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Biomedical Engineering and Bioengineering Commons

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California Polytechnic State University, San Luis Obispo

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Articles 1 - 30 of 380

Full-Text Articles in Biomedical Engineering and Bioengineering

Mechanisms Of Reduced Vascular Tone Following Arteriogenesis Induced By Femoral Artery Ligation, Christopher Hatch Aug 2019

Mechanisms Of Reduced Vascular Tone Following Arteriogenesis Induced By Femoral Artery Ligation, Christopher Hatch

Biomedical Engineering

The presence of a developed, native collateral network can decrease the severity of ischemic injury proceeding arterial occlusion. The collateral network must under arteriogenesis to enlarge and increase blood flow to the ischemic region. Although there has been tremendous effort attempting to understand the mechanisms of arteriogenesis, no therapies have been successful in improving patient outcome. To better understand the mechanisms involved in arteriogenesis, the effect of nitric oxide production, myogenic tone, and a-adrenergic receptors were evaluated as these have been identified as playing an important role in vascular injury. Arteriogenesis was induced by ligating the femoral artery between the ...


Compositional Optimization Of Amyloid-Graphene Oxide Nanohybrids For Biomaterials, Claire L. Drewery Jun 2019

Compositional Optimization Of Amyloid-Graphene Oxide Nanohybrids For Biomaterials, Claire L. Drewery

Materials Engineering

Amyloid nanofibrils are natural materials capable of self-assembling into precise structures with tunable functionalities, while exhibiting excellent mechanical properties. In combination with highly conductive graphene oxide (GO), the 1-D amyloid nanofibrils and 2-D nanosheets of GO can produce a robust and bio-functional nanohybrid, hypothesized to exhibit multi-domain functional properties useful for enzyme sensing, water purification, drug delivery, and tissue scaffolding applications. Here, we examine the properties of an amyloid-graphene oxide nanohybrid film made with amyloids derived from hen egg white lysozymes in an attempt to explore the diverse toolbox of amyloid derivatives and establish ideal fabrication methods and formulations of ...


Study Of Paper Microbial Fuel Cells For Use In On-Site Wastewater Testing, William A. Tolmasoff, William A. Tolmasoff Jun 2019

Study Of Paper Microbial Fuel Cells For Use In On-Site Wastewater Testing, William A. Tolmasoff, William A. Tolmasoff

Master's Theses and Project Reports

This study demonstrated a technique for fabricating simple, low-cost Paper Microbial fuel cells (PMFC’s) in the model of a previous study to, for the first time, produce voltage from wastewater effluent. The PMFC’s were created by stacking and gluing the main components of an MFC together: reservoir layer; anode; cation exchange membrane (CEM); air cathode. A wax printer was used to create the hydrophobic borders of the PMFC’s on filter paper, and graphite paint was applied to the paper to create the anode. The CEM’s considered were filter paper, wax, and Nafion, with Nafion being the ...


Cej Ankle Support Report, Christine Prothe, James Baldwin, Erik Espinoza Jun 2019

Cej Ankle Support Report, Christine Prothe, James Baldwin, Erik Espinoza

Biomedical Engineering

This document provides information about an ankle support device designed to allow for ankle dorsiflexion and plantar flexion. In this document the product’s specifications, objectives and expectations are outlined. Included in this document is background information, stage gate process, prototype design development and considerations, and qualification requirements.


Microscope System, Virginia Brannaman, Gavin Shavey, Ricardo Lasa Jun 2019

Microscope System, Virginia Brannaman, Gavin Shavey, Ricardo Lasa

Biomedical Engineering

This project aims to improve upon the current microscope stand for the Olympus compound microscope in the Microcirculation and Vascular Regeneration (MaVR) laboratory in order to minimize angular deflection of the microscope objective with respect to surgical stage.


Sand Foot: A Prosthesis For Walking On Sand, Samantha A. Galicinao, John Dewing, Daniel Dugan Dotson, Christopher Urasaki Jun 2019

Sand Foot: A Prosthesis For Walking On Sand, Samantha A. Galicinao, John Dewing, Daniel Dugan Dotson, Christopher Urasaki

Biomedical Engineering

This critical design report describes the product development of a prosthesis for use on sand. Quality of Life Plus (QL+), a national non-profit organization aimed to develop prostheses for veterans and people with disabilities, introduced this project and its accompanying challenger, Sgt. Brady, to Cal Poly’s Interdisciplinary Senior Project class in September 2018. After consulting with Sgt. Brady and QL+ and performing extensive research, the Sand Foot team defined customer requirements and engineering specifications to meet these requirements. Comfortability, durability, and sandproof were key customer requirements. Several conceptual models were brainstormed and a final design was selected based on ...


House Calls Mobile Virtual Stethoscope, Abigail Lindquist, Abigael Donohue, Trey Nahhas Jun 2019

House Calls Mobile Virtual Stethoscope, Abigail Lindquist, Abigael Donohue, Trey Nahhas

Biomedical Engineering

The purpose of this scope of work is to outline the progress of the Virtual Stethoscope design and development project as sponsored by House Calls Mobile. This device looks to provide accessible at-home care for patients all over the country through the mobile phone stethoscope attachment. With the virtual stethoscope technology, patients will be able to perform high-quality, in-home observation of heart, stomach, and lung sounds to be transmitted to a physician in real time. Eliminating the need to travel to a doctor’s office encourages patients to perform more regular checkups, increasing their likelihood potentially of life-saving early diagnoses ...


Cooking Hand Multi-Tool, Amanda D. Meares, Amy H. Wilson, Ethan G. Littlejohn, Duania A. Evans Jun 2019

Cooking Hand Multi-Tool, Amanda D. Meares, Amy H. Wilson, Ethan G. Littlejohn, Duania A. Evans

Biomedical Engineering

The purpose of this project was to devise a solution for Jorge Segura, a US Marine who was wounded in Afghanistan and had to have his non-dominant arm amputated above the elbow. His current prosthetic attachments are not suited to cooking tasks, so he needed a way to cook more effectively with either prosthetic attachments or accessibility devices. The main tasks that he needed help with was holding down food on cutting boards and stabilizing pots, pans, and bowls especially when stirring. After background research, exploring commercially available devices, and talking with our challenger, our solution was to design three ...


Marine Chemistry Control System, Natalie Weisenburger, Kathryn Turk, Julio Sierra Jun 2019

Marine Chemistry Control System, Natalie Weisenburger, Kathryn Turk, Julio Sierra

Biomedical Engineering

The aim of this project is to design a control system that manipulates different variables of ocean chemistry including pH, temperature, DO, N2 , and CO2 content for research by ocean chemists of marine species and their environments in 2, 5 gallon tanks.


Pressure Cylinder Controlled Release Valve, Alexa Dominique Balbuena Mar 2019

Pressure Cylinder Controlled Release Valve, Alexa Dominique Balbuena

Biomedical Engineering

This project aims to integrate an automatic gas release system in a pre-existing scaffold fabrication process for tissue engineering applications.

To form the proper scaffold structure, the fabrication process is heavily influenced by the change in its surrounding pressure. The current production involves a pressure transducer and electric valve that is managed manually to create a suitable pressure environment for the scaffold. This method, although functional, proves to be ineffective when creating several batches; the user needs to constantly monitor the developing pressure profile and alter voltage parameters accordingly to create a linear gas release under a predetermined slope.

To ...


Slit Lamp Ophthalmoscope Redesign, Michael Hostetler, Austin Mattmiller, Alexis Brewer Mar 2019

Slit Lamp Ophthalmoscope Redesign, Michael Hostetler, Austin Mattmiller, Alexis Brewer

Biomedical Engineering

The slit lamp ophthalmoscope is used by ophthalmologists for diagnosis of pathologies in the eye. The device is used for identifying ocular diseases or indications of other possible systemic diseases to treat them before the diseases progress. Redesign of the ergonomics and adjustment mechanisms of the slit lamp ophthalmoscope will attempt to improve the compatibility of the device across a greater variety of patients. The wider headrest tower of 12.75 inches, the wider table cutout of 12 inches, and the 12 inches of extension of the headrest tower creates a better ergonomic fit for the patient and doctor. The ...


Development Of A Myoelectric Detection Circuit Platform For Computer Interface Applications, Nickolas Andrew Butler Mar 2019

Development Of A Myoelectric Detection Circuit Platform For Computer Interface Applications, Nickolas Andrew Butler

Master's Theses and Project Reports

Personal computers and portable electronics continue to rapidly advance and integrate into our lives as tools that facilitate efficient communication and interaction with the outside world. Now with a multitude of different devices available, personal computers are accessible to a wider audience than ever before. To continue to expand and reach new users, novel user interface technologies have been developed, such as touch input and gyroscopic motion, in which enhanced control fidelity can be achieved. For users with limited-to-no use of their hands, or for those who seek additional means to intuitively use and command a computer, novel sensory systems ...


Perturbation Based Decomposition Of Semg Signals, Rachel Huettinger Mar 2019

Perturbation Based Decomposition Of Semg Signals, Rachel Huettinger

Master's Theses and Project Reports

Surface electromyography records the motor unit action potential signals in the vicinity of the electrode to reveal information on muscle activation. Decomposition of sEMG signals for characterization of constituent motor unit action potentials in terms of amplitude and firing times is useful for clinical research as well as diagnosis of neurological disorders. Successful decomposition of sEMG signals would allow for pertinent motor unit action potential information to be acquired without discomfort to the subject or the need for a well-trained operator (compared with intramuscular EMG). To determine amplitudes and firing times for motor unit action potentials in an sEMG recording ...


Fluid Delivery System For A Cell Culture On A Microfluidic Chip, Austin J. Roeder, Colleen A. Richards, Emily A. Matteson Mar 2019

Fluid Delivery System For A Cell Culture On A Microfluidic Chip, Austin J. Roeder, Colleen A. Richards, Emily A. Matteson

Biomedical Engineering

This project report provides a description of the progress made in the development of a fluid delivery system for a microfluidic cell culture on a chip. The system is intended to be used in a humidified incubator in a university laboratory and the fluid delivery system is required to exist and operate within that incubator for extended periods of time. Therefore, the system will be gravity-driven and contain no electronic components. The key specification of the system is to provide fluid flow at a constant velocity.

After manufacturing and testing the device, all specifications were met except for the fluid ...


Automated Microscope Stage, Corin Nishimoto, Alison Flesch, Theo Anastos Mar 2019

Automated Microscope Stage, Corin Nishimoto, Alison Flesch, Theo Anastos

Biomedical Engineering

This document seeks to describe the background information, customer requirements, design specifications, indications for use, selected materials, proposed budget, prototypes, final design, manufacturing processes, and testing methods regarding the CellOptimizer automated microscope stage product.


Concussion Indication Device, Taylor O'Donoghue, Isabel Jellen, Eric Shechter Mar 2019

Concussion Indication Device, Taylor O'Donoghue, Isabel Jellen, Eric Shechter

Biomedical Engineering

In this document we summarize our intent to design and manufacture a device that will be used in conjunction with a football helmet, will detect impact forces to the head, and notify the user to seek out further medical attention when subjected to forces large enough to cause concussions. We describe the large market including all levels of football players and the need for improved technology that will not only be effective in elucidating risks but encouraging players to use the device over the alternatives. To design the device, we have researched the problem of concussions in football and have ...


Plga Scaffold Device, Tyler D. Tackabery, Bryce Powada, Tate Morell Mar 2019

Plga Scaffold Device, Tyler D. Tackabery, Bryce Powada, Tate Morell

Biomedical Engineering

No abstract provided.


Parkinson's Freezing Of Gait Device Attachment, Reagan Burns, Sidney Collin, Hadley Rose Mar 2019

Parkinson's Freezing Of Gait Device Attachment, Reagan Burns, Sidney Collin, Hadley Rose

Biomedical Engineering

The Freezing of Gait Project aims to design and develop an attachment mechanism for a medical device to help Parkinson’s patients overcome freezing of gait (FOG). The mechanism will allow the device to attach to a variety of canes or walkers, while being easy for Parkinson’s patients to use. It will interface with a device produced by De Oro Devices. The project includes an analysis of current competitive devices, a summary of customer needs, design of experiments to test significant features of the attachment, and project plan. The customer needs are translated to engineering metrics. Failures and mitigation ...


Heat Stress Identification, Nathanial Nyberg, Christina Santini, Zachary Miller Mar 2019

Heat Stress Identification, Nathanial Nyberg, Christina Santini, Zachary Miller

Biomedical Engineering

This document contains all information pertinent to the creation of the desired product and how the desired product fulfills the problem statement. This document clearly defines the customer requirements and how they relate to engineering specifications, metrics that will define the boundaries that the desired product must lie within. This document will then reveal all concepts that were considered during the design phase of this project and how those concepts were compared. This includes all quantitative parameters that provided a clear front-runner concept and the rationale for those parameters and the values and weight assigned to them.

Then this document ...


Flash-Mold Machine For Manufacturing Drug Implants, Conor Vache, Sonja Daebelliehn, Ryan Thomson Mar 2019

Flash-Mold Machine For Manufacturing Drug Implants, Conor Vache, Sonja Daebelliehn, Ryan Thomson

Biomedical Engineering

This Final Project Report provides the reader with a comprehensive detailing of all of the actions and work that has been completed for this Senior Design Project. In this report, the Cal Poly Biomedical Engineering Senior Project Team will discuss some background on the existing Mark I Flash-Mold Machine currently in use by Gesea Biosciences, background information on Gesea Biosciences, the Customer Requirements and Design Specifications of the new machine, Quality Engineering considerations, design concepts discussed, design concepts chosen, safety considerations, prototype development, manufacturing, testing protocols, and testing results, etc.


Hands-Free Ultrasound Transducer Attachment, Christina Harrison, Glenn Farina, Harshveer Dhaliwal Mar 2019

Hands-Free Ultrasound Transducer Attachment, Christina Harrison, Glenn Farina, Harshveer Dhaliwal

Biomedical Engineering

This document describes a background on current ultrasound technologies and the troubles that have inspired the need for a hands-free ultrasound transducer device, as well as the regulatory requirements, like patents and standard codes, for the intended invention. It also explains the Stage Gate Review process used to project plan the design of the device, a description of the final design and how it was developed, and the IQ/OQ/PQ. The objectives necessary to design this device, in order to meet all the requirements of the sponsor, are also summarized here. The design process including manufacturing instructions, prototype evolution ...


Esophageal Mapping And Temperature Regulation For Catheter Ablation, Madison J. Keith, Morgan A. Jawitz, Sarah L. Sanders Mar 2019

Esophageal Mapping And Temperature Regulation For Catheter Ablation, Madison J. Keith, Morgan A. Jawitz, Sarah L. Sanders

Biomedical Engineering

The purpose of this document is to provide a development summary for a proposed esophageal temperature mapping device used during catheter ablation. Catheter ablation therapy is performed in the left atria with hot or cold materials to create scar tissue to treat atrial fibrillation. However, utilized temperatures and absorbed energies from the catheter can cause undesired esophageal damage. Therefore, this medical device is designed to monitor esophageal temperature and map its location during catheter ablation. If dangerous temperatures are reached, the device will alarm the surgeon.

This document provides an in-depth overview of the esophageal temperaturemapping device’s development and ...


Foot Support Taping Device For Off-Loading Wounds, Andres Fojaco Gomez, Mikaela Williams, Josh Pelegrin Mar 2019

Foot Support Taping Device For Off-Loading Wounds, Andres Fojaco Gomez, Mikaela Williams, Josh Pelegrin

Biomedical Engineering

No abstract provided.


Accelerated Wear Reactor Testing, Tristan Frisella, Daniel Alanis, Kian Ashoubi Mar 2019

Accelerated Wear Reactor Testing, Tristan Frisella, Daniel Alanis, Kian Ashoubi

Biomedical Engineering

Carbon dioxide accounts for a large amount of global greenhouse gases released into the environment. Because plastic degradation emits carbon dioxide, there has been interest to investigate how much carbon dioxide various plastics generate as they degrade. We have been tasked to create a dehumidifier and carbon dioxide sensor assembly for an accelerated wear testing apparatus that degrades plastic. Several products and literature currently exist that share similarity with our assembly but have not been manufactured to achieve the same combination of measurements we are expecting of our accelerated wear testing device. The following report shall introduce these products and ...


Surf Leg, Samantha Campbell, Oyundari Altansukh, Caroline Swanson, Kurtis Barth Jan 2019

Surf Leg, Samantha Campbell, Oyundari Altansukh, Caroline Swanson, Kurtis Barth

Mechanical Engineering

The Surf Leg Prosthetic project team in conjunction with QL+ and Operation Surf designed a transtibial prosthetic to be used for surfing. The senior project team focused on the missions of QL+ and Operation Surf as they went through the design process during the 2018-2019 academic year. The problem solved was that a standard prosthetic for a transtibial amputee does not provide the flexibility in enough degrees of freedom for a user to squat and balance on a surfboard. The goal of this project was to create a device specifically designed to improve the user’s balance and control while ...


Assessing Endothelial Dysfunction Estimating The Differences Between 3 Minute And 5 Minute Reactive Hyperemia, Tamiko K. Saldin Jan 2019

Assessing Endothelial Dysfunction Estimating The Differences Between 3 Minute And 5 Minute Reactive Hyperemia, Tamiko K. Saldin

Master's Theses and Project Reports

The purpose of this study was to define a lower standard cuff occlusion time to induce reactive hyperemia in assessing endothelial dysfunction. In this study, strong evidence was found by a novel technique that used oscillometric methods, which supported that 3 minute reactive hyperemia was sufficient to elicit a significant difference in arterial compliance from baseline. Twenty healthy Cal Poly students were assessed, (n=12 female, n=8 male) aged 22 years old with a standard deviation of 2.04 years. Arterial compliance was estimated by measuring the peak-to-peak oscillations for baseline, 3 minute reactive hyperemia, and 5 minute reactive ...


Upright Sleep Device For Patients Required To Sleep Upright Post Surgery/Medical Procedure, Kristin J. Abele, Madeleine H. Hummel, Tayler R. Kastlunger Jan 2019

Upright Sleep Device For Patients Required To Sleep Upright Post Surgery/Medical Procedure, Kristin J. Abele, Madeleine H. Hummel, Tayler R. Kastlunger

Biomedical Engineering

No abstract provided.


Hip And Knee Biomechanics For Transtibial Amputees In Gait, Cycling, And Elliptical Training, Greg Orekhov Dec 2018

Hip And Knee Biomechanics For Transtibial Amputees In Gait, Cycling, And Elliptical Training, Greg Orekhov

Master's Theses and Project Reports

Transtibial amputees are at increased risk of contralateral hip and knee joint osteoarthritis, likely due to abnormal biomechanics. Biomechanical challenges exist for transtibial amputees in gait and cycling; particularly, asymmetry in ground/pedal reaction forces and joint kinetics is well documented and state-of-the-art passive and powered prostheses do not fully restore natural biomechanics. Elliptical training has not been studied as a potential exercise for rehabilitation, nor have any studies been published that compare joint kinematics and kinetics and ground/pedal reaction forces for the same group of transtibial amputees in gait, cycling, and elliptical training. The hypothesis was that hip ...


In Vitro Growth Of Osteoblasts On Poly Lactic-Co-Glycolic Acid Scaffolds Created Via Gas Foaming, Matthew James Thomas Sep 2018

In Vitro Growth Of Osteoblasts On Poly Lactic-Co-Glycolic Acid Scaffolds Created Via Gas Foaming, Matthew James Thomas

Master's Theses and Project Reports

This study analyzed the feasibility of using gas foaming to create Poly Lactic-co-Glycolic Acid (PLGA) scaffolds for use as a substrate in bone tissue engineering and set out to determine whether the presence of osteoblasts on these scaffolds enhanced their material stiffness. The process of bone formation involves osteoblasts depositing extracellular matrix and calcifying this matrix with calcium phosphate crystals (Hasegawa et al., 2017) and pits between 30-40μm in diameter on tissue engineering scaffold surfaces have been shown to best promote osteogenic activity in the presence of bone-forming cells (Halai et al., 2014).The scaffolds were determined to contain pits ...


Microfluidic Electrical Impedance Spectroscopy, John J. Foley Sep 2018

Microfluidic Electrical Impedance Spectroscopy, John J. Foley

Master's Theses and Project Reports

The goal of this study is to design and manufacture a microfluidic device capable of measuring changes in impedance valuesof microfluidic cell cultures. Tocharacterize this, an interdigitated array of electrodes was patterned over glass, where it was then bonded to a series of fluidic networks created in PDMS via soft lithography. The device measured ethanol impedance initially to show that values remain consistent over time. Impedance values of water and 1% wt. saltwater were compared to show that the device is able to detect changes in impedance, with up to a 60% reduction in electrical impedance in saltwater. Cells were ...