Engineering Commons^™

Advances In Bone And Orthopedics 2025 – 5th Edition, Jean-Philippe Berteau, Laurent Pujo-Menjouet, Hélène Follet, Aurélie Levillain

Publications and Research

This volume brings together selected works from the 2025 Bone and Orthopedics Interdisciplinary Symposium (BONITOS), underscoring our community’s ongoing commitment to advancing research in biomechanics, bone health, and orthopedic science. The symposium unites leading experts from around the world, fostering collaboration and the exchange of ideas across disciplines. Organized in partnership with the French-speaking Society of Biomechanics, the French National Institute of Health and Medical Research (INSERM), the University of Lyon, the College of Staten Island of the City University of New York (CUNY), and the American Association of Physical Therapists (APTA) – Brooklyn Staten Island Chapter, BONITOS 2025 represents …

Supercritical Co2 Technology For Biomass Extraction: Review, Bahare Nozari, Ron Kander

School of Design and Engineering Papers

Supercritical carbon dioxide extraction is increasingly recognized as a green and efficient alternative to conventional solvent-based techniques for valorizing plant biomass. This review provides a comprehensive overview of recent advances in a scCO₂ extraction method, focusing on its advantages in isolating high-value compounds from agricultural feedstocks. The unique physicochemical properties of scCO₂, combining gas-like diffusivity with liquid-like solvating power, enable selective extraction under mild and tunable conditions, which preserves the integrity of thermally sensitive molecules. In addition, scCO₂ reduces energy consumption, eliminates toxic solvent residues, and offers greater extraction precision than traditional methods. These features have …

Tunable Methacrylated Decellularized Heart Matrix: A Versatile Scaffold For Cardiac Tissue Engineering, Valinteshley Pierre, Douglas H. Wu, Chao Liu, Elif Ertugral, Chandrasekhar R. Kothapalli, Samuel E. Senyo

Chemical & Biomedical Engineering Faculty Publications

Therapeutic tissue regeneration remains a significant unmet need in heart failure and cardiovascular disease treatment, which are among the leading causes of death globally. Decellularized heart matrix (DHM) offer promising advantages for tissue engineering, including low immunogenicity and seamless integration into biological processes, facilitating biocompatibility. However, DHM is challenged by weak mechanical properties that limit its utility to biomedical applications like tissue engineering. To address this limitation, we functionalized DHM with methacryloyl functional groups (DHMMA) that support UV-induced crosslinking to enhance mechanical properties. By modulating the degree of methacryloyl substitution, a broad range of stiffness was achieved while maintaining cell …

Remote Sensing Of Seismic Signals Via Enhanced Moiré-Based Apparatus Integrated With Active Convolved Illumination, Adrian A. Moazzam, Anindya Ghoshroy, Durdu Güney, Roohollah Askari

Michigan Tech Publications

The remote sensing of seismic waves in challenging and hazardous environments, such as active volcanic regions, remains a critical yet unresolved challenge. Conventional methods, including laser Doppler interferometry, InSAR, and stereo vision, are often hindered by atmospheric turbulence or necessitate access to observation sites, significantly limiting their applicability. To overcome these constraints, this study introduces a Moiré-based apparatus augmented with active convolved illumination (ACI). The system leverages the displacement-magnifying properties of Moiré patterns to achieve high precision in detecting subtle ground movements. Additionally, ACI effectively mitigates atmospheric fluctuations, reducing the distortion and alteration of measurement signals caused by these fluctuations. …

Sees Presentation: Small Satellites Power Systems, Robert J. Twiggs

Robert "Bob" Twiggs STEM Education Collection

A PowerPoint Presentation created by Professor Bob Twiggs titled "SEES Presentation: Small Satellites Power Systems" from June 12, 2025.

How Education Sats Started, Robert J. Twiggs

Robert "Bob" Twiggs STEM Education Collection

A PowerPoint Presentation created by Professor Bob Twiggs titled "How Education Sats Started" from June 12, 2025.

Space Program, Robert J. Twiggs

Robert "Bob" Twiggs STEM Education Collection

A PowerPoint Presentation created by Professor Bob Twiggs titled "Space Program" from June 12, 2025.

Highly Adaptable Dendrimer Gel Nanoparticles With Dual Targeting Of Upar And Ribonucleotide Reductase R2 For Better Retention And Improved Therapeutic Outcomes In Triple-Negative Breast Cancer, Hsin Yin Chuang, Da Huang, Lin Qi, Vidit Singh, Anna Chernatynskaya, Yue-Wern Huang, Hu Yang

Biological Sciences Faculty Research & Creative Works

Triple-negative breast cancer (TNBC) accounts for approximately 15% of breast cancers and lacks estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), rendering it unresponsive to hormonal or anti-HER2 therapies. Due to its poor prognosis and limited treatment options, there is an urgent need for targeted therapies. In this study, we developed highly adaptable polyamidoamine (PAMAM) dendrimer-based gel nanoparticles with dual-targeting capabilities against urokinase-type plasminogen activator receptor (uPAR) and ribonucleotide reductase R2 (R2). These nanoparticles were designed to target both TNBC cells and cancer-associated stromal cells by leveraging uPA-uPAR interactions and delivering the antisense oligonucleotide …

Measurement Of Moisture Levels In Oils And Lubricants Using A Novel Moisture Sensor, Aaron Swartz, Ronak Ali

Electrical and Computer Engineering Graduate Research

It is very challenging to measure moisture levels in oils. There is not a good method to measure it. Using the novel moisture sensor invented by Dr. Zhi David Chen, we tried various methods to measure the moisture levels in oils. The initial trials are to immerse the sensor chip into the oils to see any sensor reading changes with the change of moisture levels in oils. It was observed that the sensor reading was unstable even after immersion into the oil for two weeks. The idea for immersion of the sensor chip into the oils failed due to the …

Western Kentucky University Stormwater Utility Survey 2025, Warren Campbell

SEAS Faculty Publications

This survey provides data on 2147 U.S. and 82 Canadian stormwater utilities. The data is intended to provide useful data to communities that wish to enact stormwater utilities. Different fee systems are examined with the goal of avoiding legal exposure. Recently, the major source of pre-disaster mitigation funds was eliminated. States should consider state-wide stormwater utilities to make up for this loss.

Towards A Robust Hydrologic Data Assimilation System For Hurricane-Induced River Flow Forecasting, Peyman Abbaszadeh, Fatemah Gholizadeh, Keyhan Gavahi, Hamid Moradkhani

Civil and Environmental Engineering Faculty Publications and Presentations

The Hybrid Ensemble and Variational Data Assimilation framework for Environmental Systems (HEAVEN) is a method developed to enhance hydrologic model predictions while accounting for different sources of uncertainties involved in various layers of model simulations. While the effectiveness of this data assimilation in forecasting streamflow has been proven in previous studies, its potential to improve flood forecasting during extreme events remains unexplored. This study aims to demonstrate this potential by employing HEAVEN to assimilate streamflow data from United States Geological Survey (USGS) stations into a conceptual hydrologic model to enhance its capability to forecast hurricane-induced floods across multiple locations within …

Human Gut Commensal Alistipes Timonensis Modulates The Host Lipidome And Delivers Anti-Inflammatory Outer Membrane Vesicles To Suppress Colitis In An Il10-Deficient Mouse Model, Ethan Older, Mary K. Mitchell, Andrew Campbell, Xiaoying Lian, Michael Madden, Yuzhen Wang, Lauren E. Van De Wal, Thelma Zaw, Brandon N. Vanderveen, Rodney Tatum, E. Angela Murphy, Yan-Hua Chen, Daping Fang, Melissa Ellermann, Jie Li

Faculty Publications

Correlative studies have linked human gut microbes to specific health conditions. Alistipes is one such microbial genus negatively linked to inflammatory bowel disease (IBD). However, the protective role of Alistipes in IBD is understudied, and the underlying molecular mechanisms remain unknown. In this study, colonization of Il10-deficient mice with Alistipes timonensis DSM 27924 delays colitis development. Colonization does not significantly alter the gut microbiome composition, but instead shifts the host plasma lipidome, increasing phosphatidic acids while decreasing triglycerides. Outer membrane vesicles (OMVs) derived from Alistipes are detected in the plasma of colonized mice, carrying potentially immunomodulatory metabolites into the …

Selective Anti-Tumor And Normal Tissue Sparing Effects Of Flash Radiotherapy In A Simple Algebraic Model Of Radiochemical Kinetics, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

Background: This short paper presents the solution to an open problem in medical physics: how and when FLASH radiotherapy can have a selective anti-tumor effect. FLASH radiotherapy gives a single large dose of ionizing radiation to a cancer patient within a time span of a few milliseconds, unlike conventional radiotherapy which is divided into several dose fractions given weekly, each lasting about 10 minutes. In some animal models FLASH seems to improve tumor cell killing without damaging normal tissues. However, the mechanism of the selective anti-tumor effect remains elusive. Methods: To explore effects of tissue hypoxia in tumors, a model …

A Versatile Platform For Designing And Fabricating Multi-Material Perfusable 3d Microvasculatures, Nathaniel Harris, Charles Miller, Min Zou

Mechanical Engineering Faculty Publications and Presentations

Perfusable microvasculature is critical for advancing in vitro tissue models, particularly for neural applications where limited diffusion impairs organoid growth and fails to replicate neurovascular function. This study presents a versatile fabrication platform that integrates mesh-driven design, two-photon lithography (TPL), and modular interfacing to create multi-material, perfusable 3D microvasculatures. Various 2D and 3D capillary paths were test-printed using both polygonal and lattice support strategies. A double-layered capillary scaffold based on the Hilbert curve was used for comparative materials testing. Methods for printing rigid (OrmoComp), moderately stiff hydrogel (polyethylene glycol diacrylate, PEGDA 700), and soft elastomeric (photocurable polydimethylsiloxane, PDMS) materials were …

Synergizing Stem And Ela: Exploring How Small-Group Interactions Shape Design Decisions In An Engineering Design-Based Unit, Deana Lucas, Emily Haluschak, Christine H. Mcdonnell, Selcen Guzey, Greg J. Strimel, Morgan Hynes, Tamara J. Moore

School of Engineering Technology Faculty Publications

While small group learning through engineering design activities has been shown to enhance student achievement, motivation, and problem-solving skills, much of the existing research in this area focuses on undergraduate engineering education. Therefore, this study examines how small-group interactions influence design decisions within a sixth-grade engineering design-based English Language Arts unit for multilingual learners. Multilingual Learners make up 21% of the U.S. school-aged population and benefit from early STEM opportunities that shape future educational and career trajectories. Grounded in constructivist learning theories, the research explores collaborative learning in the engineering design process, using a comparative case study design. Specifically, this …

The Engineering Mindset: Blueprint For Change, Vol. 1: Institutional Guidelines For Implementing Change In Undergraduate Engineering And Engineering Technology Education, Rebecca Bates, Ron Ulseth

Integrated Engineering Department Publications

Volume 1 of the Blueprint Report presents a comprehensive framework for transforming undergraduate engineering and engineering technology education in the United States. It builds on the 2024 Engineering Mindset Report and provides institutional-level strategies to implement its recommendations. The goal is to create a student-centered curriculum, increase access and success for underserved students, and create a future-ready engineering education system that broadens access and aligns with societal and technological needs.

Treatment And Activation Effects On Kaolinite-Based Earth Concrete, Mojtaba Kohandelnia, Maroua Zerzouri, Ammar Yahia, Kamal H. Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Self-consolidating earth concrete (SCEC) addresses the long construction process of conventional earthen constructions and their structural limitations, while further efforts are needed to enhance its sustainability. This study explores the development of a kaolinite-based self-consolidating earth paste (SCEP) due to their blended powder system, incorporating raw and treated (calcined and ground-calcined) kaolinite under various activation techniques, such as water hydration, sodium hexametaphosphate (NaHMP), and sodium hydroxide (NaOH) activation. The synergistic effect of calcination and mechanosynthesis on rheological, mechanical, structural, and microstructural properties of SCEP were investigated. Mechanically treated kaolinite increased yield stress, plastic viscosity, storage modulus evolution, and build-up index, …

Tellings Of The Pacific Ocean: A Landscape-Based Approach For Multispecies Design And Hci, Maliheh Ghajargar

Engineering Faculty Articles and Research

Environmental disturbances induced by climate change have caused significant changes in our ecosystems and are threatening the health of our environments. As a response to this issue, a growing body of work has emerged in HCI and design, which seeks to foreground more-than-human stories in support of making more sustainable and just futures. This research contributes to this broad agenda by probing graphic novels as a multispecies storytelling method for design and HCI. Combining ideas from Anna Tsing’s adventures of landscape and from HCI and design’s use of sequential art (e.g., storyboards), we use landscape as the main protagonist of …

Low-Cost, High-Performance Electrodes For Pgm-Free Aem Water Electrolyzers: Structural Optimization Of Nimo-Based Cathodes, Mahmoud Amirsalehi, Noor Ul Hassan, Venkata Sai Sriram Mosali, Ian Street, Marjanul Manjum, Saheed Adewale Lateef, Jasmine Bohannon, Sam Mckinney, Ashutosh G. Divekar, Paul A. Kohl, Mustain E. William

Faculty Publications

Water electrolysis technologies for hydrogen production are receiving significant attention due to a drastic reduction in the cost of renewable energy sources in recent years. Though traditional alkaline and proton exchange membrane water electrolyzers are receiving the most commercial attention, the anion exchange membrane water electrolyzer (AEMEL) has the potential to be much lower in cost. AEMELs have recently shown remarkable progress in terms of performance and durability. However, they are still mostly operated with expensive platinum group metal (PGM) catalysts on both the anode and cathode. To achieve low cost, either PGM-free or ultra-low loading PGM catalysts are needed. …

Investigation Of Stability And Control Shortcomings Of The North American X-15, William Lorenzo, Ramana Grandhi, Timothy T. Takahashi

Faculty Publications

There is growing interest in the design of maneuvering high-speed aircraft to fly within or at the edge of the atmosphere. We identify and develop novel quasi-static vehicle screening methodologies, suitable for use during preliminary design, to better predict an incipient loss of control due to the dynamic effects of feedback. We validate these metrics by reverse-engineering Neil Armstrong’s 1962 loss of control and inadvertent atmospheric skip while piloting the X-15. In 1962, then-extant flight dynamics screening methods did not forecast likely troubles. We assemble and refine a collection of predictive metrics which operate upon basic quasi-static aerodynamic data and …

Bloom Pattern Data, Zhongyuan Wang, Robert J. Lang, Larry L. Howell

ScholarsArchive Data

This data is the supplementary material of the paper "Bloom Patterns: Radially Expansive, Developable, and Flat-Foldable Origami" by Zhongyuan (Kelvin) Wang , Robert J. Lang, and Larry L. Howell.

We present bloom patterns as a family of radially expansive, flat-foldable, and developable origami patterns, many of which are rotationally symmetric. Bloom patterns are defined with a generalized definition and a standardized definition. A classification scheme for bloom patterns is identified, and several types of bloom patterns are analysed. The distinct helical nature that characterizes bloom patterns is described, and a set of compatibility conditions is derived to help determine if …

Eliminating Assay Background Of A Low-Cost, Colorimetric Glutamine Biosensor By Engineering An Alternative Formulation Of Cell-Free Protein Synthesis, Joseph P. Talley, Tyler J. Free, Tyler P. Green, Dallin M. Chipman, Bradley Charles Bundy

Faculty Publications

Glutamine is an essential biomolecule that plays a pivotal role in many diseases, such as cancer, where it can serve as fuel for rapid proliferation. Treatments for these diseases can be monitored and optimized through the detection of glutamine, though standard glutamine detection procedures are costly and require complex instrumentation. Cell-free protein synthesis (CFPS) has recently enabled a paper-based, colorimetric glutamine sensor that carries the potential to increase test accessibility while dramatically reducing consumer cost to enable at-home, rapid treatment monitoring. Test sensitivity remained limited by residual assay background, thus motivating this work where CFPS reactions traditionally formulated with glutamate …

On Closed-Form Preintegration For A Class Of Mixed-Invariant Systems In Seₙ(3), Li-Yu Lin, Kartik A. Pant, Benjamin Perseghetti, James Goppert

School of Aeronautics and Astronautics Faculty Publications

A large class of nonlinear systems in engineering and robotics evolves on geometric manifolds, such as fixed-wing aircraft, quadrotors, etc., whose kinematic motion can be described using Lie groups, in particular SEn(3) . The existing techniques involve numerical integration methods such as Runge-Kutta integration to propagate their motion forward in time. However, these methods are approximate solutions and do not respect the geometric constraints of the nonlinear differential equation, leading to higher computational costs and numerical integration errors. To this end, we propose a geometric closed-form approach to solve the initial value problem for a class of nonlinear systems that …

Highway-Transportation-Asset Criticality Estimation Leveraging Stakeholder Input Through An Analytical Hierarchy Process (Ahp), Kwadwo Amankwah, Sarah Hernandez, Suman Kumar Mitra

Civil Engineering Faculty Publications and Presentations

Transportation agencies face increasing challenges in identifying and prioritizing which infrastructure assets are most critical to maintain and protect, particularly amid aging networks, limited budgets, and growing threats from climate change and extreme events. However, existing prioritization approaches often lack consistency and fail to adequately incorporate diverse stakeholder perspectives. This study develops a systematic, stakeholder-informed method for ranking transportation assets based on their criticality to the overall transportation system. As a novel approach, we use the analytical hierarchy process (AHP) and present a case study of the applied approach. Six criteria were identified for ranking assets: annual average daily traffic …

Derivation And Experimental Validation Of A Parameterized Nonlinear Froude–Krylov Force Model For Heaving-Point-Absorber Wave Energy Converters, Houssein Yassin, Tania Demonte Gonzalez, Gordon Parker, Giorgio Bacelli, Carlos Michelen

Michigan Tech Publications

Wave energy converters (WECs) have gained significant attention as a promising renewable energy source. Optimal control strategies, crucial for maximizing energy extraction, have traditionally relied on linear models based on small motion assumptions. However, recent studies indicate that these models do not adequately capture the complex dynamics of WECs, especially when large motions are introduced to enhance power absorption. The nonlinear Froude–Krylov (FK) forces, particularly in heaving-point-absorbers with varying cross-sectional areas, are acknowledged as key contributors to this discrepancy. While high-fidelity computational models are accurate, they are impractical for real-time control applications due to their complexity. This paper presents a …

A Ka-Band Omnidirectional Metamaterial-Inspired Antenna For Sensing Applications, Khan Md. Zobayer Hassan, Nantakan Wongkasem, Heinrich D. Foltz

Electrical and Computer Engineering Faculty Publications

A Ka-Band, 26.5–40 GHz, omnidirectional metamaterial-inspired antenna was designed, built, and tested to develop a simple printed compact (10.3 mm × 10.3 mm × 0.0787 mm) multiple-point sensor for air pollution monitoring. This Ka-band antenna generated a dual band at 27.49–29.74 GHz and 33.0–34.34 GHz. The VSWR values within the two bands are less than 1.5. The radiation and total efficiency are 97% and 92% in the first band and they are both 96% in the second band. The maximum gain is between 3.26 and 5.50 dBi and between 5.09 and 6.52 dBi in the first and second bands, respectively. …

From Context To Connection: Client Letters In Stem Integration Curricula, Christine Mcdonnell, Imani N. Adams, Morgan Hynes, Selcen Guzey, Mary K. Pillotte, Greg J. Strimel, Kristina M. Tank, Tamara J. Moore

School of Engineering Technology Faculty Publications

Real-world contexts play a crucial role in engaging students and promoting disciplinary synergy in integrated STEM education. One underexplored pedagogical tool for supporting such integration is the “client letter”—a narrative device used to frame engineering design challenges around authentic, real-world problems. This study investigates the role of client letters in synergizing knowledge within immersive engineering design-based STEM integration curricula. We conducted a qualitative document analysis of 107 client letters embedded in 18 freely available K-12 STEM integration curricular units. Using a theoretical framework that aligns immersive education principles with the STEM Integration Framework, we analyzed how these letters support curricular …

Economic And Environmental Impact Of Recovering And Upgrading Lignin Via The Alpha Process On An Ethanol Biorefinery, Daniel G. Kulas, Robert Handler, Graham Tindall, Bronson Lynn, Mark Thies, David Shonnard

Michigan Tech Publications

Lignin valorization is limited by both impurities and broad molecular weight (MW) distributions. The Aqueous Lignin Purification using Hot Agents (ALPHA) process exploits the novel liquid–liquid equilibrium that exists between lignin and hot, one-phase solutions of aqueous renewable solvents to simultaneously purify and fractionate raw bulk lignins. Our analysis considered the valorization of lignin recovered from two ethanol biorefinery waste streams, black liquor and lignin cake. By applying sequential ALPHA stages, distinct lignin fractions of controlled MW and purity were isolated suitable for producing carbon fibers, polyurethane foams (PUF), and activated carbons (ACs). Surprisingly, only a single extraction stage was …

Atp8b1 Regulates Pip2 Localization And Cleavage Of Pyroptotic Executioner Gasdermin D, Nilam Bhandari, Ashutosh Prince, Mariam R. Khan, Alicia Traughbera, Kalash Neupane, Shuhui W. Lorkowski, Gregory Brubaker, Elif G. Ertugral, Chandrasekhar R. Kothapalli

Chemical & Biomedical Engineering Faculty Publications

Mutations in ATP8B1 cause progressive familial intrahepatic cholestasis, with symptoms including pruritus, pancreatitis, fat malabsorption, intestinal inflammation, and failure to thrive. High-throughput studies showed interconnection between ATP8B1 and phosphoinositide (PIPs), but the mechanism linking ATP8B1, lipid metabolism, and inflammation remains unclear. Atp8b1G308V/G308V mouse model, unbiased RNAseq, high-resolution-stimulation emission depltion (STED)-microscopy, and Crispr-Cas9 generated ATP8B1-/- knockouts in hepatocytes/monocytes/macrophages were used to determine role of ATP8B1 in phosphatidylinositol,4-5-bisphosphate (PIP2) trafficking and inflammation. Human ATP8B1, purified from Sf9 insect cells and reconstituted in proteoliposomes, was used to test cell-free PIP2 flip. Various in-vitro techniques were used for testing direct interaction between PIP2 and …

Safe Human–Robot Collaboration With Risk Tunable Control Barrier Functions, Vipul K. Sharma, Pokuang Zhou, Zhengtong Xu, Yu She, S. Sivaranjani

School of Industrial Engineering Faculty Publications

In this article, we consider the problem of guaranteeing safety constraint satisfaction in human–robot collaboration (HRC) with uncertain human position. We pose this problem as a chance-constrained problem with safety (chance) constraints represented by uncertain control barrier functions, where the probability of safety constraint satisfaction under uncertainty is bounded by a tunable user-defined risk. We solve this stochastic optimization problem using a sampling-based approach and obtain a risk-tunable controller to safely accomplish HRC tasks. We demonstrate the safety and performance of this approach through both simulation and hardware experiments on a 7 degree-of-freedom Franka–Panda manipulator and characterize the tradeoff between …