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Biomedical Engineering and Bioengineering Commons™
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- Hydrogen peroxide (2)
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Articles 1 - 9 of 9
Full-Text Articles in Biomedical Engineering and Bioengineering
Gui For Mri-Compatible Neural Stimulator And Recorder, Soo Han Soon, Nishant Babaria, Ranajay Mandal, Zhongming Liu
Gui For Mri-Compatible Neural Stimulator And Recorder, Soo Han Soon, Nishant Babaria, Ranajay Mandal, Zhongming Liu
The Summer Undergraduate Research Fellowship (SURF) Symposium
Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) are useful tools to analyze brain activities given active stimulation. However, the electromagnetic noise from the MRI distorts the brain signal recording and damages the subject with excessive heat generated on the electrodes attached to the skin. MRI-compatible recording and stimulation systems previously developed at LIBI lab were capable of removing the electromagnetic noise during the imaging process. Previously, the hardware systems had required the integrative software that could control both circuits simultaneously and enable users to easily change recording and stimulation parameters. Graphical user interface (GUI) programmed with computer language informed …
Measurement Of Hydrogen Peroxide Influx Into Cells: Preparation For Measurement Using On-Chip Microelectrode Array, Hannah R. Kriscovich, Sarah M. Libring, Siddarth V. Sridharan, James K. Nolan, Jose F. Rivera, Jenna L. Rickus, David B. Janes
Measurement Of Hydrogen Peroxide Influx Into Cells: Preparation For Measurement Using On-Chip Microelectrode Array, Hannah R. Kriscovich, Sarah M. Libring, Siddarth V. Sridharan, James K. Nolan, Jose F. Rivera, Jenna L. Rickus, David B. Janes
The Summer Undergraduate Research Fellowship (SURF) Symposium
Hydrogen peroxide (H2O2) is commonly known as a toxic reactive oxidative species (ROS) for cells. Recent studies have found evidence that H2O2 is also an important cellular signalling molecule. Quantifying cellular influx of H2O2 will contribute to researchers’ understanding of the role H2O2 plays in healthy cells and cells involved in the progression of cancers and degenerative diseases. This work utilizes an assay kit and fluorescence techniques to evaluate cell lines and conditions to create a model biological system for measuring cellular H2O2 consumption. …
Cellular Model Of Hydrogen Peroxide Release: In Preparation For On-Chip Sensor Measurements, Sarah M. Libring, Hannah R. Kriscovich, James K. Nolan, Siddarth V. Sridharan, Jose F. Rivera, David B. Janes, Jenna L. Rickus
Cellular Model Of Hydrogen Peroxide Release: In Preparation For On-Chip Sensor Measurements, Sarah M. Libring, Hannah R. Kriscovich, James K. Nolan, Siddarth V. Sridharan, Jose F. Rivera, David B. Janes, Jenna L. Rickus
The Summer Undergraduate Research Fellowship (SURF) Symposium
Hydrogen peroxide is traditionally associated with cellular damage; however, recent studies show that low levels of H2O2 are released by cells as part of normal intercellular communication. The mechanisms of hydrogen peroxide transport, uptake and release, and biological effects are not yet well known but have important implications for cancer, stem cells, and aging. Standard H2O2 assays cannot make spatially or temporally resolved quantitative measurements at a cellular scale. Previously we developed a microelectrode array (MEA) and calibration methods for quantifying H2O2 gradients in space and time. The sensor was validated …
Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, Christian G. Figueroa-Espada, Qi Yang, Hyowon Lee
Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, Christian G. Figueroa-Espada, Qi Yang, Hyowon Lee
The Summer Undergraduate Research Fellowship (SURF) Symposium
Hydrocephalus is a neurological disorder that typically requires a long-term implantation of a shunt system to manage its symptoms. These shunt systems are notorious for their extremely high failure rate. More than 40% of all implanted shunt systems fail within the first year of implantation. On average, 85% of all hydrocephalus patients with shunt systems undergo at least two shunt-revision surgeries within 10 years of implantation. A large portion of this high failure rate can be attributed to biofouling-related obstructions and infections. Previously, we developed flexible polyimide-based magnetic microactuators to remove obstructions formed on hydrocephalus shunts. To test the long-term …
The Effects Of Vagus Nerve Stimulation On Neuroinflammation In Epilepsy, Elizabeth A. St. Clair, Gabriel O Albors, Pedro Irazoqui Dr., Amy Brewster
The Effects Of Vagus Nerve Stimulation On Neuroinflammation In Epilepsy, Elizabeth A. St. Clair, Gabriel O Albors, Pedro Irazoqui Dr., Amy Brewster
The Summer Undergraduate Research Fellowship (SURF) Symposium
Epilepsy is a neurological disorder characterized by chronic, unexplainable seizures. Recurring epileptic seizures are associated with long-term structural damage and cognitive deficits, and can even lead to sudden, unexplainable death. Approximately 30% of epilepsy cases are not responsive to medication. Epileptic seizures often induce inflammation in the brain and may increase the frequency of future seizures, resulting in a detrimental cycle. Vagus nerve stimulation (VNS) is a non-pharmaceutical treatment method for epilepsy that has been shown to reduce inflammation in peripheral pathways. The role of VNS in the modulation of neuroinflammation has yet to be demonstrated experimentally. To explore this, …
Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis, Joseph C. Muskat, Matthew C. Pharris, Charles F. Babbs
Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis, Joseph C. Muskat, Matthew C. Pharris, Charles F. Babbs
The Summer Undergraduate Research Fellowship (SURF) Symposium
Cardiovascular thrombosis may result in critical ischemia to a range of anatomical regions, constituting a leading cause of death in the United States. Current invasive treatments for such arterial blockages often yield blood clot recurrence, resulting in repeated hospitalization of patients. This research aims to show how internally introduced pressure oscillations may be used to initiate thrombolysis. We present a novel computational model for determining the resonant frequency and corresponding deformation of an idealized thrombus. Sinusoidal pressure differences across the thrombus induce axial displacements of frequency dependent amplitude. The maximum peak displacement occurs at a resonant frequency of 73 Hz …
Multi-Channel Analysis For Gradient Artifact Removal From Concurrent Eeg-Fmri Studies, Miguel R. Castellanos, Zhongming Liu
Multi-Channel Analysis For Gradient Artifact Removal From Concurrent Eeg-Fmri Studies, Miguel R. Castellanos, Zhongming Liu
The Summer Undergraduate Research Fellowship (SURF) Symposium
Concurrent electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) recordings are susceptible to large amounts of noise due to the static and dynamic magnetic fields present inside the MR scanner. EEG-fMRI studies are conducted to provide better spatial and temporal resolution for each recording, respectively, but the artifacts found in the EEG render the data impossible to interpret. Past studies have focused on signal post-processing techniques which are able to effectively remove noise upon the completion of a study, but there are no techniques able to process the data in real-time without extensive calibration. This research addresses this issue by …
Medical Applications Of Mrc, Kyle Thackston, Henry Mei, Pedro Irazoqui
Medical Applications Of Mrc, Kyle Thackston, Henry Mei, Pedro Irazoqui
The Summer Undergraduate Research Fellowship (SURF) Symposium
Consistent powering is a limiting reagent for many medical implants and sensors. Powering in-vivo devices in animal studies requires either transcutaneous wiring (limiting mobility and increasing the chance of infection) or an implanted battery (limited lifetime and limits size of device). Wireless power transfer (WPT) would be able to overcome these challenges and permit the use of more advanced implantable devices in a research setting. Magnetic resonance coupling (MRC), an advanced form of inductive charging, allows good transfer efficiencies over significant air gaps, but works best a specific location and frequency, limiting mobility in animal studies. Using band-pass filter theory, …
A Quantitative Analysis Of A Paper-Based, Laser-Defined, Oxygen-Generating Platform For Chronic Wounds, Tiffany L. Huang, Babak Ziaie
A Quantitative Analysis Of A Paper-Based, Laser-Defined, Oxygen-Generating Platform For Chronic Wounds, Tiffany L. Huang, Babak Ziaie
The Summer Undergraduate Research Fellowship (SURF) Symposium
Chronic wounds affect 6.5 million patients a year while consuming US$25 billion in health care costs (Sen 2009 Wound Repair Regen.). Despite advances in wound management therapies, modern treatment for chronic wounds still requires continual professional attention and expensive equipment, posing serious practical and financial burdens for the regular patient. To provide an alternative solution, we are developing a low-cost smart bandage platform that integrates actuators and sensors to monitor and treat chronic wounds. One component of the integrated platform is an oxygen-generating module. It is a polydimethylsiloxane (PDMS) based microfluidic device fabricated on a parchment paper substrate that …