Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons^™

Reaching The Peak, Mary I. Fisher

Physical Therapy Faculty Publications

No abstract provided.

Champ's Triathlon Training Program, Rachael Sollman

OTD Capstone Projects

Champ's Triathlon Training Program was created to provide an adaptive fitness opportunity to the community of Nashville, TN. This program was specifically targeting children 8 to 15 years old diagnosed with Down's Syndrome and Cerebral Palsy, Gross Motor Function Classification Scale levels I, II, and III. Champ's Triathlon Training Program was an extension of the Champ's Tri My Best Triathlon hosted by a team of therapists and Vanderbilt's Pediatric Clinic, including Kelley Newman. The program aimed to increase the participants' strength, flexibility, and endurance through triathlon related activities such as running/walking, swimming, and biking. Outcomes of the program were to …

Alexithymia Symptoms Are Not Associated With Childhood Trauma Or Crhr1 Rs110402 Genotype, Emily Wiatr, Grace Sullivan, Scott Stoltenberg

Center for Brain, Biology, and Behavior: Faculty Publications

Alexithymia is associated with difficulties in emotional self-regulation, and alexithymia is specifically associated with an absence of emotional experience and cognition of emotion. Past research has indicated a potential association between alexithymia and the CRHR1 gene . Situational factors may also impact the expression of the CRHR1 gene within an individual. Berenbaum (1996) found associations between PTSD/childhood trauma and alexithymia. This study examined these associations using the Online Alexithymia Questionnaire-G2 (OAQ-G2) as well as DNA samples gathered from 657 participants at the University of Nebraska-Lincoln (72% women; 78.6% white; mean age= 20.34; standard deviation of 2.6). It was hypothesized that …

Elucidation Of The Mechanisms By Which Anesthetics Induce Blood-Brain Barrier Breakdown And Delirium In The Elderly, George A. Godsey Ii

Graduate School of Biomedical Sciences Theses and Dissertations

Delirium is a highly prevalent neuropsychiatric or neurocognitive disorder that presents a major problem to modern healthcare. Patients suffering from delirium normally have a worse prognosis, prolonged hospital stay, increased hospital cost, long-term cognitive impairment, and higher mortality rates. Many factors can predispose one to develop delirium, which makes treating this disorder a daunting task. Unfortunately, delirium is the most common psychiatric syndrome found in the hospital setting. In fact, a form of delirium known as postoperative delirium (POD) is one of the most common postoperative complications faced by elderly patients undergoing surgery.

POD is a major problem in modern …

Study Of Satisfaction Of Inpatient Discharge Based On Nurses’ Perceptions, Hong Lin

Dissertations and Theses

Patient satisfaction plays an important role in providing quality health care, and discharge satisfaction is part of overall patient satisfaction since it reveals how patients feel about their stay. In this paper, we evaluated inpatient discharge satisfaction based on nurses’ perceptions. An anonymous survey was used to evaluate how satisfied the patients were when being discharged from the acute care hospital with survey questions answered by nurses who work on medical-surgical floors. Data was collected from the questionnaires and analyzed using Excel.

Towards Wide Implementation Of Dance Therapy In Mental Health, Pin-Wen Chou

Dissertations and Theses

In recent years, Dance Movement Therapy (DMT) has been increasingly mentioned in the field of mental health counseling. Despite the progress of DMT in terms of studies showing its efficiency for various forms of mental health conditions such as depression and trauma, the implementation of DMT amongst mental health therapists is still not as widespread as other forms of therapies such as verbal and art therapies. In this project, we aim to determine the underlying causes of its low implementation by surveying a set of populations, specifically mental health patients, mental health therapists that do not specialize in dance/movement therapy, …

Physical Therapy With Adjunct Therapies In Patients With Chronic Pain And Disability Post-Motor Vehicle Accidents, Lakshmi Subramanian

Dissertations and Theses

This project is a thorough literature review of studies concerning physical therapy interventions in conjunction with adjunct treatments for patients post-motor vehicle accidents focused on the therapy’s efficacy as related to functional outcome measures. Physical therapy is frequently treatment of choice for patients after minor motor vehicle accidents. However, most patients seek concomitant therapies like acupuncture, chiropractic, epidural steroid injection, and psychological counselling. This paper seeks to gather data on the efficacy of different treatment modalities when used in conjunction with each other. Often patients are traumatised or develop anxiety about driving requiring counselling and therapy. The vast majority of …

Chronic Migraine: Role Of Cgrp Antagonists And Botox, Gabriella Hassan

Dissertations and Theses

Chronic migraine (CM) is characterized by the International Headache Society classification (ICHD-3) as headache that occurs for greater than or equal to 15 days a month, lasting 4 or more hours. For chronic migraine patients, the goal with prophylactic treatment is to prevent future attacks and reduce the migraine frequency and severity. OnabotulinumtoxinA is the most universally accepted medication for the treatment of chronic migraine; and if successful, reduces migraine frequency up to 50%. The goal of CGRP (Calcitonin-gene-related peptide) antagonists is to reduce the frequency of chronic migraines by targeting the CGRP protein that is elevated during a migraine …

Perception Of Healthcare Providers On Mirror Therapy For Stroke, Dhwani Kamlesh Doshi

Dissertations and Theses

Stroke is a very important health problem faced worldwide with high mortality and incidence. The majority of stroke survivors suffer temporary or permanent disabilities of which hemiparesis is one of the most common. Hemiparesis makes it difficult for patients to perform their activities of daily living and often they have declining quality of life. Mirror therapy (MT) is a an inexpensive, easy and safe intervention which has been proven to be very effective to improve the motor function in hemiparetic stroke. Despite this, it is not often employed. Hence, the purpose of this study was to explore the awareness and …

Digital Dentistry- The Future Of Oral Health, Vidhi Shah

Dissertations and Theses

Background and objective: In the digital world, dentistry appears to be at least a decade behind in adopting the latest technologies in comparison to consumer electronics, biomedical engineering and aeronautics. However, recently, dental professionals have experienced the evolution of the dental profession as technological growth. Digital dentistry is the future of dentistry, and it will be essential to adopt and integrate technology into practice to improve the quality of care. The new generation of digital dentistry opens the exploration of innovations and advancement in technologies which will dramatically impact and improve all of dentistry. The objective of this paper is …

The Effectiveness Of Transfer Learning Systems On Medical Images, James Boit

Masters Theses & Doctoral Dissertations

Deep neural networks have revolutionized the performances of many machine learning tasks such as medical image classification and segmentation. Current deep learning (DL) algorithms, specifically convolutional neural networks are increasingly becoming the methodological choice for most medical image analysis. However, training these deep neural networks requires high computational resources and very large amounts of labeled data which is often expensive and laborious. Meanwhile, recent studies have shown the transfer learning (TL) paradigm as an attractive choice in providing promising solutions to challenges of shortage in the availability of labeled medical images. Accordingly, TL enables us to leverage the knowledge learned …

Can The Kanban Technique Reduce Medical Errors?, Juhi Hegde

Dissertations and Theses

This study discusses common medical errors and the extent of harm caused in the United States and explores the application of the Kanban technique of Lean Management in the healthcare industry to reduce medical errors. It also describes various scenarios of how the visual scheduling/ signaling system has been incorporated for continuous process improvement in the clinical and non-clinical sectors of the industry based on several review articles. Furthermore, a survey study was performed in order to assess whether ‘Kanban Visual Management System’ utilization in healthcare has the ability to reduce medical errors. A convenience sample of healthcare providers was …

Analysis Of Delays In Processing Times In An Ophthalmology Clinic, Kai Yung Natalie Lui

Dissertations and Theses

Efficiency is an important component of any medical practice. It facilitates quality care, reduction in wait time, patient and staff satisfaction, and decreased cost. The purpose of this study was to identify bottlenecks in the current processing system in the Eye Center at Hershey Penn State Medical Center. Data was obtained about patients arriving at the clinic for ancillary tests such as visual field testing and retinal imaging. Analysis of this data revealed a statistically significant longer average length of visit for patients who received testing in comparison to those who did not. However, due to the small sample size …

Managing Chronic Pain Through Advancements In Transcranial Brain Stimulation Technology Currently Used For Depression, Ashley N. Skinner

Honors Thesis

The purpose of this thesis is to bring attention to alternatives to using analgesics or painkillers and potentially addictive opioid analgesics. Transcranial Magnetic Stimulation (TMS) has been proven successful in treating medication-resistant depression. This literature review will look at the links between pain and depression and examine adaptations to TMS coils in hopes of being able to stimulate the regions of the brain that interpret pain. By looking at current advancements in TMS, we can work towards adapting TMS to stimulate deeper regions. The final section of this thesis will examine how making these alternatives more popular will impact pain …

The Usefulness Of The Left Atrial Dilation Rate In Determining Severity Of Heart Failure, Laura B. Snyder

Senior Theses

Hypertension and vascular stiffness are two physiological conditions that strain the left ventricle (LV) and cause it to gain muscle mass. Eventually, the LV is unable to fill correctly and the patient develops Heart Failure with a preserved Ejection Fraction (HFpEF). Clinically, a patient’s left atrium (LA) area is measured as a diagnostic parameter of HFpEF severity. However, this doesn’t offer a prognosis or threshold of LA size necessitating hospitalization because of variation in patient demographics, genetics, and lifestyle which affect rates of HFpEF progression.

Since there are no medications or effective treatment options for HFpEF patients, there is a …

Analysis Of Ptv Margins For Vmat Treatment Of Rectal Cancers Utilizing Prone Bellyboard Device., Ben Armbuster

Masters Projects

Utilization of a bellyboard device reduces small bowel dose for patients receiving radiation therapy for rectal cancer. The reduction of small bowel dose with the bellyboard is even more significant in intensity modulated radiation therapy rectal treatments, as opposed to conventional 3D treatments. However, there is evidence of increased setup variation with prone bellyboard positioning, especially in pitch and roll. The purpose of this study is to determine the margin needed between the clinical target volume and the planning target volume to adequately account for these setup variations when planning volumetric modulated arc therapy rectal cases utilizing the bellyboard device. …

Design, Development And Evaluation Of Dual Drug Nanomedicine For Non-Small Cell Lung Cancer, Elham Hatami

Theses and Dissertations (ETD)

Resistance to conventional chemotherapy is a big challenge in the treatment of cancer including non-small cell lung cancer (NSCLC). A combination of natural chemo sensitizer agents with chemotherapy offers unique advantages over monotherapy alone. However, free unbound drugs, (in combination or as a single agent), lack tumor-targeted accumulation and therefore can be easily eliminated from the patient body. Moreover, some drugs are hydrophobic, and their organic solvents cause in vivo toxicity, thereby limiting their capability in clinical translation. Herein, dual loaded biocompatible and biodegradable nanoparticles (NPs) using Gemcitabine (Gem)a pyrimidine nucleoside antimetabolite and Gambogic acid (GA) (a highly hydrophobic chemo …

A Case Of Pacemaker Syndrome Mimicking A Heart Failure Exacerbation, Seline Haci, Som Aftabizadeh, Senthil Thambidorai, Karan Gupta, Ahsan Khan, Aman Patel, Kimberly Wilson, Anand Subramanian

Cardiology

No abstract provided.

Functional Blockade Of E-Selectin In Tumor-Associated Vessels Enhances Anti-Tumor Effect Of Doxorubicin In Breast Cancer, Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, Ganesh L R Lokesh, Norihisa Ichimura, Rachel Davis, Natalie Hills, Nafis Hasan, Roy Zhang, Yuji Kondo, David G Gorenstein, David E Volk, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45+ immune cell density adjacent to E-selectin expressing inflamed vessels in doxorubicin (DOX)-treated residual human breast tumors. While CD45 level was significantly elevated in DOX-treated wildtype mice, it remained unchanged in DOX-treated tumors from E-selectin null mice. Similarly, intravenous administration of anti-E-selectin aptamer (ESTA) resulted in a significant reduction in CD45+ immune cell density in DOX-treated residual tumors, which coincided with a delay in tumor growth and lung metastasis in MMTV-pyMT mice. Additionally, both …

Management Of Childhood Migraine By Headache Specialist Versus Non-Headache Specialists, Kelly Valentini, Radhika Gutta, Gunjanpreet Kaur, Ahmad Farooqi, Lalitha Sivaswamy

Medical Student Research Symposium

This study aims to compare the management practices of a headache specialist with non-headache specialists in the treatment of pediatric migraine. The use of appropriate rescue medications and prophylactic agents, application of neuro-imaging, and short-term outcomes are compared in children treated by the two groups of physicians. A retrospective cohort study was conducted utilizing the electronic medical records of children 3-18 years of age with migraine, who were evaluated at a tertiary care children’s hospital from 2016-2018. Of the 849 patients that met the study criteria, 469 were classified as having chronic migraine or high-frequency episodic migraine and were followed …