Other Pharmacy and Pharmaceutical Sciences Commons^™

Flipping The Script: Active Learning In Drug Information, Albert Bach, Ivan Portillo

Pharmacy Faculty Articles and Research

This presentation will highlight successful strategies that incorporate drug information skills into pharmacy laboratory courses across the curriculum. Attendees will gain insights on collaboration between clinical faculty and library services, active learning techniques, and drug information assignments to utilize within a laboratory based course.

Objectives:

Plan an active learning session that introduces first-year students to drug information sources.

Describe how clinical faculty and library services can collaborate to introduce drug information to students.

Explain the implementation of a DI Question during an Order Verification module in the hospital laboratory setting.

Provide students a tool for self-reflection prior to conducting …

Physicochemical Property Effects On Immune Modulating Polymeric Nanoparticles: Potential Applications In Spinal Cord Injury, Daniel J. Kolpek, Jaechang Kim, Hisham Mohammed, John C. Gensel, Jonghyuck Park

Markey Cancer Center Faculty Publications

Nanoparticles (NPs) offer promising potential as therapeutic agents for inflammation-related diseases, owing to their capabilities in drug delivery and immune modulation. In preclinical studies focusing on spinal cord injury (SCI), polymeric NPs have demonstrated the ability to reprogram innate immune cells. This reprogramming results in redirecting immune cells away from the injury site, downregulating pro-inflammatory signaling, and promoting a regenerative environment post-injury. However, to fully understand the mechanisms driving these effects and maximize therapeutic efficacy, it is crucial to assess NP interactions with innate immune cells. This review examines how the physicochemical properties of polymeric NPs influence their modulation of …

Synthesis Of Photocleavable Molecules For Neurological Applications, Nishal Madujith Egodawaththa Arachchilage Don

Theses and Dissertations

In recent biomedical research, the precise control of molecular dynamics through light activation has emerged as a powerful tool, particularly in the field of neurobiology. This approach involves the use of photocleavable cages or photoprotective groups (PPGs) that are chemically tethered to biologically active molecules such as neurotransmitters or calcium chelators. These cages remain inert until exposed to specific wavelengths of light, typically in the visible range, triggering the release of the active compound with high spatiotemporal precision.

For neurotransmitter systems, such as glutamate (Glu), which plays a critical role in synaptic transmission and memory formation, researchers have developed novel …

Unravelling The Erythropoietin Heterodimeric Complex: In Silico Analysis Of Complex Assembly And Binding Interface, Atiya Habib, Urooj Qureshi, Mohammad Nur-E-Alam, Aftab Ahmed, Zaheer Ul-Haq

Pharmacy Faculty Articles and Research

Erythropoietin (Epo), a glycosylated protein categorized as a member of the cytokine family, is responsible for the modulation of erythrogenesis. Besides this, the nonhaematopoietic effects of Epo are associated with tissue-protective activity via an antiapoptotic pathway. This function of Epo is linked with its heterodimeric form, i.e. EpoR/βcR belonging to the cytokine family as well. Both receptors are dissected into three domains: extracellular (also known as ligand-binding domain), transmembrane and cytoplasmic domain. The transmembrane and cytoplasmic domains are assumed to play a paramount role in dimerization and tissue protection. However, the tertiary structure of cytoplasmic domains of both …

Leveraging Quantitative Systems Pharmacology For Dose Optimization In Oncology Drug Development, Blerta Shtylla

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Predicting And Monitoring Immune Checkpoint Inhibitor Therapy Using Artificial Intelligence In Pancreatic Cancer, Guangbo Yu, Zigeng Zhang, Aydin Eresen, Qiaoming Hou, Farideh Amirrad, Sha Webster, Surya M. Nauli, Vahid Yaghmai, Zhuoli Zhang

Pharmacy Faculty Articles and Research

Pancreatic cancer remains one of the most lethal cancers, primarily due to its late diagnosis and limited treatment options. This review examines the challenges and potential of using immunotherapy to treat pancreatic cancer, highlighting the role of artificial intelligence (AI) as a promising tool to enhance early detection and monitor the effectiveness of these therapies. By synthesizing recent advancements and identifying gaps in the current research, this review aims to provide a comprehensive overview of how AI and immunotherapy can be integrated to develop more personalized and effective treatment strategies. The insights from this review may guide future research efforts …

A Protocol For Immunostaining Of Macrophages In Whole-Mount Mouse Cornea, Conjunctiva, And Lacrimal Gland, Saleh Alfuraih, Dhruv Patel, Wonsuk Choi, Karthikeyan Ramasamy, Rais Ansari, Ajay Sharma

Pharmacy Faculty Articles and Research

The healthy lacrimal functional unit contains a resident macrophage population. Here, we present a protocol for immunofluorescent staining of macrophage markers, CD11b, F4/80, and CD206, in whole-mount mouse cornea, conjunctiva, and 50-μM-thick lacrimal gland section. We describe steps for dissection, fixation, permeabilization, and blocking. We then detail procedures for the detection and spatial localization of macrophages through immunostaining and confocal imaging. This approach circumvents the need to obtain thin tissue sections and acquire macrophage images from each tissue section.

Table B: Impacts Of Utensil Use In Preparation, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Coffee Beans, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Creamer, Non-Dairy, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Tea Infusion, Unspecified Tea Type, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Puer Tea Infusion, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Energy, Isotonic, Sports, And Nutritional Drinks, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Butter, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Sugar, Syrup And Molasses, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Oils, Fats, And Their Products, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Pepper, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Rice, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Cookies And Snacks, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Barley, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.