Neuroscience and Neurobiology Commons^™

Effects Of A Play-Based Intervention On Locomotor Skills And Strength Performance Of Children With Autism Spectrum Disorder, Amber Bardsley

Honors Scholar Theses

Emerging evidence indicates that around 80-100% of children with autism spectrum disorder (ASD) have motor impairments in gross motor skills, strength, and endurance. In the current study, which is a multisite collaboration with the physical therapy programs at the University of Connecticut and the University of Delaware, we are assessing the effects of two types of movement-based interventions compared to a standard-of-care seated play control intervention on motor performance in children with ASD. This thesis will analyze data from one of the movement training groups, i.e., the play group, that involved children engaging in activities based on music, dance, and …

The Development And Evaluation Of Novel Da Transport Inhibitors And Their Effects On Effort-Related Motivation: A Review, Mukund Desibhatla

Honors Scholar Theses

Depression is a debilitating disorder that can cause motivational deficits such as psychomotor retardation, anergia, apathy, and fatigue. Recent research indicates that these motivational deficits, and potential pathways of therapeutic intervention, can be studied in animal models involving rats and mice. Treatments with the VMAT-2 inhibitor tetrabenazine (TBZ) and cytokine interleukin-1ß (IL-1ß) can create a low-effort bias and impair effort-related motivation (Nunes et al. 2013, 2014). A number of high-affinity DA transport inhibitors such as d-amphetamine, methylphenidate, and cocaine can restore extracellular DA, albeit with the cost of undesirable effects such as high abuse liability. These observations have led researchers …

An Eeg Source-Space Analysis Of The Neural Correlates Underlying Self-Regulation, Stephanie M. Long

Graduate Theses and Dissertations

Self-regulation is the cognitive process of controlling our thoughts and behaviors to be aligned with our goals. This process is used in many different contexts and has been associated with contributions from several brain regions. This research aimed to investigate differences in four prefrontal areas of the brain while participants applied four different self-regulation strategies. We recorded EEG while participants (N = 132) performed three tasks which engaged each of the four self-regulation strategies: the AX-CPT task engaged proactive and reactive control, the Go/Nogo task engaged inhibitory control, and the hybrid Flanker Global/Local task engaged the resolution of response conflict. …

You Might Think This Article Is About You: A Neurological Overview Of Narcissistic Personality Disorder, Kaitlyn Griffith

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Loosen Up, Sleep Tight: How Relaxation Techniques May Be The Solution To Stress-Induced Insomnia, Afomia Ayele

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Soak Up The Sun: How Sun Affects And Protects The Brain, Benjamin Dorfman

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Stress, Stress, The More You Drink The Better You Feel, But Let's Not Have Alcohol For Every Meal, Elena Schaub

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

The Brain And Swiping For Love, Samantha Beck

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Actually, Say Yes To Dope: A Much-Maligned Drug May Be The Key To Saving The Brain From Concussions, Charles Adams

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Are We There Yet? How Our Brains Understand Time, Laura Grosh

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Contents

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

A Look Into The Crystal Ball: Should Genetic Testing Tell Your Future?, Elisabeth Bradford

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Separation Of Art And Science, That's A Wap (Wasted Academic Potential), Amna Tahir

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Cheese, Please! Depression Curing Cultures: How Diet Can Alter Your Mood, Julia Borys

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

The Enemy Of My Enemy Is My Friend? How Viruses Can Be Used To Treat Brain Cancer, Kai Wilczewski-Shirai

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Scientific Kenyon: Neuroscience Edition (Full Issue)

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Worrisome Weight Gain: How Stress Affects Eating Behavior, Madison Ladd

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

It's Not You, It's Me (Your Genes), Gillian Heckler

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Closed Eyes, Open Mind: An Exploration Of Consciousness, Arlo Durham

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Head To Head: How Concussion Research Shapes How We Play Football, Jaryd Jones

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Mind Control 101: A Recipe For Memory Manipulation, Richard Fu

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

From Stagger To Swagger, Frank Zhao

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Investigating Mechanisms In Nociceptors Driving Ongoing Activity And Ongoing Pain, Elia Lopez

Dissertations and Theses (Open Access)

Ongoing (apparently spontaneous) pain at rest is a major complaint of patients suffering from many forms of acute and chronic pain, including acute and persistent postsurgical pain. Accumulating evidence suggests ongoing activity in nociceptors is a major driver of ongoing pain. Ongoing activity can be generated in sensory neurons in the absence of sensory generator potentials if one or more of three neurophysiological alterations occur – prolonged depolarization of resting membrane potential (RMP), hyperpolarization of action potential (AP) threshold, and/or increased amplitude of depolarizing spontaneous fluctuations of membrane potential (DSFs) to bridge the gap between RMP and AP threshold. Cellular …

Cortical Dynamics Of Language, Kiefer Forseth

Dissertations and Theses (Open Access)

The human capability for fluent speech profoundly directs inter-personal communication and, by extension, self-expression. Language is lost in millions of people each year due to trauma, stroke, neurodegeneration, and neoplasms with devastating impact to social interaction and quality of life. The following investigations were designed to elucidate the neurobiological foundation of speech production, building towards a universal cognitive model of language in the brain. Understanding the dynamical mechanisms supporting cortical network behavior will significantly advance the understanding of how both focal and disconnection injuries yield neurological deficits, informing the development of therapeutic approaches.

Characterization Of A Novel Oncogenic Mirna Inhibitor In Cancer Therapy, Iman Sahnoune

Dissertations and Theses (Open Access)

As cancer research continues to move towards more personalized methods, targeted inhibitors of oncogenic drivers of cancer are found to be an innovative and promising therapeutic approach. Previously thought to be undruggable regions of the genome, RNA has become an area of increasing interest in cancer due to the identification of more targetable regions and their relationship to tumor growth and progression. This work reports on the development of IACS-13743, a novel small molecule found to directly bind and inhibit microRNA-10b. Oncogenic miR-10b has been found to be overexpressed in several malignant cancer types, making it an attractive biomarker for …

Development Of A Novel Cognitive-Motor Dual Task Assessment Battery In Neurodegenerative Disease, Jason Longhurst

UNLV Theses, Dissertations, Professional Papers, and Capstones

Automaticity --- the ability to perform a task with directing attentional resources to its completion --- is commonly reduced among individuals with neurodegenerative diseases. These automaticity deficits result in impaired functional and daily activities and are sensitive to subtle, subclinical impairments. However, current measurement of automaticity by dual task paradigms is methodologically limited. In order to gain insight into the current state of the literature regarding cognitive-motor interference in symptomatic and prodromal neurodegenerative disease, the author of this dissertation conducted a scoping review (Chapter 1). To address the methodological limitations of current measurement of automaticity, a new measurement tool was …

Headache-Related Disability Among Individuals With And Without Migraine Aura, Delora Denney

Honors Theses

Migraine is a neurological disease marked by recurrent headache and migraine attacks. Migraine is one of the most common diseases in the world, and as a result of high prevalence and symptoms, migraine is also quite disabling. One-third of people who have migraine experience aura, and these individuals have a greater risk for stroke, psychiatric comorbidities, and suicide attempts. The present study aimed to evaluate if there was a difference in headache-related disability between those who have migraine with and without aura, and any headache or psychiatric factors that may account for observed difference in disability.

The present study is …

Meta-Analysis Of Long Term Executive Functioning Deficits In Individuals With Mild Traumatic Brain Injuries, Dominique Ballinger

Neuroscience Honors Papers

Performed a meta-analysis of studies examining the long-term executive functioning deficits after suffering several mild traumatic brain injuries. Data was collected from multiple primary sources under several, specific criteria to find the best methods in demonstrating the longevity and urgencies in suffering several mTBIs.

The Role Of The Dal Neurons In Modulating Circadian Rhythms In Olfactory Short-Term Memory In Drosophila Melanogaster, Cooper Ruwe

Honors Theses

Depressed short-term memory (STM) abilities during non-adaptive times of the day can significantly impact those who work occupations that require peak levels of cognitive functioning around the clock. While much work has gone into understanding the endogenous clock and circadian rhythms, there is still much to learn about the neural circuity that underlies the daily rhythms that define these regular oscillations in STM performance. The DAL neurons in the Drosophila brain are part of the circadian network and innervate the mushroom bodies (MBs), the species’ olfactory learning center, making them compelling candidates to be involved in circadian circuitry for olfactory …

The Effects Of Acute Exercise On Retrieval Induced Forgetting, Walter Simpson

Honors Theses

Retrieval Induced Forgetting (RIF) is a type of active forgetting that may play beneficial and detrimental roles in long-term memory. The benefit of the retrieval of certain information is that information will become more readily available following subsequent retrieval; a concept termed the retrieval practice effect (RP). The detrimental effect of RIF may be that, upon the subsequent recall of certain information, related information may be inhibited from recall. The effects and mechanisms of RIF have remained a topic of debate among neuroscientists, psychologists, and other related scholars. The goal of this study was to evaluate the effects of acute …