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Full-Text Articles in Neuroscience and Neurobiology
Polymorphisms Of The 5-Httlpr Gene: Associations To Ern And Depression, Curtis Killpack, Michael J. Larson
Polymorphisms Of The 5-Httlpr Gene: Associations To Ern And Depression, Curtis Killpack, Michael J. Larson
Journal of Undergraduate Research
Our aim with this study of polymorphisms in the serotonin transporter gene (5-HTTLPR) was to investigate the association between performance monitoring capabilities (i.e., detecting errors in performance using the error-related negativity [ERN] component of the scalp recorded event-related potential [ERP]) against three variations of gene 5-HTTLPR allelic pairs: homozygous short (S/S), heterozygous short-long (S/L), and homozygous long (L/L). The serotonin transporter gene is associated with our ability to cope with stress and regulate serotonin, which affects mood, social behavior, appetite, and sleep (Adam, Doane, Zinbarg, Mineka, Craske, & Griffith, 2010). Previous studies (Barnes, Dean, Nandam, O’Connell, & Bellgrove, 2011) have …
Depression, Suicide, And Performance Monitoring: Identifying Neuroelectric Markers Of Suicidal Behavior, Kaylie Carbine, Michael Larson
Depression, Suicide, And Performance Monitoring: Identifying Neuroelectric Markers Of Suicidal Behavior, Kaylie Carbine, Michael Larson
Journal of Undergraduate Research
From 2000-2009, suicide mortality rates increased by 15% (Rockett, et al., 2012) and 98% of individuals who complete suicide have diagnosable psychopathology (Bertolote, Fleischmann, De Leo, & Wasserman, 2003). Individuals at risk for suicide exhibit cognitive impairments in decision-making and problem-solving abilities (Pollock & Williams, 2004; Jollant, et al., 2005). These cognitive deficits may be related to deficits in performance monitoring. Performance monitoring is the ability to continually assess behavior in order to make adjustments and improve performance. Performance monitoring is mediated by the anterior cingulate cortex (ACC), which is related to cognitive control abilities. Furthermore, suicidal thoughts and behaviors …