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Articles 571 - 600 of 3580

Full-Text Articles in Pharmacology

A Review On Ethnomedicinal And Phytopharmacological Potential Of Traditionally Wild And Endemic Plant Berberis Tinctoria Lesch., Arumugam Vignesh, Ramamoorthy Sivalingam, Subramaniam Selvakumar, Krishnan Vasanth Jan 2022

A Review On Ethnomedicinal And Phytopharmacological Potential Of Traditionally Wild And Endemic Plant Berberis Tinctoria Lesch., Arumugam Vignesh, Ramamoorthy Sivalingam, Subramaniam Selvakumar, Krishnan Vasanth

The Thai Journal of Pharmaceutical Sciences

Introduction: Berberis tinctoria an evergreen shrub, endemic and predominantly found at a higher altitude of the Nilgiri Biosphere Reserve, India. This leaf and fruit are edible, which are also used in homeopathic remedies for countless illnesses. Objectives: B. tinctoria with diverse ethnomedicinal uses was focused in the prevailing study to detailed the phytochemical and pharmacological properties for further imminent research in this species. Materials and methods: Published data in this review were all gathered from the online bibliographical databases: PubMed, Elsevier, Scopus, Google Scholar, Web of Science, and local ethnic community peoples of Kurumba and Toda. Results: B. tinctoria was …

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Gastroprotective Effect Of Phyllanthus Reticulatus Poir. Against Pylorus Ligation-, Ethanol-Induced, And Stress-Induced Ulcer Models In Wistar Rats, Saravanan Jayaram, G. Thamotharan, N. Senthilkumar Jan 2022

Gastroprotective Effect Of Phyllanthus Reticulatus Poir. Against Pylorus Ligation-, Ethanol-Induced, And Stress-Induced Ulcer Models In Wistar Rats, Saravanan Jayaram, G. Thamotharan, N. Senthilkumar

The Thai Journal of Pharmaceutical Sciences

Objective: The objective of the present study is to evaluate the antiulcer property of ethanolic extract of Phyllanthus reticulatus Poir. against pylorus ligation-, ethanol-induced, and stress-induced ulcer models in Wistar albino rats. Materials and Methods: Three models – pylorus ligation-induced ulcer, ethanol-induced ulcer, and swim stress-induced ulcer – were used to induce ulcer in Wistar rats. The animals were treated with 200 mg/kg and 400 mg/kg p. o of the ethanolic extract of P. reticulatus Poir, to estimate the gastroprotective potential. The effect of P. reticulatus Poir. on pH of the gastric juice, volume of acid secretion, total and free …

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Synthesis And Cytotoxic Activity Of N-(2,4-Dichloro)Benzoyl-N’-Phenylthiourea Against Human Breast Cancer Cell Line, Dini Kesuma, Anwar Medika, Tegar Achsendo Yuniarta Jan 2022

Synthesis And Cytotoxic Activity Of N-(2,4-Dichloro)Benzoyl-N’-Phenylthiourea Against Human Breast Cancer Cell Line, Dini Kesuma, Anwar Medika, Tegar Achsendo Yuniarta

The Thai Journal of Pharmaceutical Sciences

Introduction: Urea- and thiourea-based compound has shown a potency to be further developed as anticancer compound. Objective: Another novel phenylthiourea analog (N-(2,4-dichloro)benzoyl-N’-phenylthiourea) was synthesized through Schotten-Baumann reaction followed by the assessment of its cytotoxic activity. Methods: N-(2,4-dichloro)benzoyl-N’-phenylthiourea was synthesized using N-Phenylthiourea and 2,4-dichlorobenzoyl chloride as starting materials. The reaction started at low temperature for 30 min followed by reflux for 8 h to yield target compound. Cytotoxicity assay was then performed against MCF-7, T47D, and Vero normal cell line. Results: The compound has been synthesized and its structure has been verified using infrared, 1H-nuclear magnetic resonance (NMR), 13C-NMR, various 2D …

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Job Scheduling For Stability Testing Of Pharmaceutical Products Using Mathematical Model, Kantanat Pridaphatrakun, Nuchanad Bunkerd, Netnawee Umin, Narueporn Sutanthavibul, Wipawee Tharmmaphornphilas, Phanphen Wattanaarsakit Jan 2022

Job Scheduling For Stability Testing Of Pharmaceutical Products Using Mathematical Model, Kantanat Pridaphatrakun, Nuchanad Bunkerd, Netnawee Umin, Narueporn Sutanthavibul, Wipawee Tharmmaphornphilas, Phanphen Wattanaarsakit

The Thai Journal of Pharmaceutical Sciences

The pharmaceutical industry plays an important role in the nation’s economy and society since pharmaceutical products are one of the factors that affect people’s lives and their health. At present, the domestic pharmaceutical industry is developing and adapting to meet the needs of customers and is also very competitive. Therefore, each stage of the production process must be as efficient as possible to achieve competitive advantages without compromising the product quality. One important process in production is pharmaceutical product stability testing, which ensures that the products have the necessary quality, efficacy, and safety. Managing time in a way that maximizes …

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Review On Drug Delivery Applications Of Ethosomes: Current Developments And Prospects, Mayuri Shitole, Sopan Nangare, Udaykumar Patil, Namdeo R. Jadhav Jan 2022

Review On Drug Delivery Applications Of Ethosomes: Current Developments And Prospects, Mayuri Shitole, Sopan Nangare, Udaykumar Patil, Namdeo R. Jadhav

The Thai Journal of Pharmaceutical Sciences

Transdermal drug delivery system networks are primarily affected by poor penetration of therapeutically active compounds. The stratum corneum (SC) is the foremost barrier of the skin, which restricts the permeation of the drug molecule. In this context, to date, numerous approaches have been implemented to overcome the SC barrier limitations. Out of this, few advanced approaches including liposomes, niosomes, ethosomes, and transferosomes are majorly used to boost the permeation of drug and cosmetic agents across the SC barrier. Among these vesicles, ethosomes are stand out as the best substitute for topical drug delivery. In a nutshell, ethosomes are the elastic …

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Amelioration Of Cadmium Chloride Testicular Toxicity By Plukenetia Conophora Aqueous Leaves Extract In Wistar Rats, Tomilola Olaolu, Tamaratare Ogu, Damilare Rotimi, Charles Nwonuma, Oluwakemi Awakan, Ayotunde Olaolu, Akpor Oghenerobor Jan 2022

Amelioration Of Cadmium Chloride Testicular Toxicity By Plukenetia Conophora Aqueous Leaves Extract In Wistar Rats, Tomilola Olaolu, Tamaratare Ogu, Damilare Rotimi, Charles Nwonuma, Oluwakemi Awakan, Ayotunde Olaolu, Akpor Oghenerobor

The Thai Journal of Pharmaceutical Sciences

Cadmium accumulates in different organ and tissues of the body including the testes, impeding normal metabolism. This study aimed at evaluating the effect of Plukenetia conophora leaves extract on antioxidants and testicular function indices of cadmium chloride (CdCl2)-administered Wistar rats. A total of 25 Wistar rats (100–120 g) were randomly divided into 5 groups (A-E) and received orally, once daily for 21 d as follows: A (distilled water); B (6.5 mg/kg body weight of CdCl2; C (CdCl2 + 150 mg/kg body weight of extract); D (CdCl2 + 300 mg/kg body weight extract); and E (CdCl2 + 600 mg/kg body weight …

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Analytical Method For Simultaneous Estimation Of Ranolazine And Metformin Hydrochloride By Validated Rp-Hplc-Dad Method, Ashok B. Patel, Dhruvanshi A. Gol, Rahul L. Makwana, Amitkumar J. Vyas, Ajay I. Patel, Nilesh K. Patel, Shital D. Faldu, Arvind N. Lumbhani Jan 2022

Analytical Method For Simultaneous Estimation Of Ranolazine And Metformin Hydrochloride By Validated Rp-Hplc-Dad Method, Ashok B. Patel, Dhruvanshi A. Gol, Rahul L. Makwana, Amitkumar J. Vyas, Ajay I. Patel, Nilesh K. Patel, Shital D. Faldu, Arvind N. Lumbhani

The Thai Journal of Pharmaceutical Sciences

Background: In the present study, a simple, sensitive, rapid, accurate, and precise reverse-phase high-performance liquid chromatography (RP-HPLC) method with diode array detection was developed and validated for simultaneous estimation of Metformin hydrochloride (MET) and Ranolazine (RANO) in a synthetic mixture. Material and Method: The method was developed using isocratic elution mode on a reversed-phase. Chromatographic separation was performed on ACE CN C18 (250 mm, 4.5 mm, 5 μm) column and a mobile phase consisting of methanol: acetonitrile:ammonium formate (45:45:10% v/v/v) with 10% formic acid to adjust the pH to 6.0, at a flow rate of 1.0 ml/min. Detection and quantification …

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Preparation And Characterization Of Curcumin-Loaded Liposomes For Delivery To The Lungs, Safura Binti Mohd Mohari, Kevin M. G. Taylor, Nattika Nimmano Jan 2022

Preparation And Characterization Of Curcumin-Loaded Liposomes For Delivery To The Lungs, Safura Binti Mohd Mohari, Kevin M. G. Taylor, Nattika Nimmano

The Thai Journal of Pharmaceutical Sciences

Curcumin-loaded liposomes comprising dipalmitoylphosphatidylcholine, cholesterol, and dioleoylphosphatidylethanolamine (72:8:20 mole ratio) were prepared by the thin-film hydration method, followed by probe sonication to achieve a mean diameter (FSI) pre-cooled at 2–8°C for at least 90 min at 15 L/min. Curcumin recovered from the impactor and nebulizer was quantified using a validated high-performance liquid chromatography method. Overall, 2.5% w/w curcumin-loaded liposomes was the optimal formulation based on the maximum encapsulation efficiency of approximately 87% and mean hydrodynamic diameter of 97 nm. This chosen curcumin concentration was effectively aerosolized with a fine particle fraction of 53.25%, and a fine particle dose of 53 …

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Phytochemical Screening And Potential Anticonvulsant Activity Of Aqueous Root Extract Of Decalepis Nervosa Wight & Arn., Kuntal Das, M. Saifulla Khan, A. Muthukumar, Sayani Bhattacharyya, M. Usha, S. Venkatesh, James Sounder Jan 2022

Phytochemical Screening And Potential Anticonvulsant Activity Of Aqueous Root Extract Of Decalepis Nervosa Wight & Arn., Kuntal Das, M. Saifulla Khan, A. Muthukumar, Sayani Bhattacharyya, M. Usha, S. Venkatesh, James Sounder

The Thai Journal of Pharmaceutical Sciences

The effect of phytochemicals in the aqueous root extracts of Decalepis nervosa Wight & Arn. (ARDN) (Family: Apocynaceae) was investigated on an anticonvulsant action in laboratory animals (mice). The DN roots were extracted using microwave extraction method with aqueous solvent using two parameters, such as temperature variation and extraction time. The phytochemical screening followed by thin-layer chromatography (TLC) and high-performance thin-layer chromatography (HPTLC) studies was performed. The pentylenetetrazole and isoniazid models were used with two doses, 250 mg and 500 mg, for the anticonvulsant effects of the ARDN extract. The microwave extraction during 15 min at 60°C temperature revealed the …

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Development Of A Notification System For Intravenous-To-Oral Antibiotic Switch Therapy In Pediatric Wards Using Value Stream Mapping, Nissara Srisura, Nusaraporn Kessomboon, Ancharee Leechaipichikul, Thawatchai Khummuang Jan 2022

Development Of A Notification System For Intravenous-To-Oral Antibiotic Switch Therapy In Pediatric Wards Using Value Stream Mapping, Nissara Srisura, Nusaraporn Kessomboon, Ancharee Leechaipichikul, Thawatchai Khummuang

The Thai Journal of Pharmaceutical Sciences

Objective: This research developed a notification intravenous-to-oral antibiotic switch therapy system using value stream mapping (VSM) through the Plan-Do-Study-Act (PDSA) method. Materials and Methods: The action research took place in two target groups: Group 1 included a multidisciplinary team and Group 2 included pneumonia patients admitted to two pediatric wards. The system had two phases: In Phase I, Situation analysis reviewed 400 medical records and In Phase II, a system was developed that used PDSA as follows: Plan: analysis of the methods. Do: The demonstrated process used VSM. Study: A system designed. Act: Comparing each step used VSM. The system …

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Antibacterial Activity Of Ethanol Extract Of Asam Gelugur (Garcinia Atroviridis) Fruits From Southern Thailand, Atchara Niyomdecha, Chaiyawan Wattanachant, Jessada Rattanawut, Patimaporn Plodpai, Wanwisa Ngampongsai Jan 2022

Antibacterial Activity Of Ethanol Extract Of Asam Gelugur (Garcinia Atroviridis) Fruits From Southern Thailand, Atchara Niyomdecha, Chaiyawan Wattanachant, Jessada Rattanawut, Patimaporn Plodpai, Wanwisa Ngampongsai

The Thai Journal of Pharmaceutical Sciences

Objective: The present study investigated the antibacterial activities of asam gelugur (Garcinia atroviridis) fruit extracts against two Gram-negative bacterial strains (Escherichia coli (gi: CP033762.1) and Salmonella enterica (gi: KX355299.1)). Materials and Methods: The powder form of G. atroviridis fresh fruit was extracted with 95% ethanol (2:4 L) (w/v). The mixtures were filtered and evaporated using a rotary evaporator at 50–55°C. High-performance liquid chromatography (HPLC) was used to measure hydroxycitric acid (HCA) in the extract. The antibacterial assay was determined by disk diffusion method, the minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). Results: HPLC analysis measured approximately 495.01 ± …

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Mechanisms And Treatment Of Pain-Depressed Behavior In Male And Female Mice, Clare M. Diester Jan 2022

Mechanisms And Treatment Of Pain-Depressed Behavior In Male And Female Mice, Clare M. Diester

Theses and Dissertations

One of the largest discrepancies between preclinical and clinical assessment of pain and analgesia is the type of behavioral endpoint used. Although most preclinical research has historically focused on drug effectiveness to block reflexive withdrawal behaviors stimulated by a noxious stimulus, increasing evidence shows that drug-induced restoration of pain-depressed behaviors provides increased clinical translation with decreased susceptibility to false-positives. Accordingly, the first portion of this dissertation designed a behavioral battery that featured pain-depressed behaviors as well as more conventional pain-stimulated behaviors for testing candidate analgesics in male and female mice. The main findings are as follows. (1) Intraperitoneal injection of …

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Modulating Ketamine’S Locomotor Activating And Reinforcing Effects Through Drug Combinations, Tegshjargal Baasansukh Jan 2022

Modulating Ketamine’S Locomotor Activating And Reinforcing Effects Through Drug Combinations, Tegshjargal Baasansukh

Theses and Dissertations

Major Depressive Disorder (MDD) affects approximately 280 million people worldwide. The standard of care for pharmacological treatment of MDD has been monoaminergic antidepressants (MAA). However, MAAs have serious clinical limitations including a relatively slow onset of action and up to 40% of patients failing to respond and being diagnosed as “treatment resistant”. Ketamine, an N-methyl-D-aspartate antagonist, was originally approved for use as an injectable anesthetic. In addition, ketamine has been shown to rapidly improve depressive symptoms in patients with treatment resistant depression. In 2019, (S)-ketamine was approved as a nasal spray (Spravato®) for patients with MDD and treatment-resistant depression in …

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Behavioral Screening And Chiral Bioanalysis Of Emerging Stimulant-Type Drugs In Rats, Tyson R. Baird Jan 2022

Behavioral Screening And Chiral Bioanalysis Of Emerging Stimulant-Type Drugs In Rats, Tyson R. Baird

Theses and Dissertations

The epidemic of drug use in the United States and elsewhere in the world has resulted in tragic loss of life and substantial economic costs. Novel psychoactive substances (NPS) are one of the contributors to this problem, and the lack of information about many of these drugs compounds their risk. This dissertation proposes a strategy to use intracranial self-stimulation (ICSS) as a behavioral screening tool to assess emerging drugs of abuse for their abuse potential in order to generate a proactive threat assessment. A series of stimulant-type drugs including methcathinone, α-pyrrolidinohexanophenone (α-PHP), cocaine, and the phenyltropane analogs of cocaine WIN35428 …

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Exploiting Modulation Of The Blood-Brain And Blood-Tumor Barrier Permeability By Translational Focused Ultrasound For Therapeutic Delivery To Cns Metastases, Tasneem A. Arsiwala Jan 2022

Exploiting Modulation Of The Blood-Brain And Blood-Tumor Barrier Permeability By Translational Focused Ultrasound For Therapeutic Delivery To Cns Metastases, Tasneem A. Arsiwala

Graduate Theses, Dissertations, and Problem Reports (ETD)

Transcranial low-intensity focused ultrasound is a unique technology to modulate the integrity of tight endothelial junctions and transiently increase BBB/BTB permeability to enhance therapeutic delivery. Despite promising early studies, present literature lacks agreement on key experimental conditions, which restricts our knowledge and the technique's widespread translation. This dissertation first provides a critical review of the current gaps in knowledge regarding the universal use of LiFUS in preclinical and clinical use. We then identify key parameters for translational and predictable opening of the BBB using a 3T MRI coupled with a clinical device. Our investigation highlights that passive permeability of the …

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The Effect Of Acute And Chronic Arsenic Exposure On Malignant Transformation Of The Human Bronchial Epithelial Cell (Beas-2b), Bandar Almutairy Jan 2022

The Effect Of Acute And Chronic Arsenic Exposure On Malignant Transformation Of The Human Bronchial Epithelial Cell (Beas-2b), Bandar Almutairy

Wayne State University Dissertations

Arsenic (As3+), a metalloid abundant in the environment, is classified as a group I carcinogen associated with several common human cancers, including cancers in the lung, skin, bladder, liver, and prostate (Wei, Zhang & Tao, 2019b). The mechanisms of As3+-induced carcinogenesis had been extensively studied, and different mechanisms might be involved in various types of cancer (Wei, Zhang & Tao, 2019b). Recent studies showed that exposure to a high dose of arsenic is able to induce lung cancer. Moreover, arsenic activates oncogenic signaling pathways such as MAPKs, EGFR/RAS/RAF, PI3K/AKT, and JNK/STAT3 pathways as well as epigenetic alterations such as miRNAs …

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The Benefits Of Astaxanthin To Improve Pain Relief In Patients With Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial, Rizaldy Taslim Pinzon, Mary Rose Angelina Budi Harsana Dec 2021

The Benefits Of Astaxanthin To Improve Pain Relief In Patients With Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial, Rizaldy Taslim Pinzon, Mary Rose Angelina Budi Harsana

Pharmaceutical Sciences and Research

Treatment of diabetic neuropathy is still carried out by providing symptomatic therapy, which only improves ± 50% of the total symptoms felt by patients, but does not tackle the underlying causes of the disease. Astaxanthin is a potent antioxidant, anti-inflammatory, and anti-diabetic carotenoid that could be an additional treatment option. We aimed to measure the effectiveness of administering astaxanthin as an additional therapy to improve the impact of pain and discomfort experienced daily by diabetes mellitus patients with painful diabetic neuropathy. We conducted a randomized experimental study with an open label design of 36 patients who had been diagnosed with …

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Heavy Metal Contamination And Potential Ecological Risks In Surface Sediments Along Dar Es Salaam Harbour Channel, Benard Mwakisunga, Harishchandra B. Pratap, John F. Machiwa, Flora Stephano Dec 2021

Heavy Metal Contamination And Potential Ecological Risks In Surface Sediments Along Dar Es Salaam Harbour Channel, Benard Mwakisunga, Harishchandra B. Pratap, John F. Machiwa, Flora Stephano

Tanzania Journal of Science

Investigation of heavy metal contamination along Dar es Salaam harbour channel was carried out in order to determine their current concentrations, sources and potential ecological risks to benthic biota. Sampling was carried out from January to May 2019 and samples analysed using ICP-OES and C-H-N-S analyser. Analysis of heavy metal relationships showed that, Cu, Zn, Cr, As, Ni, Co, Fe, Cd had strong relationships with each other, while Pb only related to Zn. Principal component analysis partitioned metals into two groups; PC1: Ni, Cr, Fe, Co, As, Cu, Cd, and Zn explaining 73.6% variance and PC2: Pb, Zn, and Cd …

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“Data Architecture For Pharmaceutical Product Development At Alkermes”, Peter Couture, Damon Warnock, Marcus O'Mahony Dec 2021

“Data Architecture For Pharmaceutical Product Development At Alkermes”, Peter Couture, Damon Warnock, Marcus O'Mahony

Level 3

This paper describes how Alkermes built a data architecture for efficient management of non-GXP and R&D data. Using a ‘Create’, ‘Store’, Describe’ ‘Access’ stepwise model, the ingredients to making the journey a success are described.

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Acknowledgment Of Reviewers Dec 2021

Acknowledgment Of Reviewers

Journal of Food and Drug Analysis

No abstract provided.

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Molecular Cartography Of Residue Pesticides On Grape Surface In 3d By Ambient Ionization Tandem Mass Spectrometry, Hung Su, Tiao-Lai Huang, Cheng-Ting Chi, Yi-Tzu Cho, Chi-Wei Lee, Jingyueh Jeng, Jentaie Shiea Dec 2021

Molecular Cartography Of Residue Pesticides On Grape Surface In 3d By Ambient Ionization Tandem Mass Spectrometry, Hung Su, Tiao-Lai Huang, Cheng-Ting Chi, Yi-Tzu Cho, Chi-Wei Lee, Jingyueh Jeng, Jentaie Shiea

Journal of Food and Drug Analysis

Thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) was used to characterize the residual pesticides that were collected from the surface of a grape with metallic sampling probes. Fungicides, insecticides, and miticides were detected, where results were validated by simple solvent extraction followed by gas chromatography tandem mass spectrometry and liquid chromatography tandem mass spectrometry analyses. To explore the distribution of pesticide residues on grape surfaces, 149 locations of a grape surface were collected and followed by TD-ESI/MS/MS analysis. The molecular cartography was then generated from analysis of residual pesticides on the grape surface in 3D.

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Variations In Bovine Milk Oligosaccharides After Calving Using P-Aminobenzoic Ethyl Ester Closed-Ring Labeling And Negative Ion Electrospray Lc/Ms/Ms, Han-Ju Chien, Yi-Chun Ma, Yi-Feng Zheng, Cheng-Yu Kuo, Wei-Chen Wang, Guor-Rong Her, Chien-Chen Lai Dec 2021

Variations In Bovine Milk Oligosaccharides After Calving Using P-Aminobenzoic Ethyl Ester Closed-Ring Labeling And Negative Ion Electrospray Lc/Ms/Ms, Han-Ju Chien, Yi-Chun Ma, Yi-Feng Zheng, Cheng-Yu Kuo, Wei-Chen Wang, Guor-Rong Her, Chien-Chen Lai

Journal of Food and Drug Analysis

A strategy was proposed to analyze bovine milk oligosaccharides using p-aminobenzoic ethyl ester (ABEE) closed-ring labeling and C18 capillary liquid chromatography negative ion electrospray tandem mass spectrometry. Linkage specific fragment ions were used to identify oligosaccharide isomers. By constructing the mass chromatograms using linkage specific fragment ions, isomers were differentiated based on m/z values as well as temporal separation provided by liquid chromatography. In addition to disialyllactose and the single isomer lacto-N-neohexaose, four pairs of linkage isomers including 3’/6’-sialyllactose (3’/6’-SL), 3’/6’-sialyllactosamine (3’/6’-SLN), 3’/6’-sialylgalactosyl-lactose (3’/6’-SGL), and lacto-N-tetraose/lacto-N-neotetraose (LNT/LNnT) in bovine milk were investigated. Variations of bovine milk oligosaccharides in a …

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Analysis Of Heterocyclic Aromatic Amines Using Selective Extraction By Magnetic Molecularly Imprinted Polymers Coupled With Liquid Chromatography – Mass Spectrometry, Shih-Ci Jhu, Jing-Ying Wang, Hsueh-Ting Wang, Sung-Fang Chen Dec 2021

Analysis Of Heterocyclic Aromatic Amines Using Selective Extraction By Magnetic Molecularly Imprinted Polymers Coupled With Liquid Chromatography – Mass Spectrometry, Shih-Ci Jhu, Jing-Ying Wang, Hsueh-Ting Wang, Sung-Fang Chen

Journal of Food and Drug Analysis

Heterocyclic aromatic amines (HCAs) are highly carcinogenic and mutagenic chemicals. This study reports on the development of magnetic molecularly imprinted polymers (MMIPs) for the purification and quantification of HCAs. A novel magnetic molecularly imprinted polymer was successfully prepared using a surface molecular imprinting method using functionalized Fe particles as the magnetic cores. 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) was used as a molecular template; methacrylic acid (MAA), ethylene glycol dimethyl acrylate (EGDMA), 2, 2′-Azobis (2-methylpropionitrile) were used as the functional monomer, crosslinker, and initiator, respectively. The use of the template/functional monomer/crosslinking agent at a ratio of 1:4:20 resulted in a product with better adsorption …

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The Impact Of The Rare Disease And Orphan Drug Act In Taiwan, Ning-Chun Hsiang, Weng-Foung Huang, Churn-Shiouh Gau, Teng-Wen Tsai, Lin-Chau Chang Dec 2021

The Impact Of The Rare Disease And Orphan Drug Act In Taiwan, Ning-Chun Hsiang, Weng-Foung Huang, Churn-Shiouh Gau, Teng-Wen Tsai, Lin-Chau Chang

Journal of Food and Drug Analysis

The Rare Disease and Orphan Drug Act (the Act) was enacted in 2000 in Taiwan for the facilitation of the research, development, and accessibility of orphan drugs and special nutritional foods; for the prevention and early diagnosis of rare diseases; and for providing intensive care for patients with rare diseases. The aim was to investigate the impact of the Act on the availability and use of orphan drugs in Taiwan in the hope of identifying the remaining challenges and possible solutions to assist future policy making, which may be applicable in other countries as well. The information and statistics for …

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Determination Of Quetiapine And Its Metabolites In Plasma By Field-Enhanced Sample Stacking, Tai-Ling Liu, Li-Shan Fang, Jing-Ru Liou, Jia-Shan Dai, Yen-Ling Chen Dec 2021

Determination Of Quetiapine And Its Metabolites In Plasma By Field-Enhanced Sample Stacking, Tai-Ling Liu, Li-Shan Fang, Jing-Ru Liou, Jia-Shan Dai, Yen-Ling Chen

Journal of Food and Drug Analysis

Quetiapine is an atypical antipsychotic drug that can be used to treat mental disorders, including schizophrenia, bipolar disorder and Alzheimer's disease. Quetiapine is mainly converted into the active metabolites of norquetiapine and 7-hydroxyquetiapine by the liver enzymes CYP3A4 and CYP2D6. In this study, liquid-liquid extraction (LLE) was used as a sample pretreatment method to eliminate interferences in plasma. tert-Butyl methyl ether was chosen as the extraction solvent. Field-enhanced sample injection (FESS), an online preconcentration technique, was used to analyze quetiapine and its metabolites norquetiapine and 7-hydroxyquetiapine in plasma. The optimal separation condition was 120 mM phosphate (pH 4.0) containing …

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Quantitative Analysis Of Fragrance Allergens In Various Matrixes Of Cosmetics By Liquid-Liquid Extraction And Gc-Ms, Chia-Hui Lu, Ming-Chih Fang, Yu-Zi Chen, Shou-Chieh Huang, Der-Yuan Wang Dec 2021

Quantitative Analysis Of Fragrance Allergens In Various Matrixes Of Cosmetics By Liquid-Liquid Extraction And Gc-Ms, Chia-Hui Lu, Ming-Chih Fang, Yu-Zi Chen, Shou-Chieh Huang, Der-Yuan Wang

Journal of Food and Drug Analysis

Fragrances are the most common chemicals in cosmetics to which people expose every day. However, the unwanted allergic reactions such as contact dermatitis caused by direct contact with fragrances may happen. In Directive 2003/15/EC of the EU, cosmetic product containing one or more of 26 fragrance allergens must be declared on the package label. In addition, commission regulation (EU) 2017/1410 amending Annexes II and III of cosmetic regulation 1223/2009 restricted fragrance chemical of methyl eugenol, and prohibited Lyral, atranol, chloroatranol to be used in cosmetic. In this study, an efficient and sensitive GC-MS method for 3 banned fragrances, 26 fragrance …

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Diagnostic Ions Guided 2d-Locating Strategy For Characterization Of Chemical Analogues In Complex Herbal Medicines Using Liquid Chromatography-Ion Mobility-Mass Spectrometry, Meng-Ning Li, Zi-Xuan Zhang, Hui-Ying Wang, Wen Gao, Ping Li, Hua Yang Dec 2021

Diagnostic Ions Guided 2d-Locating Strategy For Characterization Of Chemical Analogues In Complex Herbal Medicines Using Liquid Chromatography-Ion Mobility-Mass Spectrometry, Meng-Ning Li, Zi-Xuan Zhang, Hui-Ying Wang, Wen Gao, Ping Li, Hua Yang

Journal of Food and Drug Analysis

Rapid characterization of chemical analogues in potentially toxic complex matrix was essential for prevention of accidental poisoning. On the basis of the fragment ions possessed not only the same retention times (RT) but the same drift times (DT) on liquid chromatography-ion mobility-mass spectrometry (LC-IM-MS), an alternating frames (AF)-data independent acquisition (DIA) was utilized for simultaneous detection and rapid match of precursor/product ions with a fast switch of low/high collision energy (CE). A diagnostic ions guided 2D-locating strategy was developed for identification of chemical analogues in potentially toxic herbal medicines using LC-IM-MS. Firstly, the 2D-locations (RT, DT) of diagnostic ions were …

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Pharmacokinetics Of Panduratin A Following Oral Administration Of A Boesenbergia Pandurata Extract To Rats, Jihyun Won, Keumhan Noh, Jae-Kwan Hwang, Beom Soo Shin, Wonku Kang Dec 2021

Pharmacokinetics Of Panduratin A Following Oral Administration Of A Boesenbergia Pandurata Extract To Rats, Jihyun Won, Keumhan Noh, Jae-Kwan Hwang, Beom Soo Shin, Wonku Kang

Journal of Food and Drug Analysis

Boesenbergia pandurata and its major active ingredient, panduratin A (PAN), exhibit antibacterial, anti-oxidant, anti-inflammatory, and anti-obesity effects. We explored the time course of the plasma and tissue (in the major organs, gums and skin) concentrations of PAN after oral administration of a B. pandurata extract to rats. Model-dependent analysis was used to quantify the skin distribution of PAN after systemic exposure. The PAN level peaked at 1.12 ± 0.22 μg/mL after 3 h, and then biexponentially decayed with a terminal half-life of 9 h. The mean clearance (Cl/F) was 2.33 ± 0.68 L/h/kg. The PAN levels in organs were in …

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Identification Of Oxytocin Receptor Activating Chemical Components From Traditional Japanese Medicines, Yuko Maejima, Shoichiro Horita, Shoko Yokota, Tomoyuki Ono, Peter Proks, Hiromi Yoshida-Komiya, Yoichi Ueta, Katsuhiko Nishimori, Shingen Misaka, Kenju Shimomura Dec 2021

Identification Of Oxytocin Receptor Activating Chemical Components From Traditional Japanese Medicines, Yuko Maejima, Shoichiro Horita, Shoko Yokota, Tomoyuki Ono, Peter Proks, Hiromi Yoshida-Komiya, Yoichi Ueta, Katsuhiko Nishimori, Shingen Misaka, Kenju Shimomura

Journal of Food and Drug Analysis

Oxytocin (Oxt) is known to regulate social communication, stress and body weight. The activation of Oxt receptors (OTR) has clinical potential to abate stress disorders and metabolic syndrome. Kamikihito (KKT) is a traditional Japanese medicine used to treat psychological stress-related disorders. We investigated the effects of KKT, its ingredients and chemical components on Oxt neurons and OTR. C-Fos expression was examined after oral and peripheral administration of KKT in rats. Electrophysiological change of Oxt neurons and Oxt release upon application of KKT were measured in rat brain slice. The direct effect of KKT, its ingredients and its chemical components were …

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A Novel Nrf2/Are Inhibitor Gossypol Induces Cytotoxicity And Sensitizes Chemotherapy Responses In Chemo-Refractory Cancer Cells, Ya-Chu Tang, Hsin-Huei Chang, Huang-Hui Chen, Jau-Ying Yao, Yu-Tsen Chen, Yung-Jen Chuang, Jang-Yang Chang, Ching-Chuan Kuo Dec 2021

A Novel Nrf2/Are Inhibitor Gossypol Induces Cytotoxicity And Sensitizes Chemotherapy Responses In Chemo-Refractory Cancer Cells, Ya-Chu Tang, Hsin-Huei Chang, Huang-Hui Chen, Jau-Ying Yao, Yu-Tsen Chen, Yung-Jen Chuang, Jang-Yang Chang, Ching-Chuan Kuo

Journal of Food and Drug Analysis

NRF2/ARE signaling pathway is a principal regulator of cellular redox homoeostasis. The stress-induced transcription factor, NRF2, can shield cells from the oxidative damages via binding to the consensus antioxidant-responsive element (ARE) and driving several cyto-protective genes expression. Increasing evidence indicated that aberrant activation of NRF2 in malignant cells may support their survival through various pathways to detoxify chemotherapy drugs, attenuate drug-induced oxidative stress, or induce drug efflux, all of which are crucial in developing drug resistance. Accordingly, NRF2 is a potential drug target for improving the effectiveness of chemotherapy and to reverse drug resistance in cancer cells. A stable ARE-driven …

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