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Full-Text Articles in Biomedical Engineering and Bioengineering

Heel Down And Toe-Off Time Measured With Ultrasonic Doppler System And Force Plate Sensor, Sabin Timsina May 2020

Heel Down And Toe-Off Time Measured With Ultrasonic Doppler System And Force Plate Sensor, Sabin Timsina

Honors Theses

Collie Box is a medical device that measures the gait parameters of the person walk- ing in front of it. This device uses the Ultrasonic Doppler system to extract the heel-contact and toe-off times of a person walking within the range of 2-10 meters. These times are used to determine the leg’s swing phase and double stance times. The ultrasonic transducer of 10mm diameter is driven at 40kHz. At the time of the heel-contact and toe-off, foot velocity is zero while the torso part of the human body is still in motion. The wide directivity of 10mm diameter ultrasonic ...


Design Of An Affordable Rotating Drum Electrospinner For Classroom Education, Peder Solberg Mar 2020

Design Of An Affordable Rotating Drum Electrospinner For Classroom Education, Peder Solberg

The Journal of Undergraduate Research

Electrospinning is a technology used to generate small fibers down to nano-scale size. This method of fiber creation has been around for many years. However, in recent years electrospinning has found increased applications, especially in the area of tissue engineering due to its ability to create fibers with properties similar to the extracellular matrix in tissue. An electrospinning platform can illustrate concepts of engineering, electro-mechanical system design, manufacturing, and biomedical applications in one single package. Hence, it provides an excellent opportunity to integrate into secondary (middle and high school) and post-secondary (undergraduate) technology education.

Furthermore, just as integration of 3D ...


Cdse Quantum Dots Synthesis Laboratory Course For High School Students, Danlin Zuo, Gyuseok Kim, David Jones Dec 2019

Cdse Quantum Dots Synthesis Laboratory Course For High School Students, Danlin Zuo, Gyuseok Kim, David Jones

Protocols and Reports

Cadmium selenide quantum dot is a fascinating subject for leading high school students to the quantum world. An 8-hour laboratory course for up to 12 high school students is proposed. The 8-hour course consist of two 4-hours sections. This laboratory course includes the quantum dot syntheses, absorption and emission characterization, and data analysis. The proposes process runs at relatively lower temperature which means safe and easy, and shows apparent experimental results.


A Wearable Mechatronic Device For Hand Tremor Monitoring And Suppression: Development And Evaluation, Yue Zhou Dec 2019

A Wearable Mechatronic Device For Hand Tremor Monitoring And Suppression: Development And Evaluation, Yue Zhou

Electronic Thesis and Dissertation Repository

Tremor, one of the most disabling symptoms of Parkinson's disease (PD), significantly affects the quality of life of the individuals who suffer from it. These people live with difficulties with fine motor tasks, such as eating and writing, and suffer from social embarrassment. Traditional medicines are often ineffective, and surgery is highly invasive and risky. The emergence of wearable technology facilitates an externally worn mechatronic tremor suppression device as a potential alternative approach for tremor management. However, no device has been developed for the suppression of finger tremor that has been validated on a human.

It has been reported ...


Blood Glucose Predictor, Jessica Patterson Dec 2019

Blood Glucose Predictor, Jessica Patterson

Electrical Engineering

For my senior project, I perform data analysis using statistical methods to determine body metrics that correlate with blood glucose levels. Working with Dr. Tina Smilkstein, I take repeat measurements from 6 different volunteers to establish trends in bodily metric data. The data taken includes weight, body fat, pulse rate, VO2, blood glucose, blood pressure, hours slept, and quality of sleep. Using these values, I use the program MiniTab to view results.

A few examples of correlations with blood glucose found in this project are:

  • Systolic blood pressure for females had a regression line of 124.0 -0.3366*Blood ...


Effect Of Annealing On The Contact Resistance Of Aluminum On A P-Type Substrate, Shrey Shah, George Patrick Watson Nov 2019

Effect Of Annealing On The Contact Resistance Of Aluminum On A P-Type Substrate, Shrey Shah, George Patrick Watson

Protocols and Reports

Aluminum contacts are widely used to form both ohmic and rectifying contacts. The process to form these contacts involves annealing, thus it is important to study the effect of annealing on the electrical properties of the contacts. Here, we present a way to measure the contact resistance of aluminum contacts formed on a p-type silicon substrate. It was found the contact resistivity decreased by an average of 18%. It was thus found that annealing at 400°C in a forming gas environment improves the electrical properties of aluminum contacts.


#43 - Gesture Recognition Of Eeg Signals Using Wavelet Transform And Artificial Neural Networks For Bci Applications, Hugo Flores Garcia Nov 2019

#43 - Gesture Recognition Of Eeg Signals Using Wavelet Transform And Artificial Neural Networks For Bci Applications, Hugo Flores Garcia

Georgia Undergraduate Research Conference (GURC)

Brain-Computer Interface (BCI) systems present many advantages for their use in the fields of robotics and prosthetics. BCIs enable the control of electronic systems using only the central nervous system, allowing, for example, patients with motor neuron disease to control prosthetic limbs or electronic devices. In this study, an electroencephalographic (EEG) signal gesture recognition process for BCI applications is described. The gesture recognition process receives a raw EEG signal as an input and classifies the received input into its corresponding gesture.

The gesture data was acquired from different subjects using the EMOTIVR EPOC, a 14-channel EEG headset. 402 samples ...


Enhancing Cpr Training: Development And Assessment Of An Affordable, Open-Source Real-Time Feedback Manikin, Anish Sangari, Nitish Sood, Joseph Andrew Hauger Nov 2019

Enhancing Cpr Training: Development And Assessment Of An Affordable, Open-Source Real-Time Feedback Manikin, Anish Sangari, Nitish Sood, Joseph Andrew Hauger

Georgia Undergraduate Research Conference (GURC)

Cardiopulmonary Resuscitation (CPR) is a life-saving technique used in cases of cardiac arrest. Immediate CPR can increase survival rates two to three-fold. While many CPR training courses use non-electronic CPR manikins, recent literature has shown that training on a real-time feedback CPR manikin improves functional outcomes such as chest compression rate and mean tidal volume. However, current commercially available real-time feedback manikins only measure metrics on chest compressions or can be prohibitively expensive ( >$200). Accordingly, we have designed, constructed, and tested a low-cost Arduino microcontroller-based CPR manikin that provides real-time feedback to trainees on eight critical metrics including force of ...


Influence Of Flow Rate, Nozzle Speed, Pitch And The Number Of Passes On The Thickness Of S1805 Photoresist In Suss Microtec As8 Spray Coater, Rohan Sanghvi, Gyuseok Kim Oct 2019

Influence Of Flow Rate, Nozzle Speed, Pitch And The Number Of Passes On The Thickness Of S1805 Photoresist In Suss Microtec As8 Spray Coater, Rohan Sanghvi, Gyuseok Kim

Tool Data

S1805 positive photoresist has been deposited on single crystalline Si wafers using a Suss MicroTec Alta Spray. The influence of flow rate, nozzle speed, pitch and number of passes on the thickness of the photoresist was studied. Results show that the thickness of S1805 is linearly proportional to the flow rate and number of passes, and inversely proportional to the nozzle speed and pitch.


Correction Of Pattern Size Deviations In The Fabrication Of Photomasks Made With A Laser Direct-Writer, Ningzhi Xie, George Patrick Watson Oct 2019

Correction Of Pattern Size Deviations In The Fabrication Of Photomasks Made With A Laser Direct-Writer, Ningzhi Xie, George Patrick Watson

Protocols and Reports

When using Heidelberg DWL66+ laser writer to fabricate the photomask, the pattern feature dimensions may have deviations. These deviations can be caused by the lithography process and the undercut in the metal etch process. The same deviation value of 0.8µm was found to appear in all the patterns independent of the pattern original size and local pattern density. To overcome this universal deviation, a universal bias is suggested to be applied to the original patterns during the data preparation for the lithography process. In order to ensure this pre-exposure bias method can work, both the laser direct-write exposure conditions ...


Paper-Based Flexible Electrode Using Chemically-Modified Graphene And Functionalized Multiwalled Carbon Nanotube Composites For Electrophysiological Signal Sensing, Md Faruk Hossain, Jae Sang Heo, John Nelson, Insoo Kim Oct 2019

Paper-Based Flexible Electrode Using Chemically-Modified Graphene And Functionalized Multiwalled Carbon Nanotube Composites For Electrophysiological Signal Sensing, Md Faruk Hossain, Jae Sang Heo, John Nelson, Insoo Kim

Bioelectrics Publications

Flexible paper-based physiological sensor electrodes were developed using chemically-modified graphene (CG) and carboxylic-functionalized multiwalled carbon nanotube composites (f@MWCNTs). A solvothermal process with additional treatment was conducted to synthesize CG and f@MWCNTs to make CG-f@MWCNT composites. The composite was sonicated in an appropriate solvent to make a uniform suspension, and then it was drop cast on a nylon membrane in a vacuum filter. A number of batches (0%~35% f@MWCNTs) were prepared to investigate the performance of the physical characteristics. The 25% f@MWCNT-loaded composite showed the best adhesion on the paper substrate. The surface topography and ...


A Heterogeneous Patient-Specific Biomechanical Model Of The Lung For Tumor Motion Compensation And Effective Lung Radiation Therapy Planning, Parya Jafari Sep 2019

A Heterogeneous Patient-Specific Biomechanical Model Of The Lung For Tumor Motion Compensation And Effective Lung Radiation Therapy Planning, Parya Jafari

Electronic Thesis and Dissertation Repository

Radiation therapy is a main component of treatment for many lung cancer patients. However, the respiratory motion can cause inaccuracies in radiation delivery that can lead to treatment complications. In addition, the radiation-induced damage to healthy tissue limits the effectiveness of radiation treatment. Motion management methods have been developed to increase the accuracy of radiation delivery, and functional avoidance treatment planning has emerged to help reduce the chances of radiation-induced toxicity. In this work, we have developed biomechanical model-based techniques for tumor motion estimation, as well as lung functional imaging. The proposed biomechanical model accurately estimates lung and tumor motion ...


Influence Of Naoh Concentration On Transfer Process Of Graphene, Francisco Saldana, Chengyu Wen, George Patrick Watson Sep 2019

Influence Of Naoh Concentration On Transfer Process Of Graphene, Francisco Saldana, Chengyu Wen, George Patrick Watson

Protocols and Reports

The process of transferring a monolayer of graphene using two different concentrations of sodium hydroxide (NaOH) solution unto a silicon dioxide (SiO2) coated Si chip using electrochemistry was performed. The transfer process is crucial for the delamination of a continuous graphene monolayer film from copper foil. After examining and inspecting the integrity of the graphene monolayer, it was observed that the lower concentration to NaOH led to slower rate of hydrogen bubble generation; this condition was found to be less destructive and yielded a graphene film with fewer visible tears.


Investigation Of The Electrode Polarization Effect For Biosensor Applications, Anil Koklu Aug 2019

Investigation Of The Electrode Polarization Effect For Biosensor Applications, Anil Koklu

Mechanical Engineering Research Theses and Dissertations

My research focuses on electrokinetic transport. Particularly, in this dissertation, we focus on fabrication and testing of micro electrodes with nanostructured surfaces to minimize the electrode polarization (EP) effects for biosensor applications. In the first study, electrochemical deposition of gold nanoparticles on to planar gold electrodes was used to generate rough surfaces. Dendritic nanostructures that reduced EP up to two orders of magnitude was obtained by optimizing the deposition conditions. These structures also enhanced dielectrophoresis (DEP) response of our bio-chips, making them usable in physiological buffers. In further studies we discovered a universal scaling of EP in the frequency domain ...


Large Scale Electronic Health Record Data And Echocardiography Video Analysis For Mortality Risk Prediction, Alvaro Emilio Ulloa Cerna Jul 2019

Large Scale Electronic Health Record Data And Echocardiography Video Analysis For Mortality Risk Prediction, Alvaro Emilio Ulloa Cerna

Electrical and Computer Engineering ETDs

Electronic health records contain the clinical history of patients. The enormous potential for discovery in such a rich dataset is hampered by their complexity. We hypothesize that machine learning models trained on EHR data can predict future clinical events significantly better than current models. We analyze an EHR database of 594,862 Echocardiography studies from 272,280 unique patients with both unsupervised and supervised machine learning techniques.

In the unsupervised approach, we first develop a simulation framework to evaluate a family of different clustering pipelines. We apply the optimized approach to 41,645 patients with heart failure without providing any ...


Improving 3d Printed Prosthetics With Sensors And Motors, Rachel Zarin Jul 2019

Improving 3d Printed Prosthetics With Sensors And Motors, Rachel Zarin

Honors Projects

A 3D printed hand and arm prosthetic was created from the idea of adding bionic elements while keeping the cost low. It was designed based on existing models, desired functions, and materials available. A tilt sensor keeps the hand level, two motors move the wrist in two different directions, a limit switch signals the fingers to open and close, and another motor helps open and close the fingers. All sensors and motors were built on a circuit board, programmed using an Arduino, and powered by a battery. Other supporting materials include metal brackets, screws, guitar strings, elastic bands, small clamps ...


Investigating The Role Of Coil Designs And Anatomical Variations In Cerebellar Tms, Xiaojing Zhong, Priyam Rastogi, Yifei Wang, Erik G. Lee, David C. Jiles Jul 2019

Investigating The Role Of Coil Designs And Anatomical Variations In Cerebellar Tms, Xiaojing Zhong, Priyam Rastogi, Yifei Wang, Erik G. Lee, David C. Jiles

Electrical and Computer Engineering Publications

Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique that is used for treating various neurological disorders such as major depressive disorder. TMS has been gaining popularity in the field of neurostimulation of the cerebellum, since the cerebellum is a complex structure connected with almost the entire central nervous system and TMS has promise for non-invasively probing cerebellar function. Recent studies have discovered that the cerebellum plays an important role not only in motor planning and behavior but also in the cognitive domain. However, few studies have explored how different coil designs and anatomical variations affect the effectiveness of cerebellar ...


Inverted Cone Convolutional Neural Network For Deboning Mris, Oliver John Palumbo Jun 2019

Inverted Cone Convolutional Neural Network For Deboning Mris, Oliver John Palumbo

Theses and Dissertations

Data plenitude is the power but also the bottleneck for data-driven approaches, including neural networks. In particular, Convolutional Neural Networks (CNNs) require an abundant database of training images to achieve a desired high accuracy. Current techniques employed for boosting small datasets are data augmentation and synthetic data generation, which suffer from computational complexity and imprecision compared to original datasets. In this thesis, we intercalate prior knowledge based on the temporal relation between the images in the third dimension. Specifically, we compute the gradient of subsequent images in the dataset to remove extraneous information and highlight subtle variations between the images ...


Epic: Examining Patch Impedance Characteristics, Shane Buck, Jyotsna Gopinath, Kyle Markfield Jun 2019

Epic: Examining Patch Impedance Characteristics, Shane Buck, Jyotsna Gopinath, Kyle Markfield

Interdisciplinary Design Senior Theses

In the United States, approximately one in 4 adults have at least one chronic illness, making up approximately 84% of US Healthcare Spending. Unfortunately, 50% of patients with chronic diseases do not take their medication properly and as such spend more money trying to get better – approximately $100 billion in annual preventable costs. One solution to this issue is digital medicine as it allows for the monitoring of patient medicine consumption.

Our industry partner has developed a three-part digital medicine system with the aim of allowing patients with chronic health issues to better reach their health goals through monitoring of ...


Designing A Low-Cost Ultrasound Pulser, Andrea Huey Jun 2019

Designing A Low-Cost Ultrasound Pulser, Andrea Huey

Honors Theses

Ultrasound imaging allows for those studying living beings to see inside a subject without causing it harm. This allows for real-time images to be taken, leading to ease of observational research. However, while this technology is beneficial to those who utilize it, the devices used to create and receive ultrasound pulses can be incredibly complex, allowing for precise adjustment of the output signal and various other functions, and therefore expensive. The focus of this senior project is the design of a low-cost pulser for use with an ultrasound transducer. While it does not have all the high-level functions of the ...


Dual Modality Optical Coherence Tomography : Technology Development And Biomedical Applications, Farzana Rahmat Zaki May 2019

Dual Modality Optical Coherence Tomography : Technology Development And Biomedical Applications, Farzana Rahmat Zaki

Dissertations

Optical coherence tomography (OCT) is a cross-sectional imaging modality that is widely used in clinical ophthalmology and interventional cardiology. It is highly promising for in situ characterization of tumor tissues. OCT has high spatial resolution and high imaging speed to assist clinical decision making in real-time.

OCT can be used in both structural imaging and mechanical characterization. Malignant tumor tissue alters morphology. Additionally, structural OCT imaging has limited tissue differentiation capability because of the complex and noisy nature of the OCT signal. Moreover, the contrast of structural OCT signal derived from tissue’s light scattering properties has little chemical specificity ...


Developing An Optomechanical Approach For Characterizing Mechanical Properties Of Single Adherent Cells, Ali Mehrnezhad May 2019

Developing An Optomechanical Approach For Characterizing Mechanical Properties Of Single Adherent Cells, Ali Mehrnezhad

LSU Doctoral Dissertations

Mechanical properties of a cell reflect its biological and pathological conditions including cellular disorders and fundamental cellular processes such as cell division and differentiation. There have been active research efforts to develop high-throughput platforms to mechanically characterize single cells. Yet, many of these research efforts are focused on suspended cells and use a flow-through configuration. Therefore, adherent cells are detached prior to the characterization, which seriously perturbs the cellular conditions. Also, methods for adherent cells are limited in their throughput.

My study is aimed to fill the technical gap in the field of single cell analysis, which is a high-throughput ...


Stability Analysis Of A More General Class Of Systems With Delay-Dependent Coefficients, Chi Jin, Keqin Gu, Islam Boussaada, Silviu-Iulian Niculescu May 2019

Stability Analysis Of A More General Class Of Systems With Delay-Dependent Coefficients, Chi Jin, Keqin Gu, Islam Boussaada, Silviu-Iulian Niculescu

SIUE Faculty Research, Scholarship, and Creative Activity

This paper presents a systematic method to analyse the stability of systems with single delay in which the coefficient polynomials of the characteristic equation depend on the delay. Such systems often arise in, for example, life science and engineering systems. A method to analyze such systems was presented by Beretta and Kuang in a 2002 paper, but with some very restrictive assumptions. This work extends their results to the general case with the exception of some degenerate cases. It is found that a much richer behavior is possible when the restrictive assumptions are removed. The interval of interest for the ...


The Effects Of Bone Morphogenic Protein 2 On The Viability And Proliferation Of Dental Pulp Stem Cell Isolates, Joseph Cinelli May 2019

The Effects Of Bone Morphogenic Protein 2 On The Viability And Proliferation Of Dental Pulp Stem Cell Isolates, Joseph Cinelli

UNLV Theses, Dissertations, Professional Papers, and Capstones

Growth factor is an umbrella term used to describe a signaling molecule present in organisms that serves the purpose of influencing a stimulatory or inhibitory response from the target cell it acts on. Growth factors are categorized and classified by the types of tissues they act on and the cellular responses they illicit. For example, there are growth factors that act primarily in connective tissue on fibroblasts and they are aptly classified as the fibroblast growth factor family. Similarly, there is another family of growth factors that act on bone forming cells, among others, and they are known as bone ...


The Affective Perceptual Model: Enhancing Communication Quality For Persons With Pimd, Jadin Tredup May 2019

The Affective Perceptual Model: Enhancing Communication Quality For Persons With Pimd, Jadin Tredup

UNLV Theses, Dissertations, Professional Papers, and Capstones

Methods for prolonged compassionate care for persons with Profound Intellectual and Multiple Disabilities (PIMD) require a rotating cast of import people in the subjects life in order to facilitate interaction with the external environment. As subjects continue to age, dependency on these people increases with complexity of communications while the quality of communication decreases. It is theorized that a machine learning (ML) system could replicate the attuning process and replace these people to promote independence. This thesis extends this idea to develop a conceptual and formal model and system prototype.

The main contributions of this thesis are: (1) proposal of ...


Development And Assessment Of Signal Processing Algorithms For Assistive Hearing Devices, Farid Moshgelani Apr 2019

Development And Assessment Of Signal Processing Algorithms For Assistive Hearing Devices, Farid Moshgelani

Electronic Thesis and Dissertation Repository

Speech identification in the presence of background noise is difficult for children with auditory processing disorder and adults with sensorineural hearing loss. The listening difficulty arises from deficits in their temporal, spectral, binaural, and/ or cognitive processing. Given the lack of improvement with conventional assistive hearing devices, alternate speech processing methodologies, which exaggerate the temporal and spectral cues, need to be developed to improve speech intelligibility for individuals who have poor temporal and/ or spectral processing.

This thesis first, reports results from a series of experiments on subjective and objective assessments of two different schemes of envelope enhancement algorithms (dynamic ...


Vision Beyond Optics: Standardization, Evaluation And Innovation For Fluorescence Microscopy In Life Sciences, Maximiliaan Huisman Apr 2019

Vision Beyond Optics: Standardization, Evaluation And Innovation For Fluorescence Microscopy In Life Sciences, Maximiliaan Huisman

GSBS Dissertations and Theses

Fluorescence microscopy is an essential tool in biomedical sciences that allows specific molecules to be visualized in the complex and crowded environment of cells. The continuous introduction of new imaging techniques makes microscopes more powerful and versatile, but there is more than meets the eye. In addition to develop- ing new methods, we can work towards getting the most out of existing data and technologies. By harnessing unused potential, this work aims to increase the richness, reliability, and power of fluorescence microscopy data in three key ways: through standardization, evaluation and innovation.

A universal standard makes it easier to assess ...


Reactive Ion Etching Selectivity Of Si/Sio2: Comparing Of Two fluorocarbon Gases Chf3 And Cf4, Meiyue Zhang, Pat Watson Mar 2019

Reactive Ion Etching Selectivity Of Si/Sio2: Comparing Of Two fluorocarbon Gases Chf3 And Cf4, Meiyue Zhang, Pat Watson

Protocols and Reports

Two reactive ion etching (RIE) processes were studied to show the relative etch selectivity between SiO2 and Si using two fluorocarbon gases, CF4 and CHF3. Results show that CHF3 gives better selectivity (16:1) over CF4 (1.2 :1). On the other hand, the etch rate of SiO2 of CF4 is approximately 52.8 nm/min, faster than CHF3 (32.4 nm/min).


Development Of A Myoelectric Detection Circuit Platform For Computer Interface Applications, Nickolas Andrew Butler Mar 2019

Development Of A Myoelectric Detection Circuit Platform For Computer Interface Applications, Nickolas Andrew Butler

Master's Theses and Project Reports

Personal computers and portable electronics continue to rapidly advance and integrate into our lives as tools that facilitate efficient communication and interaction with the outside world. Now with a multitude of different devices available, personal computers are accessible to a wider audience than ever before. To continue to expand and reach new users, novel user interface technologies have been developed, such as touch input and gyroscopic motion, in which enhanced control fidelity can be achieved. For users with limited-to-no use of their hands, or for those who seek additional means to intuitively use and command a computer, novel sensory systems ...


Long-Term, Super-Resolution Imaging Of Amyloid Structures Using Transient Amyloid Binding Microscopy, Tianben Ding, Kevin Spehar, Jan Bieschke, Matthew D. Lew Feb 2019

Long-Term, Super-Resolution Imaging Of Amyloid Structures Using Transient Amyloid Binding Microscopy, Tianben Ding, Kevin Spehar, Jan Bieschke, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Amyloid fibrils and tangles are signatures of Alzheimer disease, but nanometer-sized aggregation intermediates are hypothesized to be the structures most toxic to neurons. The structures of these oligomers are too small to be resolved by conventional light microscopy. We have developed a simple and versatile method, called transient amyloid binding (TAB), to image amyloid structures with nanoscale resolution using amyloidophilic dyes, such as Thioflavin T, without the need for covalent labeling or immunostaining of the amyloid protein. Transient binding of ThT molecules to amyloid structures over time generates photon bursts that are used to localize single fluorophores with nanometer precision ...