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Articles 2521 - 2550 of 5792

Full-Text Articles in Neuroscience and Neurobiology

Lessons From Miniature Brains: Cognition Cheap, Memory Expensive (Sentience Linked To Active Movement?), Giorgio Vallortigara Jan 2020

Lessons From Miniature Brains: Cognition Cheap, Memory Expensive (Sentience Linked To Active Movement?), Giorgio Vallortigara

Animal Sentience

Studies on invertebrate minds suggest that the neural machinery for basic cognition is cheap, and that bigger brains are probably associated with greater memory storage rather than more advanced cognition. Sentience may be linked to feedforward mechanisms (Reafferenzprinzip) that allow organisms with active movement to distinguish active and passive sensing. Invertebrates may offer special opportunities for testing these hypotheses.

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Novel Post-Translational Modification And Function Of Fus: The Relevance To Amyotrophic Lateral Sclerosis, Alexandra Arenas Jan 2020

Novel Post-Translational Modification And Function Of Fus: The Relevance To Amyotrophic Lateral Sclerosis, Alexandra Arenas

Theses and Dissertations--Toxicology and Cancer Biology

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the preferential death of motor neurons. Approximately 10% of ALS cases are familial and 90% are sporadic. Fused in Sarcoma (FUS) is a ubiquitously expressed RNA binding protein implicated in familial ALS and frontotemporal dementia (FTD). FUS is ubiquitously expressed in cells and has a variety of functions in the nucleus and cytoplasm. FUS mutations in the nuclear localization sequence (NLS) causes mislocalization of FUS in the cytoplasm, where it can undergo liquid-liquid phase separation and become stress granules or protein inclusions. Although FUS inclusion bodies can be found in …

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Alzheimer's Disease Drug Development Pipeline: 2020, Jeffrey Cummings, Garam Lee, Aaron Ritter, Marwan Sabbagh, Kate Zhong Jan 2020

Alzheimer's Disease Drug Development Pipeline: 2020, Jeffrey Cummings, Garam Lee, Aaron Ritter, Marwan Sabbagh, Kate Zhong

School of Medicine Faculty Research

© 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. Introduction: Alzheimer's disease (AD) is a growing public health concern affecting millions of patients worldwide and costing billions of dollars annually. We review the pipeline of drugs and biologics in clinical trials for the treatment of AD. We use the Common Alzheimer's and Related Dementias Research Ontology (CADRO) to classify treatment targets and mechanisms of action. We review our annual pipeline reports for the past 5 years to provide longitudinal insight into clinical trials and drug development for …

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Open Peer Commentary To “Failure To Demonstrate Efficacy Of Aducanumab: An Analysis Of The Emrge And Engage Trials As Reported By Biogen December 2019”, Marwan Noel Sabbagh, Jeffrey Cummings Jan 2020

Open Peer Commentary To “Failure To Demonstrate Efficacy Of Aducanumab: An Analysis Of The Emrge And Engage Trials As Reported By Biogen December 2019”, Marwan Noel Sabbagh, Jeffrey Cummings

School of Medicine Faculty Research

No abstract provided.

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Consciousness As A Factor In Evolution, Kenneth A. Augustyn Jan 2020

Consciousness As A Factor In Evolution, Kenneth A. Augustyn

Michigan Tech Publications, Part 1

What I call the mind began as a non-conscious robotic biochemical process control system in the very earliest forms of life. As life evolved, problems in control became more difficult and exceeded the computational capabilities of the organisms. Nature discovered a means of transcending computable physical processes resulting in non-computational subjective mental capabilities that, while still not conscious, had a degree of genuine autonomy from the physical world. These autonomous subjective wants and goals now affected the course of (but not the mechanism of) evolution. The integrated amalgam of robotic and transrobotic unconscious capabilities eventually gave rise to consciousness, which …

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Automated And Standardized Tools For Realistic, Generic Musculoskeletal Model Development, Trevor Rees Moon Jan 2020

Automated And Standardized Tools For Realistic, Generic Musculoskeletal Model Development, Trevor Rees Moon

Graduate Theses, Dissertations, and Problem Reports (ETD)

Human movement is an instinctive yet challenging task that involves complex interactions between the neuromusculoskeletal system and its interaction with the surrounding environment. One key obstacle in the understanding of human locomotion is the availability and validity of experimental data or computational models. Corresponding measurements describing the relationships of the nervous and musculoskeletal systems and their dynamics are highly variable. Likewise, computational models and musculoskeletal models in particular are vitally dependent on these measurements to define model behavior and mechanics. These measurements are often sparse and disparate due to unsystematic data collection containing variable methodologies and reporting conventions. To date, …

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The Wiring Logic Of Identified Serotonergic Neurons Across Olfactory Networks In Drosophila, Kaylynn E. Coates Jan 2020

The Wiring Logic Of Identified Serotonergic Neurons Across Olfactory Networks In Drosophila, Kaylynn E. Coates

Graduate Theses, Dissertations, and Problem Reports (ETD)

Serotonin is a ubiquitous neuromodulator that confers flexibility in networks to modulate a wide array of behavioral and physiological processes. However, due to the complexity and heterogeneity of serotonergic systems, it has been challenging to determine the patterns of connectivity as well as the physiological contexts that influence individual serotonin neurons. In this dissertation, I use two serotonergic neurons which innervate the Drosophila olfactory system, the CSDns, as a model to explore these broad questions comprehensively using anatomical approaches. I first show that the CSDns have distinct connectivity relationships with populations of antennal lobe principal olfactory neurons and that their …

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Image And Video-Based Autism Spectrum Disorder Detection Via Deep Learning, Mindi Ruan Jan 2020

Image And Video-Based Autism Spectrum Disorder Detection Via Deep Learning, Mindi Ruan

Graduate Theses, Dissertations, and Problem Reports (ETD)

People with Autism Spectrum Disorder (ASD) show atypical attention to social stimuli and aberrant gaze when viewing images of the physical world. However, it is unknown how they perceive the world from a first-person perspective. In this study, we used machine learning to classify photos taken in three different categories (people, indoors, and outdoors) as either having been taken by individuals with ASD or by peers without ASD. Our classifier effectively discriminated photos from all three categories but was particularly successful at classifying photos of people with >80% accuracy. Importantly, the visualization of our model revealed critical features that led …

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A Flight Sensory-Motor To Olfactory Histamine Circuit Mediates Olfactory Processing Of Ecologically And Behaviorally Natural Stimuli, Samual P. Bradley Jan 2020

A Flight Sensory-Motor To Olfactory Histamine Circuit Mediates Olfactory Processing Of Ecologically And Behaviorally Natural Stimuli, Samual P. Bradley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Environmental pressures have conferred species specific behavioral and morphological traits to optimize reproductive success. To optimally interact with their environment, nervous systems have evolved motor-to-sensory circuits that mediate the processing of its own reafference. Moth flight behavioral patterns to odor sources are stereotyped, presumably to optimize the likelihood of interacting with the odor source. In the moth Manduca sexta wing beating causes oscillatory flow of air over the antenna; because of this, odorant-antennal interactions are oscillatory in nature. Electroantennogram recordings on antennae show that the biophysical properties of their spiking activity can effectively track odors presented at the wing beat …

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Factors Influencing Huntingtin Aggregation At Surfaces: Implications For Huntington’S Disease, Sharon E. Groover Jan 2020

Factors Influencing Huntingtin Aggregation At Surfaces: Implications For Huntington’S Disease, Sharon E. Groover

Graduate Theses, Dissertations, and Problem Reports (ETD)

Huntington’s Disease (HD) is a genetic, neurodegenerative disease characterized by an abnormal polyglutamine (polyQ) expansion in the first exon of the huntingtin protein (htt). The polyQ domain facilitates aggregation and initiates the formation of a diverse collection of aggregate species, including fibrils, oligomers and annular aggregates. The first 17 amino acids of htt (Nt17) directly flank the polyQ domain and is a key factor in htt’s association to membranous structures. In addition to Nt17 being an amphipathic αhelix, it also promotes aggregation through self-association and contains numerous posttranslational modifications (PTMs) that can modulate toxicity and subcellular localization. For in depth …

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Cerebrovascular Dysfunction And Degeneration In Alzheimer’S Disease Pathophysiology, Dominic Dimitri Quintana Jan 2020

Cerebrovascular Dysfunction And Degeneration In Alzheimer’S Disease Pathophysiology, Dominic Dimitri Quintana

Graduate Theses, Dissertations, and Problem Reports (ETD)

Alzheimer’s disease (AD) is a terminal illness and the most common form of dementia, which disproportionately affects the aged population. The pathophysiology of AD is characterized by neurodegeneration that slowly progresses, affecting regions of the brain that are involved in learning, memory, language, and executive function. In patients with the disease, early symptoms include non-disruptive forgetfulness that evolves into the inability to form new memories and ultimately the loss of autonomy at late stages. Histopathological hallmarks in the brain from patients with AD is the presence of amyloid-β (Aβ)-plaques and neurofibrillary tangles (NFT) deposited in the parenchyma. Since the discovery …

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The Interplay Of Progestins, Matrix Metalloproteinases, And The Aging Brain, Keyana Nicole Porter Jan 2020

The Interplay Of Progestins, Matrix Metalloproteinases, And The Aging Brain, Keyana Nicole Porter

Graduate Theses, Dissertations, and Problem Reports (ETD)

Progestins are synthetic hormones that are designed to mimic the biological actions of progesterone. They, however, possess other pharmacological actions and properties, in addition to their progestational activities. Medroxyprogesterone Acetate (MPA) is a progestin used globally in the hormonal contraceptive, Depo Provera®, by women in their reproductive prime and is a major compound found in hormone therapy (HT) formulations used by menopausal women. MPA is used by approximately 1 in 5 adolescents and adult women in the United States who are sexually active. Globally, nearly 48 million women utilize injectable contraceptives to prevent pregnancy, with most users utilizing MPA as …

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Neuromechanical Tuning For Arm Motor Control, Russell Lee Hardesty Jr Jan 2020

Neuromechanical Tuning For Arm Motor Control, Russell Lee Hardesty Jr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Movement is a fundamental behavior that allows us to interact with the external world. Its importance to human health is most evident when it becomes impaired due to disease or injury. Physical and occupational rehabilitation remains the most common treatment for these types of disorders. Although therapeutic interventions may improve motor function, residual deficits are common for many pathologies, such as stroke. The development of novel therapeutics is dependent upon a better understanding of the underlying mechanisms that govern movement. Movement of the human body adheres to the principles of classic Newtonian mechanics. However, due to the inherent complexity of …

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Neuroimaging Of Real-World Audio-Visual Sensory Integration In High-Functioning Autism, Paula J. Webster Jan 2020

Neuroimaging Of Real-World Audio-Visual Sensory Integration In High-Functioning Autism, Paula J. Webster

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sensory processing differences are a prevalent aspect of autism spectrum disorder (ASD) that may contribute to core deficits of ASD such as repetitive behaviors as well as comorbidities including anxiety disorders. The ability to integrate information among our senses is required to comprehend the world around us and is crucial for the development of language, motor skills, and social communication. Prior studies have shown that individuals with autism differ from individuals without autism when presented with simple, non-natural audio-visual stimuli such as basic shapes accompanied by pure tones. Because the human brain processes non-natural and natural stimuli differently, more recent …

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C-Jun Nh2-Terminal Kinase Signaling Controls Cellular Mechanisms Of Guided Cortical Interneuron Migration, Skye Eleanor Smith Jan 2020

C-Jun Nh2-Terminal Kinase Signaling Controls Cellular Mechanisms Of Guided Cortical Interneuron Migration, Skye Eleanor Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

The cerebral cortex is an intricately organized brain structure responsible for high-level functions including sensory perception, movement, memory, language, and cognition. During corticogenesis, cortical excitatory neurons and inhibitory interneurons migrate from their respective progenitor zones into the developing cerebral cortex, deposit in the correct cortical layer, and establish connections with their appropriate synaptic partners. The balance between excitation and inhibition is critical for cortical circuitry development and function. Aberrant migration of inhibitory interneurons can alter the formation of cortical circuitry and lead to several neurodevelopmental disorders including epilepsy, autism spectrum disorder, and schizophrenia. Therefore, elucidating the mechanisms responsible for inhibitory …

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Reprograming Neuronal Cells By Overexpression Of Fibroblast-Specific Transcription Factors, Abdulmohsen Alanazi Jan 2020

Reprograming Neuronal Cells By Overexpression Of Fibroblast-Specific Transcription Factors, Abdulmohsen Alanazi

Masters Theses

In mammals, a complex system of regulatory signals distinguishes tissues, structures and functions. Combinations of transcription factors and co-factors regulate activation and repression of genes that result in cellular differentiation. Whole genome arrays allow the monitoring of genomic expression in specific tissues. Fibroblast microarray studies have shown candidate genes that may be involved in fibroblast identification, including genes that express transcription factors Prrx1, Snai2 and Twist1. A previous study showed that the Prrx1 and Snai2 could reactivate a fibroblast phenotype in hybrid cells that had lost fibroblast identity. Furthermore, overexpression of these factors in liver-derived cells strongly repressed liver gene …

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How Does Eye Movement Desensitization And Reprocessing (Emdr) Work? An Examination Of The Potential Mechanisms Of Action, Sara Forster Jan 2020

How Does Eye Movement Desensitization And Reprocessing (Emdr) Work? An Examination Of The Potential Mechanisms Of Action, Sara Forster

Theses and Dissertations

A mounting body of evidence suggests that Eye Movement Desensitization and Reprocessing therapy (EMDR) is successful in reducing the impact of posttraumatic symptoms. Although the exact mechanisms of action remain unknown, theories from the psychological to the neuroscientific continue to emerge, expand, and evolve. This study will examine four of the most prominent theories to date and weigh the evidence for and against each one. It will also review, compare, and contrast the theories, evaluate the research supporting each one, and propose the most likely explanation for EMDR's success given the state of the research. Neurobiological mechanisms and correlates as …

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Ethical Considerations For Invertebrates, Scarlett R. Howard, Matthew R.E. Symonds Jan 2020

Ethical Considerations For Invertebrates, Scarlett R. Howard, Matthew R.E. Symonds

Animal Sentience

Mikhalevich & Powell (2020) have built on the discussion about which species deserve inclusion in animal ethics and welfare considerations. Here, we raise questions concerning the assessment criteria. We ask how to assess different species for their ability to fulfill the criteria, which criteria are most important, how we quantify them (absolute or on a continuum), and how non-animals such as fungi and plants fit into this paradigm.

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A Kinesin Adapter Directly Mediates Dendritic Mrna Localization During Neural Development In Mice, Hao Wu, Jing Zhou, Tianhui Zhu, Ivan Cohen, Jason Dictenberg Jan 2020

A Kinesin Adapter Directly Mediates Dendritic Mrna Localization During Neural Development In Mice, Hao Wu, Jing Zhou, Tianhui Zhu, Ivan Cohen, Jason Dictenberg

Publications and Research

Motor protein-based active transport is essential for mRNA localization and local translation in animal cells, yet how mRNA granules interact with motor proteins remains poorly understood. Using an unbiased yeast two–hybrid screen for interactions between murine RNA-binding proteins (RBPs) and motor proteins, here we identified protein interaction with APP tail-1 (PAT1) as a potential direct adapter between zipcode-binding protein 1 (ZBP1, a β-actin RBP) and the kinesin-I motor complex. The amino acid sequence of mouse PAT1 is similar to that of the kinesin light chain (KLC), and we found that PAT1 binds to KLC directly. Studying PAT1 in mouse …

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Depression And Anxiety In A Female Adolescent Population With Sources Of Social Support Latent Profiles, Kathleen Kelly Jan 2020

Depression And Anxiety In A Female Adolescent Population With Sources Of Social Support Latent Profiles, Kathleen Kelly

Graduate Research Theses & Dissertations

Social support is associated with various outcomes such as depression and anxiety. Less work has investigated how support received from various sources cumulatively is associated with internalizing symptoms. Research suggests that above other sources, parents and peers are the most strongly associated with internalizing outcomes. Looking at female adolescents specifically, the current study explored 1) what patterns of social support across sources emerge in a female adolescent sample, and 2) how do depressive and anxiety symptoms vary based on those patterns of social support? The study utilized Latent Profile Analysis (LPA) on data collected from a female high school sample …

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Retrospective Unbiased Plasma Lipidomic Of Progressive Multiple Sclerosis Patients-Identifies Lipids Discriminating Those With Faster Clinical Deterioration, Mario Amatruda, Maria Petracca, Maureen Wentling, Benjamin Inbar, Kamilah Castro, Emily Y. Chen, Michael A. Kiebish, Keith Edwards, Matilde Inglese, Patrizia Casaccia Jan 2020

Retrospective Unbiased Plasma Lipidomic Of Progressive Multiple Sclerosis Patients-Identifies Lipids Discriminating Those With Faster Clinical Deterioration, Mario Amatruda, Maria Petracca, Maureen Wentling, Benjamin Inbar, Kamilah Castro, Emily Y. Chen, Michael A. Kiebish, Keith Edwards, Matilde Inglese, Patrizia Casaccia

Advanced Science Research Center

The disease course of patients with a confirmed diagnosis of primary progressive multiple sclerosis (PPMS) is uncertain. In an attempt to identify potential signaling pathways involved in the evolution of the disease, we conducted an exploratory unbiased lipidomic analysis of plasma from non-diseased controls (n = 8) and patients with primary progressive MS (PPMS, n = 19) and either a rapid (PPMS-P, n = 9) or slow (PPMS-NP, n = 10) disease course based on worsening disability and/or MRI-visible appearance of new T2 lesions over a one-year-assessment. Partial least squares-discriminant analysis of the MS/MSALL lipidomic dataset, identified lipids driving the …

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Neurodegenerative Modeling: Tau Protein, Degradative Pathways, And Gene Expression Profiling Of Human Ipsc-Derived Neural Precursors And Differentiated 3-D Neural Sphere Versus 2-D Monolayer Cultures, Kyle H. Anthoney Jan 2020

Neurodegenerative Modeling: Tau Protein, Degradative Pathways, And Gene Expression Profiling Of Human Ipsc-Derived Neural Precursors And Differentiated 3-D Neural Sphere Versus 2-D Monolayer Cultures, Kyle H. Anthoney

Cal Poly Humboldt theses and projects

Human induced pluripotent stem cells offer a model for human brain development and disease by differentiation into brain organoids; however, current neural culture systems lack the microenvironment, neuronal circuits and connectivity, vascular circulation, and immune system that exist in vivo. After differentiation and development of neuronal and non-neuronal cell types within two formats of cell cultures, we can visualize and recapitulate in vivo protein accumulation, gene expression, and degradative processes such as autophagy. Using RNA extraction, purification methods and reverse transcription I compared traditional monolayer cultures and novel 3-D neural sphere cultures via gene expression analysis. This analysis indicated …

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Effects Of Optic Nerve Head Astrocyte-Derived Exosomes On Neuronal Survival And Differentiation In Vitro In A Model For Exfoliation Glaucoma, Harsh Nilesh Hariani Jan 2020

Effects Of Optic Nerve Head Astrocyte-Derived Exosomes On Neuronal Survival And Differentiation In Vitro In A Model For Exfoliation Glaucoma, Harsh Nilesh Hariani

Master's Theses

Exfoliation glaucoma (XFG) is characterized by deposition of exfoliation material at the trabecular meshwork thereby blocking aqueous outflow and consequently increasing intraocular pressure (IOP). Elevated IOP initiates glaucomatous biomechanical damage at the optic nerve head (ONH) eventually resulting in retinal neuronal death and vision loss. The major cell type at ONH are ONH astrocytes (ONHA). A chronic downregulation of LOXL1 expression has been reported in ONH of XFG patients. We hypothesized that wild-type and LOXL1 knock-down ONHA derived exosomes have differential effects on neurons in vitro.We here report that ONHAs release exosomes, which can be taken up by astrocytes and …

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Epigenetic Alterations At Synaptic Plasticity Genes In A Genetically Heterogeneous Rat Model Of Neuropsychiatric Disorders, Doan M. On Jan 2020

Epigenetic Alterations At Synaptic Plasticity Genes In A Genetically Heterogeneous Rat Model Of Neuropsychiatric Disorders, Doan M. On

Theses and Dissertations

Sensorimotor gating impairments are observed across a range of neuropsychiatric conditions. The prepulse inhibition of the acoustic startle response (PPI) is a validated measure of sensorimotor gating. Genetic and pharmacological manipulations in rodents have shown PPI is regulated by specific brain monoaminergic systems. Using genetically heterogeneous NIH-HS rats, we stratified individuals by %PPI. In low PPI animals, we observed elevated mRNA levels of certain neurotransmitter receptors, including metabotropic glutamate receptor Grm2, dopamine receptors Drd1 and Drd2, serotonin receptors Htr1a and Htr2a, and scaffolding protein Homer1, in the frontal cortex (FC) and striatum (STR). We found Drd2 …

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Role Of Clic4 And The Synaptic Transcriptome In The Behavioral And Molecular Neurobiology Of Ethanol, Rory M. Weston Jan 2020

Role Of Clic4 And The Synaptic Transcriptome In The Behavioral And Molecular Neurobiology Of Ethanol, Rory M. Weston

Theses and Dissertations

Alcohol use disorder (AUD) is a prevalent neuropsychiatric disease with profound health, social, and economic consequences. With an estimated 50% heritability, identifying genes that engender risk and contribute to the underlying neurobiological mechanisms represents an important first step in developing effective treatments. Gene expression studies are an important source of candidate genes for studying AUD, providing windows into the molecular machinery engaged by the brain in response to ethanol. Published studies have identified chloride intracellular channel 4 (Clic4) as an ethanol-regulated gene in brain capable of modulating sensitivity to sedation in multiple species. The functions of Clic4 are …

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Effects Of Gestational Ozone Exposure On Privileged Placental And Brain Barrier Integrity, Alexander I. Hamm Jan 2020

Effects Of Gestational Ozone Exposure On Privileged Placental And Brain Barrier Integrity, Alexander I. Hamm

Theses and Dissertations

Ambient outdoor ozone, a common of component of photochemical smog and urban air pollution, is linked to various neurological and vascular pathologies. Its immediate reaction with lung surfactant after inhalation results in complete reactivity of the gas, with no active ozone passing into circulation. This indicates the presence of secondary and tertiary mediators in ozone-related systemic pathologies after pulmonary insult. In vasculature, ozone exposure is associated with an acute hypertensive phenotype apparent at least 24 hours after dose, such as experienced on a hot summer afternoon in a large metropolitan area like Los Angeles or Mexico City. However, the effects …

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Lpa Receptors Modulate Gene Expression During Oligodendrocyte Differentiation, Samantha A. Spencer Jan 2020

Lpa Receptors Modulate Gene Expression During Oligodendrocyte Differentiation, Samantha A. Spencer

Theses and Dissertations

LPA, produced by the lysoPLD activity of ATX, binds its cognate receptors and regulates the development of multiple brain cells, including oligodendrocytes (OLGs). OLGs progress through a lineage from precursor (OPC) to early OLG to immature OLG, until finally the cells mature and enwrap axons to enable saltatory conduction and provide trophic support. The studies in this dissertation characterized the receptors LPA4 and LPA6 as inhibitors of OPC differentiation. Western blot analysis of MS patient lesion tissue found a negative correlation between ATX levels and levels of LPA4 and LPA6. A previously created homology model for LPA4 was used to …

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Exosomes As Systemic Mediators Of Nanotube Induced Neurotoxicity, Christopher G. Canal Jan 2020

Exosomes As Systemic Mediators Of Nanotube Induced Neurotoxicity, Christopher G. Canal

Theses and Dissertations

Extra-pulmonary effects of nanoparticle inhalation have been well documented; however, mechanisms for conveying peripheral bioactivity remain elusive. Recent studies point to indirect molecular mediators shed into the circulation. Protein and lipid alternatives to cytokines or chemokines have been proposed, yet the diversity among responses suggests a broader assemblage of factors. Recently we have proposed proteolytic fragment peptides as an additional source of bioactivity, which interestingly were significantly associated with exosomal proteins after enrichment analysis. Here we tested whether modeled exposure to multi-walled carbon nanotubes (MWCNT) could alter the composition and bioactivity of circulating exosomes. Male C57BL/6 mice were exposed by …

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Spinal Motor Neuron Excitability And Balance Control Changes Following Downslope Walking, Nikki Aitcheson-Huehn Jan 2020

Spinal Motor Neuron Excitability And Balance Control Changes Following Downslope Walking, Nikki Aitcheson-Huehn

Theses and Dissertations (Comprehensive)

Downslope walking (DSW) has been proposed as a rehabilitation tool for people with Multiple Sclerosis (PwMS) although there are mixed findings in young adults (YA) regarding the balance control changes, despite both populations experiencing depressed spinal motor neuron (MN) pool excitability. Our aim was to determine whether YAs could demonstrate improved balance control in conjunction with SOL H reflex depression (estimate of spinal MN excitability) following DSW. We also aimed to determine whether reciprocal inhibition was a potential mechanism for H reflex depression via conditioned SOL H reflexes. Thirty young adults (23±1.4y, 6 males) were assigned to 30-minutes of DSW …

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Genetic Evidence, Maoa, And State V. Yepez, Nita A. Farahany, Roderick T. Kennedy, Brandon L. Garrett Jan 2020

Genetic Evidence, Maoa, And State V. Yepez, Nita A. Farahany, Roderick T. Kennedy, Brandon L. Garrett

Faculty Scholarship

No abstract provided.

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