Pharmacology Commons^™

A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer, Mary Elizabeth Irwin

Wayne State University Dissertations

Breast cancer can be divided into genetic sub-types including luminal, HER2+, and basal-type. With the introduction of targeted therapies against estrogen receptor and HER2 receptor mortality rates of American women with breast cancer have declined. Unfortunately, basal-type breast cancers, which have the worst clinical outcome, do not express estrogen receptor or HER2, and as such, have no targeted therapeutic option. The epidermal growth factor receptor is an attractive target for therapeutics in basal-type breast cancer, as it is over-expressed in 60% of these cases. Also, over-expression of EGFR correlates with poor patient prognosis. Unfortunately, inhibitors of EGFR have shown little …

Studies Of Antioxidant And Angiotensin Converting Enzyme Inhibitory Activity Of Orthosiphon Stamineus (Misai Kucing)., Che Wan Imanina Che Wan Takwa

Student Works (2010-2019)

Abstract NA

Studies On The Bioactive Properties Of Selected Plant And Fermented Extracts., Saravana Kumar Sinniah

Student Works (2010-2019)

The aim of this study was to isolate protein/peptide and secondary metabolites from plant and fermented sources. The extracts were used to test for antimicrobial and antioxidant properties. In the current study protein/peptide extracts of Allium sativum showed promising results with a 15mm inhibition zone against Escherichia coli, 28mm against Staphylococcus aureus, 16.3mm against Bacillus cereus and 9mm against Pseudomonas aeruginosa. The minimum bacteriocidal concentration (MBC) results showed that Allium sativum protein/peptide extract is only bacteriostatic and not bacteriocidal. Andrographis paniculata showed the most promising result for the ethanolic extracts with an inhibition zone of 14mm against B. cereus, 11.5mm …

Bioactivity And Chemical Investigations Of Pereskia Bleo And Pereskia Grandifollia., Sim Kae Shin

Student Works (2010-2019)

Ethnopharmacological data has been one of the common useful criteria in drug discovery. Pereskia bleo and Pereskia grandifolia (Cactaceae), commonly known as ‘Jarum Tujuh Bilah’ in Malay and ‘Cak Sing Cam’ in Chinese have long been used as natural remedies in Malaysia. The experimental approach in the present study was based on bioassay-guided fractionation. The crude methanol and fractionated extracts of both Pereskia spp. were initially investigated for their biological activities such as antioxidant, antimicrobial and cytotoxic effect against five human cancer cell lines, namely nasopharyngeal epidermoid carcinoma cell line (KB), cervical carcinoma cell line (CasKi), colon carcinoma cell line …

Studies On Formulation Development Of Apoorly Water - Soluble Drug Through Solid Dispersion Technique, Sunita Dahiya

The Thai Journal of Pharmaceutical Sciences

An attempt has been made to enhance dissolution of aceclofenac (AC) by solid dispersion technique using water soluble carriers PEG 6000 and β-cyclodextrin (β-CD). Solid dispersions of AC with PEG 6000 were prepared by melting solvent method and with β...

Author Index, Keyword Index, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Micelle Enhanced Spectrofluorimetric Method For The Determination Of Ofloxacin And Lomefloxacin In Human Urine And Serum, Kuldeep Kaur, Baldev Singh, Ashok Kumar Malik

The Thai Journal of Pharmaceutical Sciences

A spectrofluorimetric method for the determination of two fluoroquinolone drugs, ofloxacin and lomefloxacin in biological fluids has been developed. The method is based on native fluorescence of these drugs in micellar medium of sodium dodecyl sulfate (S...

Simultaneous Spectrophotometric Determination Of Iron (Ii) And Copper (Ii) In Tablets By Chemometric Methods, Melisew Tadele Alula, Abdel-Maaboud I., Adnan A. Bekhit

The Thai Journal of Pharmaceutical Sciences

The significant spectral overlap (Di)0.5 = 0.5667 which is about 75.3% overlapping of the UV/Visible absorption spectra of iron (II) and copper (II) complexes necessitates chemometric assisted methods for simultaneous analysis of these ions in the pharma...

Spectroscopic Study Of The Inhibition Of Calcium Oxalate Calculi By Larrea Tridentata, Luis Alonso Pinales

Open Access Theses & Dissertations

The causes of urolithiasis include such influences as diet, metabolic disorders, and genetic factors which have been documented as sources that aggravate urinary calculi depositions and aggregations, and, implicitly, as causes of urolithiasis. This study endeavors to detail the scientific mechanisms involved in calcium oxalate calculi formation, and, more importantly, their inhibition under growth conditions imposed by the traditional medicinal approach using the herbal extract, Larrea tridentata. The calculi were synthesized without and with Larrea tridentata infusion by employing the single diffusion gel technique. A visible decrease in calcium oxalate crystal growth with increasing amounts of Larrea tridentata herbal infusion …

Gabab Regulation Of Methamphetamine-Induced Associative Learning, Robin Michelle Voigt

Dissertations

Addiction is a chronic, relapsing disorder for which strikingly few effective therapies exist, and there are no FDA-approved pharmacotherapies for methamphetamine (Meth) addition. There is an immense need to identify the neurobiological underpinnings of psychostimulant addiction and develop efficacious drug therapies to compliment the current mainstay treatment of behavioral/cognitive therapy.

Re-exposure to cues associated with psychostimulants (e.g., drug paraphernalia) increase neuronal activity and can elicit drug-craving and -seeking; an effect which is profound and long-lasting. A mechanism to disrupt those brain processes which are necessary to maintain the association may reduce the incidence of cue-elicited relapse.

Conditioned place preference (CPP) …

Antitumour Activities Of Some Schiff Bases Derived From Benzoin, Salicylaldéhyde, Amino Phenol And 2,4 Dinitrophenyl Hydrazine, M. Jesmin, M.M. Ali, J.A. Khanam

The Thai Journal of Pharmaceutical Sciences

Three schiff bases PDH [N-(1-phenyl-2-hydroxy-2phenyl ethyledine)-2', 4' dinitrophenyl hydrazine], PHP [N-(1 -phenyl, 2-hydroxy-2-phenyl ethylidine)-2' hydroxy phenyl imine] and HHP [N-(2-hydroxy benzylidine)-2' hydroxy phenyl imine] have been studied ag...

Antioxidant And Neuroprotective Effects Of Standardized Extracts Of Mangifera Indica Leaf, Kanistha Kawpoomhae, Monrudee Sukma, Tanasait Ngawhirunpat, Praneet Opanasopit, Areerut Sripattanaporn

The Thai Journal of Pharmaceutical Sciences

Standardized methanol and aqueous extracts of Mangifera indica L. (mango) leaf were analyzed for antioxidant and neuroprotective activities. Antioxidant activities were evaluated by 2, 2-azinobis 3-ethylbenzothiazoline 6-sulfonate (ABTS), 1,1-diphenyl-2-...

Comparative Study Of Extraction, Purification And Estimation Of Bromelain From Stem And Fruit Of Pineapple Plant, S. S. Gautam, S. K., V. Dash, Amit K. Goyal, G. Rath

The Thai Journal of Pharmaceutical Sciences

Bromelain is a major proteinase, isolated from pineapple (Ananas comosus). In the plant, bromelain is accumulated in the entire plant to different extent and properties depending on its source. The objective of present study was to compare the amount and...

Patients’ Opinion And Practice Toward Unused Medication Disposal In Malaysia : A Qualitative Study, Redhwan Ahmed Al-Naggar, Adel Alareefi

The Thai Journal of Pharmaceutical Sciences

This study was conducted to explore the opinion and practice toward disposal of unused medication among patients in Malaysia. An in-depth interview conducted during the period from December 2009 until February 2010. A total of 28 patients participated in...

Biopharmaceuticals: An Overview, Bhupinder Singh Sekhon

The Thai Journal of Pharmaceutical Sciences

Biopharmaceuticals drugs structurally mimics compounds found within the body and are produced using biotechnologies. These have the potential to cure diseases rather than merely treat symptoms, and have fewer side effects because of their specificity, fo...

Conjugation Of Some Nsaids With 5-Phenyl-2-Aminothiazole For Reduced Ulcerogenicity, Abhilasha Verma, Nirupam Das, Meenakshi Dhanawat, Sushant K. Shrivastava

The Thai Journal of Pharmaceutical Sciences

Analgesic drugs containing free acidic group were reacted with N, N' carbonyldiimidazole to prepare the acylimidazole derivatives. They were further reacted with 5-phenyl-2-amino thiazole nucleus to obtain the corresponding amides. All the compounds were...

Anticonvulsant Activity Of Methanolic Extract Of Clerodendron Infortunatum Linn, In Swiss Albino Mice, Sudipta Das, Pallab K., Goutam Pramanik, Siva P. Panda, Samit Bera

The Thai Journal of Pharmaceutical Sciences

The present study was designed to investigate the anticonvulsant and sleep potentiation effect of methanolic extract of C lerodendron info rtun atum Linn. (MECI) leaves in Swiss albino mice. The anticonvulsant effect of the MECI (250, 500 mg/kg body weig...

Use Of Charge Transfer Complexation Reaction For The Spectrophotometric Determination Of Bupropion In Pharmaceuticals And Spiked Human Urine, Kanakapura Basavaiah, Sameer A. M.

The Thai Journal of Pharmaceutical Sciences

This is the first report on use of two visible spectrophotometric methods for the determination of bupropion hydrochloride (BUPH) in pharmaceuticals and spiked human urine. Bupropion is a second-generation antidepressant agent which is also used in the m...

Inhibitory Effect Of 2,5-Bis(4-Hydroxy-3-Methoxybenzylidene) Cyclopentanone On Mast Cell Histamine Mediated-Rat Paw Edema, Agung Endro Nugroho, Sardjiman, Kazutaka Maeyama

The Thai Journal of Pharmaceutical Sciences

2,5-Bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone, known as pentagamavunon-0 (PGV-0), is a benzylidene cyclopentanone analog of curcumin. This compound posses stronger pharmacological activities such as anti-inflammatory, antioxidative and antibacter...

Sensitive Ultraviolet Spectrophotometric Determination Of Quetiapine Fumarate In Pharmaceuticals, K. Basavaiah, N. Rajendraprasad, P.J. Ramesh, K.B. Vinay

The Thai Journal of Pharmaceutical Sciences

Quetiapine fumarate (QTF) is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives indicated for the treatment of schizophrenia. It is a selective monoaminergic antagonist with high affinity for the serotonin type 2 (5HT2), an...