Biomedical Engineering and Bioengineering Commons^™

Neurogen: Eeg And Near-Infrared Light Stimulation Control System, Arnold Nieto, Jaylinn Solis, Matthew Tamanaha

Interdisciplinary Design Senior Theses

Light stimulation or transcranial photobiomodulation (tPBM) therapy has been shown to be effective when treating patients suffering neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. While there is currently no cure, light stimulation can help alleviate symptoms for those patient’s suffering from these diseases. With this in mind, the senior design team from last year began a prototype hybrid electroencephalography (EEG) and tPBM device. They implemented a specific wavelength of 810 nanometer (nm) near-infrared (NIR) light emitting diodes (LEDs), with a 16 channel EEG headset from OpenBCI. The device was intended to serve as a potential research tool, with a …

Ultra-Low Intensity Post-Pulse Affects Cellular Responses Caused By Nanosecond Pulsed Electric Fields, Kamal Asadipour, Carol Zhou, Vincent Yi, Stephen J. Beebe, Shu Xiao

Electrical & Computer Engineering Faculty Publications

High-intensity nanosecond pulse electric fields (nsPEF) can preferentially induce various effects, most notably regulated cell death and tumor elimination. These effects have almost exclusively been shown to be associated with nsPEF waveforms defined by pulse duration, rise time, amplitude (electric field), and pulse number. Other factors, such as low-intensity post-pulse waveform, have been completely overlooked. In this study, we show that post-pulse waveforms can alter the cell responses produced by the primary pulse waveform and can even elicit unique cellular responses, despite the primary pulse waveform being nearly identical. We employed two commonly used pulse generator designs, namely the Blumlein …

Bioai For Anti-Infective Drug Discovery, Maria Esquivel, Johann Fernando, Anna Fisher, Cameron Leong, Adam Weaver

Interdisciplinary Design Senior Theses

Modern antibacterial drugs are quickly becoming insufficient for medical, agricultural and veterinary use, and the drug design techniques used to supplement the supply are not able to adequately and quickly produce enough effective candidates. We took a multi-pronged approach to remedying this problem, including shifting the target mechanism from antibiotic drugs in favor of anti-infective drugs, developing an AI which aimed to predict the interactions of small molecule fragments with the target protein, and refining wet lab testing protocols in order to make the drug design process holistically more efficient and effective. We have shown that there is potential in …

Neurogen: Eeg And Near-Infrared Light Stimulation Control System, Karina Sanchez, Sruthi Sakthivel, Michael Bose, Evan Jennings

Interdisciplinary Design Senior Theses

Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease are widespread, affecting millions of people worldwide. These diseases occur when neurons in the brain or peripheral nervous system progressively lose function and deteriorate. Current pharmacological treatments manage some of the neurological symptoms, but there is no cure yet. Interventions that mitigate or restore loss of function can fill the void until that goal is met. Light stimulation, or transcranial photobiomodulation (tPBM) therapy, can help treat people with neurodegenerative diseases, as it has been shown to improve sleep, attention, memory, and cognitive function.

The objective of this project is to develop …

3-D Silk Fibroin Porous Particles Created By The Ouzo Effect For Biomedical Applications, Ashley Nicole Lamb

UNLV Theses, Dissertations, Professional Papers, and Capstones

Due to its high biocompatibility and biodegradability, silk fibroin – produced from

Bombyx mori (B. mori) cocoons – has been at the forefront of research for many

biomedical application formats: hydrogels, films, microspheres, and porous

sponges/scaffolding, to name a few. For drug delivery, in particular, porous particles are

desirable for their large surface area, uniform and tunable pore structure, and high

porosity. This thesis focuses on the fabrication of porous particles from silk fibroin by the

very interesting Ouzo effect. The Ouzo effect, so named because of the Greek

beverage ouzo, describes the phenomenon of an ethanol + anethole oil …

Developing A Skin Phantom For The Testing Of Biowearables, Tawni Henderson, Ju Young Lee, Matthew Placide, Kiran Sutaria

Interdisciplinary Design Senior Theses

There is a demonstrated need in the biowearables industry for a benchtop model that can accurately emulate the perspiration mechanism and corresponding impedance vs. frequency spectra of skin. This model, or skin phantom, could increase the efficiency and accuracy of early-stage testing of biowearables, as well as minimize animal, human, and cadaver testing.

The objective of this project is to develop a skin phantom that can emulate the perspiration mechanism and impedance spectrum behavior of human skin for the testing of biowearables in the 2,000 - 20,000 Hz range. We also endeavored to create computer-simulated models to aid in the …

Epic: Examining Patch Impedance Characteristics, Shane Buck, Jyotsna Gopinath, Kyle Markfield

Interdisciplinary Design Senior Theses

In the United States, approximately one in 4 adults have at least one chronic illness, making up approximately 84% of US Healthcare Spending. Unfortunately, 50% of patients with chronic diseases do not take their medication properly and as such spend more money trying to get better – approximately $100 billion in annual preventable costs. One solution to this issue is digital medicine as it allows for the monitoring of patient medicine consumption.

Our industry partner has developed a three-part digital medicine system with the aim of allowing patients with chronic health issues to better reach their health goals through monitoring …

The Human Keyboard, Derek Char, Thomas Chung, Alexander Mckee, Allen Pai

Interdisciplinary Design Senior Theses

Most products that implement features for user interactions utilize buttons or switches for the user to command to select actions to perform. Such designs are typically controlled with direct motions, such as touch or voice and are seldom designed in consideration of those unable to utilize direct control. In this project, we designed technology that reads naturally occuring biosignals from the body, which then can be apply those signals with any interface. For our specific application in this project, we decided to implement a keyboard. Instead of teaching the fingers how to type on a mechanical keyboard, the body can …

Vital Sensory Kit For Use With Telemedicine In Developing Countries, Alejandra Pacheco, Jose Hernandez, Antonio Maldonado-Liu, Natalie Arrizon

Interdisciplinary Design Senior Theses

In many developing countries, a large percentage of the population lacks access to adequate healthcare. This is especially true in India where close to 70% of the population lives in rural areas and has little to no access to hospitals or clinics. People living in rural India often times cannot afford to pay to see a doctor should they need to make the journey to a hospital. Telemedicine, a breakthrough in the past couple decades, has broken down the barrier between the patient and the physician. It has slowly been implemented in India to make doctors more available to patients …