Biomedical Engineering and Bioengineering Commons^™

Functionality Of The Gracilis Collateral Is Impaired Following Arteriogenesis And Cell Transplantation, Ada A. Tadeo

Biomedical Engineering

Peripheral Arterial Disease involves narrowed arteries, reducing blood flow to limbs. Increasing blood flow to those extremities is possible by redirecting the blood to flow through natural bypasses (i.e. collateral arteries), which can enlarge via arteriogenesis to maintain blood supply once the prominent arteries have become occluded. This study aims to investigate how arteriogenesis affects collateral function, if myoblast transplantation can stimulate collateral growth, and how that in turn may affect collateral function. Femoral artery ligation was performed to mimic the blockage that occurs in patients with ischemic diseases on lean mice and mice with diet induced obesity (DIO). A …

Self-Balancing Bicycle Device, Charles Cole, Raffy Lorenzo, Neil Boyal

Biomedical Engineering

The sponsor, Justin Shaw, is currently developing a bicycle for an athlete who has lost movement in their legs. This athlete can no longer experience the unmatched feeling of naturally banking a bicycle at corners. The Self-Balancing Bike Device Team will create a device that can self-balance an electric recumbent bicycle at low speeds while being almost undetectable while turning. This document will outline the team’s background research into self-balancing vehicles, define the needs that must be solved, and delineate a schedule for future milestones.

Wire Cutting Saw For Spinal Fusion Surgery, Connor Kilzer Kilzer, Kayla Hong, Kyle Himmelein

Biomedical Engineering

The purpose of this project was to design and prototype a spinal facetectomy tool which will minimize the risk of spinal nerve damage and standardize this procedure for all surgeons. This Final Report for Alphatec describes the scope of the project, the process to get to the final prototype of the device, along with a project timeline for the team. A background of current devices and their issues is included to illustrate the need for a new spinal facetectomy device. Within the scope of the project includes a list of customer requirements for the device and the process of translating …

Rod Bend Approximator For Minimally Invasive Spinal Surgery, Amanda Hansell, Anise Ghandchi, Shervin Moghimi

Biomedical Engineering

This Final Report will go over the project deliverables and future steps in the making of a rod bending approximator tool by the Cal Poly Senior Design team for the client SeaSpine. The latest designs and research done regarding minimally invasive surgery (MIS) is covered including the impediments with the current methods. SeaSpine presented the need to our team for an approximating tool within the MIS procedure. Our team began project planning through task generation and schedule development. Once the product definition was fully understood, competition was evaluated and engineering specifications were created for the project. A conceptual design was …

Insole Fall Prevention Device, Nick M. Hughes, Andrew M. Slaboda

Biomedical Engineering

Falls among the aging population occur every single day, with 1 in every 5 resulting in some injury and 300,000 hospitalized every year with a hip fracture [1]. The most popular and effective way to mitigate these falls is through physical therapist intervention. However, with the increased popularity in telerehab, many patients at risk for falls cannot accurately convey their gait tendencies to their physical therapists from the comfort of their home or while not in direct contact with the PT. A device like an insole, implanted with force sensors, which measures different parts of a patient’s foot, could convey …

Impact Of Sex On Proliferation And Maturation Of Primary Isolated Myoblasts, Elsa M. Bean

Biomedical Engineering

Peripheral arterial occlusive disease (PAOD) is caused by the buildup of atherosclerotic plaque causing restriction in blood flow in tissue, known as ischemia. It affects 8 million people in the United States and can hinder daily life through the onset of symptoms such as intermittent claudication and in extreme cases ulcers and gangrene. Surgical revascularization is not accessible to certain patient populations, such those of advanced age, highlighting a need for alternative therapies. For example, naturally occurring bypass arteries, called collateral blood vessels, can remodel and enlarge to bypass the occlusion. This process, known as arteriogenesis, has been studied as …

Live Cell Imaging Heated Stage, Kerri Byrne, Anna Frauenheim, Simon Park

Biomedical Engineering

Live cell imaging is a method used by scientists to obtain a better understanding of tissue and cell functions through the study and imaging of cellular dynamics, however it is often detrimental to cell cultures due to effects of changing environment on dynamic cellular events. In order to combat the effects of a changing environment, our team has designed, manufactured, and tested an incubation chamber that will control the heat and pH environment that these cells are experiencing throughout the imaging process. This project is sponsored by the BMED microscopy core group to be used with the Olympus IX73P2F inverted …

Pickleball Paddle For Minimizing Elbow/Shoulder Joint Forces, Kaley Sapper, Nick Rodgers, Claire Steines

Biomedical Engineering

The goal of this project was to design a pickleball paddle to prevent overuse injuries. This was accomplished through a design that minimizes joint forces experienced by the player during backhand strokes.

Feverdots, Kameryn Laureano, Heidi Silk, Rita Grigorian

Biomedical Engineering

FeverDots are wearable temperature sensitive stickers that change color from black to pink at 99°F when placed on the temple or forehead. The objective of this project was to develop an efficient manufacturing method for FeverDots, and manufacture a device along with it. To create the FeverDots manufacturing device, the full design process was executed. The team went through a thorough ideation phase before ultimately defining and specifying the scope of the project.

The key customer requirements of this device include that it is lightweight, portable, durable, simple to assemble, easy to use, and able to generate uniform ink and …

Live Cell Imaging Gas Control, Elsa M. Bean, Brady C. Berg, Abby A. Jens

Biomedical Engineering

The following document outlines the entire process for designing and manufacturing a Live Cell Imaging Gas Control subsystem in tandem with the Heated Stage subsystem to make a CO₂ and temperature-controlled chamber for use with the Olympus IX73P2F Microscope. It highlights the current literature and patents surrounding live cell imaging and touches on the existing live cell imaging setups currently being used by other entities. Following this, it defines the scope of the project, key customer requirements, and engineering specifications to ensure the design meets all the needs of its users. This document includes project planning steps to establish …

Bone And Cartilage Compression Simulator, Karoline M. Wucherer, Benjamin A. Parmentier, Thomasina E. Hinkle

Biomedical Engineering

A device was developed that delivers mechanical loads to bone and soft tissue samples under physiological conditions to aid in the research of tissue engineering bone and cartilage. To begin the design process, a Network Diagram and Gantt Chart were produced to create a general timeline for the project to follow. This allowed us to measure our progress and determine what effects (if any) delays could have on our project.

Minivette Integrated Sample Prep Funnel For Cepheid Cartridges, Hanna N. Blumer, Sophia Arias, Camille Porciuncula, Ben Runkle

Biomedical Engineering

This report covers the redesign of the Sample Prep Funnel for Cepheid’s engineering team. The Sample Prep Funnel, responsible for relaying liquid from the sample collection device to the testing cartridge, experiences fluid loss that causes invalid test results. Our group's task was to redesign this funnel to minimize fluid loss and, overall, increase efficiency and effectiveness.

Astm Test Fixture For Spinal Screws, Sarah K. Pickering, Matthew W. Rowen, Kaajal N. Khanna, Thomas A. Sunding

Biomedical Engineering

This document is an overview report of the Cal Poly Senior Project ASTM Test Fixture for SeaSpine orthopedic bone screws. The main application of orthopedic screws is to fasten implants directly to the bone structure, enhancing structural integrity. Testing for breaking angle, insertion torque, removal torque, axial pullout strength, and self-tapping force as specified in the ASTM F543 Annexes provides the FDA with vital screw mechanics and ensures manufacturing uniformity. The test system is comprised of custom and off the shelf components allowing for interchangeability, in case of part failure, and a low overall cost. It is mechanically capable of …

Wearable Spinal Cord Stimulator: Transcutaneous Delivery Of Electrical Impulses For Chronic Lower Back Pain, Abby Mae Gilstrap, Emma Katharina Jacobs, Jonathan Michael Campas, Sydney Michelle Moore

Biomedical Engineering

The purpose of this project was to create a wearable spinal cord stimulator capable of delivering transcutaneous electrical stimulation for the treatment of chronic lower back pain. Chronic lower back pain impacts a large percentage of the population, and current treatment options require either invasive surgery or management through pain medication. Therefore, there is a need for a treatment option that is non-invasive, convenient, and does not require medication. To meet these needs, a wearable device was created that consists of internal circuitry contained within external housing that allows for the delivery of user-controlled stimulation via electrodes that are plugged …