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Articles 91 - 96 of 96
Full-Text Articles in Neuroscience and Neurobiology
Expression Of Nicotinic Acetylcholine Receptor Mrna As A Function Of Age In Whole Hippocampus Preparations From Wistar Rats, Kasey C. Welch
Expression Of Nicotinic Acetylcholine Receptor Mrna As A Function Of Age In Whole Hippocampus Preparations From Wistar Rats, Kasey C. Welch
Theses and Dissertations
Whole hippocampus preparations, isolated bilaterally, from untreated Wistar rats at various ages (10-90 days old) were analyzed for the mRNA expression of the alpha 2, alpha 3, alpha 4, alpha 5, alpha 7, beta 2, beta 3, and beta 4 neuronal nicotinic acetylcholine receptor subunits. To do so, RNA was isolated from acutely isolated hippocampal samples, converted to cDNA by means of a reverse transcription reaction, then analyzed with quantitative real-time PCR to determine the relative levels of the mRNAs the cells were expressing at the age when the samples were obtained. The relative expression of the levels of RNA …
Neuronal And Molecular Adaptations Of Gaba Neurons In The Ventral Tegmental Area To Chronic Alcohol, Kimberly Hales
Neuronal And Molecular Adaptations Of Gaba Neurons In The Ventral Tegmental Area To Chronic Alcohol, Kimberly Hales
Theses and Dissertations
The purpose of this thesis project was to examine the effects of chronic alcohol on the excitability and molecular adaptation of GABA neurons of the ventral tegmental area (VTA). GABA neurons are of interest with regards to ethanol intoxication, reinforcement, and dependence due to their widespread distribution and connectivity to mesocorticolimbic dopamine (DA) neurons implicated in alcohol reward and addiction. Since we have previously shown adaptation of VTA GABA neuron firing rate to chronic ethanol (Gallegos, Criado et al. 1999) and suppression of gap-junction (GJ) mediated coupling between these neurons by acute ethanol (Stobbs, Ohran et al. 2004), we wanted …
Palmitoylation And Oxidation Of The Cysteine Rich Region Of Snap-25 And Their Effects On Protein Interactions, Derek Luberli Martinez
Palmitoylation And Oxidation Of The Cysteine Rich Region Of Snap-25 And Their Effects On Protein Interactions, Derek Luberli Martinez
Theses and Dissertations
Neurons depend upon neurotransmitter release through regulated exocytosis to accomplish the immense processing performed within the central nervous system. The SNARE hypothesis points to a family of proteins that are thought to enable the membrane fusion that leads to exocytosis. The secondary structure of SNAP-25 is unique among SNARE proteins in that it has two alpha helical SNARE motifs and a cysteine rich (C85, C88, C90, C92) membrane interacting region but notransmembrane domain. The cysteines may be modified by palmitoylation or oxidation but the role of these modifications in vivo is not well understood. Our goal is to elucidate possible …
Effects Of Exposure To Perinatal Ultrasound Radiation On Information Processing In The Auditory System, Jennifer Burnett
Effects Of Exposure To Perinatal Ultrasound Radiation On Information Processing In The Auditory System, Jennifer Burnett
Theses and Dissertations
Ultrasound (US) has become a standard procedure used during pregnancy to document the health and development of a fetus. When ultrasound was first developed, some researchers urged caution, suggesting that the possibility of hazard should be kept under constant review. Given the routine application of fetal ultrasound imaging, any possibility of deleterious developmental effects resulting from its use is an important public health issue. Rats have a well characterized central nervous system whose neurochemical pathways and neuronal electrophysiology qualitatively correspond to those of humans. Because of this, we opted to use Wistar rats as an animal model to document effects …
Brain Stimulation Reward Is Integrated By A Network Of Electrically-Coupled Gaba Neurons, Matthew Brian Lassen
Brain Stimulation Reward Is Integrated By A Network Of Electrically-Coupled Gaba Neurons, Matthew Brian Lassen
Theses and Dissertations
Although it is well-established that animals will self-stimulate electric current to various diverse brain structures, the neural substrate of brain stimulation reward (BSR) has eluded identification since its discovery more than a half-century ago. We show that GABA neurons in the midbrain, hypothalamus and thalamus express connexin-36 (Cx36) gap junctions and couple electrically with dopamine application or by stimulation of the internal capsule (IC), which also supports self-stimulation. The threshold for responding for self-stimulation of the IC is the threshold for coupling between these GABA neurons, the degree of responding for IC ICSS is proportional to the magnitude of electrical …
Classification Of Neuronal Nicotinic Acetylcholine Receptors In Rat Ca1 Hippocampal Interneuron Subpopulations Defined By Calcium-Binding Protein Mrna Expression, Richard M. Burgon
Classification Of Neuronal Nicotinic Acetylcholine Receptors In Rat Ca1 Hippocampal Interneuron Subpopulations Defined By Calcium-Binding Protein Mrna Expression, Richard M. Burgon
Theses and Dissertations
In this study, the single-cell relative quantitative mRNA expression of three Calcium-binding proteins (CaBPs; calbindin, calretinin, parvalbumin) and eight nicotinic acetylcholine receptor (nAChR) subunits (alpha2-alpha5, alpha7, beta2-beta4) from interneurons from the stratum radiatum or stratum oriens within the CA1 region of rat hippocampi was analyzed using quantitative real time RT-PCR. Eighty-seven percent of the interneurons examined expressed CaBP mRNA. Parvalbumin mRNA was detected in 64%, while calbindin and calretinin expression was detected in 26% and 40% of interneurons, respectively. CaBP expression was not exclusive; the average number of CaBP mRNA detected per interneuron of the 47 interneurons examined for CaBP …