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Full-Text Articles in Neuroscience and Neurobiology

Novel Calibrated Short Tr Recovery (Castrr) Method For Brain-Blood Partition Coefficient Correction Enhances Gray-White Matter Contrast In Blood Flow Measurements In Mice, Scott W. Thalman, David K. Powell, Ai-Ling Lin Apr 2019

Novel Calibrated Short Tr Recovery (Castrr) Method For Brain-Blood Partition Coefficient Correction Enhances Gray-White Matter Contrast In Blood Flow Measurements In Mice, Scott W. Thalman, David K. Powell, Ai-Ling Lin

Biomedical Engineering Faculty Publications

The goal of the study was to develop a novel, rapid Calibrated Short TR Recovery (CaSTRR) method to measure the brain-blood partition coefficient (BBPC) in mice. The BBPC is necessary for quantifying cerebral blood flow (CBF) using tracer-based techniques like arterial spin labeling (ASL), but previous techniques required prohibitively long acquisition times so a constant BBPC equal to 0.9 mL/g is typically used regardless of studied species, condition, or disease. An accelerated method of BBPC correction could improve regional specificity in CBF maps particularly in white matter. Male C57Bl/6N mice (n = 8) were scanned at 7T using CaSTRR …


Sexual Assault On College Campuses: The Links Between Hegemonic Masculinity, College Sports, And Sexual Violence, Vanessa Iroegbulem Apr 2019

Sexual Assault On College Campuses: The Links Between Hegemonic Masculinity, College Sports, And Sexual Violence, Vanessa Iroegbulem

Sexual Ethics

This paper seeks to explore the social and neurobiological factors that shape men into sexual aggressors by rewarding violent behaviors. It will critique the exploitation and the commodification of male bodies through sports, namely football.


Breastfeeding And How It Affects Cognitive Development, Kylie Farris, Barbara Mcclaskey Apr 2019

Breastfeeding And How It Affects Cognitive Development, Kylie Farris, Barbara Mcclaskey

Posters

If one was asked “which is better: breastfeeding or formula feeding?” the most common answer would be “breastfeeding.” This would be the answer 9 times out of 10. It is a known fact by a wide range of people, that in general, breastfeeding is the better option. Infants who are breastfed exclusively in the first six months of life tend to have better overall health outcomes than children that are fed only iron-fortified formula or a combination of the two. Therefore, it is likely that breastfeeding will indeed also improve cognitive developmental outcomes. That is the purpose of this study. …


An Effective Model For Engaging Faculty And Undergraduate Students In Neuroscience Outreach With Middle Schoolers, Peter J. Vollbrecht, Riley S. Frenette, Andrew J. Gall Apr 2019

An Effective Model For Engaging Faculty And Undergraduate Students In Neuroscience Outreach With Middle Schoolers, Peter J. Vollbrecht, Riley S. Frenette, Andrew J. Gall

Faculty Publications

Engaging undergraduate students in science outreach events is critical for improving future communication between scientists and community members. Outreach events are opportunities for faculty and undergraduates to utilize active learning strategies to engage non-scientists in scientific questions and principles. Through careful design of outreach events, undergraduate students can practice science communication skills while reaching populations of the public that remain underserved and underrepresented in scientific fields. Here we describe a classroom outreach event designed to give a broad overview of the field of neuroscience to middle school students of all backgrounds by delivering the content in school, during school hours. …


Redefining Burnout: Exploring Common Conceptualizations And The Neurophysiology Of Chronic Stress To Establish An Integrated Allostatic Model, Danny A. Guzzi Apr 2019

Redefining Burnout: Exploring Common Conceptualizations And The Neurophysiology Of Chronic Stress To Establish An Integrated Allostatic Model, Danny A. Guzzi

Dissertations

Burnout is a widely researched stress-related phenomenon associated with numerous adverse outcomes for employees and organizations. Unfortunately, burnout is not well understood and research to this point has been flawed due to a lack of consensus on the definition, dimensionality, and context of the construct. Prevalent conceptualizations of burnout have been criticized for being arbitrarily developed without solid theoretical foundation and for failing to clearly distinguish burnout from depression or other work-related conditions such as compassion fatigue, secondary traumatization, and vicarious traumatization. The current project first examines relevant literature to identify commonalities among prevalent burnout conceptualizations. Then relevant stress research …


Strong Neuron-To-Body Coupling Implies Weak Neuron-To-Neuron Coupling In Motor Cortex, Patrick A. Kells, Shree Hari Gautam, Leila Fakhraei, Jingwen Li, Woodrow L. Shew Apr 2019

Strong Neuron-To-Body Coupling Implies Weak Neuron-To-Neuron Coupling In Motor Cortex, Patrick A. Kells, Shree Hari Gautam, Leila Fakhraei, Jingwen Li, Woodrow L. Shew

Physics Faculty Publications and Presentations

Cortical neurons can be strongly or weakly coupled to the network in which they are embedded, firing in sync with the majority or firing independently. Both these scenarios have potential computational advantages in motor cortex. Commands to the body might be more robustly conveyed by a strongly coupled population, whereas a motor code with greater information capacity could be implemented by neurons that fire more independently. Which of these scenarios prevails? Here we measure neuron-to-body coupling and neuron-to-population coupling for neurons in motor cortex of freely moving rats. We find that neurons with high and low population coupling coexist, and …


The Role Of Ash1l During Human Neurodevelopment, Anna Bagnell Apr 2019

The Role Of Ash1l During Human Neurodevelopment, Anna Bagnell

Senior Theses

Autism spectrum disorders (ASD) are associated with defects in neuronal connectivity and are highly heritable. A significant proportion of ASD cases are of complex genetic etiology; complexity which might reflect the impact of gene-environment interactions. However, there is a gap in our understanding of the mechanisms that underlie the gene-environment interaction in autism complex etiology. Genome wide association studies in large ASD cohorts identified high risk variants associated with autism in genes that regulate histone modifications and remodel chromatin. These findings highlight the relevance of chromatin regulatory mechanisms in the pathology of ASD. Changes in Histone H3 methylation have been …


The Generalization Of Fear Condition Between Viewed And Imagined Percepts, Lauryn Michelle Burleigh Mar 2019

The Generalization Of Fear Condition Between Viewed And Imagined Percepts, Lauryn Michelle Burleigh

LSU Master's Theses

Mental images can provoke intense emotional states (Holmes & Matthews, 2010). Imagery and perception have common neural and physiological mechanisms, including activation of the early visual areas (Albers et al., 2013). We tested the prediction that individuals can acquire fear to imagined percepts and if this fear transfers to viewing percepts, using fMRI and self-reported measures to determine participants’ fear. The participants completed a task in which they viewed and imagined two stimuli, and were fear conditioned when imagining the CS+. Participants are only told that mild electrical stimulation will be paired with one of the stimuli, but not which …


Proximal And Distal Control For Ligand Binding In Neuroglobin: Role Of The Cd Loop And Evidence For His64 Gating, Cécile Exertier, Lisa Milazzo, Ida Freda, Linda Celeste Montemiglio, Antonella Scaglione, Gabriele Cerutti, Giacomo Parisi, Massimiliano Anselmi, Giulietta Smulevich, Carmelinda Savino, Beatrice Vallone Mar 2019

Proximal And Distal Control For Ligand Binding In Neuroglobin: Role Of The Cd Loop And Evidence For His64 Gating, Cécile Exertier, Lisa Milazzo, Ida Freda, Linda Celeste Montemiglio, Antonella Scaglione, Gabriele Cerutti, Giacomo Parisi, Massimiliano Anselmi, Giulietta Smulevich, Carmelinda Savino, Beatrice Vallone

Advanced Science Research Center

Neuroglobin (Ngb) is predominantly expressed in neurons of the central and peripheral nervous systems and it clearly seems to be involved in neuroprotection. Engineering Ngb to observe structural and dynamic alterations associated with perturbation in ligand binding might reveal important structural determinants, and could shed light on key features related to its mechanism of action. Our results highlight the relevance of the CD loop and of Phe106 as distal and proximal controls involved in ligand binding in murine neuroglobin. We observed the effects of individual and combined mutations of the CD loop and Phe106 that conferred to Ngb higher CO …


The Effects Of Bacterial Endotoxin Lps On Synaptic Transmission At The Neuromuscular Junction, Robin L. Cooper, Micaiah Mcnabb, Jeremy Nadolski Mar 2019

The Effects Of Bacterial Endotoxin Lps On Synaptic Transmission At The Neuromuscular Junction, Robin L. Cooper, Micaiah Mcnabb, Jeremy Nadolski

Biology Faculty Publications

The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.


Forgotten Children & Bonds That Heal: The Critical Nature Of Attachment, August Ashbaker Mar 2019

Forgotten Children & Bonds That Heal: The Critical Nature Of Attachment, August Ashbaker

Lesley University Community of Scholars Day

Human attachment is one of the most critical factors in proper neurological and physiological development. Attachment is built through the mutuality of emotional impact, as well as the regular reception of physical touch. Infants and children who have been deprived of these vital necessities through the lacking initiatives of their caregivers—through neglect—display visible signs of its physiological, cognitive, emotional, and behavioral impact. Research has found neglect to be the highest risk factor for permanent damage to brain development in comparison to other forms of complex trauma (i.e. chronic caregiver interpersonal trauma in childhood); it is also the most prevalent …


Effects Of Altered Gravity On The Central Nervous System Of Drosophila Melanogaster, Amber M. Paul, Siddhita Mhatre, Janani Iyer, Jhony A. Zavaleta, Ravikumar Hosamani Mar 2019

Effects Of Altered Gravity On The Central Nervous System Of Drosophila Melanogaster, Amber M. Paul, Siddhita Mhatre, Janani Iyer, Jhony A. Zavaleta, Ravikumar Hosamani

Publications

A comprehensive understanding of the effects of spaceflight and altered gravity on human physiology is necessary for continued human space exploration and long-term space habitation. Spaceflight includes multiple factors such as microgravity, hyper gravity, ionizing radiation, physiological stress, and disrupted circadian rhythms and these have been shown to contribute to pathophysiological responses that target immunity, bone and muscle integrity, cardiovascular and nervous systems. In terrestrial conditions, some of these factors can lead to cancer and neuroimmunological disorders. In this study, we used a well-established spaceflight model organism, Drosophila melanogaster, to assess spaceflight-associated changes in the nervous system. We hypothesize that …


Obstacle Negotiation And Dual-Tasking In People With A Unilateral Transtibial Amputation., Humberto Omana, Michael Payne, Ricardo Viana, Susan Winnifred Hunter Mar 2019

Obstacle Negotiation And Dual-Tasking In People With A Unilateral Transtibial Amputation., Humberto Omana, Michael Payne, Ricardo Viana, Susan Winnifred Hunter

Western Research Forum

Background: Falls in people with a lower limb amputation (PLLAs) are common and most often occur while walking, resulting in physical and psychological consequences that adversely affect quality of life. Walking is a complex motor task requiring cognitive resources. Due to walking with a prosthesis, PLLAs report focussing on every step they take, indicating greater cognitive needs. However, cognitive resources are limited, and most of our everyday activities also involve the simultaneous performance of motor and cognitive tasks, known as dual-tasking. The inter-relationship between mobility, cognition and postural stability in PLLAs using a prosthesis is just starting to be understood. …


Strengthening Relationships Between Neural Ideals And Receptive Fields, Angelique Morvant Mar 2019

Strengthening Relationships Between Neural Ideals And Receptive Fields, Angelique Morvant

Rose-Hulman Undergraduate Mathematics Journal

Neural codes are collections of binary vectors that represent the firing patterns of neurons. The information given by a neural code C can be represented by its neural ideal JC. In turn, the polynomials in JC can be used to determine the relationships among the receptive fields of the neurons. In a paper by Curto et al., three such relationships, known as the Type 1-3 relations, were linked to the neural ideal by three if-and-only-if statements. Later, Garcia et al. discovered the Type 4-6 relations. These new relations differed from the first three in that they were …


The Drosophila Neuroblasts: A Model System For Human Ribosomopathies, Sonu Shrestha Baral Mar 2019

The Drosophila Neuroblasts: A Model System For Human Ribosomopathies, Sonu Shrestha Baral

LSU Doctoral Dissertations

This dissertation describes the use of Drosophila neuroblasts (NBs) to model human ribosomopathies; the overall goal is to understand why specific stem cell and progenitor cell populations are the primary targets in nucleolar stress as seen in the ribosomopathies. Chapter 1 provides an overview of relevant literature. Chapter 2 describes nucleolar stress in Drosophila neuroblasts as a model for human ribosomopathies. For this, we induce nucleolar stress by using the UAS-GAL4 system to express RNAi that depletes Nopp140 transcripts, and we also employ homozygous, CRISPR-Cas9-generated Nopp140 gene disruptions with a systemic null phenotype (Nopp140-/-). Embryonic lethality was observed …


"Where Was I?": Linguistic Reprocessing In Distracted Reading, Katrina Hillam Mar 2019

"Where Was I?": Linguistic Reprocessing In Distracted Reading, Katrina Hillam

Undergraduate Honors Theses

This thesis examines the impact of repeated auditory and task-oriented distractors on linguistic processing. Impact was measured through eye tracking software recording first fixation duration, gaze duration, and total time spent on distractor words. This study found consistent significant difference only in the total time category, suggesting that the processing stage most impacted by distraction is global context—our awareness of how a word fits in to the paragraph at large. Participants were skilled at regaining reading speed after distraction, showing no overall impairment for other processing levels. This phenomenon could be dangerous for student comprehension, as reading speed will be …


The Effects Of Huntingtin-Lowering: What Do We Know So Far?, William F. Kaemmerer, Richard C. Grondin Mar 2019

The Effects Of Huntingtin-Lowering: What Do We Know So Far?, William F. Kaemmerer, Richard C. Grondin

Neuroscience Faculty Publications

Therapies targeting mutant huntingtin DNA, mRNA, and protein have a chance at becoming the first disease-modifying treatments for Huntington’s disease, a fatal inherited neurodegenerative disorder for which only symptom management treatments are available today. This review focuses on evidence addressing several key questions pertinent to huntingtin-lowering, ranging from the functions of wild-type huntingtin (wtHTT) that may be disrupted by huntingtin-lowering treatments through the various ways huntingtin can be lowered, the tolerability of wtHTT-lowering in mice and primates, what has been found in the Ionis Pharmaceutical safety trial of a huntingtin-lowering therapy, and to the question of how much mutant huntingtin …


The Intersection Of Neuroscience And Art, Matilde Mendes Pinto Mar 2019

The Intersection Of Neuroscience And Art, Matilde Mendes Pinto

UNO Student Research and Creative Activity Fair

The Interaction of Neuroscience and Art will give you an insight into how they interact with each other by analyzing visual art, musical art and theatrical art.


Neural Mechanisms Underlying Sensorimotor Synchronization With Different Forms Of Rhythms, Ryan Meidinger, Vivien Marmelat Mar 2019

Neural Mechanisms Underlying Sensorimotor Synchronization With Different Forms Of Rhythms, Ryan Meidinger, Vivien Marmelat

UNO Student Research and Creative Activity Fair

Introduction: Neural activity exhibits non-periodic rhythm [2] but it is unknown if neural activity synchronizes with non-periodic, as it does with periodic rhythms [1]. The purpose of this research is to determine the neural mechanisms present leading to synchronized finger tapping to varying rhythms. Methods: Twenty young healthy adults will be recruited to participate in the present study (see Figure 1 for the protocol). Electroencephalography (EEG) will be used to measure the amplitude (AE) and beats for interbeat intervals (IBIs), and a pressure sensor will be used to measure intertap intervals (ITIs). The AE will be assessed for …


Effects Of Chronic Ethanol Exposure On Stress Coping Style And Genetic States Of Zebrafish (Danio Rerio), Alexander Goodman Mar 2019

Effects Of Chronic Ethanol Exposure On Stress Coping Style And Genetic States Of Zebrafish (Danio Rerio), Alexander Goodman

UNO Student Research and Creative Activity Fair

Neurotransmitter systems are important in regulating the stress response. If a behavioral response is disproportional to a stressor it is characterized as anxiety-like behavior. Many anxiolytic compounds, such as ethanol, increase stressor engagement, but how these compounds interact with an organism on a neurogenetic level is less understood. In this study, I assessed the impact of chronic ethanol treatment on behavior and gene expression of GABAAreceptors subunits on two strains of zebrafish. Each strain was selectively bred to display the proactive or reactive stress coping style where proactive individuals will actively engage a stressor more than reactive individuals. …


Investigating Comt Influence On The Proactive-Reactive Stress Coping Axis In Zebrafish, Sean T. Bresnahan, Ryan Y. Wong Mar 2019

Investigating Comt Influence On The Proactive-Reactive Stress Coping Axis In Zebrafish, Sean T. Bresnahan, Ryan Y. Wong

UNO Student Research and Creative Activity Fair

Individuals of the same species often display differences in correlated suites of behaviors which are made conspicuous when challenges – stressful, fear-inducing, etc. – are presented. In many species, a specific suite of behaviors (risk-aversion, aggression, exploration, learning, and memory) characterize an alternative set of stress coping styles (proactive and reactive). Such behaviors are regulated in the brain by specific neurotransmitters along with proteins that regulate them. One neurotransmitter regulator protein, catechol-O-methyltransferase (COMT) shows higher baseline whole-brain expression in proactive relative to reactive animals. However, it is not known whether its expression is a cause or a consequence of the …


Pilot Study Of Empathy In Adults, Libby Moberg Mar 2019

Pilot Study Of Empathy In Adults, Libby Moberg

UNO Student Research and Creative Activity Fair

Empathy is of critical public health importance due to its association with relationship satisfaction and well-being (Davis & Oathout, 1987; Davis, 1983). There is growing evidence that bilingual individuals may have higher levels of empathy (Javor, 2016). One potential mechanism for this relationship is that bilingual individuals tend to have higher levels of executive functioning (Costa et al, 2008), which is linked to higher empathy because individuals are able to more easily adopt others’ perspectives. Previous studies examining this question have largely relied on self-report questionnaires assessing empathy as a general tendency (i.e., trait). No studies have examined differences in …


Spaces Between, Sara Kapadia Mar 2019

Spaces Between, Sara Kapadia

The Transdisciplinary STEAM+ Journal

No abstract provided.


Request For Applications: Neuroscience Summer Research Education Program, University Of Mississippi. Brain Wellness Constellation Mar 2019

Request For Applications: Neuroscience Summer Research Education Program, University Of Mississippi. Brain Wellness Constellation

Brain Wellness

The Brain Wellness Undergraduate Summer Research Program is an initiative of the UM-UMMC Flagship Constellations. The program will provide stipends to undergraduate students for collaborative research experiences in neuroscience related to brain wellness. In this way it will serve to develop new pipelines for pre-graduate and pre-medical students interested in neuroscience to gain research experience and develop collaborative connections between neuroscience faculty at the Oxford and Jackson campuses.


Cognition And The Brain Of Brood Parasitic Cowbirds., David F Sherry, Mélanie F Guigueno Mar 2019

Cognition And The Brain Of Brood Parasitic Cowbirds., David F Sherry, Mélanie F Guigueno

Psychology Publications

Cowbirds are brood parasites. Females lay their eggs in the nests of other species, which then incubate the cowbird eggs and raise the young cowbirds. Finding and returning to heterospecific nests presents cowbirds with several cognitive challenges. In some species, such as brown-headed cowbirds (Molothrus ater), females but not males search for and remember the locations of potential host nests. We describe recent research on sex differences in cognition and the hippocampus associated with this sex difference in search for host nests. Female brown-headed cowbirds perform better than males on some, but not all, tests of spatial memory and females …


Design And Actuation Of A Fabric-Based Worm-Like Robot, Akhil Kandhari, Anna Mehringer, Hillel J. Chiel, Roger D. Quinn, Kathryn A. Daltorio Mar 2019

Design And Actuation Of A Fabric-Based Worm-Like Robot, Akhil Kandhari, Anna Mehringer, Hillel J. Chiel, Roger D. Quinn, Kathryn A. Daltorio

Faculty Scholarship

Soft-bodied animals, such as earthworms, are capable of contorting their body to squeeze through narrow spaces, create or enlarge burrows, and move on uneven ground. In many applications such as search and rescue, inspection of pipes and medical procedures, it may be useful to have a hollow-bodied robot with skin separating inside and outside. Textiles can be key to such skins. Inspired by earthworms, we developed two new robots: FabricWorm and MiniFabricWorm. We explored the application of fabric in soft robotics and how textile can be integrated along with other structural elements, such as three-dimensional (3D) printed parts, linear springs, …


A Hindbrain Inhibitory Microcircuit Mediates Vagally-Coordinated Glucose Regulation, Carie R. Boychuk, Katalin Cs. Smith, Laura E. Peterson, Jeffery A. Boychuk, Corwin R. Butler, Isabel D. Derera, John J. Mccarthy, Bret N. Smith Feb 2019

A Hindbrain Inhibitory Microcircuit Mediates Vagally-Coordinated Glucose Regulation, Carie R. Boychuk, Katalin Cs. Smith, Laura E. Peterson, Jeffery A. Boychuk, Corwin R. Butler, Isabel D. Derera, John J. Mccarthy, Bret N. Smith

Physiology Faculty Publications

Neurons in the brainstem dorsal vagal complex integrate neural and humoral signals to coordinate autonomic output to viscera that regulate a variety of physiological functions, but how this circuitry regulates metabolism is murky. We tested the hypothesis that premotor, GABAergic neurons in the nucleus tractus solitarius (NTS) form a hindbrain micro-circuit with preganglionic parasympathetic motorneurons of the dorsal motor nucleus of the vagus (DMV) that is capable of modulating systemic blood glucose concentration. In vitro, neuronal activation or inhibition using either excitatory or inhibitory designer receptor exclusively activated by designer drugs (DREADDs) constructs expressed in GABAergic NTS neurons increased …


A Cross-Species Analysis Reveals A General Role For Piezo2 In Mechanosensory Specialization Of Trigeminal Ganglia From Tactile Specialist Birds, Eve R. Schneider, Evan O. Anderson, Viktor V. Feketa, Marco Mastrotto, Yury A. Nikolaev, Elena O. Gracheva, Sviatoslav N. Bagriantsev Feb 2019

A Cross-Species Analysis Reveals A General Role For Piezo2 In Mechanosensory Specialization Of Trigeminal Ganglia From Tactile Specialist Birds, Eve R. Schneider, Evan O. Anderson, Viktor V. Feketa, Marco Mastrotto, Yury A. Nikolaev, Elena O. Gracheva, Sviatoslav N. Bagriantsev

Biology Faculty Publications

A major challenge in biology is to link cellular and molecular variations with behavioral phenotypes. Here, we studied somatosensory neurons from a panel of bird species from the family Anatidae, known for their tactile-based foraging behavior. We found that tactile specialists exhibit a proportional expansion of neuronal mechanoreceptors in trigeminal ganglia. The expansion of mechanoreceptors occurs via neurons with intermediately and slowly inactivating mechanocurrent. Such neurons contain the mechanically gated Piezo2 ion channel whose expression positively correlates with the expression of factors responsible for the development and function of mechanoreceptors. Conversely, Piezo2 expression negatively correlates with expression of molecules mediating …


Influence Of Stimulus Intensity On Multimodal Integration In The Startle Escape System Of Goldfish, Camille Mcintyre, Thomas Preuss Feb 2019

Influence Of Stimulus Intensity On Multimodal Integration In The Startle Escape System Of Goldfish, Camille Mcintyre, Thomas Preuss

Publications and Research

Processing of multimodal information is essential for an organism to respond to environmental events. However, how multimodal integration in neurons translates into behavior is far from clear. Here, we investigate integration of biologically relevant visual and auditory information in the goldfish startle escape system in which paired Mauthner-cells (M-cells) initiate the behavior. Sound pips and visual looms as well as multimodal combinations of these stimuli were tested for their effectiveness of evoking the startle response. Results showed that adding a low intensity sound early during a visual loom (low visual effectiveness) produced a supralinear increase in startle responsiveness as compared …


Commentary: Sugar Metabolism Regulates Flavor Preferences And Portal Glucose Sensing, Anthony Sclafani, Karen Acroff Feb 2019

Commentary: Sugar Metabolism Regulates Flavor Preferences And Portal Glucose Sensing, Anthony Sclafani, Karen Acroff

Publications and Research

No abstract provided.