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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 22 of 22
Full-Text Articles in Biomedical Engineering and Bioengineering
Final Design Report: Polymer Fatigue Characterization Test Method, Wyatt Ayling, Tyler Price, Brandon Stell, Michela Upson
Final Design Report: Polymer Fatigue Characterization Test Method, Wyatt Ayling, Tyler Price, Brandon Stell, Michela Upson
Mechanical Engineering
Polylogix is a team dedicated to the design, build, and testing of a fatigue machine to simulate cyclic loading on a biomedical polymer. This project is sponsored by Endologix, Inc. to provide test data characterizing mechanical material properties of various formulations of polymer used in abdominal aortic aneurysm surgeries. With this project goal, the machine must be able to test the polymer at body conditions; these include a testing temperature of 37°C and a cycling frequency ranging from 1 Hz to 10 Hz. This report proposes the following solution to this design challenge: an AC motor-driven mechanism utilizing a planetary …
Functional 3-D Cellulose And Nitrocellulose Paper-Based, Microfluidic Device Utilizing Elisa Technology For The Detection/Distinction Between Hemorrhagic And Ischemic Strokes, Alicia Leanne Holler
Functional 3-D Cellulose And Nitrocellulose Paper-Based, Microfluidic Device Utilizing Elisa Technology For The Detection/Distinction Between Hemorrhagic And Ischemic Strokes, Alicia Leanne Holler
Master's Theses
The purpose of this thesis project is to demonstrate and evaluate an enzyme-linked immunosorbent assay (ELISA) on a paper microfluidic device platform. The integration of ELISA technology onto paper microfluidic chips allows for a quantitative detection of stroke biomarkers, such as glial fibrillary acidic protein (GFAP). Dye experiments were performed to confirm fluid connectivity throughout the 3D chips. Several chip and housing designs were fabricated to determine an optimal design for the microfluidic device. Once this design was finalized, development time testing was performed. The results confirmed that the paper microfluidic device could successfully route fluid throughout its channels at …
The Impacts Of Arterial Occlusion, Sex, And Exercise On Arteriogenesis And Functional Vasodilation, Megan Tze-Mei Chu
The Impacts Of Arterial Occlusion, Sex, And Exercise On Arteriogenesis And Functional Vasodilation, Megan Tze-Mei Chu
Master's Theses
The most frequent clinical presentation of peripheral arterial occlusive disease (PAOD) is intermittent claudication, which may be caused by impaired vasodilation. Patients demonstrate both local and systemic impairments in vasodilation, but as the collateral circulation is the primary site of resistance to the ischemic zone, impaired collateral vasodilation would have the greatest potential to induce claudication. Collateral function following arterial occlusion is not well defined, but immature collaterals may demonstrate impaired vasodilation in animal models, although this is potentially improved with exercise training. Furthermore, as females exhibit poorer physical function with ischemia and less improvement with therapeutic exercise, there appears …
Quantifying Parkinson's Disease Symptoms Using Mobile Devices, Charles R. Aylward
Quantifying Parkinson's Disease Symptoms Using Mobile Devices, Charles R. Aylward
Master's Theses
Current assessments for evaluating the progression of Parkinson’s Disease are largely qualitative and based on small sets of data obtained from occasional doctor-patient interactions. There is a clinical need to improve the techniques used for mitigating common Parkinson’s Disease symptoms. Available data sets for researching the disease are minimal, hindering advancement toward understanding the underlying causes and effectiveness of treatment and therapies. Mobile devices present an opportunity to continuously monitor Parkinson’s Disease patients and collect important information regarding the severity of symptoms. The evolution of digital technology has opened doors for clinical research to extend beyond the clinic by incorporating …
Nanoindentation Techniques For The Evaluation Of Silicon Nitride Thin Films, Weston T. Mangin
Nanoindentation Techniques For The Evaluation Of Silicon Nitride Thin Films, Weston T. Mangin
Master's Theses
Silicon nitride thin films are of interest in the biomedical engineering field due to their biocompatibility and favorable tribological properties. Evaluation and understanding of the properties of these films under diverse loading and failure conditions is a necessary prerequisite to their use in biomedical devices. Three wafers of silicon nitride-coated silicon were obtained from Lawrence Livermore National Laboratory and used to create 96 samples. Samples were subjected to nanoindentation testing to evaluate the mechanical properties of the film. Samples were subjected to nanoimpact testing to compare the damage resistance of the film to separate nanoimpact types. Samples were subjected to …
A 3-D Multiplex Paper-Microfluidic Platform, Mitchell Patrick Young
A 3-D Multiplex Paper-Microfluidic Platform, Mitchell Patrick Young
Master's Theses
3-D paper-based microfluidic devices (micoPADs) are small and portable devices made out of paper that offer a promising platform for diagnostic applications outside of a laboratory. These devices are easy to use, low cost, require no power source, and capable of detecting multiple targets simultaneously. The work in this thesis demonstrated the ability of a 3-D paper-microfluidic platform to simultaneously detect 5 targets. Rubber cord stock was used in conjunction with an acrylic housing unit to apply pressure along the edge of the channel. The indirect pressure application was successful in promoting vertical fluid flow between layers. Average channel development …
Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation Of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Ahsley H. Fong, Mónica Romero-López, Christopher M. Heylman, Mark Keating, David Tran, Agua Sobrino, Anh Q. Tran, Hiep H. Pham, Cristhian Fimbres, Paul D. Gershon, Elliot L. Botvinick, Steven C. George, Christopher C.W. Hughes
Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation Of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Ahsley H. Fong, Mónica Romero-López, Christopher M. Heylman, Mark Keating, David Tran, Agua Sobrino, Anh Q. Tran, Hiep H. Pham, Cristhian Fimbres, Paul D. Gershon, Elliot L. Botvinick, Steven C. George, Christopher C.W. Hughes
Biomedical Engineering
Pluripotent stem cell-derived cardiomyocytes (CMs) have great potential in the development of new therapies for cardiovascular disease. In particular, human induced pluripotent stem cells (iPSCs) may prove especially advantageous due to their pluripotency, their self-renewal potential, and their ability to create patient-specific cell lines. Unfortunately, pluripotent stem cell-derived CMs are immature, with characteristics more closely resembling fetal CMs than adult CMs, and this immaturity has limited their use in drug screening and cell-based therapies. Extracellular matrix (ECM) influences cellular behavior and maturation, as does the geometry of the environment—twodimensional (2D) versus three-dimensional (3D). We therefore tested the hypothesis that native …
Functional Vasodilation And Vascular Reactivity In Arteriolar Collaterals In The Spinotrapezius Of Males And Females, Britta C. Nelson
Functional Vasodilation And Vascular Reactivity In Arteriolar Collaterals In The Spinotrapezius Of Males And Females, Britta C. Nelson
Biomedical Engineering
Peripheral arterial occlusive disease (PAOD) occurs when there is narrowing or blockage of the peripheral arteries that carry blood to the extremities, most commonly the legs. The most common symptom of PAOD is intermittent claudication, or ischemic pain during exercise. Women with PAOD experience a greater extremity functional impairment than men. Since impaired vasodilation might cause the ischemic pain from PAOD, we should evaluate vasodilation post ligation in males and females in collateral vessels, which connect two arterial segments to maintain blood flow to an otherwise hypoxic area. First, we need to examine collateral vasodilation in unoperated male and female …
Fluid Flow Characterization And In Silico Validation In A Rapid Prototyped Aortic Arch Model, Alexandra Mariel Knauer
Fluid Flow Characterization And In Silico Validation In A Rapid Prototyped Aortic Arch Model, Alexandra Mariel Knauer
Master's Theses
Transcatheter aortic heart valve replacement (TAVR) is a procedure to replace a failing aortic valve and is becoming the new standard of care for patients that are not candidates for open-heart surgery [2]. However, this minimally invasive technique has shown to cause ischemic brain lesions, or “silent infarcts”, in 90% of TAVR patients, which can increase the patient’s risk for stroke by two to four times in future years [3]. Claret Medical Inc., a medical device company, has developed a cerebral protection system that filters and captures embolic debris released during endovascular procedures, such as TAVR. This thesis utilized CT …
Modification Of Offset Hip Impactor, Anton Gebert, Michael Rumery, Mark Sidor
Modification Of Offset Hip Impactor, Anton Gebert, Michael Rumery, Mark Sidor
Mechanical Engineering
More than 300,000 total hip replacement surgeries are performed in the US each year. Minimally invasive total hip replacement surgery requires modified tools to access the smaller incision. An offset hip impactor was redesigned to improve tool lifetime, ease of use, and manufacturing cost. The redesigned tool had an increased lifetime and a significant reduction in the number of parts. The report contains detail drawings, a manufacturing plan, and physical testing results.
Improvement Of Mounting Techniques For Accelerated Wear Testing Of Artificial Heart Valves, Kyle Koon, Clay Bougher, Lawrence Yang
Improvement Of Mounting Techniques For Accelerated Wear Testing Of Artificial Heart Valves, Kyle Koon, Clay Bougher, Lawrence Yang
Mechanical Engineering
Confidential
Prosthetic Socket Cooling System, Benjamin K. Kraw, Kathy Ha, Derek Piastrelli, Cuong Lai
Prosthetic Socket Cooling System, Benjamin K. Kraw, Kathy Ha, Derek Piastrelli, Cuong Lai
Mechanical Engineering
A team of four senior-level undergraduate students in the Interdisciplinary Senior Project Design course in the Engineering Department of California Polytechnic State University: San Luis Obispo have worked to develop a prosthetic socket cooling system, namely for veteran Taylor Morris and exclusively for a transfemoral prosthetic socket, under the Quality of Life+ Laboratory. This cooling system will utilize the thermoelectric effect known as the Peltier effect to transmit heat generated from the residual limb to the surrounding environment by means of forced convection over small aluminum heat sinks. Two measurement devices have also been developed to, one, measure the heat …
Portable Sensory Room For The West Orange County Consortium For Special Education, Lindsey Chase, Emma Eskildsen, Alex Fox, Claire Francis, Nate Hoffman, Kaylee Keck, Sarah Sullivan
Portable Sensory Room For The West Orange County Consortium For Special Education, Lindsey Chase, Emma Eskildsen, Alex Fox, Claire Francis, Nate Hoffman, Kaylee Keck, Sarah Sullivan
Biomedical Engineering
This report discusses the development of a Portable Sensory Room to be used at Newland Elementary School in Huntington Beach. Newland Elementary has an exceptional Special Needs program that teaches the children with the most severe cases of autism in its school district. People with autism typically also have sensory processing disorders, which can be extremely disruptive for a child’s development and can make it difficult for a child to be able to concentrate long enough to gain necessary life skills. The idea behind a Sensory Rooms is to create a place to calm the students and to expose them …
Prosthetic Leg Kit For Deployment In Developing Countries, Brian Murphy, Dominique Porcincula, Derek Morgan, Kendall Ruggles, Christian Aguayo
Prosthetic Leg Kit For Deployment In Developing Countries, Brian Murphy, Dominique Porcincula, Derek Morgan, Kendall Ruggles, Christian Aguayo
Biomedical Engineering
The World Health Organization estimates that over 30 million people require some sort of prosthetic technology. However, traditional prosthetic fitting practices take a lot of time and cost a lot of money, making them inaccessible to millions of people around the world. StandUP Worldwide is an interdisciplinary project team devoted to creating low-cost prosthetic technologies for use around the world, especially in resource poor areas. They are currently developing a low cost, below-the-knee prosthetic kit that can be easily deployed in a resource-poor area. The following presents their solution for a below-the-knee prosthetic socket, foot, and leg.
Empirical Validation Of An In Silico Model Predicting The Fluid Dynamics Of An Iliac Artery Aneurysm, Rachel E. Willis
Empirical Validation Of An In Silico Model Predicting The Fluid Dynamics Of An Iliac Artery Aneurysm, Rachel E. Willis
Master's Theses
Iliac artery aneurysms are considered rare and difficult to detect and treat. Prompt diagnosis and timely intervention are essential, because the incidence of rupture is as high as 50%. The reported mortality rate for patients who undergo surgery for ruptured iliac artery aneurysm ranges from 50% to 70%. This study developed an in-vitro mechanical model of an iliac artery aneurysm to verify the accuracy of computer simulation software. Both the in vitro model and the in silico model can be used for further research to develop better treatment technology. This study also looks at the different types of iliac artery …
The Effects Of Obesity On Resultant Knee Joint Loads For Gait And Cycling, Juan Gutierrez-Franco
The Effects Of Obesity On Resultant Knee Joint Loads For Gait And Cycling, Juan Gutierrez-Franco
Master's Theses
Osteoarthritis (OA) is a degenerative disease of cartilage and bone tissue and the most common form of arthritis, accounting for US$ 10.5 billion in hospital charges in 2006. Obesity (OB) has been linked to increased risk of developing knee OA due to increased knee joint loads and varus-valgus misalignment. Walking is recommended as a weight-loss activity but it may increase risk of knee OA as OB gait increases knee loads. Cycling has been proposed as an alternative weight-loss measure, however, lack of studies comparing normal weight (NW) and OB subjects in cycling and gait hinder identification of exercises that may …
Characterizing Neurotransmitter Receptor Activation With A Perturbation Based Decomposition Method, Stephen Gregory Jue
Characterizing Neurotransmitter Receptor Activation With A Perturbation Based Decomposition Method, Stephen Gregory Jue
Master's Theses
The characterization of postsynaptic potentials, in terms of neurotransmitter receptor activation, is of clinical significance because information associated with receptor activation can be used in the diagnosis and study of neurological disorders. Single-unit recordings provide a method of measuring postsynaptic potentials in neurons using a microelectrode system, but yield no detailed information regarding the neurotransmitter receptors that contribute to the potential. To determine the types of neurotransmitter receptors that result in a compound postsynaptic potential from a microelectrode reading, decomposition of the potential is necessary. In this work, a perturbation-based decomposition method developed by R. Szlavik is evaluated for this …
Design And Validation Of A Fall Detection Application For Ios, Connor Lewis Mosley
Design And Validation Of A Fall Detection Application For Ios, Connor Lewis Mosley
Master's Theses
Despite significant preventative efforts, falls continue to be a major source of morbidity and mortality among the elderly. Additionally, the fear of falling can be a major obstacle to independent living for otherwise self-sufficient individuals. This fear is significantly heightened in individuals who have sustained a fall and often results in self-imposed restrictions on mobility and exercise, causing weakening in these individuals and further exacerbating the danger. Much time has been spent developing alert systems in an attempt to mitigate these problems. Unfortunately these systems typically involve dedicated monitoring centers and therefore often come with substantial upfront and recurring costs. …
Fluid Flow Characterization In Rapid Prototyped Common Iliac Artery Aneurysm Molds, Daniel Cole Greinke
Fluid Flow Characterization In Rapid Prototyped Common Iliac Artery Aneurysm Molds, Daniel Cole Greinke
Master's Theses
The goal of this project was to determine whether i) fused deposition modeling could be employed to manufacture molds for vascular constructs, ii) whether vascular constructs could be created from these molds, and iii) to verify practical equivalence between observed fluid velocities. Dye tracking was to be employed to characterize fluid velocity profiles through the in vitro vascular constructs, including a half-vessel model and a full vessel model of an iliac artery aneurysm. A PDMS half-vessel construct was manufactured, and the movement of dye through the construct was tracked by a cellphone camera. Thresholds were applied to each video in …
Design And Analysis Of A Lift Assist Walker, Deep P. Shah
Design And Analysis Of A Lift Assist Walker, Deep P. Shah
Master's Theses
Walkers provided stability to the elderly but cannot assist a person from sitting to standing. The objective of this project is to present the design and analysis of a lift assist walker. This report discusses the design and analysis of a collapsible lift assist walker capable of lifting a patient up to 250 lbs. from seated to standing in under 10 seconds. The designed walker utilized a two stage scissor mechanism with a gas spring assisted embedded linear actuator.
Label-Free Imaging Of Metabolism And Oxidative Stress In Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Rupsa Datta, Christopher M. Heylman, Steven C. George, Enrico Gratton
Label-Free Imaging Of Metabolism And Oxidative Stress In Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Rupsa Datta, Christopher M. Heylman, Steven C. George, Enrico Gratton
Biomedical Engineering
In this work we demonstrate a label-free optical imaging technique to assess metabolic status and oxidative stress in human induced pluripotent stem cell-derived cardiomyocytes by two-photon fluorescence lifetime imaging of endogenous fluorophores. Our results show the sensitivity of this method to detect shifts in metabolism and oxidative stress in the cardiomyocytes upon pathological stimuli of hypoxia and cardiotoxic drugs. This non-invasive imaging technique could prove beneficial for drug development and screening, especially for in vitro cardiac models created from stem cell-derived cardiomyocytes and to study the pathogenesis of cardiac diseases and therapy.
Automated Detection And Analysis Of Depolarization Events In Human Cardiomyocytes Using Madec, Agnieszka F. Szymanska, Christopher M. Heylman, Rupsa Datta, Enrico Gratton
Automated Detection And Analysis Of Depolarization Events In Human Cardiomyocytes Using Madec, Agnieszka F. Szymanska, Christopher M. Heylman, Rupsa Datta, Enrico Gratton
Biomedical Engineering
Optical imaging-based methods for assessing the membrane electrophysiology of in vitro human cardiac cells allow for non-invasive temporal assessment of the effect of drugs and other stimuli. Automated methods for detecting and analyzing the depolarization events (DEs) in image-based data allow quantitative assessment of these different treatments. In this study, we use 2-photon microscopy of fluorescent voltage-sensitive dyes (VSDs) to capture the membrane voltage of actively beating human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). We built a custom and freely available Matlab software, called MaDEC, to detect, quantify, and compare DEs of hiPS-CMs treated with the β-adrenergic drugs, propranolol and …