Other Pharmacy and Pharmaceutical Sciences Commons^™

Optimasi Kombinasi Karbopol 940 Dan Hpmc Terhadap Sifat Fisik Gel Ekstrak Dan Fraksi Metanol Daun Kesum (Polygonum Minus Huds.) Dengan Metode Simplex Lattice Design, Rafika Sari, Siti Nani Nurbaeti, Liza Pratiwi

Pharmaceutical Sciences and Research

Indonesia especially Kalimantan Barat well known by its biodiversity, one of the potential resource is Kesum leaves. Kesum leaves are potential by its antibacterial effect, so that it can be formulated into pharmaceutical dosage form, especially gel. This research aims to know the best comparison between Carbopol 940 and Hydroxypropyl methylcellulose (HPMC) gel base affecting the physical stability of methanol extract and fraction of kesum leaves gel by Simplex Lattice Design (SLD) method. Gels were prepared into three variation base such as gel A (100% Carbopol - 0% HPMC); gel B (0% Carbopol - 100% HPMC); and gel C (50% …

Skrining Aktivitas Antibakteri Bakteriosin Dari Minumance Hun Tiau, Rafika Sari, Lia Deslianri, Pratiwi Apridamayanti

Pharmaceutical Sciences and Research

Lactic acid bacteria is one of the beneficial bacteria because it can produce an antimicrobial peptide called bacteriocin. Bacteriocin has been applied as a natural food preservative because it effectively prevents the growth of pathogenic bacteria in food or drink. This study aims to identify the lactic acid bacteria as producers of bacteriocin from Ce hun tiau which have inhibitory activity againts pathogenic bacteria such as Escherichia coli, Staphylococus aureus and Salmonella typhi. In this study, Lactic acid bacteria were isolated from Ce Hun Tiau using streak plate method on media deMan Rogose Sharpe. Screening bacteriocin using disc diffusion method …

Antibiotic Sensitivity In Pseudomonas Aeruginosa Of Diabeticpatient’S Foot Ulcer, Pratiwi Apridamayanti, Khairunnisa Azani Meilinasary, Rafika Sari

Pharmaceutical Sciences and Research

Diabetes Mellitus (DM) patients are at risk to have the diabetic ulcer. The main reason for DM’s patient with ulcer complication to be treated and healed in hospital is bacterial infection. One of many bacteria that infects diabetic ulcer is Pseudomonas aeruginosa. The effort to treat this infection is by using antibiotic. The use of antibiotic unfortunately, is often found inaccurate causing the microbe resistance to occur. To choose the right antibiotic, it needs to test the antibiotic’s sensitivity towards Pseudomonas aeruginosa. The aim of this study is to determine the sensitivity of antibiotics against Pseudomonas aeruginosa. Sample used was …

Potensi Ekstrak Etanol Daun Petai (Parkia Speciosa Hassk.) Terhadap Kadar Superoksida Dismutase (Sod) Pada Plasma Tikus Yang Mengalami Stres Oksidatif, Ruth Haryati Butarbutar, Robiyanto Robiyanto, Eka Kartika Untari

Pharmaceutical Sciences and Research

Cigarette smoke is free radicals superoxide resources that contains, hydrogen peroxide, hidrosil and peroksil. Superoxide dismutase (SOD) is an enzymatic antioxidants that protect cells from oxidative stress by catalyzing superoxide dismutase (O2 *) into O2 and H2O2 . This study aims to determine the potential of ethanolic extract petai leaves against plasma SOD enzyme activity in animals exposed by cigarette smoke. The simplicia extracted by maseration using ethanol 96%. Thirty-six rats Sprague Dawley strain were divided into six groups: normal group was not given treatment, negative group received 10% CMC-Na, positive control group received vitamin E, and treatment group received …

A Murine Model Of Inflammation-Induced Cerebral Microbleeds, Rachita K. Sumbria, Mher Mahoney Grigoryan, Vitaly Vasilevko, Tatiana B. Krasieva, Miriam Scadeng, Alexandra K. Dvornikova, Annlia Paganini-Hill, Ronald Kim, David H. Cribbs, Mark J. Fisher

Pharmacy Faculty Articles and Research

Background: Cerebral microhemorrhages (CMH) are tiny deposits of blood degradation products in the brain and are pathological substrates of cerebral microbleeds. The existing CMH animal models are β-amyloid-, hypoxic brain injury-, or hypertension-induced. Recent evidence shows that CMH develop independently of hypoxic brain injury, hypertension, or amyloid deposition and CMH are associated with normal aging, sepsis, and neurodegenerative conditions. One common factor among the above pathologies is inflammation, and recent clinical studies show a link between systemic inflammation and CMH. Hence, we hypothesize that inflammation induces CMH development and thus, lipopolysaccharide (LPS)-induced CMH may be an appropriate model to …

Stability And Kinetics Of Dna Pseudoknots: Formation Of T∗A•T Base-Triplets And Their Targeting Reactions, Calliste Steffensmeier

Theses & Dissertations

Pseudoknots have been found to play important roles in the biology of RNA. These stem-loop motifs are considered to be very compact and the targeting of their loops with complementary strands is accompanied with lower favorable free energy terms. We used a combination of spectroscopic (UV, CD and fluorescence), calorimetric (DSC, PPC and ITC) and kinetic (SPR) techniques to investigate: 1) Local base-triplet formation in pseudoknots; 2) energetic contributions for the association of pseudoknots with their complementary strands; and 3) the kinetic rates as a function of targeting strand length.

We investigated a set of DNA pseudoknots with sequence: d(TCTCT …

Novel Ph-Sensitive Cyclic Peptides, Dhammika Weerakkody, Anna Moshnikova, Naglaa Salem El-Sayed, Ramona-Cosima Adochite, Gregory Slaybaugh, Jovana Golijanin, Rakesh Tiwari, Oleg A. Andreev, Keykavous Parang, Yana K. Reshetnyak

Pharmacy Faculty Articles and Research

A series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as pH-sensitive agents for targeting of acidic tissue and pH-dependent cytoplasmic delivery of molecules. Biophysical studies revealed the molecular mechanism of peptides action and localization within the lipid bilayer of the membrane at high and low pHs. The symmetric, c[(WE)4WC], and asymmetric, c[E4W5C], cyclic peptides translocated amanitin, a polar cargo molecule of similar size, across the lipid bilayer and induced cell death in a pH- and concentration-dependent manner. Fluorescently-labelled peptides were evaluated for targeting of acidic 4T1 mammary tumors in …

What And How Do Students Learn In An Interprofessional Student-Run Clinic? An Educational Framework For Team-Based Care, Désirée A. Lie, Christopher Forest, Anne Walsh, Yvonne Banzali, Kevin Lohenry

Physician Assistant Studies Faculty Articles and Research

Background: The student-run clinic (SRC) has the potential to address interprofessional learning among health professions students.

Purpose: To derive a framework for understanding student learning during team-based care provided in an interprofessional SRC serving underserved patients.

Methods: The authors recruited students for a focus group study by purposive sampling and snowballing. They constructed two sets of semi-structured questions for uniprofessional and multiprofessional groups. Sessions were audiotaped, and transcripts were independently coded and adjudicated. Major themes about learning content and processes were extracted. Grounded theory was followed after data synthesis and interpretation to establish a framework for interprofessional …

Admission Criteria As Predictors Of Student Success, Kelly M. Shields, Eunhee Kim, Jennifer K. Grundey, Lindsey M. Peters

Pharmacy Faculty Scholarship

Objective: Evaluate impact of various admission criteria elements (cognitive, behavioral) as predictors of first-term college GPA and on-time graduation.

Methods & Results: Predictive models were developed to examine if the current admission criteria: high school GPA (HSGPA), ACT Composite score, interview score, etc are significant predictors for student success defined as first-term college GPA, on-time graduation among PharmD students at a direct entry private university. The study sample consisted of 395 pharmacy students matriculated as first-time freshmen students during fall 2007 through fall 2009. Results from the hierarchical linear regression analysis indicated that both HSGPA and ACT Composite score were …

Career Mentoring: Helping Students Climb The Ladder To Success, Kelly Shields, Jennifer K. Grundey, Jenelle Sobotka

Pharmacy Faculty Scholarship

No abstract provided.

Gene Delivery Using Calcium Phosphate Nanoparticles: Optimization Of The Transfection Process And The Effects Of Citrate And Poly(L-Lysine) As Additives, Mohammed A. Khan, Victoria M. Wu, Shreya Ghosh, Vuk Uskoković

Pharmacy Faculty Articles and Research

Despite the long history of nanoparticulate calcium phosphate (CaP) as a non-viral transfection agent, there has been limited success in attempts to optimize its properties for transfection comparable in efficiency to that of viral vectors. Here we focus on the optimization of: (a) CaP nanoparticle precipitation conditions, predominantly supersaturation and Ca/P molar ratios; (b) transfection conditions, mainly the concentrations of the carrier and plasmid DNA; (c) the presence of surface additives, including citrate anion and cationic poly(l-lysine) (PLL). CaP nanoparticles significantly improved transfection with plasmid DNA encoding enhanced green fluorescent protein (eGFP) in pre-osteoblastic MC3T3-E1 cells compared to a commercial …

Commencement Program 2016, Loma Linda University

Commencement Programs

CONTENTS

1 | Message from the President

3 | 2016 Events of Commencement

5 | The Academic Procession

7 | Significance of Academic Regalia

9 | The Good Samaritan

10 | University History Highlights

12 | Loma Linda University Song - "Healing Love"

13 | The Speakers

21 | The University Honorees

36 | The School Honorees

56 | The President's Award Recipients

66 | The Program

• School of Medicine, 67
• School of Pharmacy, 90
• School of Dentistry, 98
• School of Allied Health Professions - Allied Health Studies, Cardiopulmonary Sciences, Clinical Laboratory Science, Health Informatics and Information Management, Nutrition and …

Calcium Phosphate As A Key Material For Socially Responsible Tissue Engineering, Vuk Uskoković, Victoria M. Wu

Pharmacy Faculty Articles and Research

Socially responsible technologies are designed while taking into consideration the socioeconomic, geopolitical and environmental limitations of regions in which they will be implemented. In the medical context, this involves making therapeutic platforms more accessible and affordable to patients in poor regions of the world wherein a given disease is endemic. This often necessitates going against the reigning trend of making therapeutic nanoparticles ever more structurally complex and expensive. However, studies aimed at simplifying materials and formulations while maintaining the functionality and therapeutic response of their more complex counterparts seldom provoke a significant interest in the scientific community. In this review …

Factors And Outcomes Associated With Potentially Inappropriate Medication Use In Rural Community-Dwelling Older Adults, Marcia Y. Shade

Theses & Dissertations

Potentially inappropriate medications (PIMs) use in older adults is a significant public health concern. The use of PIMs to avoid may lead to negative outcomes such as adverse drug events. Prior conceptual analysis of PIMs use and observation of health-related factors in rural adults led to the design of this dissertation study. A sample was recruited from a population of rural community-dwelling older adults to examine the following specific aims: 1) Describe the use of PIMs to avoid, 2) Explore individual demographic characteristics (age, gender, income, education, and rural home location), health experience (comorbidity, number of medications and health providers), …

Uji Aktivitas Penghambatan Xantin Oksidase Secara In-Vitro Oleh Isolat 6,4’-Dihidroksi-4-Metoksibenzofenon-2-O-Β-D Glukopiranosida(C20h22o10) Yang Diisolasi Dari Mahkota Dewa (Phaleria Macrocarpa (Scheff.) Boerl), Aprilita Rina Yanti Eff, Sri Teguh Rahayu, Resta Dwi Syachfitri

Pharmaceutical Sciences and Research

Hyperuricemia is a condition in which an increasing in uric acid levels abovenormal. Hyperuricemia is a major factor in the development of gout. Gout is adisease caused by the accumulation of monosodium urate crystals in the tissues dueto elevated levels of uric acid. Crown gods (Phaleria macrocarpa (Scheff.) Boerl) is Indonesia native medicinal that has effect such as lowering blood pressure, diabetes mellitus drugand lowering uric acid levels. One of the chemical constituents of this plant is abenzopheneon compound that is 6,4’-dihydroxy-4-metoksi benzofenon-2-O-β-D-glukopiranosida (C20H22O10). Research was conducted to determine the activity of 6,4’-dihydroxy -4-metoksi benzofenon-2-O-β-D-glukopiranosida (C20H22O10) that isolated from Crown …

Uji Penghambatan Xantin Oksidase Secara In Vitro Ekstrak Kulit Rambutan, Nurul Eka Putri, Rissyelly Rissyelly, Marista Gilang Mauldina

Pharmaceutical Sciences and Research

Hyperuricemia is a condition have higher uric acid levels that can cause a cumulation uric acid crystals in the tissues. Xanthine oxidase is an enzyme which catalyze the oxidation of hypoxanthine into xanthine and into uric acid.Therefore, the inhibition of xanthine oxidase will reduce ammount of uric acid. This research aims to determine xanthine oxidase inhibition activity and also to identify chemical constituent group of extract rambutan (Nephelium lappaceum Linn.) skin. Rambutan fruit skin was extracted by graded maceration using a three solvent, based on polarity the solvent are n-hexane, ethyl acetate and methanol. The test of inhibition xanthine oxidase …

Pengaruh Pemberian Minyak Atsiri Daun Kemangi (Ocimum Americanum L.) Terhadap ~ Motilitas Usus Mencit Putih Jantan, Dewi Sriyani, Fadlina Chany Saputri

Pharmaceutical Sciences and Research

Kemangi (Ocimum americanum L.) is a well known plant that contains essential oils with citral as a major compound. Citral is reported to have beneficial effect on intestinal motility. In the present study, we investigated the effect of essential oil of kemangi leaves (Ocimum americanum L.) on male DDY mices intestinal motility. Thirty mices were divided into six groups and each group was pretreated with 0,2 ml of 0,5% CMC (negative control), 1 mg/kg BW of atropine sulfate (positive control), 5 mg/kg BW of citral (comparative control), and three dose variation of volatile oil of kemangi leaves (25 mg/kg BW; …

Karakterisasi Dan Stabilitas Fisik Mikroemulsi Tipe A/M Dengan Berbagai Fase Minyak, Endang Wahyu Fitriani, Erlina Imelda, Christina Kornelis, Christina Avanti

Pharmaceutical Sciences and Research

This research consists of formulation, characterization and physical stability of the microemulsion of water-in-oil type. On the microemulsion, VCO, palm oil, olive oil and soybean oil were used as oil phase, aqua demineralisata used as the aqueous phase, a combination of Span® 80 and Tween® 80 as a surfactant and propanol as cosurfactant. Each formula was three times replication done and determined the physical characteristics including organoleptic observations, measurements of density, droplet, viscosity, flow properties, and pH. Determination of physical characteristics was done at the beginning of the microemulsion formed and after 5 weeks storage at room temperature. The physical …

Uji Aktivitas Antiproliferasi Formula Liposom Ekstrak Etanol Kunyit (Curcuma Domestica) Terhadap Sel Kanker Payudara T47d, Gabriella Pasaribu, Iskandarsyah Iskandarsyah, Erny Sagita

Pharmaceutical Sciences and Research

Breast cancer is one of deadliest diseases in world. Turmeric extract was known to have antiproliferative activity. To minimize its toxicity, turmeric extract was encapsulated with liposome, a vesicle lipid bilayer functioned as cancer drug carrier in body. This research aimed to determine encapsulation effect of turmeric ethanol extract against antiproliferative activity in T47D breast cancer cells through in vitro assay. Liposomes was made using thin layer method and particle size was reduced by extrusion. Materials used are phosphatidylcholine, cholesterol, and turmeric extract. Optimization of liposomes was made in three formulations with different concentrations of extract. Most optimal formulation was …

Comparison Of Tranexamic Acid And Aminocaproic Acid In Coronary Bypass Surgery, Lisa K. Lecleir

Butler Journal of Undergraduate Research

Abstract

OBJECTIVE: Tranexamic acid (TXA) and ɛ-aminocaproic acid (EACA) are used in coronary bypass surgery for antifibrinolytic therapy. Since the removal of aprotinin, data directly comparing their blood sparing effect and their side effects is still missing.

METHODS: Fifty patients undergoing coronary bypass cardiac surgery at St. Vincent’s Hospital and Health Services in Indianapolis, IN were evaluated in a retrospective cohort study. Perioperative data was collected by a thorough chart review. Patients received EACA from 01/01/2013 to 04/05/2013 or TXA from 05/07/2013 to 12/31/2013. Primary outcome was the amount of chest tube output throughout the hospital stay. Secondary …