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Author Correction: Short Amylin Receptor Antagonist Peptides Improve Memory Deficits In Alzheimer’S Disease Mouse Model, Rania Soudy, Ryoichi Kimura, Aarti Patel, Wen Fu, Kamaljit Kaur, David Westaway, Jing Yang, Jack Jhamandas 2022 University of Alberta

Author Correction: Short Amylin Receptor Antagonist Peptides Improve Memory Deficits In Alzheimer’S Disease Mouse Model, Rania Soudy, Ryoichi Kimura, Aarti Patel, Wen Fu, Kamaljit Kaur, David Westaway, Jing Yang, Jack Jhamandas

Pharmacy Faculty Articles and Research

Correction to: Scientific Reports https://doi.org/10.1038/s41598-019-47255-9, published online 29 July 2019

The original Article contained an error in Figure 1A where the control trace for both the HEK-AMY3 and HEKWT cells was duplicated...

The original Article has been corrected.


Toxic Shock Syndrome Toxin-1 (Tsst-1) More Prevalent In Staphylococcus Aureus Strains Taken From Men Than From Women, Bethany Rother 2022 Concordia University, St. Paul

Toxic Shock Syndrome Toxin-1 (Tsst-1) More Prevalent In Staphylococcus Aureus Strains Taken From Men Than From Women, Bethany Rother

Research and Scholarship Symposium Posters

S. aureus is an opportunistic bacteria present in the anterior nares of roughly one third of the human population. One of the toxins certain strains are known to produce is toxic shock syndrome toxin 1 (TSST-1). This can cause both menstrual and non-menstrual toxic shock syndrome (TSS), but is more widely known for the menstrual variation due to the high onset of TSS in women from high absorbency tampons in the 1980s. An analysis of survey data found that surprisingly more men carried S. aureus strains with the TSST-1 gene than women.


Staphylococcus Aureus Isolates From People That Use Antibacterial Soap Have A Higher Percentage Of Penicillin Resistance, Xou Xiong 2022 Concordia University, St. Paul

Staphylococcus Aureus Isolates From People That Use Antibacterial Soap Have A Higher Percentage Of Penicillin Resistance, Xou Xiong

Research and Scholarship Symposium Posters

The Staph Study at CSP aims to identify bacteria from voluntary students. Swabs of bacteria were collected and cultured. Then, a series of tests were performed to identify the type of bacteria present. It was found that 8 of 12 strains collected were Staphylococcus aureus because of the presence of bubbles, light halos, purple clustered bacteria, dark purple halos, and agglutination.


Quadruped Gait And Regulation Of Apoptotic Factors In Tibiofemoral Joints Following Intra-Articular Rhprg4 Injection In Prg4 Null Mice, Daniel S. Yang, Edward E. Dickerson, Ling X. Zhang, Holly Richendrfer, Padmini N. Karamchedu, Gary A. Badger, Tannin A. Schmidt, Alger M. Fredericks, Khaled A. Elsaid, Gregory D. Jay 2022 Brown University

Quadruped Gait And Regulation Of Apoptotic Factors In Tibiofemoral Joints Following Intra-Articular Rhprg4 Injection In Prg4 Null Mice, Daniel S. Yang, Edward E. Dickerson, Ling X. Zhang, Holly Richendrfer, Padmini N. Karamchedu, Gary A. Badger, Tannin A. Schmidt, Alger M. Fredericks, Khaled A. Elsaid, Gregory D. Jay

Pharmacy Faculty Articles and Research

Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome leads to diarthrodial joint arthropathy and is caused by the absence of lubricin (proteoglycan 4—PRG4), a surface-active mucinous glycoprotein responsible for lubricating articular cartilage. In this study, mice lacking the orthologous gene Prg4 served as a model that recapitulates the destructive arthrosis that involves biofouling of cartilage by serum proteins in lieu of Prg4. This study hypothesized that Prg4-deficient mice would demonstrate a quadruped gait change and decreased markers of mitochondrial dyscrasia, following intra-articular injection of both hindlimbs with recombinant human PRG4 (rhPRG4). Prg4−/− (N = 44) mice of both sexes were injected with rhPRG4 …


Good Cop/Bad Cop: A Comparative Analysis Of Affiliative And Aggressive Behaviors By Adult Female And Male Olive Baboons With Infants At Randilen Wildlife Management Area, Tanzania, Jesse Elop 2022 SIT Study Abroad

Good Cop/Bad Cop: A Comparative Analysis Of Affiliative And Aggressive Behaviors By Adult Female And Male Olive Baboons With Infants At Randilen Wildlife Management Area, Tanzania, Jesse Elop

Independent Study Project (ISP) Collection

This study investigated the infant-directed behaviors of adult male and female olive baboons in Randilen Wildlife Management Area in April of 2022. The objectives were 1) To determine the difference between olive baboon males and females in frequency and duration of listed behaviors towards infants; 2) To classify the interactions of adult male and adult female olive baboons with infants as either primarily affiliative or primarily aggressive; 3) To determine the frequency of selected behaviors at different reproductive phases (lactation, estrus, neutral, indeterminant) amongst female olive baboons towards infants. A single baboon troop in Randilen Wildlife Management Area was observed …


A Quantitative Study Of Orchids And Their Proximate Environments Over An Elevational Gradient On The Northern Slope Of Montagne D’Ambre, Hazel Schrader 2022 SIT Study Abroad

A Quantitative Study Of Orchids And Their Proximate Environments Over An Elevational Gradient On The Northern Slope Of Montagne D’Ambre, Hazel Schrader

Independent Study Project (ISP) Collection

This research investigated change in orchid populations and their proximate environments on the Northern slope of Montagne d’Ambre, a subhumid forest in Northern Madagascar. Orchid density, way of life (epiphyte or terrestrial), phenology, and associations were recorded over 100m elevation gradients and between forest types (primary, secondary, dry, and humid forests at the same altitude). Additionally, orchid preferences for certain heights in the forest and DBH of host trees were analyzed. The establishment of 50X20m plots in 100m elevation gradients combined with ground survey yielded significant results demonstrating change along with elevation as well as forest types. Orchid density increased …


The Relationship Between Substrate Composition, Community Structure And Feeding Preferences Of Parrot Fishes (Scaridae) In Anmardub, Guna Yala Coastal Reefs, Caitlin Amman 2022 SIT Study Abroad

The Relationship Between Substrate Composition, Community Structure And Feeding Preferences Of Parrot Fishes (Scaridae) In Anmardub, Guna Yala Coastal Reefs, Caitlin Amman

Independent Study Project (ISP) Collection

Coral reefs are important marine ecosystems, as they support biodiversity and generate buffer zones, yet their abundance is incredibly limited globally. One of the main threats that coral reefs face is excessive macroalgal coverage, which limits sunlight from reaching corals, and thus, limits the energy that can reach them. Parrot fish (Scaridae) are keystone herbivores, as they consume macroalgae growing on corals, which aids in reef survivability. While there is previous research on the abundances, sizes, and feeding habits of Scaridae species in the Caribbean, there is no published research on how community structure and feeding preferences of parrot fishes …


Assessing The Threat Of Coral Decline On Fish Diversity In Response To Temperature, Ryland Talmadge 2022 SIT Study Abroad

Assessing The Threat Of Coral Decline On Fish Diversity In Response To Temperature, Ryland Talmadge

Independent Study Project (ISP) Collection

Misali, a PECCA-protected island off the east coast of Pemba, Tanzania, is considered to be a marine biodiversity hotspot with a protected Non-Extractive Zone (NEZ) and remaining Extractive Zone (EZ). Upon protection, the island’s fringe reefs faced severe coral bleaching during the 1998 bleaching event, estimated to kill up to 70% of corals. Since the event, several others have occurred in addition to restructuring the management plan in 2006 to expand the region to 1000km. While the damage from the most recent coral bleaching event in 2020 has yet to be surveyed, this study investigates the current reef health in …


Behavioral And Physiological Effects Of Heavy Metals On Fish: A Review And Preliminary Results, Diana V. Morales 2022 CUNY Hunter College

Behavioral And Physiological Effects Of Heavy Metals On Fish: A Review And Preliminary Results, Diana V. Morales

Theses and Dissertations

Pollution, specifically heavy metal pollution, in various bodies of water has been a significant issue for decades. Research has been conducted on heavy metals and their effects on the environment, larger fish species, and humans since the 1970s (Skidmore, 1964; Adeniyi et al., 2007; Adeosun et al., 2015; Bawuro et al., 2018). It is known that zinc is a neurotoxin in some species and causes harm to the environment. It is also known that it causes harm to people if it is ingested or if they are exposed to it for long periods of time (Mahurpawar, 2015; Mizuno and Kawahara, …


Soy Formula Is Not Estrogenic And Does Not Result In Reproductive Toxicity In Male Piglets: Results From A Controlled Feeding Study, Martin J.J. Ronis, Horacio Gomez‐acevedo, Kartik Shankar, Leah Hennings, Neha Sharma, Michael L. Blackburn, Isabelle Miousse, Harry Dawson, Celine Chen, Kelly E. Mercer, Thomas M. Badger 2022 LSU Health Sciences Center - New Orleans

Soy Formula Is Not Estrogenic And Does Not Result In Reproductive Toxicity In Male Piglets: Results From A Controlled Feeding Study, Martin J.J. Ronis, Horacio Gomez‐Acevedo, Kartik Shankar, Leah Hennings, Neha Sharma, Michael L. Blackburn, Isabelle Miousse, Harry Dawson, Celine Chen, Kelly E. Mercer, Thomas M. Badger

School of Graduate Studies Faculty Publications

Soy infant formula which is fed to over half a million infants per year contains isoflavones such as genistein, which have been shown to be estrogenic at high concentrations. The developing testis is sensitive to estrogens, raising concern that the use of soy formulas may result in male reproductive toxicity. In the current study, male White‐Dutch Landrace piglets received either sow milk (Sow), or were provided milk formula (Milk), soy formula (Soy), milk formula supplemented with 17‐beta‐estradiol (2 mg/kg/d) (M + E2) or supplemented with genistein (84 mg/L of diet; (M + G) from postnatal day 2 until day 21. …


Mytrials: Clinical Trial Application Concept, Katie Hollister 2022 California Polytechnic State University, San Luis Obispo

Mytrials: Clinical Trial Application Concept, Katie Hollister

Graphic Communication

A clinical trial’s success is dependent upon whether a patient attends their highly-structured clinical trial visit schedule, which may include both in-person clinic visits and virtual check-in visits. MyTrials is a clinical trial journey app prototype that enables patients to schedule, reschedule, and attend join their in-person or virtual clinic visits. This product seeks to reduce the burden that scheduling places on the patient, and provides trial-provided resources and a daily and weekly timeline to help patients navigate their clinical trial journey.


A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance And Efflux Of Sucrose And Mannitol After Iv Injection In Awake Mice, Behnam Noorani, Ekram Ahmed Chowdhury, Faleh Alqahtani, Md Sanaullah Sajib, Yeseul Ahn, Ehsan Nozohouri, Dhavalkumar Patel, Constantinos Mikelis, Reza Mehvar, Ulrich Bickel 2022 Texas Tech University Health Sciences Center

A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance And Efflux Of Sucrose And Mannitol After Iv Injection In Awake Mice, Behnam Noorani, Ekram Ahmed Chowdhury, Faleh Alqahtani, Md Sanaullah Sajib, Yeseul Ahn, Ehsan Nozohouri, Dhavalkumar Patel, Constantinos Mikelis, Reza Mehvar, Ulrich Bickel

Pharmacy Faculty Articles and Research

Purpose

To evaluate a three-compartmental semi-physiological model for analysis of uptake clearance and efflux from brain tissue of the hydrophilic markers sucrose and mannitol, compared to non-compartmental techniques presuming unidirectional uptake.

Methods

Stable isotope-labeled [13C]sucrose and [13C]mannitol (10 mg/kg each) were injected as IV bolus into the tail vein of awake young adult mice. Blood and brain samples were taken after different time intervals up to 8 h. Plasma and brain concentrations were quantified by UPLC-MS/MS. Brain uptake clearance (Kin) was analyzed using either the single-time point analysis, the multiple time point graphical method, …


Cilia Proteins Are Biomarkers Of Altered Flow In The Vasculature, Ankan Gupta, Karthikeyan Thirugnanam, Madhan Thamilarasan, Ashraf M. Mohieldin, Hadeel T. Zedan, Shubhangi Prabhudesai, Meghan R. Griffin, Andrew D. Spearman, Amy Pan, Sean P. Palecek, Huseyin C. Yalcin, Surya M. Nauli, Kevin R. Rarick, Rahima Zennadi, Ramani Ramchandran 2022 Medical College of Wisconsin

Cilia Proteins Are Biomarkers Of Altered Flow In The Vasculature, Ankan Gupta, Karthikeyan Thirugnanam, Madhan Thamilarasan, Ashraf M. Mohieldin, Hadeel T. Zedan, Shubhangi Prabhudesai, Meghan R. Griffin, Andrew D. Spearman, Amy Pan, Sean P. Palecek, Huseyin C. Yalcin, Surya M. Nauli, Kevin R. Rarick, Rahima Zennadi, Ramani Ramchandran

Pharmacy Faculty Articles and Research

Cilia, microtubule-based organelles that project from the apical luminal surface of endothelial cells (ECs), are widely regarded as low-flow sensors. Previous reports suggest that upon high shear stress, cilia on the EC surface are lost, and more recent evidence suggests that deciliation—the physical removal of cilia from the cell surface—is a predominant mechanism for cilia loss in mammalian cells. Thus, we hypothesized that EC deciliation facilitated by changes in shear stress would manifest in increased abundance of cilia-related proteins in circulation. To test this hypothesis, we performed shear stress experiments that mimicked flow conditions from low to high shear stress …


Characterization Of Site-Specific Vegetation Activity In Alaskan Wet And Dry Tundra As Related To Climate And Soil State, Michael Gregory Brown, Kyle C. McDonald, Reiner Zimmermann, Nicholas Steiner, Stephanie DeVries, Laura Bourgeau-Chavez 2022 City College of New York

Characterization Of Site-Specific Vegetation Activity In Alaskan Wet And Dry Tundra As Related To Climate And Soil State, Michael Gregory Brown, Kyle C. Mcdonald, Reiner Zimmermann, Nicholas Steiner, Stephanie Devries, Laura Bourgeau-Chavez

Michigan Tech Publications

We present discrete (2-h resolution) multi-year (2008–2017) in situ measurements of seasonal vegetation growth and soil biophysical properties from two sites on Alaska's North Slope, USA, representing dry and wet sedge tundra. We examine measurements of vertical active soil layer temperature and soil moisture profiles (freeze/thaw status), woody shrub vegetation physiological activity, and meteorological site data to assess interrelationships within (and between) these two study sites. Vegetation phenophases (cold de-hardening start, physiological function start, stem growth start, stem growth end, physiological function end, cold hardening completion) were found to have greater interannual day of year (DOY) occurrence variability at the …


Barriers In Surgical Research: A Perspective From The Developing World, Nadeem Ahmed Siddiqui, Muhammad Aanish Raees, Rehan Nasir Khan, Farhan Zafar 2022 Aga Khan University

Barriers In Surgical Research: A Perspective From The Developing World, Nadeem Ahmed Siddiqui, Muhammad Aanish Raees, Rehan Nasir Khan, Farhan Zafar

Department of Surgery

Research in surgery has led to significant advances over the last century in terms of how medicine is practised in and outside the operating rooms today. Surgical research in the developed countries is responsible for most of this advancement, but it is often inapplicable in resource-limited settings in the developing world. Lower- and middle-income countries are in a unique position to take this work further, but they are limited by certain barriers. These barriers could broadly be classified under social and cultural, infrastructure, financial, ethical, and personal categories. These barriers are often not fully realised, but can potentially be addressed …


Inhibition Of Interferon-Gamma-Stimulated Melanoma Progression By Targeting Neuronal Nitric Oxide Synthase (Nnos), Shirley Tong, Maris A. Cinelli, Naglaa Salem El-Sayed, He Huang, Anika Patel, Richard B. Silverman, Sun Yang 2022 Chapman University

Inhibition Of Interferon-Gamma-Stimulated Melanoma Progression By Targeting Neuronal Nitric Oxide Synthase (Nnos), Shirley Tong, Maris A. Cinelli, Naglaa Salem El-Sayed, He Huang, Anika Patel, Richard B. Silverman, Sun Yang

Pharmacy Faculty Articles and Research

Interferon-gamma (IFN-γ) is shown to stimulate melanoma development and progression. However, the underlying mechanism has not been completely defined. Our study aimed to determine the role of neuronal nitric oxide synthase (nNOS)-mediated signaling in IFN-γ-stimulated melanoma progression and the anti-melanoma effects of novel nNOS inhibitors. Our study shows that IFN-γ markedly induced the expression levels of nNOS in melanoma cells associated with increased intracellular nitric oxide (NO) levels. Co-treatment with novel nNOS inhibitors effectively alleviated IFN-γ-activated STAT1/3. Further, reverse phase protein array (RPPA) analysis demonstrated that IFN-γ induced the expression of HIF1α, c-Myc, and programmed death-ligand 1 (PD-L1), in contrast …


Cold Shock Induces A Terminal Investment Reproductive Response In C. Elegans, Leah Gulyas, Jennifer R. Powell 2022 Gettysburg College

Cold Shock Induces A Terminal Investment Reproductive Response In C. Elegans, Leah Gulyas, Jennifer R. Powell

Biology Faculty Publications

Challenges from environmental stressors have a profound impact on many life-history traits of an organism, including reproductive strategy. Examples across multiple taxa have demonstrated that maternal reproductive investment resulting from stress can improve offspring survival; a form of matricidal provisioning when death appears imminent is known as terminal investment. Here we report a reproductive response in the nematode Caenorhabditis elegans upon exposure to acute cold shock at 2 °C, whereby vitellogenic lipid movement from the soma to the germline appears to be massively upregulated at the expense of parental survival. This response is dependent on functional TAX-2; TAX-4 cGMP-gated channels …


Self-Conscious Emotions And The Right Fronto-Temporal And Right Temporal Parietal Junction, Adriana LaVarco, Nathira Ahmad, Qiana Archer, Matthew Pardillo, Ray Nunez Castaneda, Anthony Minervini, Julian Keenan 2022 Montclair State University

Self-Conscious Emotions And The Right Fronto-Temporal And Right Temporal Parietal Junction, Adriana Lavarco, Nathira Ahmad, Qiana Archer, Matthew Pardillo, Ray Nunez Castaneda, Anthony Minervini, Julian Keenan

Department of Biology Faculty Scholarship and Creative Works

For more than two decades, research focusing on both clinical and non-clinical populations has suggested a key role for specific regions in the regulation of self-conscious emotions. It is speculated that both the expression and the interpretation of self-conscious emotions are critical in humans for action planning and response, communication, learning, parenting, and most social encounters. Empathy, Guilt, Jealousy, Shame, and Pride are all categorized as self-conscious emotions, all of which are crucial components to one’s sense of self. There has been an abundance of evidence pointing to the right Fronto-Temporal involvement in the integration of cognitive processes underlying the …


A Nationwide Virtual Research Education Program For Medical Students In Pakistan: Methodological Framework, Feasibility Testing, And Outcomes, Ali Aahil Noorali, Maha Inam, Hamna Shahbaz, Hareem Rauf, Faiqa Binte Aamir, Farah Khalid, Saadia Abbas, Abdullah Saeed, Muhammad Daniyal Musharraf, Asma Altaf Hussain Merchant, Babar Hasan, Muneera A. Rasheed, Fyezah Jehan, Muhammad Tariq, Adil Hussain Haider 2022 Aga Khan University

A Nationwide Virtual Research Education Program For Medical Students In Pakistan: Methodological Framework, Feasibility Testing, And Outcomes, Ali Aahil Noorali, Maha Inam, Hamna Shahbaz, Hareem Rauf, Faiqa Binte Aamir, Farah Khalid, Saadia Abbas, Abdullah Saeed, Muhammad Daniyal Musharraf, Asma Altaf Hussain Merchant, Babar Hasan, Muneera A. Rasheed, Fyezah Jehan, Muhammad Tariq, Adil Hussain Haider

Medical College Documents

Introduction: Equipping young medical trainees with fundamental research skills can be a promising strategy to address the need for professionals who can understand and responsibly communicate evolving scientific evidence during a pandemic. Despite an ardent interest to partake in research, most educational institutions in Pakistan and other low-middle income countries have not yet adopted a comprehensive strategy for research skills education. The authors aimed to design and assess the feasibility of implementing the first nation-wide virtual research workshop for medical students in Pakistan.
Methods: The course "Beginners Guide to Research," designed as a nation-wide virtual research workshop series, was conducted …


Comparison Of Percutaneous Vs Oral Infection Of Hamsters With The Hookworm Ancylostoma Ceylanicum: Parasite Development, Pathology And Primary Immune Response, Richard D. Bungiro, Lisa M. Harrison, Blaise Dondji, Michael Cappello 2022 Yale University

Comparison Of Percutaneous Vs Oral Infection Of Hamsters With The Hookworm Ancylostoma Ceylanicum: Parasite Development, Pathology And Primary Immune Response, Richard D. Bungiro, Lisa M. Harrison, Blaise Dondji, Michael Cappello

Biology Faculty Scholarship

Background

Hundreds of millions of people in poor countries continue to suffer from disease caused by bloodfeeding hookworms. While mice and rats are not reliably permissive hosts for any human hookworm species, adult Golden Syrian hamsters are fully permissive for the human and animal pathogen Ancylostoma ceylanicum. Similar to humans, hamsters may be infected with A. ceylanicum third-stage larvae orally or percutaneously. Oral infection typically leads to consistent worm yields in hamsters but may not accurately reflect the clinical and immunological manifestations of human infection resulting from skin penetration.

Methodology/Principal findings

In this study we compared host responses …


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