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Alpinia Galanga Extract Induces Senescence In Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Cells, Riris Istighfari Jenie, Ragil Anang Santoso, Irfani Aura Salsabila, Nadzifa Nugraheni, Edy Meiyanto Jan 2021

Alpinia Galanga Extract Induces Senescence In Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Cells, Riris Istighfari Jenie, Ragil Anang Santoso, Irfani Aura Salsabila, Nadzifa Nugraheni, Edy Meiyanto

The Thai Journal of Pharmaceutical Sciences

Background: Alpinia galanga L. (galangal) is a widely known spice in Southeast Asia. A previous study indicated that its active compounds might effectively inhibit (human epidermal growth factor receptor 2 [HER2])-overexpressing breast cancer cell proliferation. Objective: Our study aimed to investigate the antiproliferation activity of galangal extract (GE) on HER2- overexpressing breast cancer cells by analyzing GE cytotoxicity and its mechanism of action. Materials and Methods: We used HCC1954 cell line as a model. We observed the effect of GE (10–200 μg/mL) on cell growth using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The modulation of GE on cell cycle, apoptosis, and the intracellular …

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Synthesis, In Silico Analysis And Antidepressant Activity Of Pyrazoline Analogs, Natasha Naval Aggarwal, Banylla Felicity Dkhar Gatphoh, M. Vijay Kumar, Sawan Ghetia, B. C. Revanasiddappa Jan 2021

Synthesis, In Silico Analysis And Antidepressant Activity Of Pyrazoline Analogs, Natasha Naval Aggarwal, Banylla Felicity Dkhar Gatphoh, M. Vijay Kumar, Sawan Ghetia, B. C. Revanasiddappa

The Thai Journal of Pharmaceutical Sciences

Objective: This study is undertaken to design and synthesize new pyrazoline derivatives and to evaluate their antidepressant efficacy by in silico and in vivo studies. Materials and Methods: The title compounds pyrazoline derivatives (PY1-PY9) were yielded by the cyclization of chalcones (C1-C9) with phenylhydrazine HCl in glacial acetic acid. FT-IR, 1H-NMR, and mass spectral data established the structures of the newly synthesized compounds. In silico analysis was carried out using Schrodinger 2018-3 suite device Maestro and docked to the binding site of Human MAO-A enzyme (2Z5X). In vivo antidepressant study was performed by tail suspension method and forced swimming test. …

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Quality By Design (Qbd): Principles, Underlying Concepts, And Regulatory Prospects, B.G.V.S. Jagan, P. Narasimha Murthy, Anjan Kumar Mahapatra, Ruchita Kumari Patra Jan 2021

Quality By Design (Qbd): Principles, Underlying Concepts, And Regulatory Prospects, B.G.V.S. Jagan, P. Narasimha Murthy, Anjan Kumar Mahapatra, Ruchita Kumari Patra

The Thai Journal of Pharmaceutical Sciences

In the past decades, with substantial growth of pharmaceutical companies and the need in enhancement of quality paradigms, adoption of systematic science based technologies was an inherent demand of regulatory agencies and one such technology is quality by design (QbD). The approved interrelated International Council on Harmonization of Technical Requirements for pharmaceuticals for Human Use guidelines, Q8 (pharmaceutical development), Q9 (quality risk management [QRM]), and Q10 (pharmaceutical quality system) drove the path in successful implementation of QbD. The primary focus of this article is made in delivering the underlying concepts that lead in framing of seven vital elements of QbD. …

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Validated Ultra-Performance Chromatographic Method For Simultaneous Determination Of Andrographolide And Its Four Related Diterpenoids In Andrographis Paniculata Capsules, Jankana Burana-Osot, Panadda Phattanawasin, Uthai Sotanaphun, Chanokporn Sukonpan, Lawan Sriphong, Anchalee Kumsum Jan 2021

Validated Ultra-Performance Chromatographic Method For Simultaneous Determination Of Andrographolide And Its Four Related Diterpenoids In Andrographis Paniculata Capsules, Jankana Burana-Osot, Panadda Phattanawasin, Uthai Sotanaphun, Chanokporn Sukonpan, Lawan Sriphong, Anchalee Kumsum

The Thai Journal of Pharmaceutical Sciences

Introduction: Andrographis paniculata contained many pharmacologically active diterpenoids. Objectives: A simple and rapid isocratic reverse phase chromatographic method was developed using UPLC for simultaneous determination of 5 diterpenoids; andrographolide, deoxyandrographiside, neoandrographolide, 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide in A. paniculata capsules. Materials and Methods: The chromatographic separation was achieved on a Waters Acquity BEH C18, 50 × 2.1 mm, 1.7 μm column using mobile phase consisting of acetonitrile and water in a ratio of 25:75 (v/v). The flow rate was 0.4 ml/min with a runtime of 12 min. The method was validated according to the regulatory guidelines with respect to specificity, linearity, precision, …

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Synthesis And Evaluation Of Poly(Ethylene Glycol) Diacrylate-Modified Chitosan As A Mucoadhesive Polymer, Kwanputtha Arunprasert, Chaiyakarn Pornpitchanarong, Nitjawan Sahatsapan, Praneet Opanasopit, Prasopchai Patrojanasophon Jan 2021

Synthesis And Evaluation Of Poly(Ethylene Glycol) Diacrylate-Modified Chitosan As A Mucoadhesive Polymer, Kwanputtha Arunprasert, Chaiyakarn Pornpitchanarong, Nitjawan Sahatsapan, Praneet Opanasopit, Prasopchai Patrojanasophon

The Thai Journal of Pharmaceutical Sciences

This study aimed to synthesize a poly(ethylene glycol) diacrylate-modified chitosan (CS-PEGDA) as a mucoadhesive polymer for transmucosal drug delivery. Chitosan-cysteine (Cys-CS) was synthesized by coupling chemistry. Cys-CS was then employed for the synthesis of CS-PEGDA through a thiol-ene click reaction between the thiol groups of Cys-CS and alkene groups of PEGDA using triethanolamine as an activator. The obtained structure of the synthesized polymer was proved using Fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy. The mucoadhesive capability of the synthesized polymer was examined by an ex vivo mucoadhesion test using a texture analyzer. The toxicity of synthesized …

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Evaluation Of Volatile Constituents Of Fresh And Dried Herbals In Thai Traditional Compress Ball By Headspace Gas Chromatography–Mass Spectrometry Technique, Prasan Tangyuenyongwatana, Napapan Pongpoungphet, Wandee Gritsanapan Jan 2021

Evaluation Of Volatile Constituents Of Fresh And Dried Herbals In Thai Traditional Compress Ball By Headspace Gas Chromatography–Mass Spectrometry Technique, Prasan Tangyuenyongwatana, Napapan Pongpoungphet, Wandee Gritsanapan

The Thai Journal of Pharmaceutical Sciences

Introduction: There are two types of herbal compress balls, fresh and dried, which are normally used in combination with Thai traditional massage for relieving inflammation and pain. There is no comparing information about chemical compositions of these herbal compress balls. Objective: This research focused on analysis of chemical composition of two types of herbal compress balls using headspace (HS) gas chromatography–mass spectrometry (GC–MS) system at a temperature of 80°C. Methods: Each herbal compress sample, Cryptolepis dubia, Cymbopogon citratus, Tamarindus indica, Curcuma longa, Zingiber montanum, and Citrus hystrix, was placed in a HS vial at 80°C for 20 min, agitated at …

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The Study Of Volatile Fractions Of Cabbage Leaves (Brassica Oleracea L. Convar. Capitata (L.) Alef. Var. Alba Dc.) And Determination Of Its Antibacterial And Antifungal Activity, Viktoriia Protska, Andriy Fedosov, Nadiia Burda, Oleksandr Dobrovolnyi, Moeen F. Dababneh, Marina Kuznetsova, Iryna Zhuravel, Liana Budanova Jan 2021

The Study Of Volatile Fractions Of Cabbage Leaves (Brassica Oleracea L. Convar. Capitata (L.) Alef. Var. Alba Dc.) And Determination Of Its Antibacterial And Antifungal Activity, Viktoriia Protska, Andriy Fedosov, Nadiia Burda, Oleksandr Dobrovolnyi, Moeen F. Dababneh, Marina Kuznetsova, Iryna Zhuravel, Liana Budanova

The Thai Journal of Pharmaceutical Sciences

Background: Along with a widespread application of cabbage as a food and fodder crop, it also possesses therapeutic properties. In traditional medicine, this plant is used in gastritis and gastric ulcer, colitis, diabetes, inflammations of upper airways, musculoskeletal system, disorders of cardiovascular system, and skin. Materials and Method: Using the method of gas chromatography, the component composition of cabbage leaves of Yaroslavna and Bilosnizhka cultivars was studied. Testing control strains of microorganisms were used for the determination of the antimicrobial activity of chloroform, ethyl acetate, and 96% ethanol extracts from cabbage cultivars leaves. Result: The general amount of volatile compounds …

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Phytochemistry And Dna˗Based Authentication Of Medicinal Lasianthus Stipularis Blume (Rubiaceae) Species Against Human Pathogenic Bacteria, Tiwtawat Napiroon, Sutee Duangjai, Srunya Vajrodaya, Markus Bacher, Henrik Balslev, Wichai Santimaleeworagun Jan 2021

Phytochemistry And Dna˗Based Authentication Of Medicinal Lasianthus Stipularis Blume (Rubiaceae) Species Against Human Pathogenic Bacteria, Tiwtawat Napiroon, Sutee Duangjai, Srunya Vajrodaya, Markus Bacher, Henrik Balslev, Wichai Santimaleeworagun

The Thai Journal of Pharmaceutical Sciences

Lasianthus stipularis Blume is a medicinal plant found in the tropical rainforests of peninsular Thailand and Malaysia. Its leaves are used in traditional medicine to treat a condition called “noise in the head” (i.e., ear infections). As such infections are often caused by Gram-negative bacteria; this species of Lasianthus may have antibacterial effects. In this study, we examined the non-polar fractions from the leaves and stem bark of L. stipularis using thin-layer chromatography and high-performance liquid chromatography (HPLC). The non-polar fractions exhibited a high coumarin content, while stem bark extracts showed a high concentration of 7-hydroxy-6-methoxycoumarin when isolated by column …

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Cost–Benefit Analysis Of Psychiatric Pharmaceutical Care With Shared Decision-Making Intervention In Complicated Schizophrenic Patients, Charkkrit Hongthong, Nusaraporn Kessomboon Jan 2021

Cost–Benefit Analysis Of Psychiatric Pharmaceutical Care With Shared Decision-Making Intervention In Complicated Schizophrenic Patients, Charkkrit Hongthong, Nusaraporn Kessomboon

The Thai Journal of Pharmaceutical Sciences

Objective: This study aims to evaluate the net benefits of psychiatric pharmaceutical care with shared decision-making (PCC-SDM) intervention in complicated schizophrenic patients for resolving drug-related problems (DRPs). Methods: Eligible inpatients for 3 months. Data were collected using an Integrated Hospital Medication Management with SDM (IHoMe-SDM) following PCC-SDM six steps: (1) data collection, (2) choice and option talk, (3) decision talk, (4) pharmaceutical care plan, (5) patients education, and (6) monitoring. Cost analysis was conducted by activity based costing. Economic evaluation was calculated as cost saving, cost avoidance, and net benefits with the view of health-care provider and reported in USD …

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Effect Of Co2 Laser Irradiation On Eudragit® L100-55, L100, And S100 Coatings To Modify Drug Release, Varin Titapiwatanakun, Wanjing Li, Simon Gaisford, Abdul W. Basit Jan 2021

Effect Of Co2 Laser Irradiation On Eudragit® L100-55, L100, And S100 Coatings To Modify Drug Release, Varin Titapiwatanakun, Wanjing Li, Simon Gaisford, Abdul W. Basit

The Thai Journal of Pharmaceutical Sciences

The aim of this work was to investigate the use of carbon dioxide (CO2) laser irradiation to modify three types of pH-dependent Eudragit® (L100-55, L100, and S100) enteric coats with the aim of modulating drug release kinetics from the tablet cores. CO2 laser irradiation causes rapid melting and resolidification/vaporization of materials locally and precisely through the absorption of infrared energy and so can potentially disrupt the barrier integrity and function of enteric coats. It was successfully utilized to shorten the lag time of drug release (T50% and T80%) during dissolution testing. These changes were mainly caused either by pore formation …

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Determination Of Antioxidant Property Of Commercially Selling Borneo Plants By 2,2′-Azino-Di-(3-Ethylbenzthiazoline- 6-Sulfonic Acid) Free Radical Scavenging Assay, Sheba R. David, Nora Syahirah Sawal, Rajan Rajabalaya Jan 2021

Determination Of Antioxidant Property Of Commercially Selling Borneo Plants By 2,2′-Azino-Di-(3-Ethylbenzthiazoline- 6-Sulfonic Acid) Free Radical Scavenging Assay, Sheba R. David, Nora Syahirah Sawal, Rajan Rajabalaya

The Thai Journal of Pharmaceutical Sciences

Background: Antioxidants from natural products are important to counter the effect of reactive oxygen species occur in chronic diseases and metabolic disorders. Objective: This study evaluated the antioxidant activities of the leaf extracts from three plants found in Brunei: Melastoma malabathricum (MM), Scurrula ferruginea (SF), and Clinacanthus nutans (CN). Methods: The plant leaves were collected from in Brunei Darussalam air-dried and pulverized into powder. The extracts obtained from Soxhlet, fractionation, and maceration were freeze-dried and the total antioxidant status was evaluated using 2,2′-azino-di-(3-ethylbenzthiazoline-6-sulfonic acid) scavenging radical activities in vitro assay. Both MM and SF extracts exhibited promising antioxidant capabilities. Results: …

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Short-Term Antenatal Corticosteroid Increases Risk Of Respiratory Morbidity In Late Preterm Infants, Nithipun Suksumek, Pithi Chanvorachote, Amuchou Soraisham, Abhay Lodha, Albert Akierman, Carlos Fajardo Jan 2021

Short-Term Antenatal Corticosteroid Increases Risk Of Respiratory Morbidity In Late Preterm Infants, Nithipun Suksumek, Pithi Chanvorachote, Amuchou Soraisham, Abhay Lodha, Albert Akierman, Carlos Fajardo

The Thai Journal of Pharmaceutical Sciences

Background/Aim: Although antenatal corticosteroid (ANCS) is beneficial for preventing respiratory distress in preterm infants, the effect of ANCS on late preterm infants (LPI) is still unknown. This study aimed at investigating the effect of ANCS on respiratory morbidity of LPI. Materials and Methods: In matched cohort study, LPI of mothers who received ANCS (ANCS group) at 24–34 weeks of GA were matched with LPI of no ANCS (non-ANCS group) by gestational age and birth weight. Results: During 2 years, the ANCS group was 10.6% (191/1,810) in LPI and only 177 neonates met the criteria for inclusion and were ANCS group. …

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An Updated Review: The Year 2020 And Coronavirus Disease-19 Pandemic, Kanwal Ashiq, Mayyda Asif Bajwa, Sana Ashiq, Mehwish Qayyum, Rabia Khokhar, Samreen Tanveer Jan 2021

An Updated Review: The Year 2020 And Coronavirus Disease-19 Pandemic, Kanwal Ashiq, Mayyda Asif Bajwa, Sana Ashiq, Mehwish Qayyum, Rabia Khokhar, Samreen Tanveer

The Thai Journal of Pharmaceutical Sciences

The recent scenario with an outbreak of novel coronavirus has led to dramatic upsurge in mortality and morbidity rates all around the globe. The objective of consolidated article is to provide an updated insight on coronavirus disease (COVID-19) based on the current literature, and it is anticipated that it may serve as a perspective reference in future studies. Scopus, Science Direct, MEDLINE, PubMed, and Google Scholar databases were used to search the literature. For the current review, both research and review articles issued in the English language were considered. The mode of Corona virus disease transmission is through direct contact …

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Group-Based Quantitative Structure And Activity Relationship On Benzothiazole Derivatives For Development Of Potent Anti-Cancer Compounds, Amit S. Tapkir, Sohan S. Chitlange, Ritesh P. Bhole Jan 2021

Group-Based Quantitative Structure And Activity Relationship On Benzothiazole Derivatives For Development Of Potent Anti-Cancer Compounds, Amit S. Tapkir, Sohan S. Chitlange, Ritesh P. Bhole

The Thai Journal of Pharmaceutical Sciences

To develop potent anticancer compounds using benzothiazole scaffolds group-based quantitative structure and activity relationship (GQSAR) analysis was performed on 41 reported benzothiazole derivatives for identification of structural fragments. Benzothiazole dataset was fragmented into two fragments (R1 and R2). GQSAR models were generated using multiple linear regression. GQSAR analysis revealed the presence of hydrophobic groups on R1 will potentiate anticancer activity. The generated models are giving insight into the benzothiazole structural requirements which will be optimized for design of anticancer drugs.

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Synthesis Of (2-Hydroxyl-3-Butoxyl) Propyl-Succinyl-Chitosan – An Amino Sugar Anionic Surfactant Under Microwave Irradiation And Its Application, P. S. Singh, Suraj N. Mali, N. R. Sangale, Amit P. Pratap Jan 2021

Synthesis Of (2-Hydroxyl-3-Butoxyl) Propyl-Succinyl-Chitosan – An Amino Sugar Anionic Surfactant Under Microwave Irradiation And Its Application, P. S. Singh, Suraj N. Mali, N. R. Sangale, Amit P. Pratap

The Thai Journal of Pharmaceutical Sciences

Introduction: Chitosan, a biopolymer with 97% degree of deacetylation, was used herein, to synthesize an amino sugar anionic surfactant of varied alkyl chain length, using a microwave-assisted synthesis. We were also examined their properties in aqueous form. Objectives: The objectives of the study were to increase the surface activity and water solubility of chitosan derivatives. Materials and Methods: Structural features and crystallinity were confirmed using Fourier transform infrared, ¹H-nuclear magnetic resonance, and X-ray diffraction. The chitosan by itself was found to have weak surface-active properties since it has no hydrophobic segment. Results: The microwave-assisted synthesized sugar amino-based anionic surfactant, synthesis …

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Anti-Inflammatory Activity Of New 1,3,4-Oxadiazole Derivatives, Banylla Felicity Dkhar Gatphoh, Natasha Naval Aggarwal, Hemanth Kumar, B. C. Revanasiddappa Jan 2021

Anti-Inflammatory Activity Of New 1,3,4-Oxadiazole Derivatives, Banylla Felicity Dkhar Gatphoh, Natasha Naval Aggarwal, Hemanth Kumar, B. C. Revanasiddappa

The Thai Journal of Pharmaceutical Sciences

A new series of 1,3,4-oxadiazole derivatives (3a-j) were synthesized by reacting p-toluic benzhydrazide (1) and substituted aromatic aldehydes (2) in the presence of ceric ammonium nitrate as catalyst and dichloromethane as a solvent medium. The structures of the new compounds were assigned based on IR, 1H-NMR, and mass spectral data and further evaluated for their in vitro anti-inflammatory potential using various protein denaturation methods following bovine serum and egg albumin assay. Some tested compounds 3e, 3f, and 3i displayed moderate anti-inflammatory activity compared to the standard diclofenac sodium.

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Evaluation Of Modified Pennisetum Glaucum Starch As A Suspending Agent In Metronidazole Benzoate Suspension, Nkemakolam Nwachukwu, Kenneth Chinedu Ugoeze, Dorathy Rokalke Igoni Jan 2021

Evaluation Of Modified Pennisetum Glaucum Starch As A Suspending Agent In Metronidazole Benzoate Suspension, Nkemakolam Nwachukwu, Kenneth Chinedu Ugoeze, Dorathy Rokalke Igoni

The Thai Journal of Pharmaceutical Sciences

The properties of modified starch derived from Pennisetum glaucum (PT) seed as a suspending agent in metronidazole benzoate suspension was evaluated. Matured PT seeds were steeped for 72h, wet milled and the slurry washed with water through a muslin cloth to obtain native PT starch (NPS) which was dried at 60°C. NPS slurry was heated (70°C), cooled (40°C), and submerged in 3.5%w/v sodium hypochlorite for 10 min, washed with 95%v/v alcohol till neutral to litmus. The modified starch (MPS) was dried (50°C), classified (180μm). NPS and MPS were characterized using standard methods. Metronidazole benzoate (MTBZ) suspensions were formulated using 2.5%w/v, …

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Evaluation Of Psychometric Properties Of The Thai Sf-12v2 In The General Thai Population, Krittaphas Kangwanrattanakul Jan 2021

Evaluation Of Psychometric Properties Of The Thai Sf-12v2 In The General Thai Population, Krittaphas Kangwanrattanakul

The Thai Journal of Pharmaceutical Sciences

Background: This study investigated the psychometric properties of the Thai Short Form-12 Health Survey (SF-12v2) and reported SF-12v2 scale scores based on the general Thai population’s age and gender. Methods: Multistage sampling was used to recruit 1200 general Thai participants. For all SF-12v2 scales, item description, ceiling/floor effects, convergent validity for item-scale and SF-12v2 and EQ-5D correlations, known-group validity, exploratory factor analysis (EFA), test-retest reliability, and responsiveness were studied. Results: Ceiling effect was observed for all scales (5.8–72.6%). Floor effect was detected for all scales except for social functioning, role emotion, and mental health. Item-scale correlation coefficients ranged from 0.65 …

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Effect Ethyl Acetate Extract Oflasiodiplodia Pseudotheobromae Industrial Biotechnology Research Laboratory Os-64 On Growth And Cell Morphology Of A Foodborne Bacterium,Bacillus Cereus, Mohd Taufiq Mat Jalil, Darah Ibrahim Jan 2021

Effect Ethyl Acetate Extract Oflasiodiplodia Pseudotheobromae Industrial Biotechnology Research Laboratory Os-64 On Growth And Cell Morphology Of A Foodborne Bacterium,Bacillus Cereus, Mohd Taufiq Mat Jalil, Darah Ibrahim

The Thai Journal of Pharmaceutical Sciences

Background: A foodborne bacterium, Bacillus cereus is one of the common food contaminants that could cause food poising with several sickness symptoms to humans. Objective: This study was undertaken to evaluate the effect of ethyl acetate extract of endophytic fungus, Lasiodiplodia pseudotheobromae Industrial Biotechnology Research Laboratory (IBRL) OS-64 towards a test bacterium, B. cereus with emphasis on bacterial growth reduction and cell morphological changes. Materials and Methods: The ethyl acetate (fermentative broth) and methanolic (fungal biomass) extracts were screened for their antibacterial activity against test bacteria via agar disc diffusion assay. Results: The results demonstrated that there is a significant …

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Inhibitory Effects Of Manosa Alliacea In Freund’S Adjuvant Arthritis On Inflammatory Markers And Its Confirmation By In-Silico Strategy, D. S.N.B.K. Prasanth, Sk. Aminabee, A. Lakshmana Rao, Chakravarthi Guntupalli, Alavala Rajasekhar Reddy, Umasankar Kulandaivelu, S. N. Koteswara, P. Rajeshwari Jan 2021

Inhibitory Effects Of Manosa Alliacea In Freund’S Adjuvant Arthritis On Inflammatory Markers And Its Confirmation By In-Silico Strategy, D. S.N.B.K. Prasanth, Sk. Aminabee, A. Lakshmana Rao, Chakravarthi Guntupalli, Alavala Rajasekhar Reddy, Umasankar Kulandaivelu, S. N. Koteswara, P. Rajeshwari

The Thai Journal of Pharmaceutical Sciences

For the assessment of the curative effect of Manosa alliacea on Freud’s adjuvant (FA) arthritis on Swiss albino rats. Methanol extract from M. alliacea (MEMA) was administered orally at 200 mg/kg and 400 mg/kg, 28 days after FA immunization. For control and treatment groups, paw volume, body weight, hematological parameters, X-ray, and histological tests were measured. In addition, reverse transcription-polymerase chain reaction (RT-PCR) was used to measure the levels of various inflammatory markers. In vitro, DPPH and H2O2 tests were used to evaluate the antioxidant capability. MEMA decreased paw volume and paw thickness, bodyweight considerably (P < 0.05, 0.01, 0.001), compared to hematological anomalies of arthritis control. X- rays tests and histological tests did not reveal significant structural changes in the rat ankle joints administered with MEMA. The levels of expression tumor necrosis factor - α, NF-Kβ, IL-1β, and COX-2 were significantly suppressed in the treatment groups. The in-silico study has shown that a number of chemical components in the plants under study can effectively bind to various inflammatory targets. That is why we say M. alliacea is a good source for treating rheumatoid arthritis.

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Assessment Of The Phytoconstituents And Optimal Applicable Concentration Of Aqueous Extract Of Azadirachta Indica Leaves For Wound Healing In Male Wistar Rats, Kenneth Chinedu Ugoeze, Princewill Chukwuebuka Aja, Nkemakolam Nwachukwu, Bruno Chukwuemeka Chinko, Jude Nnabuife Egwurugwu Jan 2021

Assessment Of The Phytoconstituents And Optimal Applicable Concentration Of Aqueous Extract Of Azadirachta Indica Leaves For Wound Healing In Male Wistar Rats, Kenneth Chinedu Ugoeze, Princewill Chukwuebuka Aja, Nkemakolam Nwachukwu, Bruno Chukwuemeka Chinko, Jude Nnabuife Egwurugwu

The Thai Journal of Pharmaceutical Sciences

Background/Aim: Plant-based medicinal agents containing phytoconstituents like extracts of Azadirachta indica leaves has been reported to heal wounds. This study evaluated the phytoconstituents and determined the optimal concentration of the aqueous extract of Azadirachta indica leaves (AEAIL) affecting wound healing in male Wistar rats. Materials and Methods: AEAIL was evaluated for phytoconstituents using GC-FID. Wounds (diameter ≈1.5cm) was excised on the dorsum of 35 rats (7 groups, n = 5). Groups 1- 6 were treated topically with 0.5, 1.5, 3.0, 5.0, 10.0 and 20.0% w/v of AEAIL respectively. Group 7 was treated with distilled water as the control. Wound contractions …

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