Differentiating The Mechanistic Role And Chemotherapeutic Potential Of Src And Podoplanin In Oncogenic Transformation,
2021
Rowan University
Differentiating The Mechanistic Role And Chemotherapeutic Potential Of Src And Podoplanin In Oncogenic Transformation, Edward P. Retzbach
Graduate School of Biomedical Sciences Theses and Dissertations
There were an estimated 20 million new cancer cases worldwide in 2020, resulting in nearly 1000 deaths per hour [1]. Oral cancer exemplifies the difficulties of treating cancer patients. The first line for oral cancer treatment is surgery and radiation that can lead to patient disfigurement and decreased quality of life in cancer survivors [2-4]. Though there have been many developments in chemotherapy in the last 30 years, the 50% mortality rate associated with oral cancer has not changed [4, 5]. Longitudinal studies that track survival rates in oral cancer patients demonstrate a 3-fold reduction in patient deaths when patients …
Translating Particulate Hexavalent Chomium-Induced Chromosome Instability, Loss Of Homologous Recombination Repair And Targeting Of Rad51 From Human Lung Fibroblasts To Human Bronchial Epithelial Cells.,
2021
University of Louisville
Translating Particulate Hexavalent Chomium-Induced Chromosome Instability, Loss Of Homologous Recombination Repair And Targeting Of Rad51 From Human Lung Fibroblasts To Human Bronchial Epithelial Cells., Idoia Meaza Isusi
Electronic Theses and Dissertations
Particulate hexavalent chromium [Cr(VI)] is a well-established human lung carcinogen. RAD51, a key protein in homologous recombination repair pathway, is inhibited after prolonged exposure to Cr(VI), leading to an increase in chromosome instability after prolonged exposures in human lung fibroblasts. chromosome instability is the proposed driver of Cr(VI) carcinogenesis. Since tumors from chromate workers develop from epithelial cells, we sought to translate these findings from human bronchial fibroblasts to human bronchial epithelial cells. We hypothesized Cr(VI) inhibits RAD51 after prolonged exposure leading to an increase in chromosome instability in human bronchial epithelial cells (BEP2D). We characterized the cytotoxicity and measured …
Toxicity And Effects Of Tire Crumb Rubber In The Aquatic Environment,
2021
Clemson University
Toxicity And Effects Of Tire Crumb Rubber In The Aquatic Environment, Stephanie Laplaca
All Dissertations
Plastic materials have provided innovative solutions to society’s evolving needs and challenges. Due to their durability and resistance to degradation, plastics remain in the environment for long periods of time and can therefore be transported to many environmental compartments such as water, sediment, and biota. Microplastics (MPs) have been defined as synthetic plastic particles that have at least one dimension less than 5 mm and are insoluble in water. Microrubber (MR), a recently acknowledged sub-group of MPs, has been documented in environmental samples more recently, frequently comprising a large portion of total MPs of various samples. In South Carolina specifically, …
Providing Pesticide License Holders Ceu Credits During The Covid 19 Pandemic,
2021
Utah State University
Providing Pesticide License Holders Ceu Credits During The Covid 19 Pandemic, Michael Wierda, Cody Zesiger, Jacob Hadfield, Micheal Pace, Paige Wray
Outcomes and Impact Quarterly
USU Extension and UDAF provide continuing education units (CEUs) for pesticide license renewal. However, in 2020, face-to-face meetings were canceled due to COVID-19. Workshop cancellation left CEU seekers with limited options. In response, programming was adapted and 2,992 CEU hours were provided via online sessions.
Organizational Networking, Leadership, And Community Engagement: A Case Study Of The Revitalization Of An Impaired Watershed In Richmond, Virginia,
2021
University of Richmond
Organizational Networking, Leadership, And Community Engagement: A Case Study Of The Revitalization Of An Impaired Watershed In Richmond, Virginia, Julia L. Roller
School of Professional and Continuing Studies Nonprofit Studies Capstone Projects
Green infrastructure is a necessary component of urban environments designed to mitigate climate instability and provide healthier living environments for urban residents. Discrimination and socio-economic status are some of the determining factors in the provision of green infrastructure, availability of green spaces, and outdoor programming available in urban communities. This paper describes an exploratory case study of the partnerships between municipal and nonprofit organizations involved in the revitalization of an impaired watershed in Richmond, Virginia. Preliminary findings suggest networking between agencies and nonprofits with strong mission alignment can increase organizational capacity by sharing specialized training and resources. Success may also …
Preliminary Results Of Measurements Of Potentially Cancerogenic 1,4-Dioxane In Surface Water Of Twin Lakes Preserve, Wantagh, Ny,
2021
University at Albany, State University of New York
Preliminary Results Of Measurements Of Potentially Cancerogenic 1,4-Dioxane In Surface Water Of Twin Lakes Preserve, Wantagh, Ny, Lijo Jose Varghese
Legacy Theses & Dissertations (2009 - 2024)
1,4-dioxane is a volatile organic compound categorized by the United States Environmental Protection agency (EPA, 2017) as a possible human carcinogen potent to cause tumors in humans. Even though this compound poses significant environmental danger when it contaminates water sources, it is surprisingly less studied, and how it behaves in surface water is less understood. The biggest 1,4-dioxane plume in the United States is located in Long Island region of New York. The purpose of this study was to investigate the presence of 1,4-dioxane in surface water and document the influence of existing 1,4-dioxane plume to Twin Lakes Preserve. To …
Examining An Intersection Of Environmental Justice And Covid-19 Risk Assessment: A Review,
2021
University of Tennessee at Chattanooga
Examining An Intersection Of Environmental Justice And Covid-19 Risk Assessment: A Review, Ashley Ellis
Honors Theses
This study views the risks associated with the novel coronavirus (COVID-19) as an environmental injustice issue due to the connection between existing environmental disparities and the disproportional negative impacts brought upon by the virus. The social and health determinants attributed to those environmental disparities have traditionally been evaluated as individual risk factors, an approach that fails to gauge the complexity of an environmental injustice issue. This study employs the emerging theory of intersectionality, a belief that phenomena cannot be linked to one principal cause but instead an interconnected web of influences, in order to synthesize the multitude of factors believed …
Characterizing The Role Of Macrophages In Cisplatin-Induced Kidney Injury And Progression To Chronic Kidney Disease.,
2021
University of Louisville
Characterizing The Role Of Macrophages In Cisplatin-Induced Kidney Injury And Progression To Chronic Kidney Disease., Sophia M. Sears
Electronic Theses and Dissertations
Cisplatin is a commonly used chemotherapeutic for treatment of many solid-organ cancers. Unfortunately, 30% of patients treated with cisplatin develop acute kidney injury (AKI), and even patients who do not develop AKI are at risk for long term declines in kidney function and development of chronic kidney disease (CKD). While traditional rodent toxicity studies have utilized a single, lethal dose of cisplatin, new models of cisplatin-induced kidney injury have revealed that repeated, low doses of cisplatin lead to development of kidney fibrosis. This model can be used to examine AKI-to-CKD transition processes. C57BL/6 mice are one of the most used …
The Role Of Sphingolipids In Aki And The Progression To Ckd: Potential Therapuetic Targets.,
2021
University of Louisville
The Role Of Sphingolipids In Aki And The Progression To Ckd: Potential Therapuetic Targets., Nicholas A. Hoffman
Electronic Theses and Dissertations
Acute Kidney Injury (AKI) is most simply defined as a rapid decline in kidney function over a period of hours to days. There is currently a lack of effective treatment options for patients with AKI, highlighting the need to identify new therapeutic targets. Sphingolipids play a number of roles in different models of AKI, suggesting they could be promising future targets for treating kidney injury. Specifically, sphingosine-1-phosphate (S1P) and its receptors (S1PRs) have been implicated in numerous inflammatory disorders and models of AKI. The purpose of this review is to better characterize the role of S1P receptors in models of …
New Titanate Bioceramic Nanomaterials For Drug Delivery And Controlled Release,
2021
University of Arkansas, Fayetteville
New Titanate Bioceramic Nanomaterials For Drug Delivery And Controlled Release, Seaab Imad Sahib
Graduate Theses and Dissertations
Nanomaterials have attracted much attention for biomedical applications due to their unique characteristics that are proven to be potential in cell sensing, drug delivery, biological membrane penetration, biocompatibility, and tissue adhesion. The outcomes of this dissertation presented in chapter III-V mainly discuss new approaches in drug delivery, cellular uptake improvement, and neuronal regeneration and protection using a well-optimized titanium-based nanomaterial. In particular, Chapter III summarizes the impact of two different versions of the titanate nanowires on ameliorating the delivery of the antimicrobial and anticancer drug in vitro. Those drugs were loaded on the surface of the fabricated nanowires and characterized …
Analyzing Effectiveness Of Rainwater Harvesting On Runoff Volume Reduction A Case Study Of Harris County In Texas,
2021
Texas Southern University
Analyzing Effectiveness Of Rainwater Harvesting On Runoff Volume Reduction A Case Study Of Harris County In Texas, Elaheh Roohbakhsh Farahati
Theses (2016-Present)
This study presents an analysis of the effectiveness of the RainWater Harvesting (RWH) system as a decentralized stormwater management system in a neighborhood scale to reduce runoff volume flows to stormwater drainage systems. For this purpose, a fit between modeled and recorded runoff during a 10-year time frame (2010 - 2019) for a considered rainfall gage station within a specific watershed was calculated. The densely populated neighborhood in Gulfton, in the city of Houston and which is located within the 100- or 500-year floodplain, was selected for this analysis. Daily water balance simulation was executed, without RWH tank and then …
Socio-Economic And Environmental Issues: Implications For Food Security In Nigeria,
2021
Covenant University
Socio-Economic And Environmental Issues: Implications For Food Security In Nigeria, Isaiah O. Olurinola, Evans Osabuohien
Economic and Financial Review
Socio-economic activities within the agricultural sector have witnessed significant changes in recent times. Two major factors account for this recent development. Available evidence shows that over the last four decades, environmental challenges (such as pollution, extreme weather, fire disaster and deforestation, among others) have been on the increase in Nigeria. This is complicated by a weak institutional framework to stem the tide (Egbetokun et al., 2018; 2020). Also, the information from Nigeria Meteorological Agency (NIMET) shows that the annual mean climatic conditions (that is rainfall and temperature) in Nigeria have witnessed huge variation (NIMET, 2020; Egbetokun et al., 2020), which …
Development And Validation Of A Method For The Determination Of Designer Benzodiazepines In Hair By Liquid Chromatography Tandem Mass Spectrometry (Lc-Ms/Ms),
2021
CUNY John Jay College
Development And Validation Of A Method For The Determination Of Designer Benzodiazepines In Hair By Liquid Chromatography Tandem Mass Spectrometry (Lc-Ms/Ms), Laura C. Defreitas
Student Theses
In recent years, new designer benzodiazepines have become a challenge in forensic toxicology. These substances are analogues of the classic benzodiazepines, but their pharmacology is not well known, and many of them have been associated with overdoses and deaths. As a result, there has been a surge in efforts to develop ways to accurately test for these compounds in different biological matrices. This study focused to develop and validate a method for determining 17 new designer benzodiazepines in hair by liquid chromatography tandem mass spectrometry (LC-MS/MS). Hair samples were decontaminated, pulverized, and 20 mg of the sample was incubated in …
Cardenolide, Potassium, And Pyrethroid Insecticide Combinations Reduce Growth And Survival Of Monarch Butterfly Caterpillars (Lepidoptera: Nymphalidae),
2021
University of Nebraska-Lincoln
Cardenolide, Potassium, And Pyrethroid Insecticide Combinations Reduce Growth And Survival Of Monarch Butterfly Caterpillars (Lepidoptera: Nymphalidae), Annie J. Krueger, Emily A. Robinson, Thomas J. Weissling, Ana M. Vélez, Troy D. Anderson
Department of Entomology: Faculty Publications
The monarch butterfly, Danaus plexippus L., has evolved to be insensitive to milkweed cardenolides via genetic modifications of Na+/K+-ATPase. There is concern for insecticide exposures near agriculture, with little information on monarch caterpillar toxicology. It is unclear how cardenolide insensitivity may affect the sensitivity of monarch caterpillars to pyrethroid insecticides. Additionally, potassium fertilizers may affect monarch caterpillar physiology and cardenolide sequestration. Here, we investigated the growth, survival, and development of caterpillars exposed to the cardenolide ouabain, bifenthrin, and potassium chloride (KCl) alone and in combination. Caterpillars were either exposed to (1) ouabain from third- to fifth-instar …
Investigation Of Toxic Chemicals In Plant-Based Milk Alternatives,
2021
Texas Southern University
Investigation Of Toxic Chemicals In Plant-Based Milk Alternatives, Chukwunonso A. Anakwue
Dissertations (2016-Present)
Milk is a dietary component consumed all over the world and is known to be essential for development in children. Despite all the nutritional advantages associated with milk consumption, several issues like lactose intolerance, and high lipid content, etc., negatively affects the perception of cow milk consumption, and has grown into general health concerns. Issues with cow milk consumption drove for a healthier alternative and this led to plant-based milk alternatives (PBMA). Several studies have linked consumption of these PBMAs with other negative effects such as: allergy, poor nutrient profile and the presence of other foreign chemicals. This study’s main …
Impact Of Blood Collection Tubes In Cannabinoid Quantitative Analysis,
2021
CUNY John Jay College
Impact Of Blood Collection Tubes In Cannabinoid Quantitative Analysis, Tega E. Obruche-Akponah
Student Theses
In forensic toxicological cases, sample stability and storage are pivotal for obtaining adequate analytical results. Currently, limited information is available about the impact of different preservatives and anticoagulants present in the blood tubes used in the collection of blood samples containing cannabinoids. This study investigated the impact of sodium fluoride (gray top) and sodium citrate (blue top) blood collection tubes on the concentrations of tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN) and 5 THC metabolites (THC-OH, THC-COOH, THC-diOH, THC-glucuronide, THCCOOH-glucuronide) in whole blood samples, stored at room temperature, 4ºC and -20ºC for up to 3.5 months. The samples were extracted using …
Effects Of Exogenous Ketone Therapy On Performance, Cardiorespiration, And Seizure Genesis During Exposure To Hbo2 In The Sprague Dawley Rat,
2021
University of South Florida
Effects Of Exogenous Ketone Therapy On Performance, Cardiorespiration, And Seizure Genesis During Exposure To Hbo2 In The Sprague Dawley Rat, Nicole M. Stavitzski
USF Tampa Graduate Theses and Dissertations
Hyperbaric oxygen (HBO2) is used for clinical HBO2 therapy and in undersea and aerospace medicine. HBO2 is a humanmade extreme environment and protracted exposures can cause several adverse physiological effects on the body. For example, HBO2 increases the partial pressure of oxygen (PO2) in the body leading to redox stress. Redox stress is, in part, a cause of oxygen toxicity that manifests as seizures in its most severe form (central nervous system oxygen toxicity, CNS-OT). This dissertation focuses on strategies to be employed specifically for the warfighter breathing HBO2. Currently, the only way to prevent CNS-OT is to lower the …
A Study On The Efficacy Of A Naloxone Training Program,
2021
Lehigh Valley Health Network
A Study On The Efficacy Of A Naloxone Training Program, Gillian A. Beauchamp Md, Hoonani M. Cuadrado, Seth A. Campbell Pa-C, Bennie Eliason Chw, Chase Jones Do, Aaron Fedor Do, Lauren Grantz Pharmd, Csp, Paige Roth Lsw, Marna Greenberg
Department of Emergency Medicine
Introduction: The use of naloxone to reverse a potentially fatal opioid overdose is a harm reduction strategy that reduces mortality and increases the potential for referral to substance use treatment for affected individuals. In the setting of outreach performed by a street medicine team, we aimed to determine the effectiveness of an educational intervention involving distribution of naloxone accompanied by a brief instructive session about opioids, opioid overdose, and medication administration. Methods: Our street medicine outreach team distributed 200 naloxone kits to clinicians and volunteers involved in caring for patients on ‘street rounds,’ as well as in shelters, soup kitchens, …
Race And Drug Toxicity: A Study Of Three Cardiovascular Drugs With Strong Pharmacogenetic Recommendations.,
2021
George Washington University
Race And Drug Toxicity: A Study Of Three Cardiovascular Drugs With Strong Pharmacogenetic Recommendations., Travis J. O'Brien, Kevin Fenton, Alfateh Sidahmed, April Barbour, Arthur F Harralson
Pharmacology and Physiology Faculty Publications
No abstract provided.
Quercetin Exhibits Potent Antioxidant Activity, Restores Motor And Non-Motor Deficits Induced By Rotenone Toxicity,
2021
University of Karachi, Karachi, Pakistan
Quercetin Exhibits Potent Antioxidant Activity, Restores Motor And Non-Motor Deficits Induced By Rotenone Toxicity, Syeda Madiha, Zehra Batool, Saiqa Tabassum, Laraib Liaquat, Sadia Sadir, Sidrah Shahzad, Fizza Naqvi, Sadia Saleem, Sarwat Yousuf, Saara Ahmad
Department of Biological & Biomedical Sciences
The rotenone-induced animal model of Parkinson's disease (PD) has been used to investigate the pathogenesis of PD. Oxidative stress is one of the main contributors of neurodegeneration in PD. Flavonoids have the potential to modulate neuronal function and combat various neurodegenerative diseases. The pre- and post-supplementation of quercetin (50 mg/kg, p.o) was done in rats injected with rotenone (1.5 mg/kg, s.c). After the treatment, behavioral activities were monitored for motor activity, depression-like behavior, and cognitive changes. Rats were decapitated after behavioral analysis and the brain samples were dissected out for neurochemical and biochemical estimation. Results showed that supplementation of quercetin …
