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The Summer Undergraduate Research Fellowship (SURF) Symposium

2015

Articles 1 - 30 of 120

Full-Text Articles in Engineering

Molexpl: A Tool For Ab Initio Data Exploration And Visualization, Xueying Wang, Nicolas Onofrio, Alejandro Strachan Sep 2015

Molexpl: A Tool For Ab Initio Data Exploration And Visualization, Xueying Wang, Nicolas Onofrio, Alejandro Strachan

The Summer Undergraduate Research Fellowship (SURF) Symposium

Density functional theory (DFT) based on ab initio theory, is a powerful method to resolve the electronic structure of atoms, molecules and solids. However, in practical, DFT is limited to few hundreds of atoms. To overcome this limitation, researchers have developed empirical interatomic potentials implemented in molecular dynamics (MD) simulations. MD ignores the movements of electrons and describes bonding and non-bonding interaction as a function of the distance between atoms called force fields (FF) or interatomic potentials. These empirical potentials are optimized against large datasets of DFT calculations relevant to describe the interactions between the atoms included in the training …

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Approach To Increasing Indiana Rural Road Safety On Intersections, Ammanuiel A. Kebede, John E. Haddock Aug 2015

Approach To Increasing Indiana Rural Road Safety On Intersections, Ammanuiel A. Kebede, John E. Haddock

The Summer Undergraduate Research Fellowship (SURF) Symposium

In 2009, there were more than 17,000 reported fatal crashes in rural areas of United States which accounted 56 percent of total fatal crashes. This number has not declined in a significant amount since 2009. Studies are undergoing on these rural area roadways, including intersections, to identify the major causes and take the necessary countermeasure. By using previous intersection related fatal and injury crash data, it is possible to identify high-risk intersections to point out and make the appropriate improvement. Five year fatal and injury crash data was collected (2008-2012) for three Indiana rural counties that had the highest frequency …

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The Effects Of Vagus Nerve Stimulation On Neuroinflammation In Epilepsy, Elizabeth A. St. Clair, Gabriel O Albors, Pedro Irazoqui Dr., Amy Brewster Aug 2015

The Effects Of Vagus Nerve Stimulation On Neuroinflammation In Epilepsy, Elizabeth A. St. Clair, Gabriel O Albors, Pedro Irazoqui Dr., Amy Brewster

The Summer Undergraduate Research Fellowship (SURF) Symposium

Epilepsy is a neurological disorder characterized by chronic, unexplainable seizures. Recurring epileptic seizures are associated with long-term structural damage and cognitive deficits, and can even lead to sudden, unexplainable death. Approximately 30% of epilepsy cases are not responsive to medication. Epileptic seizures often induce inflammation in the brain and may increase the frequency of future seizures, resulting in a detrimental cycle. Vagus nerve stimulation (VNS) is a non-pharmaceutical treatment method for epilepsy that has been shown to reduce inflammation in peripheral pathways. The role of VNS in the modulation of neuroinflammation has yet to be demonstrated experimentally. To explore this, …

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Graphene Field Effect Transistor For Radiation Detection On A Micron To Millimeter Scale, Peter C. Lamm, Robert Speer Bean, Zachary Shollar Aug 2015

Graphene Field Effect Transistor For Radiation Detection On A Micron To Millimeter Scale, Peter C. Lamm, Robert Speer Bean, Zachary Shollar

The Summer Undergraduate Research Fellowship (SURF) Symposium

Novel technology in radiation detection is critical to advancing radiation detectors for their many applications. Graphene has shown to be able to change its conductivity in the presence of an electric field; this makes it an excellent candidate to be used as a radiation detector for the detection of the charges generated during radiation interactions. Research has been done on making micron scale graphene field effect transistors (GFET) with graphene on a Si/SiO2 wafer, but it is critical that we try to increase the scale. Unknowns persist in scaling graphene to millimeter sizes. This study plans to elucidate any …

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Analysis Of The Fabrication Conditions In Organic Field-Effect Transistors, Rachel M. Rahn, Yan Zhao, Jianguo Mei Aug 2015

Analysis Of The Fabrication Conditions In Organic Field-Effect Transistors, Rachel M. Rahn, Yan Zhao, Jianguo Mei

The Summer Undergraduate Research Fellowship (SURF) Symposium

Polymer-based organic field-effect transistors have raised substantial awareness because they enable low-cost, solution processing techniques, and have the potential to be implemented in flexible, disposable organic electronic devices. The performance of these devices is highly dependent on the processing conditions, as well as the intrinsic properties of the polymer. Processing conditions play an important role in semiconductor film formation and device performance. These factors may provide an important link between structure and performance. In this study, an empirical analysis tool, Process Scout, was applied to assess processing factors such as polymer concentration and silicon modification. This sanctioned the creation of …

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3d Printing Nanostructured Thermoelectric Device, Qianru Jia, Collier Miers, Amy Marconnet Aug 2015

3d Printing Nanostructured Thermoelectric Device, Qianru Jia, Collier Miers, Amy Marconnet

The Summer Undergraduate Research Fellowship (SURF) Symposium

Thermoelectric materials convert thermal energy to electrical energy and vice versa. Thermoelectrics have attracted much attention and research efforts due to the possibility solving electronic cooling problems and reducing energy consumption through waste heat recovery. The efficiency of a thermoelectric material is determined by the dimensionless figure of merit ZT, which depends on both thermal and electrical properties. Researchers have worked for several decades to improve the ZT, but there had been little progress until nanomaterials and nanofabrication became widely available. Nanotechnology makes the ZT enhancement attainable by disconnecting the linkage between thermal and electrical transport. Printing customized, flexible thermoelectric …

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Towards In Situ Measurements Of Platinum Dissolution Using Metallothionein-Based Biosensor, Stephanie Cernera, Hyowon Lee Aug 2015

Towards In Situ Measurements Of Platinum Dissolution Using Metallothionein-Based Biosensor, Stephanie Cernera, Hyowon Lee

The Summer Undergraduate Research Fellowship (SURF) Symposium

Platinum-based (Pt) electrodes are used ubiquitously in neurostimulation for their high charge capacity and safety. However, Pt electrodes are known to dissolve during stimulation in the presence of chloride (Cl) to form Pt-Cl byproducts. These byproducts may have deleterious effects on surrounding tissue by preventing cell division and causing apoptosis. Several studies have quantified the amount of neurostimulation-induced Pt dissolution in vivo using various analytical methods; however, these approaches require disruptive sampling of tissue. Periodic measurements from a stimulating electrode using an in situ sensor may provide additional insights into Pt dissolution process. To create the sensor for detecting Pt …

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Characterizing Strain Accumulation, Residual Stress, And Microstructure Of Additive Manufactured Materials, Hannah K. Woods, Todd A. Book, Catalina Parada, Michael D. Sangid Aug 2015

Characterizing Strain Accumulation, Residual Stress, And Microstructure Of Additive Manufactured Materials, Hannah K. Woods, Todd A. Book, Catalina Parada, Michael D. Sangid

The Summer Undergraduate Research Fellowship (SURF) Symposium

Additive Manufacturing (AM) is a rapidly evolving fabrication technology beneficial for its cost-saving potential to produce complex, low-volume shapes. However, AM materials are currently limited to nonstructural applications due to variability in their structural integrity, particularly their fatigue lives. IN718, Ti64, and Al10MgSi specimens manufactured by Direct Metal Laser Sintering (DMLS) were characterized based on variation of post-processing techniques and build direction. To understand the impact of each variable, surface roughness, hardness, residual stresses, microstructure, and strain accumulation in response to Low Cycle Fatigue (LCF) were studied. The use of Electron Backscatter Diffraction (EBSD) provided grain orientation and grain size …

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Identifying And Correcting Biases In Digital Image Correlation At Multiple Length Scales, Catalina Parada, Alberto W. Da Silva Mello, Michael D. Sangid, Hannah K. Woods, Samuel E. Otto Aug 2015

Identifying And Correcting Biases In Digital Image Correlation At Multiple Length Scales, Catalina Parada, Alberto W. Da Silva Mello, Michael D. Sangid, Hannah K. Woods, Samuel E. Otto

The Summer Undergraduate Research Fellowship (SURF) Symposium

Accurate strain measurement at grain and sub-grain levels is important to predict and understand crack initiation during fatigue of materials. During cyclic loading, low magnitude strain is accumulated in the material and any distortion in the images can lead to inaccurate strain measurements and false prediction of the material’s behavior. Digital Image Correlation (DIC) is a reliable tool used to measure strain localization by correlating images before, during, and after cyclic loading. DIC tracks the deformation of nano/micro-scale patterns placed on the surface of the specimens to determine strain fields. However, DIC software does not account for biases due to …

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Visualization And Analysis Of Sensory Data, Luke Neumann, Sung Yeon Choi, Brian Olsen, Sungahn Ko, David Ebert Dr. Aug 2015

Visualization And Analysis Of Sensory Data, Luke Neumann, Sung Yeon Choi, Brian Olsen, Sungahn Ko, David Ebert Dr.

The Summer Undergraduate Research Fellowship (SURF) Symposium

Recently, California has suffered a severe drought, making water a scarce resource to its population. Many viticulturists are based in this area who rely on heavy irrigation to produce a better grape and a better wine. Not just in California, but throughout the nation, irrigation must be applied intelligently for efficient use of water and funding. By taking measurements of physical characteristics of a vineyard over time, one may be able to visualize trends in the data which lend itself to describing preferred growing methods. Wireless sensors can be used to take measurements including moisture, temperature, sunlight, and more. Sensors …

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Detecting Periods Of Flight With High Task Load, James R. Parkinson, Steven J. Landry, Quang Dao, Caitlin Surakitbanharn Aug 2015

Detecting Periods Of Flight With High Task Load, James R. Parkinson, Steven J. Landry, Quang Dao, Caitlin Surakitbanharn

The Summer Undergraduate Research Fellowship (SURF) Symposium

Tools that predict dangerous working conditions empirically in the cockpit could greatly improve aviation safety. In an effort to lay the groundwork for such tools, this study will investigate whether a link exists between task load and pilots’ control strategies, their biometric data, and their planes’ position data. Using X Plane simulation software, an experiment will be run in which licensed pilots will fly a 3-nautical-mile approach into Mineta San Jose International Airport 4 times, under different task load conditions. During the flight, participants’ pupil diameters will be recorded along with the simulated aircraft position data and cognitive control modes. …

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Development Of A Parallel Multiphase Lattice-Boltzmann Solver To Study Stokes Number Effects On Particle Trajectories, Lenan Zhang, Anand Samuel Jebakumar, John Abraham Aug 2015

Development Of A Parallel Multiphase Lattice-Boltzmann Solver To Study Stokes Number Effects On Particle Trajectories, Lenan Zhang, Anand Samuel Jebakumar, John Abraham

The Summer Undergraduate Research Fellowship (SURF) Symposium

Particle-laden flows are important owing to their relevance to many engineering devices such as coal combustors, gasifiers and solar thermochemical reactors. In a recent experimental study by Lau and Nathan [1], it was found that particles in a turbulent pipe flow tend to migrate preferentially depending on their Stokes number (St). Particles with a high St (>10) are concentrated near the axis while those with low St (

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Quantification Of Analyte Concentration From A Paper-Based Lateral Flow Assay Device Using Reflective Sensors, Megan Z. Chiu, Jacqueline Linnes Aug 2015

Quantification Of Analyte Concentration From A Paper-Based Lateral Flow Assay Device Using Reflective Sensors, Megan Z. Chiu, Jacqueline Linnes

The Summer Undergraduate Research Fellowship (SURF) Symposium

Paper-based point-of-care (POC) diagnostics is a growing field in global health due to the extreme portability, accuracy, affordability, and ease of use of these tests. Advancements in recent years have led to more accurate detection and improved functionality using multistep molecular diagnostics. Many such assays utilize lateral flow detection strips for visualization of diagnostic results by eye, which limits the results to qualitative Yes/No readouts. This project focused on combining recent developments in paper-based POC diagnostics to develop and optimize an in-house built quantitative paper-based diagnostic reader for lateral flow detection in low-resource settings. Initially different sensors, including photocell sensors, …

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Test Rig Design For Compact Variable Displacement Vane Pump, Pratik Chawla, Ryan Jenkins, Monika Ivantysynova Aug 2015

Test Rig Design For Compact Variable Displacement Vane Pump, Pratik Chawla, Ryan Jenkins, Monika Ivantysynova

The Summer Undergraduate Research Fellowship (SURF) Symposium

Variable displacement vane pumps (VDVP) are one type of positive displacement pumps used in automatic transmission vehicles for lubricating the gears, cooling the transmission and actuating the clutches. Though fixed displacement pumps are widely used, they output a constant effective flow at a given speed. Depending on pump sizing considerations, the pump can be oversized at high speeds because flow demand of the transmission is independent of engine speed. The excess flow returns to the tank through an orifice that causes the oil to heat up, increasing the energy required for cooling and reducing the efficiency of the transmission. A …

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Phase Transforming Cellular Materials (Pxcms) Design And Assembly, Nadia N. Aljabi, Pablo Zavattieri, David Restrepo Aug 2015

Phase Transforming Cellular Materials (Pxcms) Design And Assembly, Nadia N. Aljabi, Pablo Zavattieri, David Restrepo

The Summer Undergraduate Research Fellowship (SURF) Symposium

We introduce a new class of phase transforming cellular materials (PXCMs) based on locally bistable or metastable unit cells that form periodic microstructures, where the thermomechanical behavior of each unit cell exhibits snap-through type behavior. We propose to explore the capabilities of these new materials to improve structural resistance to damage caused by natural hazards including PXCM in structural members. The main benefits of this material are that it can absorb energy and is reusable. During the first part of this work, a fabrication method for PXCMs based on the assembly material slotted stripes was explored. The 1D unit cell …

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Effect Of Helium Ions Energy On Molybdenum Surfaces Under Extreme Conditions, Joseph Fiala, Jitendra K. Tripathi, Sean Gonderman, Ahmed Hassanein Aug 2015

Effect Of Helium Ions Energy On Molybdenum Surfaces Under Extreme Conditions, Joseph Fiala, Jitendra K. Tripathi, Sean Gonderman, Ahmed Hassanein

The Summer Undergraduate Research Fellowship (SURF) Symposium

Plasma facing components (PFCs) in fusion devices must be able to withstand high temperatures and erosion due to incident energetic ion radiations. Tungsten has become the material of choice for PFCs due to its high strength, thermal conductivity, and low erosion rate. However, its surface deteriorates significantly under helium ion irradiation in fusion-like conditions and forms nanoscopic fiber-like structures, or fuzz. Fuzz is brittle in nature and has relatively lower thermal conductivity than that of the bulk material. Small amounts of fuzz may lead to excessive contamination of the plasma, preventing the fusion reaction from taking place. Despite recent efforts, …

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Vast2015 Challenge Two: Event Analysis From Communication Data, Mahesh Babu Gorantla, William Hatton, Jieqiong Zhao, Abish Malik, David S. Ebert Aug 2015

Vast2015 Challenge Two: Event Analysis From Communication Data, Mahesh Babu Gorantla, William Hatton, Jieqiong Zhao, Abish Malik, David S. Ebert

The Summer Undergraduate Research Fellowship (SURF) Symposium

Social Media is a very good example of a large communication network. Typically, most data generated by social media are embedded with spatiotemporal stamps which hold crucial information than can help law enforcement agencies analyze the intensity of a calamity or chaos. Currently, not much research is done in designing a visual analytics system that incorporates clustering methods to analyze communication patterns. This research seeks to develop an analysis tool that represents such diverse data sets in user-friendly visual forms, to provide insights into the data that will improve the efficiency of event analysis. To analyze this data we have …

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Implementation Of A Speech Recognition Algorithm To Facilitate Verbal Commands For Visual Analytics Law Enforcement Toolkit, Shubham S. Rastogi, David L. Wiszowaty, Hanye Xu, Abish Malik, David S. Ebert Aug 2015

Implementation Of A Speech Recognition Algorithm To Facilitate Verbal Commands For Visual Analytics Law Enforcement Toolkit, Shubham S. Rastogi, David L. Wiszowaty, Hanye Xu, Abish Malik, David S. Ebert

The Summer Undergraduate Research Fellowship (SURF) Symposium

The VALET (Visual Analytics Law Enforcement Toolkit) system allows the user to visualize and predict crime hotspots and analyze crime data. Police officers have difficulty in using VALET in a mobile situation, since the system allows only conventional input interfaces (keyboard and mouse). This research focuses on introducing a new input interface to VALET in the form of speech recognition, which allows the user to interact with the software without losing functionality. First an Application Program Interface (API) that was compatible with the VALET system was found and initial code scripts to test its functionality were written. Next, the code …

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Freeze-Drying Silica Based Aerogels Using Cryoprotectants And Eutectic Solvent Mixtures, Alyssa R. Bass, Shane Peng, Jeffrey Youngblood Aug 2015

Freeze-Drying Silica Based Aerogels Using Cryoprotectants And Eutectic Solvent Mixtures, Alyssa R. Bass, Shane Peng, Jeffrey Youngblood

The Summer Undergraduate Research Fellowship (SURF) Symposium

Silica based aerogels have unique properties, including good thermal insulation and convective inhibition. A sol-gel process can be used to produce semi-opaque, monolithic gels, which can then be dried to produce aerogels. Multiple drying methods are available industrially, however, these methods require high temperatures and pressures, specialized equipment, and are time consuming. This project aims to experimentally study the possibility of a new method for drying wet gels through a freeze-drying process, with the use of cryoprotectants, eutectics, and polymers to inhibit and control ice formation and growth during drying. Silica wet gels were produced using tetraethylorthosilicate (TEOS), ethanol, water, …

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Effect Of Carbon Impurity On Molybdenum Nanostructure Evolution Under Helium Ion Irradiation In Extreme Conditions, Nikhil A. Bharadwaj, Jitendra Tripathi, Ahmed Hassanein, Sean Gonderman Aug 2015

Effect Of Carbon Impurity On Molybdenum Nanostructure Evolution Under Helium Ion Irradiation In Extreme Conditions, Nikhil A. Bharadwaj, Jitendra Tripathi, Ahmed Hassanein, Sean Gonderman

The Summer Undergraduate Research Fellowship (SURF) Symposium

The performance of plasma facing components (PFC) is of great important for the realization of prototype nuclear fusion. Tungsten has been considered as the leading high-Z PFC material for these reactors and tokamaks due to its superior thermophysical properties, high melting point, low sputtering yield, and low tritium inventory. However, its surface deteriorates significantly under helium ion irradiation in extreme (fusion) conditions and forms nanoscopic fiber like structures (fuzz) Recent studies show that the formation of fuzz nanostructure on tungsten can be suppressed by the presence of plasma impurities such as carbon and beryllium. In the present study, the effects …

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Assessment Of Critical Technologies For Gas Turbine Engines Using Numerical Tools, Vinicius Pessoa Mapelli, Guillermo Paniagua, Jorge Sousa Aug 2015

Assessment Of Critical Technologies For Gas Turbine Engines Using Numerical Tools, Vinicius Pessoa Mapelli, Guillermo Paniagua, Jorge Sousa

The Summer Undergraduate Research Fellowship (SURF) Symposium

In 2014 gas turbine engine has reached a market value of 82.5 billion dollars, of which 59.5% are related to aircraft propulsion. The continuous market expansion attracts more and more the interest of researchers and industries towards the development of accurate numerical techniques to model thermodynamically the entire engine. This practice allows a performance and optimization analysis before the actual experimental testing, reducing the time and required investment in the design of a new engine. In this paper, a recently developed open source numerical tool named “Toolbox for the Modeling and Analysis of Thermodynamic Systems” (T-MATS) is used to assess …

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Application Of Ultrasound In The Measurement Of Lubricant Fluid Film Thickness In The Piston-Cylinder Interface Of An Axial Piston Pump, Dhruv Subramaniam, Dan Mizell, Monika Ivantysynova Aug 2015

Application Of Ultrasound In The Measurement Of Lubricant Fluid Film Thickness In The Piston-Cylinder Interface Of An Axial Piston Pump, Dhruv Subramaniam, Dan Mizell, Monika Ivantysynova

The Summer Undergraduate Research Fellowship (SURF) Symposium

In this paper a feasibility study has been conducted to determine a technique for the measurement of lubricant fluid film thickness in the piston-cylinder interface of an axial piston pump. The thickness of the lubricant film has a significant impact on the efficiency of the piston pump yet it still remains an uncertainty. If the lubricant film is too thin then friction will cause excessive damage resulting in deformation of interacting surfaces resulting in further uncertainty in thickness measurement. If the lubricant film is too thick then there is excessive leakage which will compromise the efficiency of the system. Acoustic, …

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Securemems: Selective Deposition Of Energetic Materials, Trevor J. Fleck, Josiah R. Thomas, Lillian F. Miles, Allison K. Murray, Zane A. Roberts, Raghav Ramachandran, I Emre Gunduz, Steven F. Son, George T. Chiu, Jeffrey F. Rhoads Aug 2015

Securemems: Selective Deposition Of Energetic Materials, Trevor J. Fleck, Josiah R. Thomas, Lillian F. Miles, Allison K. Murray, Zane A. Roberts, Raghav Ramachandran, I Emre Gunduz, Steven F. Son, George T. Chiu, Jeffrey F. Rhoads

The Summer Undergraduate Research Fellowship (SURF) Symposium

There exists a pressing operational need to secure and control access to high-valued electromechanical systems, and in some cases render them inoperable. Developing a reliable method for depositing energetic materials will allow for the near-seamless integration of electromechanical systems and energetic material, and, in turn, provide the pathway for security and selective destruction that is needed. In this work, piezoelectric inkjet printing was used to selectively deposit energetic materials. Nanothermites, comprising of nanoscale aluminum and nanoscale copper oxide suspended in dimethyl-formamide (DMF), were printed onto silicon wafers, which enabled both thermal and thrust measurements of the decomposing energetic material. Various …

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Simulation, Control And Testing Of Advanced Hydraulic Hybrid Transmissions, Italo M. Ramos, Monika Ivantysynova, Michael Sprengel Aug 2015

Simulation, Control And Testing Of Advanced Hydraulic Hybrid Transmissions, Italo M. Ramos, Monika Ivantysynova, Michael Sprengel

The Summer Undergraduate Research Fellowship (SURF) Symposium

Hydraulic hybrids transmissions have the potentially to substantially improve the fuel efficiency of on road vehicles. In fact recent studies have demonstrated that this technology can improve fuel economy by upwards of 30% over competing electric hybrids. To further improve the fuel economy and performance of this technology a novel blended hydraulic hybrid transmission has been constructed at the Maha Fluid Power Research Center. While this novel hybrid architecture created by the Maha lab has many benefits over conventional systems, there are a number of control challenges present due to several discrete modes of operation. And though improving fuel economy …

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An Investigation Of The Applicability Of Sugar And Wax Valves For Rapid Molecular Diagnostics, Rui Shen, Jacqueline C. Linnes Aug 2015

An Investigation Of The Applicability Of Sugar And Wax Valves For Rapid Molecular Diagnostics, Rui Shen, Jacqueline C. Linnes

The Summer Undergraduate Research Fellowship (SURF) Symposium

Paper-based Loop-mediated Isothermal Amplification (LAMP) of nucleic acids is a low-cost molecular diagnostic method to detect biological pathogens and has been successfully combined with lateral flow devices. This invention is a low-cost visual detection technique of various disease. However, existing assays require multiple user-activated steps and are relatively complicated to use at the point of care due to steps like the heating process. This project aimed to investigate an ideal valve for integrating LAMP onto the lateral flow assay. An ideal valve needs to be able to stop the fluid flow for 20-60 minutes under 65 degree to complete the …

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Buckling-Driven Force Generation Of Cell Cortex, Pranith Lomada, Wonyeong Jung, Taeyoon Kim Aug 2015

Buckling-Driven Force Generation Of Cell Cortex, Pranith Lomada, Wonyeong Jung, Taeyoon Kim

The Summer Undergraduate Research Fellowship (SURF) Symposium

Actomyosin cortex, a thin network underlying cell membrane, is known to generate a large portion of tensile forces required for various cellular processes. Recently, theoretical studies predicted that buckling of actin filaments breaks symmetry between tensile and compressive forces developed by myosin motors, resulting in tensile stress at a network level. However, the significance of the filament buckling of the cortex has yet to be demonstrated either computationally or experimentally. Here, buckling-dependent stress generation of the cortex-like actomyosin network was investigated using an agent-based computational model consisting of actin filaments, actin cross-linking proteins (ACPs), and molecular motors. First, a wide …

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Selective Protein Labelling To Visualize Cellular Differentiation, Andrew J. Witten, Tamara L. Kinzer-Ursem Aug 2015

Selective Protein Labelling To Visualize Cellular Differentiation, Andrew J. Witten, Tamara L. Kinzer-Ursem

The Summer Undergraduate Research Fellowship (SURF) Symposium

Protein post-translational modifications serve to give proteins new cellular function, spatial localization, or enzymatic activity. Myristoylation is a common post-translational modification where the enzyme N-myristoyltransferase adds myristic acid onto the N-terminus of a variety of proteins. In this work we use a myristic acid analog, 12-azidododecanoic acid (12ADA) to facilitate the implementation of azide-alkyne cycloaddition reactions on myristoylated proteins. Selective protein labeling methods such as these are useful in research because they can be used to help determine the biological function of this protein lipid modification and can be extended to study disregulated protein myristoylation in disease states. To validate …

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Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis, Joseph C. Muskat, Matthew C. Pharris, Charles F. Babbs Aug 2015

Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis, Joseph C. Muskat, Matthew C. Pharris, Charles F. Babbs

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cardiovascular thrombosis may result in critical ischemia to a range of anatomical regions, constituting a leading cause of death in the United States. Current invasive treatments for such arterial blockages often yield blood clot recurrence, resulting in repeated hospitalization of patients. This research aims to show how internally introduced pressure oscillations may be used to initiate thrombolysis. We present a novel computational model for determining the resonant frequency and corresponding deformation of an idealized thrombus. Sinusoidal pressure differences across the thrombus induce axial displacements of frequency dependent amplitude. The maximum peak displacement occurs at a resonant frequency of 73 Hz …

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Grain Boundary Migration Of Nio-Mgo Alloys, Xin Li Phuah, David Lowing, John Blendell Aug 2015

Grain Boundary Migration Of Nio-Mgo Alloys, Xin Li Phuah, David Lowing, John Blendell

The Summer Undergraduate Research Fellowship (SURF) Symposium

Grain boundary engineering offers enhanced control of microstructure development during processing, leading to improved final material properties. However, using the effects of the interfacial energy anisotropy on grain boundary mobility to control microstructure development is not well understood. The NiO-MgO system is studied as it has complete solid solubility and a transition in the faceting behavior with composition due to changes in the interfacial energy anisotropy. NiO-MgO powders were produced through the amorphous citrate process and modifications to the process were made to reduce particle and agglomerate size. The powders were pressed and sintered in various conditions to produce fine …

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Fracture Mechanics-Based Simulation Of Pv Module Delamination, Dominic I. Jarecki, Johanna B. Palsdottir, Peter Bermel, Marisol Koslowski Aug 2015

Fracture Mechanics-Based Simulation Of Pv Module Delamination, Dominic I. Jarecki, Johanna B. Palsdottir, Peter Bermel, Marisol Koslowski

The Summer Undergraduate Research Fellowship (SURF) Symposium

Photovoltaic (PV) cells are rapidly growing as a renewable alternative to fossil fuels like coal, oil, and natural gas. However, greater adoption has also reduced government subsidies, placing the onus of making solar panels economically competitive on innovative research. While multiple methods have been considered for reducing costs, with each reduction in cost comes the associated peril of reduction in quality and useful lifetime. Several problems considered solved have now resurfaced as potential failure mechanisms with the introduction of cheaper PV cell technologies. However, to remain economically viable, PV modules will not only have to become cheaper, they will have …

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