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Articles 2881 - 2910 of 3580

Full-Text Articles in Pharmacology

Uncoupling Of Mitochondrial Oxidative Phosphorylation By Ancistrotectorine(การอันคัปปลิงของกระบวนการออกสิเดทีฟ ฟอสฟอริลเลซัน ของไมโตคอนเ..., Wiboon Wattanatorn, Nijsiri Ruangrungsi, Withaya Janthasoot Jan 1992

Uncoupling Of Mitochondrial Oxidative Phosphorylation By Ancistrotectorine(การอันคัปปลิงของกระบวนการออกสิเดทีฟ ฟอสฟอริลเลซัน ของไมโตคอนเ..., Wiboon Wattanatorn, Nijsiri Ruangrungsi, Withaya Janthasoot

The Thai Journal of Pharmaceutical Sciences

Ancistrotectorine, a new alkaloid from Ancistrocladus tectorius, was found to possess uncoupling activity on isolated rat liver mitochondria. This compound stimulated state 4 respiration and consequently reduced respiratory control index and ADP/O ratio ...


Iron And Folic Acid Contents In Traditonal Haematinic Drugs And Ha Em All Nic Herbs(ปริมาณธาตุเหล็กและกรดโฟลิกในยาบำรุงเลือดแผนใบราณ และสมุนไ..., Oranong Kangsadalampai, Suteera Selta-Apitarn Jan 1992

Iron And Folic Acid Contents In Traditonal Haematinic Drugs And Ha Em All Nic Herbs(ปริมาณธาตุเหล็กและกรดโฟลิกในยาบำรุงเลือดแผนใบราณ และสมุนไ..., Oranong Kangsadalampai, Suteera Selta-Apitarn

The Thai Journal of Pharmaceutical Sciences

Thai women used traditional haematinic drugs for a long time. However, there were no scientific evidence to show that these drugs contain sufficient essential nutrients, iron and folic acid, for red blood cell formation in human. The present study was co...


Formulation Of Dermatological Preparations From Extract Of Impatiens Balsamina Leaves.(การพัฒนาตำรับยาบำบัดโรคผิวหนังจากสารสกัดใบเทียนบ้าน), Pranom Pothiyanont, Suchada Prasertvithyakarn, Waraporn Suwakul, Saree Virunhapol, Areerat Laorpaksa, Thatree Phadungcharoen, Ekarin Saifah Jan 1992

Formulation Of Dermatological Preparations From Extract Of Impatiens Balsamina Leaves.(การพัฒนาตำรับยาบำบัดโรคผิวหนังจากสารสกัดใบเทียนบ้าน), Pranom Pothiyanont, Suchada Prasertvithyakarn, Waraporn Suwakul, Saree Virunhapol, Areerat Laorpaksa, Thatree Phadungcharoen, Ekarin Saifah

The Thai Journal of Pharmaceutical Sciences

2-Methoxy-l, 4-naphthoquinone, isolated from Impatiens balsamina leaves, was quite stable in oleaginous base, absorption base and water soluble base. In o/w type emulsion base, it could be stabilized with 0.01% citric acid. The 0.5% concentration of the ...


An Amino Add Derivative From The Leaves Of Aglaia Pyramidata Hance, Ekarin Saifah, Jindaporn Puripattanavong Jan 1992

An Amino Add Derivative From The Leaves Of Aglaia Pyramidata Hance, Ekarin Saifah, Jindaporn Puripattanavong

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


A Biscoumarin From The Seeds Of Linostoma Pauciflomm, Khanit Suwanborirux, Noppamas Suppakun, Hiroshi Noguchi, Ushio Sankawa Jan 1992

A Biscoumarin From The Seeds Of Linostoma Pauciflomm, Khanit Suwanborirux, Noppamas Suppakun, Hiroshi Noguchi, Ushio Sankawa

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Synthesis Of Monoureide Analogues Of Valproic Acid(การสังเคราะห์โมโนยูรีดแอนนะลอกของวัลโปรอิก แอชิด), Boonardt Saisorn, Chamnan Patarapanich, Wicharn Janwitayanuchit Jan 1992

Synthesis Of Monoureide Analogues Of Valproic Acid(การสังเคราะห์โมโนยูรีดแอนนะลอกของวัลโปรอิก แอชิด), Boonardt Saisorn, Chamnan Patarapanich, Wicharn Janwitayanuchit

The Thai Journal of Pharmaceutical Sciences

Two monoureide analogues of valproic acid were synthesized. N(2-propylpentanoyl) urea was synthesized by acylating urea with valproyl chloride. N(2-propylpentanoyl) thiourea was synthesized via the valproylisothio cyanate intermediate and concentrated am...


Study On Pepper Oil Content And Composition Of Sri Lankan And Sarawak Cultivars Grown In Thailand(การศึกษาหาปริมาณและองค์ประกอบของน้ำมันหอมระเหย ในพริ..., Waraporn Putalun, Wanchai De-Eknamkul Jan 1992

Study On Pepper Oil Content And Composition Of Sri Lankan And Sarawak Cultivars Grown In Thailand(การศึกษาหาปริมาณและองค์ประกอบของน้ำมันหอมระเหย ในพริ..., Waraporn Putalun, Wanchai De-Eknamkul

The Thai Journal of Pharmaceutical Sciences

Black pepper has long been a major exported spice of Thailand. It is normally obtained from two cultivars, the Sarawak and Sri Lankan, which are grown locally in Thailand. Comparison between the quality of the black pepper of these two different sources ...


Computer Program For Analysis Of Drug Release Kinetics And Mechanisms Of Sustained Release Products(โปรแกรมคอมพิวเตอร์สำหรับการวิเคราะห์หาจลนศาสตร์และ ก..., Phuriwat Leesawat, Poj Kulvanich Jan 1992

Computer Program For Analysis Of Drug Release Kinetics And Mechanisms Of Sustained Release Products(โปรแกรมคอมพิวเตอร์สำหรับการวิเคราะห์หาจลนศาสตร์และ ก..., Phuriwat Leesawat, Poj Kulvanich

The Thai Journal of Pharmaceutical Sciences

The computer program in Macro language of Lotus 123 for analysis of the drug release data obtained from the in vitro dissolution studies of sustained release products is reported. On the basis of linear regresion analysis, the program determines the corr...


Absolute Configuration Of L-Methionine Sulfoximine As A Toxic Principle In Cnestis Palala (Lour.) Merr., Isamu Murakoshi, Toshikazu Sekine, Kiyomi Maeshima, Fumio Ikegami, Koichiro Yoshinaga, Yuichi Fujii, Siriporn Okonogi Jan 1992

Absolute Configuration Of L-Methionine Sulfoximine As A Toxic Principle In Cnestis Palala (Lour.) Merr., Isamu Murakoshi, Toshikazu Sekine, Kiyomi Maeshima, Fumio Ikegami, Koichiro Yoshinaga, Yuichi Fujii, Siriporn Okonogi

The Thai Journal of Pharmaceutical Sciences

An unusual amino acid, L-methionine sulfoximine (1), has been isolated from the fresh seeds of Cnestis palala (Lour.) Merr. (Connaraceae). The absolute configuration of the natural sulfoximine (1) was confirmed to be shown as 2(S)-methionine S(S)-sulfoxi...


Implementation Of Gmp : A Challenging Match, Caroline De Bruijn Jan 1992

Implementation Of Gmp : A Challenging Match, Caroline De Bruijn

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Biosynthesis Of Heterocyclic Β-Substituted Alanines In Higher Plants, Fumio Ikegami, Isamu Murakoshi Jan 1992

Biosynthesis Of Heterocyclic Β-Substituted Alanines In Higher Plants, Fumio Ikegami, Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

Naturally occurring heterocyclic β-substituted alanines such as L-quisqualic acid and β-(pyrazol-l-yl) -Lalanine are enzymatically synthesizedfrom O-acetyl-L-serine and suitable precursors by cysteine synthases in the same manner as the formation of L-...


Simultaneous Determination Of Individual Curcuminoids In Turmeric By Tlc-Densitometric Method(การวิเคราะห์หาปริมาณเคอร์คูมินอยด์แต่ละชนิด ในเหง้าขมิ..., Supinya Tewtrakul, Wanchai De-Eknamkul, Nijsiri Ruangrungsi Jan 1992

Simultaneous Determination Of Individual Curcuminoids In Turmeric By Tlc-Densitometric Method(การวิเคราะห์หาปริมาณเคอร์คูมินอยด์แต่ละชนิด ในเหง้าขมิ..., Supinya Tewtrakul, Wanchai De-Eknamkul, Nijsiri Ruangrungsi

The Thai Journal of Pharmaceutical Sciences

A simple, rapid and accurate method of TLC-densitometry was developed to quantitate simultaneously the three curcuminoid components in the dried turmeric rhizome of Curcuma longa L. (Zingiberaceae). Practically, the curcuminoids in powdered turmeric were...


Enzymic Methylation Of Lawsone To Form 2-Methoxy-1,4-Naphthoquinone In Impatiens Bals Amin A Leaves, Pharkphoom Panichayupakaranant, Wanchai De-Eknamkul Jan 1992

Enzymic Methylation Of Lawsone To Form 2-Methoxy-1,4-Naphthoquinone In Impatiens Bals Amin A Leaves, Pharkphoom Panichayupakaranant, Wanchai De-Eknamkul

The Thai Journal of Pharmaceutical Sciences

A novel methyltransferase enzyme which catalyzes the méthylation of lawsone to form 2-methoxy-1,4- naphthoquinone has been discovered from the leaves of Impatiens balsamina L.


Hepatoprotective Effect Of Andrographis Paniculata And Andrographolide Against Carbontetrachloride(ผลของฟ้าทะลายโจรและแอนโตรกราฟโฟไลด์ ในการปกป้องตับจา..., Pornpimol Kijsanayotin, Chaiyo Chaichantipayuth Jan 1992

Hepatoprotective Effect Of Andrographis Paniculata And Andrographolide Against Carbontetrachloride(ผลของฟ้าทะลายโจรและแอนโตรกราฟโฟไลด์ ในการปกป้องตับจา..., Pornpimol Kijsanayotin, Chaiyo Chaichantipayuth

The Thai Journal of Pharmaceutical Sciences

Hepatoprotective efficacy of A. paniculata and its major diterpenoid lactone, andrographolide, was studied in CCl4 -induced hepatotoxicity in rats comparing with glycyrrhizin. A single oral administration of dried leaf pow der of A. paniculata (1,000 mg/...


Pharmaceutical Technology Of Starch: Invention Of Directly Compressible Starch(เทคโนโลยีเภสัชกรรมของแป้ง : แป้งดัดแปลงสำหรับใช้ในการตอกยาเม..., Siriyos Timaroon, Poj Kulvanich Jan 1992

Pharmaceutical Technology Of Starch: Invention Of Directly Compressible Starch(เทคโนโลยีเภสัชกรรมของแป้ง : แป้งดัดแปลงสำหรับใช้ในการตอกยาเม..., Siriyos Timaroon, Poj Kulvanich

The Thai Journal of Pharmaceutical Sciences

Physico-chemical modification of various native starches were performed and theirs compressibility were assessed in comparison with other modified starches commercially available. Modified rice starch derived by the process in this study exhibited the hi...


Author Index, Subject Index (ดัชนีผู้แต่ง, ดัชนีคำสำคัญ), N/A Jan 1992

Author Index, Subject Index (ดัชนีผู้แต่ง, ดัชนีคำสำคัญ), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Coumarins From The Leaves Of Triphasia Trifolia, Nijsiri Ruangrungsi, Gordon L., Michael G. Organ Jan 1992

Coumarins From The Leaves Of Triphasia Trifolia, Nijsiri Ruangrungsi, Gordon L., Michael G. Organ

The Thai Journal of Pharmaceutical Sciences

Examination of the leaves of Triphasia trifolia (Rutaceae ) revealed the presence of seven prenylated coumarins: murrangatin (1). triphasiol (2), byakangelicin (3), mexoticin (4), meranzin hydrate (5). aurapten (6) and heraclenol (7).


Mechanisms Of Increased Dissolution By Solid Dispersion Technique(กลไกการเพิ่มการละลายโดยวิธีการใช้ โซลิด ดีสเพอร์ชั่นเทคนิค), Somlak Kongmuang Jan 1992

Mechanisms Of Increased Dissolution By Solid Dispersion Technique(กลไกการเพิ่มการละลายโดยวิธีการใช้ โซลิด ดีสเพอร์ชั่นเทคนิค), Somlak Kongmuang

The Thai Journal of Pharmaceutical Sciences

Solid dispersion technique is a technique for changing patten of dissolution, increasing or decreasing. This changing depends on the carrier in the system. If a water soluble carrier is used, the dissolution of drug will increase. Inversely, the retard d...


Study On Naphthoquinone Formation In In Vitro Cultures Of Impatiens Balsamina L.(การศึกษาการสร้างสารแนพโทควิโนน ในเนื้อเยื่อเพาะเลี้ยงของเท..., Pharkphoom Panichayupakaranant, Wanchai De-Eknamkul Jan 1992

Study On Naphthoquinone Formation In In Vitro Cultures Of Impatiens Balsamina L.(การศึกษาการสร้างสารแนพโทควิโนน ในเนื้อเยื่อเพาะเลี้ยงของเท..., Pharkphoom Panichayupakaranant, Wanchai De-Eknamkul

The Thai Journal of Pharmaceutical Sciences

Callus, cell suspension and root cultures of Impatiens balsamina L. were established by manipulation of plant growth regulators in B5 medium. These in vitro cultures were maintained and evaluated for their potential in synthesizing 2-hydroxy-l,4-naphthoq...


Room Temperature For Stability Testing In Thailand(อุณหภูมิห้องสำหรับทดสอบความคงสภาพยาในประเทศไทย), Sompol Prakongpan, Lalita Jala Jan 1992

Room Temperature For Stability Testing In Thailand(อุณหภูมิห้องสำหรับทดสอบความคงสภาพยาในประเทศไทย), Sompol Prakongpan, Lalita Jala

The Thai Journal of Pharmaceutical Sciences

Room temperature for stability testing in Thailand was derived from the annual temperature and humidity statistics during 1990 obtained from Department of Meteorology in 4 provinces, i.e., Bangkok, Chiangmai, Ubolrajthani and Songkla. Evaluation of the d...


Optimization Method In Pharmaceutical Sciences(วิธีการหาผลเหมาะสมที่สุดทางเภสัชศาสตร์), Wibul Wongpoowarak Jan 1992

Optimization Method In Pharmaceutical Sciences(วิธีการหาผลเหมาะสมที่สุดทางเภสัชศาสตร์), Wibul Wongpoowarak

The Thai Journal of Pharmaceutical Sciences

The review summarized on basical and applicable aspects in optimization method with examples in pharmaceutical sciences, which are: defining independent variables and dependent variables; experimental designs; performing regression analysis by proper mat...


Constituents Of The Stem Bark Of Zanthoxylum Limonella, Aim-On Somanabandhu, Nijsiri Ruangrungsi, Gordon L., Michael G. Organ Jan 1992

Constituents Of The Stem Bark Of Zanthoxylum Limonella, Aim-On Somanabandhu, Nijsiri Ruangrungsi, Gordon L., Michael G. Organ

The Thai Journal of Pharmaceutical Sciences

The bark of Zanthoxylum limonella yielded five compounds: lupeol, rutaecarpine, xanthoxyletin, osthol and scopoletin


The Lupin Alkaloids Of Sophora Secundiflora In Egypt(ลูปีนแอลคาลอยด์จากตัน Sophora Secundiflora ที่ขึ้นในประเทศอียิปต์, Toshikazu Sekine, Noriko Arai, Kazuki Saito, Mahmoud H. Mohamed M.A. Makboul, Isamu Murakoshi Jan 1992

The Lupin Alkaloids Of Sophora Secundiflora In Egypt(ลูปีนแอลคาลอยด์จากตัน Sophora Secundiflora ที่ขึ้นในประเทศอียิปต์, Toshikazu Sekine, Noriko Arai, Kazuki Saito, Mahmoud H. Mohamed M.A. Makboul, Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

From the aerial parts of Sophora secundiflora growing in Egypt, the fourteen lupin alkaloids were isolated. Among them, (+)-epilupinine, (+)-mamanine and (+)-13β-hydroxymamanine have been isolatedfrom this plant for the first time. Distribution of lupin...


Cocaine And Timing: Drug Effects Under A Mixed Fixed-Interval Extinction Schedule, Vincent O. Hodge Aug 1991

Cocaine And Timing: Drug Effects Under A Mixed Fixed-Interval Extinction Schedule, Vincent O. Hodge

Masters Theses

The effects of cocaine hydrochloride (3.2-56.2 mg/kg) were determined in rats performing under a mixed fixed-interval 60-seconds extinction 120-seconds schedule of food delivery. Responses were recorded in successive 5-second bins. With the exception of the highest dose (56.2 mg/kg), cocaine did not significantly affect rate of responding under the fixed-interval component or extinction component, or the time of peak responding under the extinction component. The highest dose significantly reduced response rates and shifted the time of peak responding leftward to quicker and earlier moments. Results are discussed in terms of possible rate- and time-dependent effects of stimulant drugs.


Effects Of Phenobarbital In Combination With Phenytoin Or Valproic Acid On The Delayed-Matching-To-Sample Performance Of Pigeons, Catherine Ann Karas Apr 1991

Effects Of Phenobarbital In Combination With Phenytoin Or Valproic Acid On The Delayed-Matching-To-Sample Performance Of Pigeons, Catherine Ann Karas

Masters Theses

The present study examined the effects of phenobarbital (S, 10,20, and 40 mg/kg), phenytoin (2.5, 5, 7.5, and 15 mg/kg), and valproic acid (40, 60, 80, and 120 mg/kg), and those of phenobarbital (10 and 20 mg/kg) in combination with phenytoin (2.5,5, and 7.5 mg/kg) or valproic acid (40, 60, and 80 mg/kg), on the delayed-matching-to-sample performance of pigeons. In general, high doses of each individual drug reduced accuracy. Drug combinations also reduced accuracy relative to control values. Reductions in accuracy produced by drug combinations were very similar in magnitude to those predicted by a response-addition model of drug interaction.


A Biochemical Study Of Gossypol And Lactate Dehydrogenase X Binary Interactions, Patricia Brown Ravenell Apr 1991

A Biochemical Study Of Gossypol And Lactate Dehydrogenase X Binary Interactions, Patricia Brown Ravenell

Theses and Dissertations in Biomedical Sciences

The goal of this project was to study the mechanism of action of gossypol through its (a) binary interaction with native and trypsin digested lactate dehydrogenase-X (LD-X), a sperm-specific isozyme, and (b) its binding in vitro in primary cultures of spermatogenic cells. Mouse LD-X was cleaved with trypsin before and after treatment with gossypol. This was followed by high performance chromatography (HPLC) separation of the LD-X tryptic peptide fragments to observed alterations in separation patterns as indicators of intramolecular disturbance in the enzyme molecule. Definite alterations in peptide fragment peaks were observed in the presence of gossypol and suggest conformational …


Evidence For The Elevation Of Serum Carcinoembryonic Antigen And Tumor-Associated Glycoprotein-72 Levels In Patients Administered Interferons, John Greiner, Fiorella Guadagni, David Goldstein, Ernest Borden, Roy Ritts, Patricia Witt, Albert Lobuglio, Mansoor Saleh, Jeffrey Schlom Jan 1991

Evidence For The Elevation Of Serum Carcinoembryonic Antigen And Tumor-Associated Glycoprotein-72 Levels In Patients Administered Interferons, John Greiner, Fiorella Guadagni, David Goldstein, Ernest Borden, Roy Ritts, Patricia Witt, Albert Lobuglio, Mansoor Saleh, Jeffrey Schlom

Haematology and Oncology, East Africa

Sera were collected from 111 patients diagnosed with adenocarcinoma or nonadenocarcinoma malignancies who received different schedules of interferon (IFN)-γ or IFN-βser alone or in combination. Serum carcinoembryonic antigen (CEA) and tumor-associated glycoprotein-72 (TAG-72) antigen levels were measured to determine whether interferon could enhance the tumor shedding and, thereby, the serum level of either tumor antigen. Less than 10% of the sera samples from patients diagnosed with nonadenocarcinoma malignancies (e.g., hairy cell leukemia, melanoma) had positive titers of TAG-72 or CEA, and interferon neither increased nor resulted in the appearance of either tumor antigen in those sera. In contrast, 59.2% and …


Pharmacokinetics, Immune Response, And Biodistribution Of Iodine-131-Labeled Chimeric Mouse/Human Igg1, K 17-1a Monoclonal Antibody, Ruby Meredith, Albert Lobuglio, Walter Plott, Roger Orr, Ivan Brezovich, Charles Russell, Elizabeth Harvey, Michael Yester, Mansoor Saleh Jan 1991

Pharmacokinetics, Immune Response, And Biodistribution Of Iodine-131-Labeled Chimeric Mouse/Human Igg1, K 17-1a Monoclonal Antibody, Ruby Meredith, Albert Lobuglio, Walter Plott, Roger Orr, Ivan Brezovich, Charles Russell, Elizabeth Harvey, Michael Yester, Mansoor Saleh

Haematology and Oncology, East Africa

Pharmacokinetics,immunogenicity,and biodistributionof a 131I-Iabeledmouse/human chimenc monoclonal antibody (C17-1A) was studiedin six metastaticcoloncancerpatients. Pharmacokinetics obtalned from serum radioactivity or chi mera concentration were identical after 5 mCi of 131I(>17-1A withmeanalphahalf-livesof 17.6±2.3 and19.7±2.9 and meanbeta half-livesof 100.9±16.1 and 106.4±14.1 hr, respectively. HPLC analysis documented the monomeric chi rneiic17-lA withoutevidenceof immunecomplexesorfree 1311 None of the patients developed antibody after ‘31I-chi merle17-1A exposure.Radiolocalizationoccurredin known areas of disease >4 cm in all patients. The half-life of total body radioactivity was 58 ±7 hr by whole-body counts and 64 ±13 hr by urine measurements. Whole-body and bone marrow dose estimates ranged from 0.75-1 .03 and …


Pharmacokinetics And Effects On Blood Chemistry Of Cyclosporine In Human Infants And Kid Goats, Floyd A. Beierle Dec 1990

Pharmacokinetics And Effects On Blood Chemistry Of Cyclosporine In Human Infants And Kid Goats, Floyd A. Beierle

Loma Linda University Electronic Theses, Dissertations & Projects

Kid goats (newborn) have been used in transplantation protocols to study the techniques and problems of infant human cardiac transplantation. Immunosuppression has been by cyclosporine in both species. However, the pharmacokinetics of cyclosporine (CSA) in both the kid goat and human infant were unknown. Therefore, the pharmacokinetics of CSA were investigated. A single dose study and a long term chronic administration study were undertaken in the goat. Six Nubian goats, ages 60-90 days, were given a single IV dose of CSA, 0.25 mg/kg, over a 10 minute period and 72 hr later an oral cyclosporine dose of 20 mg/kg. The …


Molecular Mechanisms Of Physalia Physalis Venom Modulation Of Cardiac And Vascular Functions, Eva Luo Aug 1990

Molecular Mechanisms Of Physalia Physalis Venom Modulation Of Cardiac And Vascular Functions, Eva Luo

Loma Linda University Electronic Theses, Dissertations & Projects

Portuguese man-of-war (Physalia physalis)venom has profound effects on the cardiovascular system of man and animals. The venom produces vascular relaxation in norepinephrine precontracted, intact rabbit femoral arterial rings by stimulating vasodilatory prostaglandin synthesis in the endothelium. This action does not depend on endotheliumderived relaxing factor (EDRF). P. physalis venom produces a vascular constriction on KC1 depolarized, intact rings. This is completely inhibited by dibenzyline and yohimbine. Increased membrane permeability to calcium may be involved in direct vascular smooth muscle stimulation. The venom has a positive inotropic effect on rat atrial preparations, which is intensified by increased extracellular calcium concentration. …