Effects Of Electronic Cigarette Liquid Solvents Propylene Glycol And Vegetable Glycerin On User Nicotine Delivery, Heart Rate, Subjective Effects, And Puff Topography,
2018
Virginia Commonwealth University
Effects Of Electronic Cigarette Liquid Solvents Propylene Glycol And Vegetable Glycerin On User Nicotine Delivery, Heart Rate, Subjective Effects, And Puff Topography, Tory Spindle
Theses and Dissertations
Electronic cigarettes (ECIGs) are a class of tobacco products that use a heating element to aerosolize a liquid, typically containing nicotine, allowing for user inhalation. Despite their rapid growth in popularity, little is known about ECIGs including how certain device and liquid factors influence nicotine delivery, user physiological and subjective responses, and puffing behavior (puff topography). Limited pre-clinical research has demonstrated that the ratio of two solvents commonly found in ECIG liquids, propylene glycol (PG) and vegetable glycerin (VG), may have an influence on the nicotine content of ECIG aerosols. However, the extent to which PG:VG ratio in ECIG liquids …
Lorcaserin As A Potential Opioid-Sparing Adjunct,
2018
Virginia Commonwealth University
Lorcaserin As A Potential Opioid-Sparing Adjunct, Kumiko M. Lippold
Theses and Dissertations
Opioids, such as oxycodone, morphine, and fentanyl, are commonly used medications in the treatment of moderate to severe pain. In spite of their efficacious analgesic properties, their increased prescribing rates by physicians and inherent abuse-related effects have led to the ongoing opioid epidemic. Their clinical utility is limited by the risk of adverse dose-dependent side effects, such as constipation and respiratory depression, and the development of tolerance and dependence. Opioid-sparing adjunctive therapies are sought to address these issues by reducing the dose of opioid needed to achieve analgesia through alternative non-opioidergic mechanisms and as a result, reduce the incidence of …
Molecular Brain Adaptations To Ethanol: Role Of Glycogen Synthase Kinase-3 Beta In The Transition To Excessive Consumption,
2018
Virginia Commonwealth University
Molecular Brain Adaptations To Ethanol: Role Of Glycogen Synthase Kinase-3 Beta In The Transition To Excessive Consumption, Andrew D. Van Der Vaart
Theses and Dissertations
Alcoholism is a complex neuropsychiatric disease that is characterized by compulsive alcohol use and intensifying cravings and withdrawals, often culminating in physiologic dependency. Fundamental alterations in brain chemistry underlie the transition from initial ethanol exposure to repetitive excessive use. Key mediators of this adaptation include changes in gene expression and signal transduction. Here we investigated gene expression pathways in prefrontal cortex and nucleus accumbens following acute or chronic ethanol treatment, to identify genes with potentially conserved involvement in the long-term response of the corticolimbic system to repeated ethanol exposure. We investigated Gsk3b, which encodes glycogen synthase kinase 3-beta, as a …
The Development Of Novel Non-Peptide Proteasome Inhibitors For The Treatment Of Solid Tumors,
2018
University of Kentucky
The Development Of Novel Non-Peptide Proteasome Inhibitors For The Treatment Of Solid Tumors, Zachary C. Miller
Theses and Dissertations--Pharmacy
The proteasome is a large protein complex which is responsible for the majority of protein degradation in eukaryotes. Following FDA approval of the first proteasome inhibitor bortezomib for the treatment of multiple myeloma (MM) in 2003, there has been an increasing awareness of the significant therapeutic potential of proteasome inhibitors in the treatment of cancer. As of 2017, three proteasome inhibitors are approved for the treatment of MM but in clinical trials with patients bearing solid tumors these existing proteasome inhibitors have demonstrated poor results. Notably, all three FDA-approved proteasome inhibitors rely on the combination a peptide backbone and reactive …
Development And Preclinical Evaluation Of Long-Lasting Cocaine Hydrolases For Cocaine Overdose And Cocaine Use Disorder Treatment,
2018
University of Kentucky
Development And Preclinical Evaluation Of Long-Lasting Cocaine Hydrolases For Cocaine Overdose And Cocaine Use Disorder Treatment, Ting Zhang
Theses and Dissertations--Pharmacy
Cocaine is a plant-based illicit drug commonly involved in substance use disorder. Although cocaine overdose and cocaine use disorders cause adverse health consequences to individuals and the economic burden on their family and society, there are no FDA (Food and Drug Administration) approved medications for treatment. Recently, it has been recognized that delivery of cocaine hydrolase (CocH) is a promising therapeutic strategy. Human butyrylcholinesterase (hBChE), the primary enzyme involved in cocaine metabolism in human, have advantages over other candidates for the development of CocH. Previous studies in our laboratory have designed and characterized hBChE mutants that have ~4,000-fold improved catalytic …
Role Of Sex Chromosomes In Sexual Dimorphism Of Angii-Induced Abdominal Aortic Aneurysms,
2018
University of Kentucky
Role Of Sex Chromosomes In Sexual Dimorphism Of Angii-Induced Abdominal Aortic Aneurysms, Yasir Alsiraj
Theses and Dissertations--Pharmacology and Nutritional Sciences
Abdominal aortic aneurysms (AAAs), a permanent dilation in the abdominal region of the aorta, is a highly sexually dimorphic disease. AAAs prevalence is ranging from 4-10 fold higher in males than females. Defining the mechanistic basis for reduced (in females) or increased (in males) AAA formation and progression may uncover potential therapeutic targets. The majority of studies examining sexual dimorphism focus on the role of sex hormones. However, genes residing on sex chromosomes, in addition to sex hormones, may contribute to sexual dimorphism of AAAs. For example, the X chromosome contains about 5% of the whole genome, but the role …
Scalable Feature Selection And Extraction With Applications In Kinase Polypharmacology,
2018
University of Kentucky
Scalable Feature Selection And Extraction With Applications In Kinase Polypharmacology, Derek Jones
Theses and Dissertations--Computer Science
In order to reduce the time associated with and the costs of drug discovery, machine learning is being used to automate much of the work in this process. However the size and complex nature of molecular data makes the application of machine learning especially challenging. Much work must go into the process of engineering features that are then used to train machine learning models, costing considerable amounts of time and requiring the knowledge of domain experts to be most effective. The purpose of this work is to demonstrate data driven approaches to perform the feature selection and extraction steps in …
Dna Barcoding For Authentication Of The Endangered Plants In Genus Aquilaria,
2018
Chulalongkorn University
Dna Barcoding For Authentication Of The Endangered Plants In Genus Aquilaria, Worathat Thitikornpong, Chanida Palanuvej, Nijsiri Ruangrungsi
The Thai Journal of Pharmaceutical Sciences
Agarwood is a type of wood that is used in traditional Thai medicines and has been applied in several recipes; in particular, this wood is considered as a costly resinous non-wood product. However, the morphological characteristics of the plant in the ge.
Bioactivities Of Organic Riceberry Broken Rice And Crude Riceberry Rice Oil,
2018
Chulalongkorn University
Bioactivities Of Organic Riceberry Broken Rice And Crude Riceberry Rice Oil, Vijitra Luang-In, Manatchanok Yotchaisarn, Issaraporn Somboonwatthanakul, Sirirat Deeseenthum
The Thai Journal of Pharmaceutical Sciences
Objectives: Riceberry broken rice (RBR) and crude riceberry rice oil (CRO) are inevitable by-products generated from organic rice process in Thailand for several tons per year with low value. The aims of this work were to determine gamma-oryzanol content.
Effects Of Age, Hydration Level, And Cosmetic Treatment On Skin Mechanical Properties Of Thai,
2018
Chulalongkorn University
Effects Of Age, Hydration Level, And Cosmetic Treatment On Skin Mechanical Properties Of Thai, Anyarporn Tansirikongkol
The Thai Journal of Pharmaceutical Sciences
Purpose: Age and skin hydration influence skin mechanical properties. However, correlation between hydration improved by cosmetic and mechanical properties is uncertain. This study aimed to investigate the relationship between age, intrinsic skin hydrati.
Antiproliferative Effects Of Pereskiopsis Diguetii, Caralluma Speciosa And Euphorbia Ritchiei Hydroalcoholic Extract,
2018
Chulalongkorn University
Antiproliferative Effects Of Pereskiopsis Diguetii, Caralluma Speciosa And Euphorbia Ritchiei Hydroalcoholic Extract, Tossawan Jitwasinkul, Purin Charoensuksai
The Thai Journal of Pharmaceutical Sciences
To date, cancers remain to be global health problem. The toxicity and the emergence of chemotherapy resistance of currently prescribed anticancer agents highlight the need for the discovery and the development of novel anticancer drugs. The previous succ.
Development And Validation Of Hptlc And Lc Ms-Ms Method For Estimation Of Terizidone In Pharmaceutical Dosage Form,
2018
Chulalongkorn University
Development And Validation Of Hptlc And Lc Ms-Ms Method For Estimation Of Terizidone In Pharmaceutical Dosage Form, Ritesh P. Bhole, Sonali Phadke
The Thai Journal of Pharmaceutical Sciences
The estimation of Terizidone in pharmaceutical dosage form by using High Performance Thin Layer Chromatography was done using CAMAG HPTLC system. The separation was achieved using precoated silica gel 60 F254 aluminium plates with mobile phase Toluene: n.
Evaluating The Effect Of Donepezil On Depression And Obsessive–Compulsion Disorder In Mice Models And Proposing The Mechanism Involved,
2018
Chulalongkorn University
Evaluating The Effect Of Donepezil On Depression And Obsessive–Compulsion Disorder In Mice Models And Proposing The Mechanism Involved, Azadeh Mesripour, Valiollah Hajhashemi, Shahrzad Rezaie
The Thai Journal of Pharmaceutical Sciences
Introduction: Considering that donepezil (DPZ) is commonly prescribed for Alzheimer's disease patients, the aim of the present study was evaluating DPZ antidepressant effect and introducing the possible mechanism. Therefore nicotinic (mecamylamine) and m.
Anti-Hyperglycemic Effect And Subchronic Toxicity Of The Combined Extract From Sattagavata- Mathurameha -Tubpikarn Anti-Diabetic Herbal Formulae,
2018
Chulalongkorn University
Anti-Hyperglycemic Effect And Subchronic Toxicity Of The Combined Extract From Sattagavata- Mathurameha -Tubpikarn Anti-Diabetic Herbal Formulae, Penchom Peungvicha
The Thai Journal of Pharmaceutical Sciences
The three herbal formulae (Sattagavata, Mathurameha, Tubpikarn) were prescribed to diabetic patients for a long times and they included Sattagavata for circulatory system promotion, Mathurameha for diabetics and Tubpikarn for hepatoprotection with less s.
Under The Influence: An Interdisciplinary Approach To Psychedelics,
2018
Rollins College
Under The Influence: An Interdisciplinary Approach To Psychedelics, Jody Roun
Master of Liberal Studies Theses
The following research will outline the effects of psychedelics from an interdisciplinary approach, which is to say that I will explore the neuroscience behind psychedelic drugs and how it relates to creativity, as a primary focus, while examining the role of additional points included along the way. The goal of this research, is to gain a deeper understanding of psychedelics and truly decipher what it means to be under the influence, as the most important goal of this human existence is to achieve understanding. The aforementioned is a point that great minds like Albert Einstein and Humphry Osmond impressed on …
Regulatory Issues Concerning The Preclinical Testing Of Synthetic Peptides,
2018
Eastern Michigan University
Regulatory Issues Concerning The Preclinical Testing Of Synthetic Peptides, Vamsi Vardhan Niraghatam
Master's Theses and Doctoral Dissertations
Any new drug or biological product undergoes rigorous testing in animals and humans for review by the United States Food and Drug Administration (FDA) before it becomes available for human use. A sponsor files an investigational new drug (IND) application with the FDA with supporting animal data, after which testing is continued with humans. There is sufficient guidance from the FDA on new small molecules and biological products as to which preclinical studies are to be conducted. Synthetic peptides present a unique scenario in which a case-by-case approach is needed for the conduct of preclinical studies. For peptides containing components …
Design, Synthesis And Biological Evaluation Of Inhibitors Against Both Human And Mouse Microsomal Prostaglandin E2 Synthase-1 Enzymes,
2018
University of Kentucky
Design, Synthesis And Biological Evaluation Of Inhibitors Against Both Human And Mouse Microsomal Prostaglandin E2 Synthase-1 Enzymes, Kai Ding
Theses and Dissertations--Chemistry
As the principal pro-inflammatory prostanoid, prostaglandin E2 (PGE2) serves as mediator of pain and fever in inflammatory reactions. The biosynthesis of PGE2 starts from arachidonic acid (AA). Cyclooxygenase (COX)-1 and/or COX-2 converts AA to prostaglandin H2 (PGH2), and PGE2 synthases transform PGH2 to PGE2. Current mainstream approach for treating inflammation-related symptoms remains the application of traditional non-steroidal anti-inflammatory drugs (tNSAIDs) and selective COX-2 inhibitors (coxibs). As both categories shut down the biosynthesis of all downstream prostanoids, their application renders several deleterious effects including gastrointestinalulceration and cardiovascular risk. Microsomal prostaglandin …
Validated Thin-Layer Chromatography-Densitometric Method For Simultaneous Determination Of Piperine And Plumbagin In “Benjakul” Thai Polyherbal Formulation And Its Antioxidant Activities,
2018
Chulalongkorn University
Validated Thin-Layer Chromatography-Densitometric Method For Simultaneous Determination Of Piperine And Plumbagin In “Benjakul” Thai Polyherbal Formulation And Its Antioxidant Activities, Savita Chewchinda, Pattamapan Lomarat, Pongtip Sithisarn
The Thai Journal of Pharmaceutical Sciences
The purpose of this study was to evaluate antioxidant activity and quantitative analysis of piperine and plumbagin content in “Benjukul (BEN)” Thai polyherbal formulation by TLC densitometric method. BEN was recognized in the list of herbal medicinal...
Antihypercholesterol Activity Of Costus Speciosus Water Extract,
2018
Chulalongkorn University
Antihypercholesterol Activity Of Costus Speciosus Water Extract, Hari Susanti, Subagus Wahyuono, Ratna Asmah Susidarti, Ika Puspita Sari
The Thai Journal of Pharmaceutical Sciences
Hypercholesterol is one of cause of cardiovascular disease. Costus speciosus is known empirically as an antihypercholesterol remedy. The study was conducted to determine the effect of water extract of Costus speciosus (CS) on cholesterol blood serum leve.
Characterization Of Lactic Acid Producing Bacillus Coagulans Strains With Their Antibacterial Activity And L-Lactic Acid Production,
2018
Chulalongkorn University
Characterization Of Lactic Acid Producing Bacillus Coagulans Strains With Their Antibacterial Activity And L-Lactic Acid Production, Vasana Tolieng
The Thai Journal of Pharmaceutical Sciences
Objectives: Screening of antibacterial activity, identification, and L-lactic acid production of spore forming Bacillus isolates. Materials and methods: Fourteen Bacillus isolates were characterized based on their phenotypic characteristics and 16SrRNA .
