Engineering Commons^™

Solvent Selection For Liquid-Liquid Extraction Of Acetic Acid From Biomass Hydrolysate, Emma A. Barber, Mahdieh Aghazadeh, Abigail Engelberth

The Summer Undergraduate Research Fellowship (SURF) Symposium

Biofuels are one of the most hopeful alternative energy sources to fossil fuels. However, the processing and production of biofuels needs improvement to be economically competitive in the current market. One drawback is the presence of naturally occurring compounds that decrease the bioethanol production rate and yield; these are called inhibitors. A resolution to this problem is to remove the inhibitors from biomass fermentation broth prior to fermentation. This project examined liquid-liquid extraction (LLE) for removal of acetic acid, a major inhibitor. Initially, a stock solution of glucose, xylose, acetic acid, and water was combined with an additional organic solvent …

A Quantitative Analysis Of A Paper-Based, Laser-Defined, Oxygen-Generating Platform For Chronic Wounds, Tiffany L. Huang, Babak Ziaie

The Summer Undergraduate Research Fellowship (SURF) Symposium

Chronic wounds affect 6.5 million patients a year while consuming US$25 billion in health care costs (Sen 2009 Wound Repair Regen.). Despite advances in wound management therapies, modern treatment for chronic wounds still requires continual professional attention and expensive equipment, posing serious practical and financial burdens for the regular patient. To provide an alternative solution, we are developing a low-cost smart bandage platform that integrates actuators and sensors to monitor and treat chronic wounds. One component of the integrated platform is an oxygen-generating module. It is a polydimethylsiloxane (PDMS) based microfluidic device fabricated on a parchment paper substrate that …

Development Of Non-Invasive In Vivo Ultrasound Imaging Techniques For Elastase-Induced Experimental Abdominal Aortic Aneurysms, Alexa A. Yrineo, Elizabeth A. Nunamaker, Hilary D. Schroeder, Amy E. Bogucki, Craig J. Goergen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Abdominal aortic aneurysms (AAAs) are pathological dilations of the aorta which are associated with significant morbidity and mortality. The underlying mechanisms that cause this inflammatory disease are not fully understood and thus, are currently under investigation. In the hopes of preventing disease progression, rodent models that mimic the human condition have been developed to provide insight into the pathogenesis of AAAs. In this study, porcine pancreatic elastase (0.44 U; Sigma-Aldrich) was infused into the infrarenal aortas of male, Sprague Dawley rats to induce aneurysms. To perform the surgery, temporary ligatures were placed around proximal and distal sections of the abdominal …

Direct Quantitative Analysis Of Biomarkers Using Mass Spectrometry, Morgan N. Mcluckey, Zheng Ouyang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Point-of-care (POC) diagnostics describes a step in the medical treatment process where drugs can be monitored in a patient’s body on-site and in a timely fashion. Mass spectrometry (MS) can provide a quick, efficient, and highly accurate method of analysis of patient biofluids and tissues. Developing methods to bring this diagnostic mechanism to hospitals and clinics has the potential to improve patient care through, for example, personalized medicine. Our goal was to develop a way to effectively introduce internal standard (IS), a necessary chemical for the analytical process, to low-volume biofluid samples. Additionally, the effective direct quantitation of biomarkers with …

Environmental Monitoring In Preparation For The Installation Of A Green Roof, Andrew N. Martin, Ming Qu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Green roofs are becoming an increasingly popular way to improve the environmental, economic, and aesthetic performance of both new and existing buildings. Along with the green roofs themselves, it is also common to install sensors to measure various environmental parameters that are affected by or important to the operation of the roof such as precipitation, temperature, and runoff. However, for most of these systems, the sensors are installed at the same time or even after the green roof. Therefore, no before-and-after comparisons can be made for those roofs. To account for this missing data, monitoring equipment was installed on a …

Iron-Magnesium Alloy Bioabsorbable Blood Stent, Kaitlyn Jarry, L Stanciu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Bioabsorbable materials are fairly new and proper alloys for implantation in the body have not yet been established. There are a few polymers that have showed promise, but they do not provide the proper mechanical support that metal does. These materials would be used to create devices such as blood stents and orthopedic screws. Investigation into the properties of different alloys can help to establish a material that can be used for implanted devices that are only needed for a limited amount of time. In order to investigate these alloys many different experiments will to be run to test the …

Python-Based Simulation Tool For Kinetic Monte Carlo, Zaiwei Zhang, R. Edwin García

The Summer Undergraduate Research Fellowship (SURF) Symposium

Simulation tools are highly needed for testing or designing nanotechnology in university research projects.The problem in the current simulation tool used in our research, which is conducted by Prof.Garcia in MSE department at Purdue, is that users cannot observe the changing numbers of diffusivities during Vacancy Diffusion simulations between different materials. Also, there is no Graphic User Interface for the simulation tools.To solve the problem, the Virtual Kinetics of Materials Laboratory program is used to create the Graphic User Interface. Also, GTK+ toolkit has been used to create a pop-up window displaying updated diffusivities during the simulation. For user purpose, …

Mechanical Design Of Real-Time Substrate Transport Control For Stable And Efficient Thin-Film-Based Roll-To-Roll (R2r) Micro-Nanomanufacturing, Guoao Sun, Liang Pan

The Summer Undergraduate Research Fellowship (SURF) Symposium

The commercialization of electronic devices requires the high efficiency and stable mirco-nanomanufacturing processes that allow frequent design upgrades. R2R Nano is a gateway to science and engineering research that aims to impact the widespread adoption of R2R technologies for low-cost, high-volume production of high technology products on flexible substrates. However, there are lots of the mechanical and chemical factors influencing the system performance when fabricating nano-scale structures. Thus, feedback control system is increasingly playing a great role in improving the R2R performance.

The aim of my work of the project is more related to design mechanical section of the whole …

Recursive Multi-Time-Step Coupling Of Multiple Subdomains, Yukun An, Payton Lindsay, Xiaowo Wang, Arun Prakash

The Summer Undergraduate Research Fellowship (SURF) Symposium

The need for efficient computation methods for modeling of large-scale structures has become critically important over the past few years. Efficient means of analysis often involve coupling in space through domain decomposition and multi scale methods in time. The multi-time-step coupling method is a coupling method in time which allows for efficient analysis of large-scale problems for structural dynamics where a large structural model is decomposed into smaller subdomains that are solved independently and then coupled back together to obtain the global solution. For coupling of more than two subdomains that are solved at different timesteps, we employ recursive methods. …

Estimation Of Two-Stage Ditch Excavation Volume Using Lidar Data Full Paper, Kirsten E. Paff, Jane Frankenberger, Naime Celik

The Summer Undergraduate Research Fellowship (SURF) Symposium

Drainage ditches are a major pathway for sediment, nutrients, and pesticides to enter stream systems, which threaten environmental and human health. Unlike trapezoidal ditches, two-stage ditches have a vegetated bench that acts as a floodplain, which helps to prevent erosion and to increase the processing of nutrients to improve water quality. Converting a trapezoidal ditch to a two-stage ditch is expensive, due to the large volumes of soil that need to be excavated. Since ditch geometries vary significantly and surveying each potential site by hand would be time consuming and expensive, a tool based upon online Light Detection and Ranging …

Electrochemical Sensing With Metal Oxides, Isabella Ramirez, Lia Stanciu, Alexandra Snyder

The Summer Undergraduate Research Fellowship (SURF) Symposium

The effective sensing of hydrogen peroxide is important for a variety of reasons. It can be utilized as a diagnostic tool for diseases like asthma; also, the sensing can be utilized in pharmaceutical and food production for quality control. The use of silver oxide nanoparticles with varying morphologies has not been investigated as a sensing agent for hydrogen peroxide in the past. The particles’ properties and ability to oxidize and reduce hydrogen peroxide suggest that they will be effective to create a sensitive sensor. The silver oxide particles were prepared through chemical reduction using varying molar ratios of reactants. The …

Characterization Of The Saturation Level Of Nucleosome Arrays And Plasmids By Mnase Digestion, Wenjie Liu, Nathan Nurse, Chongli Yuan

The Summer Undergraduate Research Fellowship (SURF) Symposium

Studying processes involving DNA such as DNA replication and transcription is best done in the context of chromatin because the structure of DNA influences the efficiency of such processes. Chromatin structure is derived from DNA wrapping around histone octamers with the histone octamer density termed saturation level. For in vitro studies on DNA replication and transcription, it is important to maintain a constant saturation level so that saturation level can be removed as a variable. Our goal is to characterize the saturation level of plasmids using the rate of MNase digestion. MNase digestions were first performed on reconstituted nucleosome arrays …

Use Of Oscillatory Shear To Study The Effect Of Limestone Filler On The Rheology Of Early-Age Portland Cement, Christopher W. Barney, Kendra Erk

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cement is a material that has been in use since the ancient times and is the most widely manufactured material in industry today. During the production of cement, limestone undergoes a process called calcination which releases CO₂. In order to reduce the environmental impact and cost of cement production it has become standard practice to replace a portion of the cement mixture with ground limestone, but this causes a change in the rheological profile of the mixture. This change in rheology affects both the short and long term workability of the material. In this study, small amplitude oscillatory …

2-Dimensional Personal Motion Energy Harvester For Low Power Electronics, Manuel Gutierrez, Sean Scott, Dimitrios Peroulis

The Summer Undergraduate Research Fellowship (SURF) Symposium

In a lab, it becomes crucial to have a way to monitor that lab workers aren’t exposed to too much radiation. Such a device that detects this should have an energy harvester so that batteries aren’t required. The need for an energy harvester that generates power from a user’s movements in 2 dimensions is needed. This energy harvester is needed to power a radiation monitor. An energy harvester that generates power based off movements in 2 dimensions was developed. The energy harvester was created through a series of prototypes. Each prototype was built from a CAD drawing and a stereolithography …