Pharmacology Commons^™

Indinavir, Eliyah B. Pollak, Mayur S. Parmar

HPD Articles

No abstract provided.

Lamivudine, Katherine Taylor, Kristina Fritz, Mayur S. Parmar

HPD Articles

No abstract provided.

Sodium Oxybate, Alvio Dominguez, Lucia Soca Gallego, Mayur S. Parmar

HPD Articles

No abstract provided.

Pralidoxime, Rishab Gupta, Mayur S. Parmar

HPD Articles

No abstract provided.

Tolterodine, Shreya Narain, Mayur S. Parmar

HPD Articles

No abstract provided.

Epigenetic Regulation Of Drug Metabolizing Enzymes In Normal Aging, Mohamad M. Kronfol

Theses and Dissertations

Geriatric populations are at a higher risk for adverse drug reactions (ADRs). This may be partly due to changes in drug metabolism in old age, but the underlying mechanisms are poorly understood. Prior research in humans and mice has shown age-associated changes to the expression of several genes involved in drug metabolism. Furthermore, studies of human blood showed that epigenetic regulation of genes encoding drug metabolizing enzymes change with age. However, it is unknown if genes in the liver are similarly affected. Therefore, we hypothesize that genes encoding drug metabolizing enzymes may show differential epigenetic regulation in the liver with …

Novel Strategies To Overcome Carboplatin Resistance In Triple Negative Breast Cancer Using Patient Derived Xenografts, Mohammad A. Al Zubi

Theses and Dissertations

Triple-negative breast cancer (TNBC) patients have a poor prognosis and rely on chemotherapeutic treatment as standard of care. Often, they develop chemotherapy resistance, which leaves them without more therapeutic options, like targeted therapy. New models have been developed to test targeted inhibitors in human tumors, and they are known as patient-derived xenografts (PDX). These tumors are obtained from patients, then established and maintained in mice where they areused for tumor studies. In this work, we characterized 14 PDXs for their primary tumor growth rate and investigated metastatic propensity using spontaneous and experiment metastasis models. We utilized RNA-sequencing to characterize contributions …

Reducing Reperfusion Injury In An Adult Rat Stroke Model With St-115 Treatment, Morgan Rae Lenz

Master's Theses

The restoration of blood flow to ischemic cerebral tissue can result in reperfusion injury, and blocking reperfusion injury can significantly aid in recovery of ischemic tissue. Bradykinin has been shown to exhibit protective effects, but does not reach protective levels during reperfusion due to inactivation by aminopeptidase P2 (APP2). Therefore, inhibiting APP2 during reperfusion is a potential therapeutic strategy to aid in the reduction of reperfusion injury, leading to the development of ST-115, an APP2 inhibitor. It was hypothesized that administration of ST-115 during ischemic stroke, and just prior to reperfusion, will result in reduced neurological injury and increased functional …

The Effect Of Waterpipe/Hookah On Platelet Function And The Impact Of Inhibition Of Gβγ Subunits On Hemostasis And Thrombogenesis, Ahmed Alarabi

Open Access Theses & Dissertations

Abstract (Hookah)

Cardiovascular diseases (CVD’s) is a major public health problem. Among CVD’s risk factors, tobacco smoking is considered the single most preventable cause of death, with thrombosis being the main mechanism of CVD’s mortality in smokers. While tobacco smoking has been on the decline, the use of waterpipe/hookah has been rising, mainly due to the perception that they are “less harmful” than regular cigarettes. Strikingly, there are few studies on the negative effects of waterpipes on the cardiovascular system, and none regarding their direct contribution to thrombus formation. We employed a waterpipe whole-body exposure protocol that mimics real‐life human …

Poly(Lactic-Co-Glycolic Acid) - Polyethylene Glycol Copolymer For Long-Acting Injectable: Synthesis, Characterization, And In-Vivo Study, Ravindra Kamble, Manasi Kulkarni, Swati Korake, Abhishek Pawar, Krishnat Dhekale

The Thai Journal of Pharmaceutical Sciences

Aim: This work was aimed to develop a carrier system of poly(lactic-co-glycolic acid) (PLGA) by using polyethylene glycol (PEG) for longer action in various diseases by preparing a di-block copolymer by using Risperidone (RSP) as a drug. Methodology: PLG.

Optimizing The Method For Quantification Of Apigenin And Quercetin In The Thai Herbal Sattakavata Formula By Ultra-Performance Liquid Chromatography Coupled With Mass Spectrometer, Khuannara Narajeenrone, Jantanee Wattanarangsan, Kajee Pilakasiri, Pravit Akarasereenont, Suksalin Booranasubkajorn

The Thai Journal of Pharmaceutical Sciences

Introduction: Sattakavata formula (SVF) is a Thai traditional medicine from Ayurved Siriraj for a relief of joint pain. It comprises six ingredients, namely, Andrographis paniculata (Burm. F.) Wall. ex Nees (AP), Cinnamomum sp. (CN), Morus alba Linn. (MA.

Measuring Functional Brain Recovery In Regenerating Planarians By Assessing The Behavioral Response To The Cholinergic Compound Cytisine, Oné R. Pagán, Debra L. Baker, Sean Deats, Mary O'Brien, Rochelle Dymond, Gabriella Demichele

Biology Faculty Publications

Planarians are traditional model invertebrates in regeneration and developmental biology research that also display a variety of quantifiable behaviors useful to screen for pharmacologically active compounds. One such behavior is the expression of seizure-like movements (pSLMs) induced by a variety of substances. Previous work from our laboratory showed that cocaine, but not nicotine, induced pSLMs in intact but not decapitated planarians. Interestingly, as decapitated planarians regenerated their heads, they gradually recovered their sensitivity to cocaine. These results suggested a method to assess planarian brain regeneration and a possible way of identifying compounds that could enhance or hold back brain regeneration. …

Measuring The Effects Of Lobinaline-N-Bioxide (419) On Alcohol Consumption, Nicotine Locomotor Sensitization, And Conditioned Place Preference In Mice And Rats, Cocanut M. Suhail

Theses and Dissertations--Medical Sciences

Objective: Novel drug 419 was examined to see the effect it has in vivo mice and rats on alcohol consumption, nicotine locomotor sensitization, and conditioned place preference (CPP) models regarding behavioral tests on dopamine transporter activity.

Methods: Mice and rats were used to see how they react to the drug 419 and control vehicle, in each of the models. The animals were assessed to pre- and post- drug administration of novel drug 419. We examined each model to see the association between how drug 419 will help with treating drug abuse.

Results: We found that in alcohol consumption model the …

Combination Of Investigational Cell-Based Therapy And Deep Brain Stimulation To Alter The Progression Of Parkinson’S Disease, Nader El Seblani

Theses and Dissertations--Pharmacy

Parkinson’s disease (PD) is the second most common neurodegenerative disorder and the motor symptoms are caused by progressive loss of midbrain dopamine neurons. There is no current treatment that can slow or reverse PD. Our current “DBS-Plus” clinical trial (NCT02369003) features the implantation in vivo of autologous Schwann cells (SCs) derived from a patient’s sural nerve into the substantia nigra pars compacta (SNpc) in combination with Deep Brain Stimulation (DBS) therapy for treating patients with advanced PD.

The central hypothesis of our research is that transdifferentiated SCs within conditioned nerve tissue will deliver pro-regenerative factors to enhance the survival of …

Elucidating Molecular Function Of Mithramycin And Analogues For The Treatment Of Ews-Ets Expressing Cancers, Reiya Hayden

Theses and Dissertations--Pharmacy

Introduction: Chromosomal translocations are common in cancer. In many cancers such as prostate cancer, leukemia and Ewing sarcoma, chromosomal translocations are the main driver of malignancy. Ewing sarcoma is a cancer diagnosed mostly in children and adolescents that has very grim outcomes for patients with metastasis and recurrent disease. Malignancy in Ewing sarcoma is due to EWS-FLI1, an aberrant transcription factor that is the result of a chromosomal translocation. EWS-FLI1 is the main driver of oncogenesis in Ewing sarcoma and has been the target of many drugs developed to treat the disease. Mithramycin (MTM) was identified as a potent inhibitor …

Chemical Composition Of The Essential Oil Of Several Iris Species, Olha Mykhailenko N/A, Volodymyr Kovalyov, Tetyana Orlova

The Thai Journal of Pharmaceutical Sciences

The essential oil was obtained by a steam distillation from the dried leaves of Iris germanica L., Iris versicolor L., Iris graminea L., and Iris halophila Pall. (Iridaceae) and was investigated by a gas chromatography-mass spectrometry (GC/MS) method. I.

Cytotoxicity And Antiplasmodial Activity Of Alkaloid Extracts Prepared From Eight African Medicinal Plants Used In Nigeria, U. E. Uzuegbu, O. A. Opajobi, J. E. Utalor, C. O. Elu, I. Onyesom

The Thai Journal of Pharmaceutical Sciences

Objectives: Malaria morbidity and mortality rates are worsening, despite the dedicated commitment to eradicate the infestation, principally because of failing chemotherapy, the mainstay of treatment, and lack of registered vaccine. Therefore, the search .

Ocimum Gratissimum Linn. (Lamiaceae) Protects Wistar Rats Against Inflammation And Oxidative Stress In Trinitrobenzene Sulfonic Acid-Induced Colitis, O. O. Abiodun, N. Nwadike, F. N. Ogunleye, A. S. Sosanya

The Thai Journal of Pharmaceutical Sciences

Background and Aim: The activity of methanol extract of leaf of Ocimum gratissimum a plant with anti-inflammatory, antioxidant, and anti-ulcerogenic activities in a rat model of colitis was evaluated. Experimental Procedures: Colitis was induced in 30 of.

Tumor Suppressive Effect Of Artemisia Annua Extract In 7, 12-Dimethylbenz[A]Anthracene-Induced Breast Cancer In Wistar Rats, Hemmat M.M. Faheem, Sameh M. M. El Nabtity, Mohamed A. M. Nassan

The Thai Journal of Pharmaceutical Sciences

Objective: This study aimed to detect the genetic and immunohistochemical effects of the extract of Artemisia annua, a popular medicinal herb in a chemical model of breast cancer. Materials and Methods: Breast cancer was induced in female rats by 7, 12-d.

Anticonvulsant Activity Of Fumaria Schleicheri Dry Extract And Sodium Valproate: Role Of Neurotrophin And Cytokine Pathways, Vadim Tsyvunin, Sergiy Shtrygol, Tetiana Gorbatch, Diana Shtrygol

The Thai Journal of Pharmaceutical Sciences

Introduction: Cytokine and neurotrophin pathways can be potential targets for principally new anticonvulsant drugs which in perspective will be probably able to solve the problem of pharmacological resistance for people sick with epilepsy and to avoid po.

Development And Validation Of Rp-Hplc Method For Simultaneous Determination Of Ondansetron Hydrochloride And Granisetron Hydrochloride In Their Admixtures With Pantoprazole Sodium, Al Montaser Hamed Bellah, Abdel Maaboud Ismail Mohamed, Niveen Abdel-Latif Mohamed

The Thai Journal of Pharmaceutical Sciences

Objective: Development of rapid and sensitive high-performance liquid chromatography method for the quantification of ondansetron hydrochloride and granisetron hydrochloride in their admixtures with pantoprazole sodium in its dosage form using ketorolac .

The Effects Of Ball Mill Processing On The Physicochemical Properties Of Glutinous Rice Starch, Weeraya Tharanon, Jomjai Peerapattana

The Thai Journal of Pharmaceutical Sciences

Glutinous rice starch (GRS) (Oryza sativa L.) is a product derived from a staple food that is commonly cultivated and consumed in Asia. This study investigates the effect of physical modification by planetary ball mill processing on some physicochemical .

Anti-Tyrosinase And Anti-Melanogenic Potential Of Shallots (Allium Ascalonicum) From Various Cultivation Sites In Thailand, Thidarat Phetmanee, Thaniya Wunnakup, Thitiya Lukkunaprasit, Fameera Madaka, Sukanya Settharaksa, Narisa Kamkaen, Nirun Vipunnqeun, Laksana Charoenchai

The Thai Journal of Pharmaceutical Sciences

Objectives: The present study aimed to investigate the anti-tyrosinase effect of shallots (Allium ascalonicum) in Thailand and to prepare an optimised shallot extract for use as a skin-lightening agent. Materials and Methods: Aqueous and ethanolic shallo.

Monodora Myristica Seed Extracts Ameliorate Crude Oil Contaminated Diet-Induced Cardiotoxicity In Rats, G. T. Esiekpe, B. O. George, O. C. Orororo, A. A. Akpede, G. E. Okevwe, E. Onotugoma, J. Oguntola

The Thai Journal of Pharmaceutical Sciences

Aim: This study investigated the ameliorative effects of Monodora myristica seed extracts in serum and heart of rats fed crude petroleum oil-polluted diet (CPOPD). ). Materials and Methods: Thirty adult Wistar rats (180 ± 5 g) were used for the study. T..

Conditioned Medium Of Lipopolysaccharide-Treated Embryonic Stem Cell-Derived Mesenchymal Stem Cells Modulates In Vitro Secretion Of Inflammatory Cytokines, Faezeh Maghsood, Behrooz Johari, Nastaran Mohammadi Ghahhari, Mohammad Moradi, Mehdi Kadivar

The Thai Journal of Pharmaceutical Sciences

Background: The immunomodulatory properties of mesenchymal stem cells (MSCs) secretome have been considered by many investigators, and several preconditioning strategies such as pharmaceutical preconditioning have shown to strengthen the immunomodulatory.

Cell Lysis Methods And Coenzyme Q10 Production Of Methylobacterium Strains, Nattida Mingrapoch, Somboon Tanasupawat, Dusadee Charnvanich

The Thai Journal of Pharmaceutical Sciences

Objective: This research aimed to investigate the effect of cell lysis methods on a quantity of coenzyme Q10 (CoQ10) produced by Methylobacterium strains. Methods: Methylobacterium organophilum NBRC 15689T and Methylobacterium strain LRY1-08 were used to.

Proton Pump Inhibitors Use In Short Bowel Patients At A Thai Tertiary Hospital: A 10-Year Retrospective Observational Study, Sasisom Phadungkingtrakul, Namthip Iamkaeo, Piyathida Isutsiri, Prattana Sirisupamongkhon, Suyanee Pongthananikorn, Tippawan Siritientong

The Thai Journal of Pharmaceutical Sciences

Background: Proton pump inhibitors (PPIs) reduce the gastric acid secretion in short bowel patients. However, the absorptive areas of these patients are limited. In case of residual jejunum length <50 cm, the intravenous administration of PPIs should be .

The Efficacy Of Ketamine In Adult Patients With Obsessive Compulsive Disorder With Symptoms Refractory To Standard Of Care Treatment., Brooke Thornton

Capstone Showcase

First line pharmacologic treatments for adult patients with Obsessive Compulsive Disorder (OCD) involve selective serotonin/norepinephrine reuptake inhibitors (SSRI/SNRIs). These drug classes often fail to deliver timely relief of symptoms as well as maintain longevity of symptom recurrence. This research analyzed the use of ketamine in adult patients suffering with OCD for the purposes of more efficacious management of symptoms. Although ketamine demonstrated a timelier relief of symptoms in some small clinical studies, its effects were ultimately unable to be sustained long term. Additionally, a wide range of adverse effects including dissociation, and rebound symptoms were observed. As a result, large …

Sex Differences In The Mechanisms That Modulate The Neurochemical Effects Of Nicotine, Kevin Uribe

Open Access Theses & Dissertations

Prior behavioral studies in our laboratory revealed that overexpression of the stress peptide, corticotrophin-releasing factor (CRF), in the mesocorticolimbic reward pathway enhanced the reinforcing effects of nicotine. The latter effect was greater in female versus male rats, suggesting that females are uniquely susceptible to the effects of stress on nicotine reinforcement. The goal of this dissertation was to examine the neurochemical mechanisms by which overexpression of CRF in the nucleus accumbens (NAc), a terminal region of the mesocorticolimbic pathway, modulates the behavioral effects of nicotine. Specifically, we examined whether nicotine-induced dopamine levels are altered by CRF overexpression via excitatory (glutamate) …

Model-Based In-Vitro Pk/Pd Profiling Of Novel Synthetic Allosteric Effectors Of Hemoglobin (Aeh) As Potential Sickle Cell Disease (Scd) Therapeutics, Xiaomeng Xu

Theses and Dissertations

Introduction: Allosteric effectors of hemoglobin (AEH) represent a class of synthetic aromatic aldehydes that transiently form covalent interactions (Schiff-base) with hemoglobin (Hb) to form Hb-AEH adduct, preventing the HbS polymerization and sickling of red blood cells (RBC). The overall objective of this research was to aid in the optimization of novel AEH by understanding their target-site disposition of AEH in relevant biological matrices, e.g., HbA solution, whole blood (WB) and human liver cytosol (HLC), a surrogate of aldehyde dehydrogenase (ALDH)-mediated oxidative metabolism.

Methods: A “universal” HPLC-UV/Vis assay method was developed for the quantitation of HbA-AEH adduct for chemically …