Comparative Antiscabies Efficacy Of Sonneratia Alba Extracts: Evaluation Of Plant Parts And Concentrations In Mice,
2026
Department of Biology, Faculty of Science and Technology, Universitas Islam Negeri Raden Fatah Palembang, Palembang 30252, Indonesia
Comparative Antiscabies Efficacy Of Sonneratia Alba Extracts: Evaluation Of Plant Parts And Concentrations In Mice, Delima Engga Maretha, Lara Mukti Taresha, Karina Yuliana, Iis Ariska, Silvia Diah Lestari
Makara Journal of Science
This study evaluated the antiscabies efficacy of 70% ethanol extracts from various parts of the mangrove Sonneratia alba (leaves, flowers, bark, and roots) as a potential alternative therapy. The primary objective was to compare the healing effects of the extracts at different concentrations on scabies lesions in mice (Mus musculus). Using a completely randomized design, 24 male Swiss Webster mice were assigned to four groups: a control (K0) group and three treatment groups to receive 10% (K1), 20% (K2), and 30% (K3) extract concentrations topically twice daily. The results demonstrated that the S. alba extracts had significant effects …
Effect Of Variety And Seaweed Extract Spray In The Content Of Some Medically Active Phenolic Compounds In Grape Fruits,
2026
University of Alkafeel, College of Pharmacy, Najaf, Iraq
Effect Of Variety And Seaweed Extract Spray In The Content Of Some Medically Active Phenolic Compounds In Grape Fruits, Ali Ahmed Hussein Almyali, Salim Kadhim, Ali S. Hassoon, Ameer Al Fatlawy
Al-Bahir
Grape (Vitis vinifera L.) is one of the most economically significant fruit crops which has a large adaptive range, nutrition and medicine effect. A variety of 70 types of grapes are planted on more than 11.6 million plants in Iraq, generating a total annual output of more than 421,000 tons. Increasing grape quality, and particularly the phenolic composition recently has been of major interest. Leaf nutrition – particularly seaweed extracts, being rich in amino acids, trace elements and growth promoting substances – has proved to be a potential tool to enhance plant growth and fruit biochemical quality. The …
Comparison Of Heavy Metal Accumulation In Soil And Wood Core Within Tallassee And Tuskegee, Alabama,
2026
Tuskegee University, Tuskegee, Alabama
Comparison Of Heavy Metal Accumulation In Soil And Wood Core Within Tallassee And Tuskegee, Alabama, Alicia R. Wilson, Brianna Smith, Latricia Miller, Rashidah Farid
Professional Agricultural Workers Journal
Heavy metals are natural components of the environment and can be relatively non-impactful in low concentrations. However, high concentrations of heavy metal toxicity can result in air, water, and soil contamination that adversely impacts environmental, human, and wildlife health. This study focuses on detecting the presence of heavy metals in soil, Loblolly Pine tree bark, and wood core samples from sites near a landfill in the Tallassee, Alabama, community and a post-agricultural site in Tuskegee, Alabama. It has been hypothesized that heavy metals are present in soil, tree bark, and the tree’s wood core from sampling sites. Samples were taken …
Role Of Na⁺/K⁺-Atpase And Sodium–Calcium Exchanger In Digitoxin-Induced Cytotoxicity In Triple Negative Breast Cancer Cells,
2026
Belmont University
Role Of Na⁺/K⁺-Atpase And Sodium–Calcium Exchanger In Digitoxin-Induced Cytotoxicity In Triple Negative Breast Cancer Cells, Alyson Sotomayor Quispe, Marilyn Odom Phd
SPARK Symposium Presentations
Triple Negative Breast Cancer (TNBC) is characterized by the absence of estrogen, progesterone, and HER2 receptors, limiting targeted treatment options. Digitoxin, a drug used to treat heart failure and atrial fibrillation through Na⁺/K⁺-ATPase inhibition, has demonstrated anticancer effects in TNBC cells, including apoptosis via the NF-κB pathway. This study investigates whether the Na⁺/K⁺-ATPase and sodium–calcium exchanger contribute to the mechanism of action of digitoxin in TNBC cells. We hypothesize that these transporters mediate digitoxin-induced cytotoxic effects. To test this, MDA-MB-468 cells were treated with digitoxin, and protein localization and expression were analyzed using immunofluorescence and Western blot. Digitoxin treatment resulted …
Construction Of Emerging Contaminants Risk Governance System,
2026
Institute of Environmental Resources, Food and Drug Crime Governance,People’s Public Security University of China, Beijing 100038, China; School of Criminology, People’s Public Security University of China, Beijing 100038, China
Construction Of Emerging Contaminants Risk Governance System, Cheng Li, Mingcheng Wang, Chunlei Li
Bulletin of Chinese Academy of Sciences (Chinese Version)
Emerging contaminants pose considerable risks to the ecological environment, human health, and social safety. The establishment of an emerging contaminants risk governance system constitutes a crucial component of the national ecological security strategy and the ecological civilization framework in the new era. When examined through the lens of the holistic view of national security and guided by the ecological civilization philosophy of the new era, China’s current efforts in managing emerging contaminants reveal several shortcomings—including a fragmented and incomplete risk management system, as well as preliminary stages in chemical environmental management policies and related technologies. Therefore, grounded in national conditions …
Egf Enhances Re-Epithelization In Our Ex-Vivo Pig Eye Model,
2026
University of Louisville
Egf Enhances Re-Epithelization In Our Ex-Vivo Pig Eye Model, Andrew D. Le, Lisandra Plana-Ramos, Kate Tarvestad, Brian Ceresa
The Cardinal Edge
The cornea, the foremost anterior portion of the eye, plays a critical role in vision by refracting light and serving as a protective barrier. Its three distinct layers—the outermost epithelial layer, the thick stromal layer, and the innermost endothelial layer work together to maintain corneal transparency and function. The epithelial layer is particularly susceptible to damage, which can compromise the eye’s defense against foreign particles such as bacteria and viruses, potentially leading to infection and blindness. In this study, we established an ex vivo porcine corneal model to quantitatively and qualitatively investigate corneal re-epithelialization. Using adult pig eyes sourced from …
Light As An Environmental Toxin: Impacts Of Temporal Circadian Misalignment On Physiology, Behavior, And Lifespan In Drosophila,
2026
University of Louisville
Light As An Environmental Toxin: Impacts Of Temporal Circadian Misalignment On Physiology, Behavior, And Lifespan In Drosophila, Aubrey Reitzel, Krish Patel, Breanna Beard, Dae-Sung Hwangbo
The Cardinal Edge
In the modern world, we are exposed to irregular light patterns, which can disturb circadian rhythms. Circadian rhythms are patterns of behavior that operate on a 24-hour cycle and are regulated by the interactions between external signals and the internal circadian clock, which regulates sleep/wake patterns, feeding and sleep behavior, and resistance to starvation. Little is known about the impact of misalignment of these circadian rhythms as related to dietary composition on the lifespan, behaviors, and physiological changes of Drosophila. We hypothesized that circadian misalignment would significantly reduce lifespan and alter behaviors and physiologies. In this study, mated female …
Dual-Modal Tumor Imaging Using Functionalized Iron-Oxide Nanoparticles For Mri And Fluorescence,
2026
University of South Florida
Dual-Modal Tumor Imaging Using Functionalized Iron-Oxide Nanoparticles For Mri And Fluorescence, Kevin Secades
USF Tampa Graduate Theses and Dissertations
Accurate tumor imaging is essential for early cancer detection and treatment monitoring [1]. Technetium-99m (Tc-99m) is a commonly used radioisotope for medical imaging, but its reliance on gamma-ray emission poses challenges related to safety, accessibility, and regulatory constraints[2-5]. This research proposes the development of a dual-modal imaging approach by functionalizing iron-oxide nanoparticles (IONPs) with the fluorescent chromophore Cy5, enabling both MRI contrast enhancement and optical imaging for improved tumor specificity. IONPs provide strong T2-weighted MRI contrast [6], while conjugated near-infrared (NIR) chromophores allow for high-resolution fluorescence imaging [7], making this proposed system adaptable for both in vitro and in vivo …
Impact Of Statin Medication Use On Glycemic Control And Complications In Type 1 Diabetes,
2026
University of South Florida
Impact Of Statin Medication Use On Glycemic Control And Complications In Type 1 Diabetes, Ryan Bailey
USF Tampa Graduate Theses and Dissertations
Introduction: Hydroxymethylglutaryl-CoA enzyme inhibitors (statins) are frequently used to prevent cardiovascular events in individuals at high risk for cardiovascular diseases, including individuals with diabetes. Prior research has indicated that statins may increase the risk of developing type 2 diabetes (T2D) and may increase hyperglycemia among those previously diagnosed with T2D. To date, little research has investigated the impact of statins on glycemic control and diabetic complications associated with poor glycemic control in those with type 1 diabetes (T1D). The objective of this dissertation is to investigate the association between statin use and measures of glycemic control including hemoglobin A1c (HbA1c), …
Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value,
2026
University of South Carolina
Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R Sean Norman M.Sc., Ph.D., Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge
Faculty Publications
Wastewater treatment plants (WWTPs) are key reservoirs of antibiotic resistance genes (ARGs), with municipal sludge containing high bacterial densities and diverse ARGs that may spread through land application. Hydrothermal treatment (HT) is a process that inactivates pathogens and stabilizes biomass, but its performance at moderate temperatures is less understood. We evaluated HT (100°C–250°C; 2–24 h) for degrading bacterial DNA and ARGs in dewatered municipal sludge. DNA was quantified by fluorometry, bacterial presence confirmed by 16S rRNA gene PCR, and ARGs profiled by qPCR targeting 84 clinically and environmentally relevant genes. HT up to 250°C produced modest carbon densification, high solids …
Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value,
2026
University of South Carolina
Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R. Sean Norman, Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge
Faculty Publications
Wastewater treatment plants (WWTPs) are key reservoirs of antibiotic resistance genes (ARGs), with municipal sludge containing high bacterial densities and diverse ARGs that may spread through land application. Hydrothermal treatment (HT) is a process that inactivates pathogens and stabilizes biomass, but its performance at moderate temperatures is less understood. We evaluated HT (100°C–250°C; 2–24 h) for degrading bacterial DNA and ARGs in dewatered municipal sludge. DNA was quantified by fluorometry, bacterial presence confirmed by 16S rRNA gene PCR, and ARGs profiled by qPCR targeting 84 clinically and environmentally relevant genes. HT up to 250°C produced modest carbon densification, high solids …
Seafood, Mercury, And Human Health In Coastal South Carolina: Findings From A Community-Based Study,
2026
Coastal Carolina University
Seafood, Mercury, And Human Health In Coastal South Carolina: Findings From A Community-Based Study, Russell Fielding, Julia Saltzman, Rylee-Jade Bean, Jenna Monroe, Theodore R. Them Ii
Honors College Faculty Publications
Mercury (Hg), an environmental pollutant, can harm human health. Seafood consumption is a major way that people are exposed to Hg and the analysis of human hair is a standard method to measure Hg exposure. This community-based study identified demographic and dietary factors associated with elevated Hg concentrations and health outcomes of individuals with elevated Hg concentrations throughout two coastal South Carolina (SC) counties. We collected hair samples (n = 85) at local barbershops and salons; participants completed an online survey with questions on demographics, diet, and health histories; and we analyzed hair samples using a DMA-80. Between 4.9–8.4% of …
Freshwater Quality For Recreation,
2026
Clemson University
Freshwater Quality For Recreation, Heather Nix, Masha Bokar
Forestry and Natural Resources
South Carolina has many water resources that provide tremendous opportunities for people to enjoy water-based recreational activities, such as swimming, boating, and fishing. Participation in these activities produces significant economic benefits and supports many jobs throughout the state. However, at times, water quality may be unsafe for immersion or skin contact due to high levels of pollutants, such as bacteria or cyanotoxins. It is important for people to be aware of potential concerns and understand methods for determining if a waterbody’s current conditions are likely to be safe for primary or secondary recreation.
In Vitro Pharmacological Evaluation Of Novel Cmpi Derivatives As Selective Positive Allosteric Modulators Of The Alpha4 Beta2 Nicotinic Acetylcholine Receptor,
2026
University of Texas at Tyler
In Vitro Pharmacological Evaluation Of Novel Cmpi Derivatives As Selective Positive Allosteric Modulators Of The Alpha4 Beta2 Nicotinic Acetylcholine Receptor, Josue Gaona, Nataly Sanchez, Wilder Felix, Nathalia Menegasso, Brisa Cea, Ganesh Thakur, Ayman K. Hamouda
School of Medicine Student Publications and Presentations
Nicotinic acetylcholine receptors (nAChRs) contribute to the pathogenesis of neurodegenerative diseases such as Parkinson’s disease (PD), where degeneration of dopaminergic and cholinergic neurons disrupts neurotransmission. The (α4)₃(β2)₂ nAChR subtype is expressed on affected neuronal populations and represents a promising therapeutic target. Positive allosteric modulators (PAMs) may enhance receptor function while preserving endogenous signaling. We evaluated chemical derivatives of CMPI [3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazol] as selective PAMs of (α4)₃(β2)₂ nAChRs. Two-electrode voltage-clamp recordings were performed in Xenopus laevis oocytes expressing defined receptor stoichiometries to assess potentiation and generate dose–response curves. Cytotoxicity was assessed in HEK cells using the MTT assay. Substitutions at the pyrazole …
Trophic Structure And Mercury Bioaccumulation In Walleye And Yellow Perch In The Upper And Lower Red Lake Basins,
2026
Bemidji State University
Trophic Structure And Mercury Bioaccumulation In Walleye And Yellow Perch In The Upper And Lower Red Lake Basins, Marissa Pribyl
Biology Graduate Theses
Mercury is a persistent global contaminant that biomagnifies through aquatic food webs, with dietary and environmental factors serving as the primary drivers of accumulation in fishes. Trophic structure and methylmercury dynamics in Walleye (ogaa; Sander vitreus) and Yellow Perch (asaawens; Perca flavescens) were investigated in the Upper and Lower Red Lake basins in Red Lake, Minnesota, during 2024-2025. Diets of Walleye and Yellow Perch were assessed through stomach dissections, and tissue samples from both species were analyzed for total mercury concentrations. Additional analyses included shiners (gigoozens; Notropis spp., Hudsonius spp.) along with a variety of freshwater fish and …
Comparison Of Analytical Techniques From The Extraction Of Bioactive Compounds From Kratom, Curry, Ginger, And Turmeric,
2026
University of Nebraska - Lincoln
Comparison Of Analytical Techniques From The Extraction Of Bioactive Compounds From Kratom, Curry, Ginger, And Turmeric, Riley Bruno
Honors Program: Senior Projects (Public)
Plants, herbs, and spices have been used as medicines for thousands of years. Early civilizations often attributed healing properties of plants to magical or divine forces. However, as chemistry and analytical technology advanced between the 16th and 18th centuries, scientists began to understand that bioactive compounds within the plants actually caused these effects. Today, natural products remain extremely important in drug discovery. As the number of newly developed synthetic drugs declines, there has been renewed interest in identifying biologically active molecules from plants. Bioactive molecules are a group of diverse chemical compounds that stimulate a response in living tissues. The …
Conditioned Feed Aversion As A Means Of Conditioning Livestock To Avoid Consuming Toxic Plants Growing In South Africa : An Overview,
2026
Toxicology and EVM, ARC-Onderstepoort Veterinary Institute, Private Bag X05, Onderstepoort, 0110, South Africa
Conditioned Feed Aversion As A Means Of Conditioning Livestock To Avoid Consuming Toxic Plants Growing In South Africa : An Overview, Leendert D. Snyman, Frederick D. Provenza
Poisonous Plant Research (PPR)
Significant economic losses to the livestock industry are caused by the ingestion of toxic plants in South Africa, among which the most dangerous ones are Moraea pallida (geeltulp), Urginea/Drimea sanguinea (rooislangkop), Senecio latifolius (Staggers Ragwort), and Geigeria ornativa (vermeerbos). Conditioned feed aversion is a potential means to address this issue. Treating animals with an aversive substance along with an extract of the sensory characteristics of a specific plant conditions animals to avoid the plant. Geigeria ornativa, unlike the other three plants, is non-aversive. Following treatment for aversion, the induced aversion fades with time and eventually breaks down. Continuous exposure …
Rare Presentation Of Omental Tuberculosis With Drug-Induced Jaundice In A Teenage Female: A Case Report,
2026
JKKN college of pharmacy
Rare Presentation Of Omental Tuberculosis With Drug-Induced Jaundice In A Teenage Female: A Case Report, Archana Venkatesan, Krishna Ravi
Advances in Clinical Medical Research and Healthcare Delivery
Omental tuberculosis (TB) is a rare form of abdominal TB, often presenting with nonspecific symptoms that mimic malignancies. We report a case of a 16-year-old female from India who presented with abdominal distension, vomiting, weight loss, and amenorrhea. Imaging revealed an abdominal mass, and a diagnosis of omental TB was confirmed via histopathology. This case highlights the diagnostic challenge posed by such atypical presentations, especially in TB-endemic regions. The patient also developed rifampicin-induced jaundice, which resolved upon drug cessation and supportive care. Anti-TB therapy was cautiously reintroduced at a modified dose. This report underscores the need for high clinical suspicion, …
Analysis Of Active Ingredients In Medicinal Herbs With High-Performance Liquid Chromatography And Related Technologies: A Review,
2026
Taiwan Food and Drug Administration
Analysis Of Active Ingredients In Medicinal Herbs With High-Performance Liquid Chromatography And Related Technologies: A Review, T.-H. Tsai, C.-Y. Hong, C.-F. Chen
Journal of Food and Drug Analysis
An increasing number of analytical techniques have been brought to bear on the herbal drugs used in traditional Chinese medicine. This in turn has led to improved quality control of medicinal herbs, ingredient stability and shelf-life tests, ensurement of the concentrations of herbal drug ingredients in biological fluids, and pharmacokinetic studies. In the past decades, gas chromatography has been the method of choice for the analysis of volatile compounds, while liquid chromatography is a highly successful separation technique for nonvolatile molecules. Recently, high-performance liquid chromatography coupled with various column and detection systems have become some of the most important techniques …
Analysis Of Activated Carbon Fiber (Acf) As Particulate Filtration And Volatile Organic Compound (Voc) Media For The Development Of A Dual-Air Purifying Facepiece Respirator,
2026
University of Alabama at Birmingham
Analysis Of Activated Carbon Fiber (Acf) As Particulate Filtration And Volatile Organic Compound (Voc) Media For The Development Of A Dual-Air Purifying Facepiece Respirator, Brie Mcmahan
ETDs from 2020-2029
Exposure to particulate matter (PM) and volatile organic compounds (VOCs) in occupational or public settings poses adverse health outcomes such as respiratory, cardiovascular, reproductive, neurological, carcinogenic morbidity and mortality. Many occupational settings expose workers to PM and VOC concurrently, yet most commercially available respirators are designed to address either particulates or vapors alone. This includes air-purifying respirators (APRs), powered air-purifying respirators (PAPRs), and filtering facepiece respirators (FFRs) with nuisance-level vapor protection, often limited by bulk, discomfort, high pressure drop, and misuse. We identified a need for alternative dual-exposure media and a respiratory protection device that is lighter, and more comfortable …
