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Full-Text Articles in Engineering

Characterization And Quantification Of Fibrin Gel Mechanics With Fibroblast Invasion, Nicklaus Iavagnilio, Sarah Calve, Adrian Buganza-Tepole Aug 2018

Characterization And Quantification Of Fibrin Gel Mechanics With Fibroblast Invasion, Nicklaus Iavagnilio, Sarah Calve, Adrian Buganza-Tepole

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cutaneous wounds undergo an intricate healing process stimulated by a variety of local mechanical and biological stimuli that lead to patterns of growth and remodeling. Despite significant research in dermal wound healing, pathological scarring is still common particularly in wounds closed under mechanical stress, or large wounds left to heal by secondary intention. The purpose of this study is to utilize previously established wound healing models using fibrin gels and fibroblasts to better understand the functional relationships of the biological processes of normal compared to abnormal wound healing. Increases in uni-axial strain and transforming growth factor beta-1 concentration have been …


Development Of Standard Criteria To Evaluate The Effectiveness Of Helmets At Decreasing The Risk Of Concussions, Daniel Y. Shyu, Goutham N. Sankaran, Kevin G. Mciver, Nicolas Leiva, Eric A. Nauman Aug 2016

Development Of Standard Criteria To Evaluate The Effectiveness Of Helmets At Decreasing The Risk Of Concussions, Daniel Y. Shyu, Goutham N. Sankaran, Kevin G. Mciver, Nicolas Leiva, Eric A. Nauman

The Summer Undergraduate Research Fellowship (SURF) Symposium

In many sports, such as American football, accumulations of mild traumatic brain injuries have been suggested as a possible link to neurodegeneration and future mental disorders. With head impacts occurring at all levels of competition and in different sports, it is critical to develop an accurate method for quantifying the effects of head impacts and determining the efficacy of helmets. This study examines the derivation of different dimensionless numbers and ascertains the critical factors needed to predict the effects of head impacts, specifically the resulting accelerations from an impact. Given a known force of impact, parameters such as peak translation …


Ball Pressure Correlations With Peak Impact Force And The Potential For Cumulative Mtbi When Heading A Soccer Ball, Nicolas Leiva, Daniel Y. Shyu, Josh Auger, Eric Nauman Aug 2016

Ball Pressure Correlations With Peak Impact Force And The Potential For Cumulative Mtbi When Heading A Soccer Ball, Nicolas Leiva, Daniel Y. Shyu, Josh Auger, Eric Nauman

The Summer Undergraduate Research Fellowship (SURF) Symposium

Soccer is a unique sport in which athletes use their heads as tools for gameplay, which may ultimately cause cumulative traumatic brain injuries. Due to rising popularity of soccer in the United States alongside the increased occurrence of CTE and mTBI in other contact sports, there is a growing concern over how to keep the repetitive forces caused by heading, as low as possible. Different variables that can affect the peak force felt when heading a soccer ball can be simulated and compared with in-game data, however, this has never been properly tested before. In the present study two size …


Cell-Matrix Interactions During En Masse Cell Migration, Meng Zhuang, Altug Ozcelikkale, Bumsoo Han Aug 2015

Cell-Matrix Interactions During En Masse Cell Migration, Meng Zhuang, Altug Ozcelikkale, Bumsoo Han

The Summer Undergraduate Research Fellowship (SURF) Symposium

Extended wound care, including prolonged treatment of burn injuries, acute and chronic wounds, is a significant source of patient discomfort and financial burden to public healthcare programs. Both accelerated healing and prevention of scar formation are highly desired but remain to be challenging to achieve. This is primary due to limited understanding of interactions between cells and the surrounding extracellular matrix (ECM) during wound healing. Particularly, collective migration of fibroblasts through provisional matrix, so called en masse migration, is one of these interactions that play a critical role in later stages of granulation tissue formation and wound closure. In addition …