Biomedical Engineering and Bioengineering Commons^™

The Impact Of Myoblast Transplantation On Collateral Capillary Arteriogenesis And Macrophage Phenotype, Christine Hue Do

Biomedical Engineering

Gangrene, pain, loss of limb function, amputation, and death are only few of the grievous consequences associated with peripheral arterial disease (PAD), a vascular disease caused by an obstruction that narrows the blood vessels. Since some patients have collateral vessels that can re-route blood to its downstream destination, much focus has been spotlighted upon discovering the mechanism of this process, termed arteriogenesis, as well as cell therapies to increase arterial diameter of collateral vessels. Since some patients do not have native pre-existing collateral vessels, another method to re-route blood is through arterialized collateral capillaries (ACC), which is the conversion of …

Automatic Tourniquet For Military Emergencies, Arshia Nazerani Houshmand, Marina Felt, Blake Juett

Biomedical Engineering

This document contains the progress and development of an automated tourniquet that would be intended for use within the United States military. The project was student-led and sponsored. Coordination and confirmation of our device was provided by Dr. John F. Kragh, who is part of the U.S. Army Institute of Surgical Research. The document will outline the research conducted on tourniquets, specification development of the tourniquet, morphology process, and final design production of the automatic tourniquet.

Handheld Transvaginal Probe For Pap Smear Exams, Kim Knollenberg, Taeah Truong

Biomedical Engineering

This project aims to discard the use of the speculum in pap smear exams. A pap smear is a procedure that tests for cervical cancer in individuals assigned female at birth (AFAB) by screening cells collected from the cervix. Speculums are utilized in these examinations, as well as other gynecologic examinations and procedures. Due to the stigma and racist and misogynistic history of the speculum, we moved to design a device that removes the need for specula in pap smear exams. This device will aim to decrease the cervical cancer mortality rate and reduce the stigma around pap smear exams.

Hand Strength And Dexterity Enhancer, Julia Ann Denison, Autumn B. Rexford, Melissa A. Kurani, Christina K. Fong

Biomedical Engineering

Good Grips created the hand strength and dexterity enhancer project to meet the challenge presented by Bill Phelps. He has Inclusion Body Myositis (IBM), an inflammatory muscle disease characterized by progressive muscle weakness and atrophy. Bill has limited strength in both hands and lost the ability to bend his fingers, making it difficult to grip anything. He needed a device that would help with everyday tasks such as writing, lifting, and holding various objects.

Our team consists of four engineering students attending Cal Poly, San Luis Obispo. We researched, designed, manufactured, and tested a device that would fulfill the problem …

Calibrated Tensioner For Total Knee Arthroplasty Gap Balancer, Lauren Henigman, Jaypreet Dhanota, Corey Catuara

Biomedical Engineering

The purpose of this project was to design a device that interfaces with the previously created gap balancer to simultaneously measure the gap between the femur and tibia and measure the tension in the ligaments of the knee. First, we met with Dr. Delagrammaticas to outline the key customer requirements: we wanted the device to be precise, sterilizable, reliable, and compatible with the gap balancer. Based on the customer requirements, we outlined the specifications that would drive our design and testing, which included precision, ease of use, size, and material properties. The design process began by using a morphology to …

Stair Wagon To Heaven, Maria Cristina Solis Andrade, Nick Ryan Dion, Alexander Pham

Biomedical Engineering

Our design process began with developing a list of questions for our sponsor based on the problem statement we were provided. We took these questions to interview our sponsor. From this interview, we derived a series of customer requirements, which were then used to develop our more specific engineering specifications (Table 8.1). We used these engineering specifications to develop a design morphology. Each of our group mates used the concepts from our design morphology to develop their own full concept sketches. We used Pugh charts to compare the different aspects of each design. The designs were compared based off their …

Electro-Muscle-To-Muscle Transfer, Hailey Quinn Casino, Jake Keola Javier, Samuel Joseph Borda, Charlotte Amalie Anderson

Biomedical Engineering

The Electro Muscle to Muscle Transfer (EMMT) system will entail designing, manufacturing, and providing a wearable device that stimulates paralyzed muscles in the hand by sampling and amplifying muscles from the forearm. With further development, the system may be capable of using different muscle inputs other than the forearm muscles along with different stimulated muscle outputs other than the hand. The system functions as a rehabilitative device for spinal cord injuries, irreparable nerve loss and/or damage, and improper neuromuscular function. It is not for total treatment nor for curing of the disabilities listed above but to alleviate the side effects …

Hypoxic Incubation Chamber, Makenzie Jones, Andrea Skattenborg, Henry Elsner

Biomedical Engineering

In developing a model to test anti-tumor drugs, Dr. Christopher Heylman’s lab requires the ability to culture cells in a hypoxic environment. The purpose of this project was to make this possible. Funding for this project comes from the Biomedical Engineering Department, the Hannah-Forbes Fund, and Dr. Heylman’s lab. The chamber must be able to reach a user-defined oxygen concentration and hold that concentration for 48 hours while creating an environment conducive to cell culture. Importantly, the chamber must also be sterilizable and cleanable for repeated use. While several products exist to create hypoxic environments for cell culture, they are …

The Tierni Resistance Training System, Michael J. Hansen, Abigail M. Youngblood, Gabriel M. Johnson

Biomedical Engineering

The purpose of the Tierni Resistance Training System project was to design and construct functional workout apparel that has built-in resistance. For this product, the key customer requirements we set out to address were most importantly material comfort and functionality, followed by stylishness, lack of latex, safety for injured and uninjured users, and washer safety. To meet these customer requirements, we started by researching current resistance training technology, and used the findings as a springboard for our own design development. After initial brainstorming, engineering specifications were generated based on the customer requirements. These specifications revolved around the thermal insulation, pressure, …