Biomedical Engineering and Bioengineering Commons^™

Electro-Muscle-To-Muscle Transfer, Hailey Quinn Casino, Jake Keola Javier, Samuel Joseph Borda, Charlotte Amalie Anderson

Biomedical Engineering

The Electro Muscle to Muscle Transfer (EMMT) system will entail designing, manufacturing, and providing a wearable device that stimulates paralyzed muscles in the hand by sampling and amplifying muscles from the forearm. With further development, the system may be capable of using different muscle inputs other than the forearm muscles along with different stimulated muscle outputs other than the hand. The system functions as a rehabilitative device for spinal cord injuries, irreparable nerve loss and/or damage, and improper neuromuscular function. It is not for total treatment nor for curing of the disabilities listed above but to alleviate the side effects …

Hypoxic Incubation Chamber, Makenzie Jones, Andrea Skattenborg, Henry Elsner

Biomedical Engineering

In developing a model to test anti-tumor drugs, Dr. Christopher Heylman’s lab requires the ability to culture cells in a hypoxic environment. The purpose of this project was to make this possible. Funding for this project comes from the Biomedical Engineering Department, the Hannah-Forbes Fund, and Dr. Heylman’s lab. The chamber must be able to reach a user-defined oxygen concentration and hold that concentration for 48 hours while creating an environment conducive to cell culture. Importantly, the chamber must also be sterilizable and cleanable for repeated use. While several products exist to create hypoxic environments for cell culture, they are …

The Tierni Resistance Training System, Michael J. Hansen, Abigail M. Youngblood, Gabriel M. Johnson

Biomedical Engineering

The purpose of the Tierni Resistance Training System project was to design and construct functional workout apparel that has built-in resistance. For this product, the key customer requirements we set out to address were most importantly material comfort and functionality, followed by stylishness, lack of latex, safety for injured and uninjured users, and washer safety. To meet these customer requirements, we started by researching current resistance training technology, and used the findings as a springboard for our own design development. After initial brainstorming, engineering specifications were generated based on the customer requirements. These specifications revolved around the thermal insulation, pressure, …

Concussion Detection Device, Jenna C. Sussex, Mark B. Edin, Bianca X. Aleman

Biomedical Engineering

No abstract provided.

Alternative Epinephrine Auto-Injector, Joshua Wong, Uriel Nieves-Cruz, Tara Howard

Biomedical Engineering

Project: Alternative Epinephrine Injector started as a solution for Bianca Aleman’s little brother however the scope has evolved to include the many millions of individuals across the world who struggle with a life-threatening allergen. The stakeholders of this project are Cal Poly and Dr. Michael D. Whitt. Our goals are the following:

● Develop a foolproof method of injection that consistently delivers a dosage of epinephrine

● Be equal or less than the current size of an EpiPen (6 in)

● Be easy to transport or store when not-in-use

● Create an isolated environment where the epinephrine will not be …

Septal Closure Device, Olivia N. Welch, Hillal H. Jarrar, Kai Harrison

Biomedical Engineering

The septal closure device was designed to seal defects in the atrial septum. To fully seal an atrial defect, the device was designed to consist of two circular seals to cover the defect in both the right and left atria, attached with a central rod. The materials were chosen for compressibility (for ease of insertion), biocompatibility, and tissue ingrowth. A CAD model was drafted in SolidWorks. Key customer requirements include ease of implantation (specifications: adjustable sizing and clear directions for use), physician controlled (specifications: short implantation time and compatibility with current catheter/scope techniques), and a long lifetime (specifications: materials that …

Non-Invasive Peripheral Venous And Arterial Line Air Detector For Embolization Prevention, Alexandria Kwong, Kevin Shu, Dylan Meinster

Biomedical Engineering

The scope of this project includes designing a non-invasive bubble detector for peripheral venous and arterial lines. For minimally invasive cardiac procedures, arterial and venous access is necessary for these procedures as is constant flow through the tubing to prevent clotting and to administer drugs. Air bubbles are common in these lines and can be consequential if enough air is introduced into the human system. Air embolisms are the most common and relevant issues during these procedures. The goal of this device is to create an attachable detector for air bubbles in saline that can also terminate flow and alert …

Virtual Stethoscope - Otoscope, Ermen J. Elenes-Cazares, Ceasar A. Hurtado, Thomas M. Margolle

Biomedical Engineering

The purpose of this report was to develop a working prototype for a virtual stethoscope and otoscope. Sponsored by Courtney Farr, the virtual diagnostic care system – HouseCalls Mobile digital stethoscope/otoscope is meant for use by medical professionals and non – medical professionals for preliminary medical exams while physically not in a medical setting. The HouseCalls Mobile device is to characterize key biometric parameters such as breathing patterns, heart irregularities, and visual clinical evaluation of the inner ear. This device is intended for pediatric use.

Tmtt Chimera Valve Attachment Process, Paulina Nguyen, Devin Debouk, Tamar Kazazian, Noah Thompson

Biomedical Engineering

No abstract provided.

D.I.Y. Clean Hood, Samuel G. Porter, Ryan E. Shimogaki, Ryan S. Staples

Biomedical Engineering

The DIY Clean Hood is a low-cost, sterile, and accessible scientific workspace intended for installation in the BioElectroFluidics Lab of California Polytechnic State University’s (San Luis Obispo) Biomedical Engineering Department (BMED), under the sponsorship of Dr. Benjamin Hawkins, PhD. As normal Clean Hood, Biosafety Cabinets, and the like are generally too expensive for a university, a competitive solution to an expensive problem can assist research students and professors alike continue their own work with an inexpensive yet effective environment.

Specific design elements that the customer requirements entailed for the project include a low-particle-count air filtration system, positive pressure air flow …

Opendrop Elisa: Surface Development For Digital Microfluidic Elisa Testing, Michaela Q. Mead, Madeline G. Jackson, Jacob G. Taylor

Biomedical Engineering

This project aimed to develop a process to create a hydrophobic coating with capture antibodies attached. This process was developed in an attempt to create a digital microfluidic platform upon which an enzyme-linked immunosorbent assay (ELISA) could be run, indicated for clinicians and educators in low-resource settings. Four requirements dictated the course of the design process: 1) the contact angle with water of the hydrophobic layer must be greater than 90º, 2) the colorimetric response of a positive ELISA result on our platform must be at least 85% of that run on polystyrene with the same result, 3) the platform …

On-Body Pressure For Subcutaneous Infusion Of Drug, Hannah Cole, Kayla Meacham, Eleanor Moran, Kaylee Voss

Biomedical Engineering

No abstract provided.

Pulsed Electrical Field Ablation Modulation, Camille Lousie Dozois, Jason Tyler Arias, Courtnee Lin Madsen

Biomedical Engineering

This document comprises the steps taken by the senior project team to create a Proof-of-Concept Review for a Variable Pulsed Electric Field Ablation Catheter. First, the team did a significant amount of background research on related literature to better understand the current status of the project topic. After sufficient background information was obtained, project objectives and deliverables were finalized. Once customer requirements and the indications for use were completed, engineering specifications for the product and project were documented. All key customer requirements and engineering specs were related to the variable pulse functionality, maneuverability, as well as overall dimensioning of the …

Solostand, Hau Nhat Doan, Sydney Gray, Celina Dioso

Biomedical Engineering

The purpose of this scope of work is to highlight the progress and development of SoloStand sponsored by Derek Herrera, chief technical officer and founder of SpinalSingularity. SoloStand is an attachment to a wheelchair that will benefit paraplegics that use wheelchairs. A portable and customizable attachment to a wheelchair will allow the user to do everyday tasks without transferring into a separate standing wheelchair and travel more easily. This document outlines everything that has been done in fulfillment of our senior project requirements.

Diy Incubator, Aryan Zia, Grace Spurlock, Garrett Janney

Biomedical Engineering

This project report provides detailed information on designing and building a DIY Incubator. The device is indicated for growing and maintaining BSL-1 mammalian or bacterial cell culture with a temperature control in the range of 25-45°C ± 1°C. The device is made fully programmable via an Arduino, and is structurally designed to fit two T75 cell culture flasks at a time. The device is able to return to a specified temperature set point within 10 minutes and maintains 5% CO2 partial pressure conditions. The incubator has a small physical footprint, with an overall dimension of 22in x 16in x 15.5in …

Prosthetic Thumb, Allison M. Sigdestad, Sahil Sharma, Cale Foreman

Biomedical Engineering

The Prosthetic Thumb Project is a senior design project completed by Biomedical Engineering Undergraduate students at California Polytechnic State University. This senior design project is aimed at designing a prosthetic thumb for a Cal Poly Pomona student who lost their thumb in an accident last year. The patient has ultimately lost between 30-40% of functionality of his left hand, and so we would like to give him that mobility back. Originally, the patient was worried about having a prosthesis, and wanted something more stagnant that would resemble the look of the thumb he lost. However, after working with him, we …

Ikioo Flying Robot, Nicholas Michael Lapidus, Bosung Josh Kim, Jenny Fong

Biomedical Engineering

No abstract provided.

Esophageal Temperature Mapping And Monitoring Sheath, Nicole M. Rogers, Hillary Johnson, Alexander Silva

Biomedical Engineering

The purpose of this document is to provide a product development summary for an accessory device that joins an esophageal temperature probe and a mapping catheter together to be used during cardiac ablation. Catheter ablation therapy is performed in the left atrium, utilizing extremely hot or cold temperatures to create scar tissue and treat atrial fibrillation and other arrhythmias. The close positioning of the left atria adjacent to the esophagus presents a large risk as the extreme temperatures used during ablation can lead to esophageal damage or fistulas. This device is designed to integrate correlate data from the temperature probe …

Gesea Biosciences - Core Shell Pellet Manufacturing Device, Claire Edelman, Maria Medrano, Rachel Longoria

Biomedical Engineering

No abstract provided.

Cumulative Shear In Vitro Model, Jared Olson, Alex Deppe, Braden Andrews

Biomedical Engineering

The purpose of our project is to find a reliable method of Subclinical Atherosclerosis detection by measuring the pressure drop across an artery. This model is intended to display how a pressure change correlates with arterial shear rate, and how a decrease in shear rate is ultimately related to atherosclerosis wherein early detection could prove life saving for millions of patients worldwide.

Integrity Testing Of Gas Permeable Silicone Filters, Maggie M. Baker, Thomas P. Humann, Kevin J. Yerina

Biomedical Engineering

This report investigates the most reasonable, cost efficient, and reliable ways to integrity test a filter made from a permeable silicone membrane for future biomedical and pharmaceutical applications. The goal of the project was to create a fixture that a pharmaceutical company can use to quickly and reliably test the integrity of the filter. A variety of methods are outlined to test the integrity of the filter, after a series of quantitative tests, a single method was established that meet the requirements most thoroughly. The method that was determined to be most effective involves a series of components including a …

Left Atrial Appendage Printing Process, Areli Reyes, Brandon James Mukai, Mia Noelle Von Knorring

Biomedical Engineering

The left atrial appendage senior design team aims to assist in closing off the left atrial appendage that is susceptible to coagulation due to non-valvular atrial fibrillation. Coagulation in the left atrial appendage (LAA) can be life threatening as it can lead to a stroke. Dr. Chris Porterfield performs a procedure that uses the Boston Scientific Watchman to close the appendage. He finds that sizing the Watchman properly is difficult with limited visuals from live CT scans. He proposed converting the CT scans into a 3D printed model of the left atrial appendage and left atrium so he can visually …

Mechanisms Of Reduced Vascular Tone Following Arteriogenesis Induced By Femoral Artery Ligation, Christopher Hatch

Biomedical Engineering

The presence of a developed, native collateral network can decrease the severity of ischemic injury proceeding arterial occlusion. The collateral network must under arteriogenesis to enlarge and increase blood flow to the ischemic region. Although there has been tremendous effort attempting to understand the mechanisms of arteriogenesis, no therapies have been successful in improving patient outcome. To better understand the mechanisms involved in arteriogenesis, the effect of nitric oxide production, myogenic tone, and a-adrenergic receptors were evaluated as these have been identified as playing an important role in vascular injury. Arteriogenesis was induced by ligating the femoral artery between the …

Microscope System, Virginia Brannaman, Gavin Shavey, Ricardo Lasa

Biomedical Engineering

This project aims to improve upon the current microscope stand for the Olympus compound microscope in the Microcirculation and Vascular Regeneration (MaVR) laboratory in order to minimize angular deflection of the microscope objective with respect to surgical stage.

Marine Chemistry Control System, Natalie Weisenburger, Kathryn Turk, Julio Sierra

Biomedical Engineering

The aim of this project is to design a control system that manipulates different variables of ocean chemistry including pH, temperature, DO, N2 , and CO2 content for research by ocean chemists of marine species and their environments in 2, 5 gallon tanks.

Cej Ankle Support Report, Christine Prothe, James Baldwin, Erik Espinoza

Biomedical Engineering

This document provides information about an ankle support device designed to allow for ankle dorsiflexion and plantar flexion. In this document the product’s specifications, objectives and expectations are outlined. Included in this document is background information, stage gate process, prototype design development and considerations, and qualification requirements.

House Calls Mobile Virtual Stethoscope, Abigail Lindquist, Abigael Donohue, Trey Nahhas

Biomedical Engineering

The purpose of this scope of work is to outline the progress of the Virtual Stethoscope design and development project as sponsored by House Calls Mobile. This device looks to provide accessible at-home care for patients all over the country through the mobile phone stethoscope attachment. With the virtual stethoscope technology, patients will be able to perform high-quality, in-home observation of heart, stomach, and lung sounds to be transmitted to a physician in real time. Eliminating the need to travel to a doctor’s office encourages patients to perform more regular checkups, increasing their likelihood potentially of life-saving early diagnoses. This …

Sand Foot: A Prosthesis For Walking On Sand, Samantha A. Galicinao, John Dewing, Daniel Dugan Dotson, Christopher Urasaki

Biomedical Engineering

This critical design report describes the product development of a prosthesis for use on sand. Quality of Life Plus (QL+), a national non-profit organization aimed to develop prostheses for veterans and people with disabilities, introduced this project and its accompanying challenger, Sgt. Brady, to Cal Poly’s Interdisciplinary Senior Project class in September 2018. After consulting with Sgt. Brady and QL+ and performing extensive research, the Sand Foot team defined customer requirements and engineering specifications to meet these requirements. Comfortability, durability, and sandproof were key customer requirements. Several conceptual models were brainstormed and a final design was selected based on the …

Cooking Hand Multi-Tool, Amanda D. Meares, Amy H. Wilson, Ethan G. Littlejohn, Duania A. Evans

Biomedical Engineering

The purpose of this project was to devise a solution for Jorge Segura, a US Marine who was wounded in Afghanistan and had to have his non-dominant arm amputated above the elbow. His current prosthetic attachments are not suited to cooking tasks, so he needed a way to cook more effectively with either prosthetic attachments or accessibility devices. The main tasks that he needed help with was holding down food on cutting boards and stabilizing pots, pans, and bowls especially when stirring. After background research, exploring commercially available devices, and talking with our challenger, our solution was to design three …

Automated Microscope Stage, Corin Nishimoto, Alison Flesch, Theo Anastos

Biomedical Engineering

This document seeks to describe the background information, customer requirements, design specifications, indications for use, selected materials, proposed budget, prototypes, final design, manufacturing processes, and testing methods regarding the CellOptimizer automated microscope stage product.