Neuroscience and Neurobiology Commons^™

The Role Of Interleukin-1 Beta In Methamphetamine Mediated Increases In Dopamine Release Within The Mesolimbic Pathway, Anneke Klomp, Ben Lee, Dr. Scott Steffensen

Journal of Undergraduate Research

In this study we wanted to determine the effect that Interleukin-1 Beta (IL-1𝛃) would have in changing the effects that methamphetamines have on dopamine release in the nucleus accumbens (reward center of the brain). It has been well established previously that methamphetamines increases dopamine levels in the nucleus accumbens. Given that IL-1𝛃 increases inflammation in the brain which has been seen to be involved in dopamine release and that IL-1𝛃 is able to act on other parts of the brain, we suspected that by inhibiting IL-1𝛃 we would see a decrease in dopamine response to methamphetamines. If the IL-1𝛃 blocker, …

The Involvement Of The Ip3 Receptor In The Rewarding/Addictive Properties Of Methamphetamine, Mark Woodbury, Dr. Scott Steffensen

Journal of Undergraduate Research

Methamphetamine (METH) is a very powerful psychoactive drug that is highly addictive and toxic to the brain. Its use and abuse has been rising in recent years, and certain reports indicate that amphetamine-like drugs are the second most abused drugs worldwide. The side effects of METH abuse are varied and serious in nature, including: hyperthermia, tooth decay, heart attack, seizures, stroke, skin lesions, memory loss, confusion, anxiety, depression, psychosis, Parkinson’s Disease, and increased severity of HIV/AIDS (Chang et al., 2005; Curtin et al., 2015; Thanos et al., 2017). Despite these devastating effects, many of those addicted do not or cannot …

Fixation-Related Fmri And Syntactic Networks In The Brain, Brent Foster, Dr. Steven Luke

Journal of Undergraduate Research

Humans comprehend language at varying levels of complexity. Syntax, in particular, deals with the arrangement of words and phrases into meaningful sentences. For instance, in English we expect most sentences to follow some variation of the order “Subject–Verb–Object” such as “The boy (Subject) ate (Verb) cake (Object).” On the surface, such grammatical rules seem simple. However, our understanding of how the brain implements these rules to understand sentences is incomplete.

Polymorphisms Of The 5-Httlpr Gene: Associations To Ern And Depression, Curtis Killpack, Michael J. Larson

Journal of Undergraduate Research

Our aim with this study of polymorphisms in the serotonin transporter gene (5-HTTLPR) was to investigate the association between performance monitoring capabilities (i.e., detecting errors in performance using the error-related negativity [ERN] component of the scalp recorded event-related potential [ERP]) against three variations of gene 5-HTTLPR allelic pairs: homozygous short (S/S), heterozygous short-long (S/L), and homozygous long (L/L). The serotonin transporter gene is associated with our ability to cope with stress and regulate serotonin, which affects mood, social behavior, appetite, and sleep (Adam, Doane, Zinbarg, Mineka, Craske, & Griffith, 2010). Previous studies (Barnes, Dean, Nandam, O’Connell, & Bellgrove, 2011) have …

The Role Of Bdnf Expression In Chronic Ethanol Usage, Caleb Porter, Scott Steffensen

Journal of Undergraduate Research

It has been observed that chronic exposure to drugs of abuse, particularly opiates, increases brain-derived neurotrophic factor (BDNF) levels in ventral tegmental area (VTA) neurons. In particular, BDNF expression is dramatically increased during drug withdrawal, which would suggest a direct connection between the aversive state of withdrawal and BDNFinduced neuronal plasticity. The purpose of this project was to evaluate the relationship between brain-derived neurotrophic factor (BDNF) expression, which is dramatically increased within the ventral tegmental area (VTA) during drug abuse, and alcohol withdrawal symptoms.

Role Of Exercise And Stress In Memory And Learning Of The Hippocampus, Paul Baker, Jeff Edwards

Journal of Undergraduate Research

Some of the most devastating diseases today are diseases of the mind. Common side effects of Alzheimer’s disease are dementia and memory loss and more than 44 million people suffer from the disease worldwide [1]. Other mental diseases such as Parkinson’s also have a dramatic impact on the memory and learning pathways. Understanding the mechanism involved with memory and learning will bring science that much closer to finding a permanent cure to these devastating diseases.

Response Time Scores On A Reflexive Attention Task Predict A Child's Inattention Score From A Parent Report, Erica Suh, Katherine Christensen, Sarah Kamhout, Kahala Thompson, Yoojin Kim, Cooper Hodges

FHSS Mentored Research Conference

● Children with attention deficits have problems with sustained and reflexive attention tasks

● Few studies measure reflexive attention as a component of day-to-day attention in children

● Parents also have valuable insight into children’s behavior

● We want to identify associations between computer-based reflexive attention task performance and parent-rated attention-related problems.

Identifying Novel Cognitive Therapy Targets: Expression Of Nachr Mrna In Rat Hippocampal Interneurons, Spencer Thompson, Maxwell Wright, Taylor Grant, Brady Vance, Nicholas Ahern, Jeffrey Ogden, Romaine Drecketts, David Pugh, Zach Fisher, Sara Werner, Jaron Fowlers, Bradley Klienstuber, Richard Burgon, Ashley Sego, Doris Jackson, Sterling N. Sudweeks

FHSS Mentored Research Conference

We quantified mRNA subunit expression in the CA1 rat hippocampus. The a3 and B2 nAChR subunits are the highest expressed mRNA subunits while the a4 is the least. Current nAChR targeted cognitive therapies focus on the a4B2 and a7 nAChRs. These results provide a new avenue in cognitive therapies by targeting a3 containing nAChRs.

Fixation-Related Fmri And Syntactic Networks In The Brain, Brent Foster, Ben Carter, Steven Luke

FHSS Mentored Research Conference

Humans comprehend language at varying levels of complexity. Syntax, in particular, deals with the arrangement of words and phrases into meaningful sentences. For instance, in English we expect most sentences to follow some variation of the order "Subject-Verb-Object: such as "The boy (Subject) ate (Verb) cake (Object)." On the surface, such grammatical rules seem simple. However, our understanding of how the brain implements these rules to understand sentences is incomplete.

Syntax appears to be associated with Broca's area in the frontal lobe and various regions of the left temporal lobe. However, recent research has provided controversial data suggesting that the …

Diabetic Peripheral Neuropathy, Michael Bradshaw, Jeffrey Brown, Kyril Cole, Whitney Harris, Kody Hasebi, Ysabella Del Rosario, Sara Werner, Bryan Witt, Alonzo Cook

Biomedical Engineering Western Regional Conference

No abstract provided.

Nerve Growth Factor And Lysophosphatidylcholine In Peripheral Nerve Repair, Keaton Karlinsey 8741888

Biomedical Engineering Western Regional Conference

NGF, Nerve Growth Factor, Lysophosphatidylcholine, Peripheral nerve regeneration, Sciatic nerve, Sciatic crush injury

Neural Changes Associated With Rewards And Punishment Following Ego Depletion Or Boredom, Travis Z. Johnson, Michael Larson, Marina Milyavskaya, Michael Inzlicht

FHSS Mentored Research Conference

Our brain power is exhaustible. We are constantly trying to find ways to perform at our highest levels. There has been research that has shown that willpower--the capacity to exert self-control--is a limited resource that is depleted after exertion of the brain. Many studies have shown the negative effect that depletion has on daily decisions. Depletion can influence our day-to-day choices and actions in a variety of important ways. The neural mechanisms for ego-depletion are relatively unknown so our purpose is to measure the effects of ego-depletion, and then test ways that it can be decreased or reversed, thus finding …

Novel Pharmacological Target: Characterization Of A3b2 Nachrs Expressed In Xenopus Laevis Oocytes, Doris Jackson, Marcel Hall, J. Kolb, B. Todd Jr., D. Pugh, B. Vance, B. Klienstuber, R. Drecketts, S. N. Sudweeks

FHSS Mentored Research Conference

We have identified two subtypes of the novel a3b2 nicotinic acetylcholine receptor (nAChR) found within interneurons of the hippocampus. This novel receptor may be a valuable pharmacological target in drug development for disease such as Alzheimer’s disease (AD) which is largely characterized by degeneration of the hippocampus.

Pams: A Growing Field In Pharmacological Drug Development, Marcel Hall, J. Kolb, B. Todd Jr., D. Pugh, B. Vance, B. Klienstuber, R. Drecketts, Doris Jackson, H. R. Arias, S. N. Sudweeks

FHSS Mentored Research Conference

Positive Allosteric Modulators (PAMs) are a growing field in pharmacology. PAM-5 and genisteincause acetylcholine (ACh) to elicit larger currents on nicotinic acetylcholine receptors (nAChRs) without activating the channel themselves. In effect, PAMs increase the amplitude of currents at a synapse without altering the normal firing rate of the neurons.

Treatment Of Diabetic Neuropathy With Nitric Oxide Gel, Daniel R. Lathen, David Walton, Yukino Strong, Jeff Ward, Conner Sugrue, Jonathan Trout, Devin Vanderwood, Alonzo Cook Ph.D.

FHSS Mentored Research Conference

Our study investigates a novel therapy to address a vascular factor that contributes to the development of diabetic peripheral neuropathy (DPN) using five experimental groups of a mouse model that spontaneously develops diabetes. The compound under investigation is a nitric oxide (NO)-donating topical gel which has potential as a treatment for preventing and treating DPN.

Marital Satisfaction, Error-Observation, And The Brain: Harmful Or Beneficial Effects Of Spouse Observation?, Chelsea Romney, Michael Larson

Journal of Undergraduate Research

Romney, Chelsea Marital Satisfaction, Error-observation, and the Brain: Harmful or Beneficial Effects of Spouse Observation? Faculty Mentor: Larson, Michael, Department of Psychology and Neuroscience Introduction Rewarding marital relationships are associated with many positive outcomes in one’s physical and mental health (Robles, & Kiecolt-Glaser, 2003). These benefits include improved cardiovascular functioning (Kiecolt-Glaser, & Newton, 2001), decreased depression risk (Robins & Reiger, 1991), higher self-reported levels of happiness (Proulx & Snyder-Rivas, 2013), and overall lower rates of mortality (Manzoli, Villari, Pirone & Boccia, 2007). Furthermore, positive health outcomes are not only due to marital status, but also to the quality of one’s …

Receiving Reward’S Effect On Ego-Depletion, Travis Johnson, Michael J. Larson, Phd

Journal of Undergraduate Research

Recent research suggests that willpower–the capacity to exert self-control–is a limited resource that is depleted after exertion (Job, Dweck & Walton, 2010). We aimed to explore the influence of ego-depletion on how we process rewards and punishment. Ego depletion specifically refers to the idea that self-control or willpower draws upon a limited pool of mental resources that can be used up (i.e., depleted) after cognitive exertion. For example, an experiment performed by Kathleen Vohs and Todd Heatherton (2000) demonstrated how ego depletion was relevant in how it affected chronic dieters compared to non-dieters. Their results showed that dieters, in responding …

Electrophysiological Testing Of Iterhemispheric Transfer In Individuals With Mild Traumatic Brain Injury, Nathan Alder, Michael J. Larson, Phd

Journal of Undergraduate Research

A key issue in mild traumatic brain injury (TBI; also known as concussion) research is the identification and validation of a cost-effective, physiological measure that accurately identifies individuals who have experienced a mild TBI, is robust against motivation difficulties, and aids in the prediction of which individuals will experience persisting cognitive or emotional side effects. Nearly two million cases of TBI occur each year (Langlois, Rutland-Brown, & Thomas, 2004). Mild TBI is considered a major health concern (Ragnarsson, 2002) and can be associated with some long-term functional deficits including memory decline and decreased job satisfaction (Carroll et al., 2004; Iverson, …

Cognitive Control And Obsessive-Compulsive Disorder, Katherine Slinn, Michael Larson

Journal of Undergraduate Research

This project was an in-depth statistical analysis of previously collected data in order to explore the hypothesis that obsessive-compulsive disorder (OCD) is associated with a decrease in the ability to regulate behavior and to apply top-down cognitive control. OCD has been diagnosed in approximately 2.2 million Americans, typically appearing in early adulthood. Approximately half of these cases show severe functional impairment (Kessler, Chiu, Demler, & Walters, 2005). Obsessions are defined as unwanted and recurrent thoughts or impulses, and compulsions are repetitive behaviors that are driven by these obsessions, such as ordering or counting (American Psychiatric Association, 2013). 20% to 30% …

Electrophysiological Testing Of Iterhemispheric Transfer In Individuals With Mild Traumatic Brain Injury, Nathan Alder, Michael J. Larson

Journal of Undergraduate Research

A key issue in mild traumatic brain injury (TBI; also known as concussion) research is the identification and validation of a cost-effective, physiological measure that accurately identifies individuals who have experienced a mild TBI, is robust against motivation difficulties, and aids in the prediction of which individuals will experience persisting cognitive or emotional side effects. Nearly two million cases of TBI occur each year (Langlois, Rutland-Brown, & Thomas, 2004). Mild TBI is considered a major health concern (Ragnarsson, 2002) and can be associated with some long-term functional deficits including memory decline and decreased job satisfaction (Carroll et al., 2004; Iverson, …

Cognitive Control And Obsessive-Compulsive Disorder, Katherine Slinn, Michael Larson

Journal of Undergraduate Research

This project was an in-depth statistical analysis of previously collected data in order to explore the hypothesis that obsessive-compulsive disorder (OCD) is associated with a decrease in the ability to regulate behavior and to apply top-down cognitive control. OCD has been diagnosed in approximately 2.2 million Americans, typically appearing in early adulthood. Approximately half of these cases show severe functional impairment (Kessler, Chiu, Demler, & Walters, 2005). Obsessions are defined as unwanted and recurrent thoughts or impulses, and compulsions are repetitive behaviors that are driven by these obsessions, such as ordering or counting (American Psychiatric Association, 2013). 20% to 30% …

Marital Satisfaction, Error-Observation, And The Brain: Harmful Or Beneficial Effects Of Spouse Observation?, Chelsea Romney, Michael Larson

Journal of Undergraduate Research

Romney, Chelsea Marital Satisfaction, Error-observation, and the Brain: Harmful or Beneficial Effects of Spouse Observation? Faculty Mentor: Larson, Michael, Department of Psychology and Neuroscience Introduction Rewarding marital relationships are associated with many positive outcomes in one’s physical and mental health (Robles, & Kiecolt-Glaser, 2003). These benefits include improved cardiovascular functioning (Kiecolt-Glaser, & Newton, 2001), decreased depression risk (Robins & Reiger, 1991), higher self-reported levels of happiness (Proulx & Snyder-Rivas, 2013), and overall lower rates of mortality (Manzoli, Villari, Pirone & Boccia, 2007). Furthermore, positive health outcomes are not only due to marital status, but also to the quality of one’s …

Effects Of Exercise On Food-Related Cognition, Tyshae Davis, Michael J. Larson

Journal of Undergraduate Research

Since the Yerkes-Dodson theory was initially put forward (as early as 1906), multiple theorists have suggested an inverted-U relationship between physiological arousal and cognitive performance. Literature on this topic, however, is mixed, with some studies showing evidence supporting the inverted-U relationship and others showing a more linear relationship. Exercise and food-related cognition is one area where the inverted-U hypothesis could be applied. Some studies have shown that high-intensity exercise induces an acute, but temporary suppression to hunger and energy intake compared to low-intensity exercise (King, Tremblay, & Blundell, 1997) and that high-intensity exercise favors negative energy balance to a greater …

Polymorphisms Of The Glucocorticoid Receptor Gene And The Association With Stress, Randall Beck, Michael J. Larson

Journal of Undergraduate Research

Polymorphisms in the GR gene are an interesting and important area of research as these polymorphisms may be associated with an attenuated ability to cope with stress. This project bridged an unexplored gap between cellular and environmental stress and the expression of the GR gene—specifically the Bcl1 polymorphism of the GR gene. Cellular stress is any damage caused to the cell that alters its ability to function properly (Milisav, 2011). The Bcl1 polymorphism has what are known as C and G alleles that are genotyped as either homozygous GG, homozygous CC, or heterozygous CG (Srivastava et al., 2011). The homozygous …

The Effects Of Chronic Ethanol In Δ Knockout Mice, Zachary Gardner, Scott Steffensen

Journal of Undergraduate Research

Substance abuse is a prolific problem with serious consequences. Specifically, alcohol abuse is the third leading cause of preventable mortality in the world (Mokdad et al., 2004). Each year the far-reaching effects of alcohol abuse cost the United States several hundred billion dollars annually (Office of National Policy, 2004). Treatment for individuals who suffer from this crippling disease is limited. In order to develop effective treatments we need to know more about the mechanisms of addiction and the changes that occur in the brain as a person becomes addicted.

The Effects Of Chronic Ethanol In Δ Knockout Mice, Zachary Gardner, Scott Steffensen

Journal of Undergraduate Research

Substance abuse is a prolific problem with serious consequences. Specifically, alcohol abuse is the third leading cause of preventable mortality in the world (Mokdad et al., 2004). Each year the far-reaching effects of alcohol abuse cost the United States several hundred billion dollars annually (Office of National Policy, 2004). Treatment for individuals who suffer from this crippling disease is limited. In order to develop effective treatments we need to know more about the mechanisms of addiction and the changes that occur in the brain as a person becomes addicted.

Polymorphisms Of The Glucocorticoid Receptor Gene And The Association With Stress, Randall Beck, Michael J. Larson

Journal of Undergraduate Research

Polymorphisms in the GR gene are an interesting and important area of research as these polymorphisms may be associated with an attenuated ability to cope with stress. This project bridged an unexplored gap between cellular and environmental stress and the expression of the GR gene—specifically the Bcl1 polymorphism of the GR gene. Cellular stress is any damage caused to the cell that alters its ability to function properly (Milisav, 2011). The Bcl1 polymorphism has what are known as C and G alleles that are genotyped as either homozygous GG, homozygous CC, or heterozygous CG (Srivastava et al., 2011). The homozygous …

Depression, Suicide, And Performance Monitoring: Identifying Neuroelectric Markers Of Suicidal Behavior, Kaylie Carbine, Michael Larson

Journal of Undergraduate Research

From 2000-2009, suicide mortality rates increased by 15% (Rockett, et al., 2012) and 98% of individuals who complete suicide have diagnosable psychopathology (Bertolote, Fleischmann, De Leo, & Wasserman, 2003). Individuals at risk for suicide exhibit cognitive impairments in decision-making and problem-solving abilities (Pollock & Williams, 2004; Jollant, et al., 2005). These cognitive deficits may be related to deficits in performance monitoring. Performance monitoring is the ability to continually assess behavior in order to make adjustments and improve performance. Performance monitoring is mediated by the anterior cingulate cortex (ACC), which is related to cognitive control abilities. Furthermore, suicidal thoughts and behaviors …

The Effects Of Sleep-Dependent Memory Consolidation On The Discriminability And Generalizability Of Learning, Bengt Grua, Dr. C Brock Kirwan

Journal of Undergraduate Research

The goal of this study was to determine how sleep affects memory recall in an academic setting with relation to memory discrimination and memory generalization. Memory generalization depends on the computational process of pattern completion, which is the brain’s ability to retrieve a memory representation based on a partial or modified stimulus (such as viewing a false statement as true if it has many true elements embedded in it). Memory discrimination depends on the computational process of pattern separation, which is the brain’s ability to store a memory as distinct and separate from other, similar memories. Current models of sleep …

The Effects Of Sleep-Dependent Memory Consolidation On The Discriminability And Generalizability Of Learning, Bengt Grua, Dr. C Brock Kirwan

Journal of Undergraduate Research

The goal of this study was to determine how sleep affects memory recall in an academic setting with relation to memory discrimination and memory generalization. Memory generalization depends on the computational process of pattern completion, which is the brain’s ability to retrieve a memory representation based on a partial or modified stimulus (such as viewing a false statement as true if it has many true elements embedded in it). Memory discrimination depends on the computational process of pattern separation, which is the brain’s ability to store a memory as distinct and separate from other, similar memories. Current models of sleep …