Pharmacology Commons^™

Effect Of Valproyl Morpholine On Rat Hepatic Cytochrome P450 : In Vivo And In Vitro Studies(ผลของวัลโปรอิล มอร์โฟลิน ต่อเอนไซม์ไซโตโครมพี 450 ในตับหนู..., Somsong Lawanprasert, Pornpimol Kijsanayotin, Nuansri Niwattisaiwong, Kanlayanee Yana, Mayuree Tantisira, Chamnan Patarapamch

The Thai Journal of Pharmaceutical Sciences

Effect of valproyl morpholine (VPM) on rat hepatic cytochrome P450 (CYP) was investigated. Median effective anticonvulsant dose of VPM in mice (100 mg/kg/day) as well as of valproic acid (VPA, the prototype of VPM) (250 mg/kg/day) were given intraperiton...

The Enhancing Effects Of Common Pharmaceutical Solvents On The In Vitro Skin Permeation Of Estradiol(ผลเร่งของตัวทำละลายสามัญทางเภสัชกรรมต่อการดูดซึมสู่..., Punolpan Pithayanukul, Nanti Chansri, Kenji Sugibayashi

The Thai Journal of Pharmaceutical Sciences

Permeation of a model lipophilic drug, estradiol, through newborn pig skin was investigated using Franz’s diffusion cell at 30° c to evaluate the penetration-enhancing effect of common pharmaceutical solvents: ethanol, propylene glycol, isopropyl myri...

Risk Factors Of Antituberculosis Drugs-Induced Hepatotoxicity In Thai Patients(ปัจจัยเสี่ยงของการเกิดพิษต่อตับจากยาต้านวัณโรคในผู้ป่วยคนไ..., Sarinee Kiittiyanunt, Rungpetch Sakulbamrungsil, Supakit Wongwiwatthananukit, Wisan Suthiputthanangoon

The Thai Journal of Pharmaceutical Sciences

The purpose of this retrospective-analytical research, unmatched case-control was to determine the rate and risk factors of hepatotoxicity in inpatients with tuberculosis at King Chulalongkorn Memorial Hospital. The patients who received three antituberc...

Sufficiency And Consistency Of Drug In Formation On Drug Labels And Leaflets(ความพอเพียงและความคงที่ของข้อมูลยาบนฉลากและเอกสารกำกับยา), Siriporn Burapadaja, Busabong Jamroendararasamee, Jaratbhan Sanguansermsri

The Thai Journal of Pharmaceutical Sciences

According to the official regulation, it was compulsory to provide w ritten drug inform ation on the drug labels and leaflets w ith the drug products. But the content of drug inform ation w as not totally specified by the regulation. Thus this study aime...

Treatment Of Drug Addicts By A Monk At The Temjai Center, Pathumthani Province(การบำบัดรักษาผู้ติดสารเสพติดโดยพระสงฆ์ในศูนย์เต็มใจจังหวัด..., Ruangthip Tunyapisit

The Thai Journal of Pharmaceutical Sciences

A treatm ent and rehabilitation of drug addicts has now been conducted inside and outside health institutions. Public health academ icians pay little attention to "informal" treatm ents initiated by monks. No study has so far been carried out to clarify ...

บทคัดย่อ การประชุมเสนอผลงานวิจัยทางเภสัชศาสตร์ครั้งที่ 19 : 4 ธันวาคม 2545 (เพิ่มเติม), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Assessment Of Heavy Metal Pollution In The Lupa Gold Field, Sw Tanzania, S. R. Mnali

Tanzania Journal of Science

The concentrations of AS, Cd, Cr, Cu, Hg and Pb were determined in water, stream sediments, soil, and mine tailings from Lupa Gold Field (LGF), SW Tanzania, in order to assess their pollution levels. As, Cd and Cr were determined by automated Graphite Furnace Absorption Spectrophotometry. Cu and Pb were analysed by Air-Acetylene Flame, while Hg was analysed by Cold Vapour Atomic Absorption Spectrophotometry. The mean concentrations obtained were: As: 0.44 ppb (water), 1.2 ppm (sediments), 0.44 ppm (soil) and 5.2 ppm (tailings); Cd: 0.03 ppb (water), 0.03 ppm (sediments), 0.03 ppm (soil) and 0.50 ppm (tailings); Cr: 1.4 ppb …

Heavy Metals In Green Vegetables And Soils From Vegetable Gardens In Dar Es Salaam, Tanzania, O C Othman

Tanzania Journal of Science

Edible portions of five varieties of green vegetables, namely amaranth, chinese cabbage, cowpea leaves, leafy cabbage and pumpkin leaves, collected from several areas in Dar es Salaam, were analyzed for lead, cadmium, chromium, zinc, nickel and copper. Except for zinc, the levels of heavy metals in the vegetables grown at Tabata area were much higher than in the vegetables from Ukonga and Kiwalani. Amaranth and pumpkin leaves had more than 60% higher content of heavy metals, especially copper, chromium and lead, than the other vegetables. All vegetables from Tabata, Buguruni and Sinza had lead-levels higher then the FAO/WHO recommended permissible …

Age Related Changes In Contractile Sensitivity To Cyclic Gmp And Intracellular Calcium Compartmentalization In Ovine Arteries, Surya Margono Nauli

Loma Linda University Electronic Theses, Dissertations & Projects

The study examines the hypothesis that maturation changes the ability of cGMP to produce cerebral vasodilatation and alters the relative intracellular calcium pool sizes in ovine arteries. In ovine basilars taken from near-term fetal and young adult sheep, 8- pCPT-cGMP relaxed potassium- and serotonin-induced tone with pD2 values of 4.4±0.1 and 4.9±0.1 (fetal basilar) and 4.0±0.1 and 4.7±0.1 (adult basilar), respectively. In fura-2 loaded arteries, 8-pCPT-cGMP significantly lowered increases in cytosolic calcium concentration induced by serotonin but not potassium regardless of age. When calcium sensitivity was calculated in the same arteries as the slope of the relation between calcium concentration …

Bronchodilator, Spasmolytic And Calcium Antagonist Activities Of Nigella Sativa Seeds (Kalonji): A Traditional Herbal Product With Multiple Medicinal Uses, A H. Gilani, N Aziz, I M. Khurram, K S. Chaudhary, A Iqbal

Department of Biological & Biomedical Sciences

Objective: The seeds of Nigella sativa locally known as "Kalonji" has been used in traditional medicine for the treatment of a variety of diseases including diarrhoea and asthma. The crude extract of N. sativa seeds (Ns.Cr) was studied in vitro for its possible spasmolytic and bronchodilator activities to rationalize the folkloric uses.
Methods: Isolated rabbit jejunum and guinea-pig tracheal preparations were set up in Tyrode's and Kreb's solutions respectively and aerated with 5% CO2 in oxygen. Isotonic and isometric responses were measured on Bioscience oscillograph and Grass polygraph respectively.Results: The Ns.Cr caused a dose-dependent (0.1-3.0 mg/ml) relaxation of spontaneous contractions …

Efficacy And Safety Of Fluconazole Combined With Amphotericin B For Treatment Of Cryptococcal Meningitis In Patients With Aids(ประสิทธิผลและความปลอดภัยของการใช้ฟลูโคนาโซ..., Chankig Puttilerpong, Somsit Tansuphaswadikul, Duangchit Panomvana Na Ayudhya

The Thai Journal of Pharmaceutical Sciences

Cryptococcal meningitis (CM) is the most common life-threatening opportunistic fungal infection in patients with AIDS. The purpose of this study was to compare the efficacy and safety of giving high dose of amphotericin B for the first two weeks of thera...

In Vitro Hepatotoxicity Study Of Barakol Using Human Hepatoma Cell Line Hepg2(การศึกษาความเป็นพิษของบาราคอลต่อตับ โดยการทดสอบด้วยเซลล์มะเ..., Somsong Lawanprasert, Chaiyo Chaichantipyuth, Surachai Unchern, Yupin Lawanprasert, Daret St.Clair

The Thai Journal of Pharmaceutical Sciences

Human hepatoma cell line HepG2 was used to assess the hepatotoxic effects of barakol, isolated from young leaves of Cassia siamea. Barakol at concentrations of 0.25, 0.50, 0.75 and 1 mM were added to HepG2 cells for 24, 48, 72 and 96 hours. Cytotoxicity ...

Production Of Colchicine From Root Cultures Of Gloriosa Superba L.(สารโคลชิซีนจากรากเพาะเลี้ยงดองดึง), Waraporn Putalun, Boonyean Kitvijarn

The Thai Journal of Pharmaceutical Sciences

The plant Gloriosa superba L. is a source of colchicine which is used in medicine and agriculture. Study of G. superba using plant tissue and cell culture technique was performed in vitro in order to observe its ability to produce colchicine. The medium ...

The Cost-Effectiveness Of Ace Inhibitor Treatment Of Nephropathy In Type 2 Diabetic Patients(ต้นทุน-ประสิทธิผลของการรักษาด้วยยา Ace Inhibitors สำหรับโรคไตในผู..., Phantipa Sakthong

The Thai Journal of Pharmaceutical Sciences

This study aimed to evaluate the cost-effectiveness ACE inhibitor treatment of nephropathy in type 2 diabetic patients. The evaluation was carried out by using related literature (1988-2000). The semi-Markov models were performed to assess lifetime direc...

Microbial Contamination Of Medicinal Plant Products(การปนเปีอนจสินทรีย์ของผลิตภัณฑ์สมุนไพร), Areerat Laorpaksa, Nongluksna Sriubolmas, Peerapun Khruddhaveacho

The Thai Journal of Pharmaceutical Sciences

The study of microorganism contamination in 120 samples of medicinal plant products showed that 46 samples (38.3%) were microbiologically acceptable. These samples were 12 oral preparations (10.0%), 1 herbal sachet (0.8%), 4 topical preparations (3.3%), ...

Issues For The Consideration Of A Report On Meta-Analysis(ประเด็นที่ควรพิจารณาในรายงาน Meta-Analysis), Supon Limwattananon, Chulaporn Limwattananon

The Thai Journal of Pharmaceutical Sciences

In several occasions, a systematic review of study reports called meta-analysis is necessary in order to make a conclusion on the benefits and risks of drug therapy. Clarity on how the data are retrieved and analyzed statistically is as important as the ...

Consumer Protection On The Sale And Advertisement Of Pharmaceuticals Via Internet In The United States(การคุ้มครองผู้บริโภคในการจำหน่ายและโฆษณายาทางอินเท..., Vithaya Kulsomboon

The Thai Journal of Pharmaceutical Sciences

In the United States, internet sales of pharmaceuticals have been growing rapidly. An estimated three million prescriptions were dispensed via internet in 1999. Numerous studies indicate the sales that violated the U.S. FDA regulations including the sale...

Attitudes Of Southern Health Care Professionals Toward The Roles Of Pharmacists In Inpatient Care Team(ทัศนคติของบุคลากรทางการแพทย์ในภาคใต้ต่อบทบาทของเภส..., Woranuch Saengcharoen, Sanguan Lerkiatbundit, Kwanta Na-Thalang, Thittapa Prompech, Kullaphat Aeng, Rassamee Chatdomrong, Rungnapa Songsiriphan, Sujita Kulthawiporn, Thippawan Thongchi, Wibul Ratthanakul, Wilawan Jarungkhiatkajohn, Weerapong Sa-Au, Sasithon Pithakbut, Sonthaya Chaewchanchamnankhit

The Thai Journal of Pharmaceutical Sciences

Pharmacists who deliver pharmaceutical care to inpatients need to team up with other health care professionals. Different professionals may have different attitudes toward the pharmacist’s roles. The objective of this study is to examine the attitudes ...

Physical Characterization And Aging Studies Of Fast Release Phenobarbital-Urea Solid Dispersions(คุณ ลักษณะทางกายภาพและการศึกษาความคงตัวของฟีโนบาร์บิท..., Nattha Kaewnopparat, Amaravadee Jangwang, Daungkhae Maneenaun, Leefung Kooskulkunakorn, Saowarak Pongsaurupong

The Thai Journal of Pharmaceutical Sciences

Solid dispersions (SD) of phenobarbital-urea in the ratio of 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were prepared in an attempt to improve the solubibty and dissolution. Solubibty, dissolution, powder Xray diffraction and differential scanning calorimetry (DSC...

Chemical Compositions And Antimicrobial Activities Of Essential Oil From Melaleuca Leucadendron Var. Minor(องค์ประกอบทางเคมีและฤทธิ์ต้านจุลินทรีย์ของน้ำมันห..., Puangnoi Lohakachornpan, Watcharin Rangsipanuratn

The Thai Journal of Pharmaceutical Sciences

The fresh leaves of Melaleuca leucadendron Linn. var. minor Duthie (Myrtaceae) was hydrodistilled by Clevenger apparatus. Gas chromatography-mass spectrometry analyses revealed the presence of 45 components. Terpinolene (29.21 %), a-terpinene (22.55%), 2...

ความเป็นไปได้ที่กวาวเครือขาวจะมีผลต่อการขยายขนาดของเต้านม, วันชัย ดีเอกนามกูล, ชาลี ทองเรือง

The Thai Journal of Pharmaceutical Sciences

สรรพคุณของกวาวเครือขาว ที่มีผลต่อการขยายขนาดของเต้านมสตรีให้ใหญ่ขึ้นนั้น เดิมเชื่อว่าเ...

Ribosome Modulation Factor (ไรโบโซมโมดูเลชันแฟคเตอร์), Auayporn Apirakaramwong

The Thai Journal of Pharmaceutical Sciences

The functional form of ribosomes in growing Escherichia coli cells is the 70S monomer, consisting of 30S and 50S subunits. The 70S ribosomes converted into 100S dimers during the transition from exponential phase to stationary phase of growth. 100S ribos...

A Novel Treatment For Removal Of Unwanted Facial Hair In Women(แนวทางใหม่ในการรักษาภาวะขนดกบนใบหน้าของผู้หญิง), Auayporn Apirakaramwong

The Thai Journal of Pharmaceutical Sciences

Many women suffer from excess facial hair since they regard this as a defect in their appearance. Recently, U.S. FDA has approved eflornithine HC1 13.9% topical cream (Vaniqa™) for the management of unwanted facial hair in women. Eflornithine or a-difl...

Evidence-Based Pharmacotherapy: Concepts And Practices(เภสัชบำบัดบนพื้นฐานของหลักฐานทางวิชาการ: แนวคิดและการปฏิบัติ), Nalinee Poolsup

The Thai Journal of Pharmaceutical Sciences

As evidence-based practice has been recognized increasingly in health care, pharmacist as a healthcare professional needs to learn how to perform evidence-based pharmacotherapy (EBPharm). The approach involves integrating the best currently available evi...

Principle Of Meta-Analysis Of Clinical Trials(การสังเคราะห์ข้อมูลโดยวิธี Meta-Analysis), Nalinee Poolsup

The Thai Journal of Pharmaceutical Sciences

A meta-analysis is a type of systematic review that employs statistical methods to synthesize the evidence from several primary studies. It has been increasingly applied to combine results from randomized controlled trials of health interventions. Severa...

Vegetables And Yoghurt Fermentation Of Lactobacillus Strains(การหมักผักและโยเกิร์ตของสายพันธุ์แล็กโตบาซิลลัส), Suchada Jongrungruangchok, Somboon Tanasupawat, Surai Saisorn

The Thai Journal of Pharmaceutical Sciences

Lactobacillus sp. L2-1, Lactobacillus farciminis 73-1, and Lactobacillus plantarum P7-1 were used for fermenting green mustard and mixed vegetables in comparison to natural fermentation. The salt and sugar concentration were varied to 1-2% and 2-4%, resp...

Keyword Index, Author Index(ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Heavy Metals And Organic Pollutants In Sediments Of Dar Es Salaam Harbour Prior To Dredging In 1999, J F Machiwa

Tanzania Journal of Science

Heavy metals and organic contaminants were analysed in the sediments of the inner area of the Dar es Salaam harbour. Complementary analytical parameters, such as, the organic carbon content and the silt/clay fraction of the sediments showed good positive correlation (r = 0.64). Stations that had high content of fine grain material in the sediment also indicated relatively high level of organic carbon and pollutants. The Florida criteria (MacDonald 1993) for assessment of pollution of tropical marine sediments was adopted in oredr to evaluate the extent of pollution in Dar es Salaam harbour sediments. The Florida criteria is one of …

Towards Gene Therapy Of Parkinson’S Disease: Implantation Of Ruc-Gdnf Secreting Mammalian Cell Lines Into Rat Brain, Hua Liu

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study is to develop a new approach for monitoring the function of implanted cells by a Renilla luciferase -glial cell line derived neurotrophic factor (RUC-GDNF) fusion protein in CSF. The RUC-GDNF protein is expected to report GDNF secreted from the cell by bioluminescence through luciferase activity.

Current ex vivo gene therapy using GDNF is limited by lack of a monitoring mechanism to determine the expression of GDNF once transformed cells or vector DNA are injected into animal models. Since the therapeutic concentration of GDNF secreted into cerebrospinal fluid (CSF) by implanted cells is too low for …

Mechanisms Of Calcium Buffering And Aging In Neurons: Testing The Limits Of Homeostasis, William James Pottorf Ii

Loma Linda University Electronic Theses, Dissertations & Projects

Intracellular calcium ([Ca²⁺]i) is an ubiquitous second messenger that integrates multiple and diverse neuronal pathways that include development and maturation, gene expression, synaptic plasticity, transmitter release, excitability, and even cell death. Upon neuronal excitation the [Ca²⁺]i increases rapidly and the calcium buffering system reacts quickly to restore [Ca²⁺]i to basal levels in order to reset the cell for the next stimulus and avoid prolonged exposure to cytotoxic levels of high [Ca²⁺]i. The aging process appears to causes multiple changes in the ability of neurons to regulate [Ca²⁺]i homeostasis and an …