Biomedical Engineering and Bioengineering Commons^™

The Effect Of Anisotrophy On The Potential Distribution In Biological Tissues And Its Impact On Nerve Excitation Simulations, Robert B. Szlavik, Hubert De Bruin

Biomedical Engineering

Presents a finite difference solution of the potential distribution associated with electrical current stimulation in an anisotropic in-homogeneous tissue environment and compare it to the isotropic case. The results demonstrate that there can be significant errors associated with the assumption of isotropic tissue properties in calculating the potential distribution along an axon in nerve excitation simulations. These errors can have a significant impact on predicted nerve fiber recruitment patterns when evaluating the efficacy of specific surface or intramuscular stimulus electrode configurations. The results of this study also suggest when a more comprehensive tissue model should be implemented in an electrode …