Analysis Of Pharmaceutical Inventory Management In A State Hospital In Myanmar,
2022
Chulalongkorn University
Analysis Of Pharmaceutical Inventory Management In A State Hospital In Myanmar, Mya Pann Thazin, Rungpetch Sakulbumrungsil
The Thai Journal of Pharmaceutical Sciences
Inventory management analysis for a state-level hospital pharmacy of Myanmar was conducted using ABC-VEN matrix analysis to identify the drug categories that require stringent management control. The annual expenditure of all drug items managed by pharmacy department for the years 2016 and 2017 was analyzed and application of ABC, VEN, and ABC-VEN matrix analysis was performed. The study showed that the average annual expenditure was 288,414 USD. Of the total 297 items of medicines, 7.7% (23), 16.8% (50), and 75.4% (224) were classified as A, B, and C category items, respectively, accounting for 70.4%, 19.7%, and 9.9% of drug expenditure. …
Population Pharmacokinetics Of Phenytoin In Epileptic Children And Dosage Regimens Using Monte Carlo Simulation,
2022
Chulalongkorn University
Population Pharmacokinetics Of Phenytoin In Epileptic Children And Dosage Regimens Using Monte Carlo Simulation, Leena Mekloy, Wanchai Treyaprasert
The Thai Journal of Pharmaceutical Sciences
Objective: The study aimed at a population pharmacokinetic analysis of phenytoin in epileptic children so as to determine optimal dosage regimen for achieving the therapeutic range. Materials and Methods: A total of 370 blood level concentrations from 225 patients were collected retrospectively from clinical routine therapeutic drug monitoring data. The data were analyzed based on population pharmacokinetics using NONMEM software.A base model was developed to handle covariates, including age, gender, weight, liver function test results, and co-anticonvulsants. The final model was done until the precision of parameters with minimum objective function value achieved. Monte Carlo simulation was utilized to determine …
Effects Of The Mobile Serious Game (Herbarian) With Location-Based Learning On Students’ Retention Of Botanical Terms And Their Experiences,
2022
Chulalongkorn University
Effects Of The Mobile Serious Game (Herbarian) With Location-Based Learning On Students’ Retention Of Botanical Terms And Their Experiences, Sornkanok Vimolmangkang, Nattanichcha Kulthanachairojana, Taksina Chuanasa, Supotchana Sitthigool, Anuchai Theeraroungchaisri
The Thai Journal of Pharmaceutical Sciences
Background: A serious game was developed from the use of learning through drill and practice principle to enhance the knowledge memorizing together with the principle of game-based learning in education application. The aim of this study was to investigate the effectiveness of using game-based and location-based learning concepts on the student knowledge score and knowledge retention score. Methods: A mobile application game named “Herbarian” was developed and used in the pharmaceutical botany course as a part of the undergraduate pharmacy curriculum. The content in the game was botanical jargon linked to plant morphology. Twenty-one and 51 undergraduate students voluntarily used …
Chloroquine And Eye Problems At A General Hospital In Western Thailand,
2022
Chulalongkorn University
Chloroquine And Eye Problems At A General Hospital In Western Thailand, Nunthaluxna Sthapornnanon, Chattraporn Chumchit, Supakarn Suksajjee, Sukanya Boonnum, Suphitchaya Neramitwanchai, Chitthathep Chaisaen
The Thai Journal of Pharmaceutical Sciences
Objective: This study aimed to explore the eye problems after CQ use, to review if the eye examinations were performed during patients were treated with CQ and to identify factors related to those eye problems. Method: Retrospective study was done. Data were collected from both electronic medical records and medical records. Patients who were treated with CQ during May15, 2010- May 31, 2019 at a general hospital in western Thailand were included. Results: There were 123 patients who were treated with CQ. Eye problems were found in 26 patients (21.14 %). Majority of those had blurred vision (13/26; 50.00%). Focus …
Investigation Of Film Thickness Uniformity On Tablets By Handheld Raman Spectrometer,
2022
Chulalongkorn University
Investigation Of Film Thickness Uniformity On Tablets By Handheld Raman Spectrometer, Srisakul Srisuk, Jittima Chatchawalsaisin
The Thai Journal of Pharmaceutical Sciences
Purpose: The aim of this study was to investigate the uniformity of film thickness on coated tablets using handheld Raman spectrometer. Methods: Oval-shaped tablets were coated with Opadry® II blue at a pan speed of 8 rpm and spray rates of 8.2 and 10.5 g/min. The coating process was also carried out at the pan speed of 14 rpm and spray rate of 8.2 g/min. Other process parameters, that is, inlet air temperature and atomizing air pressure were kept constant. Twenty coated tablets were taken at 10 min intervals for determination of weight gain. The film deposited on both faces …
Recent Advancements On Biological Activity Of Indole And Their Derivatives: A Review,
2022
Chulalongkorn University
Recent Advancements On Biological Activity Of Indole And Their Derivatives: A Review, Punet Kumar, Md Iftekhar Ahma, Sangam Singh, Mohammad Rizki Fadhil Pratam, Arun K. Mishra
The Thai Journal of Pharmaceutical Sciences
Indole, a versatile outstanding heterocyclic compound, engaged in numerous pharmacological properties due to their multiple biochemical processes. The remarkable indole moiety resembles with numerous protein structures. The fascinating molecular framework of indole makes its suitable for drug development. Indole derivatives mimic the peptides structure and bind reversibly to several enzymes, which contribute enormous opportunities to develop novel drugs with distinct mechanism of action. The presence of nitrogen-based heterocycles in several compounds has been investigated enormously as the core structures comprise several biologically appropriate molecules found active in different diseases. The investigations conducted worldwide have shown outstanding impact for scientists, working …
Complexity Of Implementing Harm Reduction Services In Community Hospitals: A Two-Phase Qualitative Study,
2022
Chulalongkorn University
Complexity Of Implementing Harm Reduction Services In Community Hospitals: A Two-Phase Qualitative Study, Kanittha Nimsakul, Puckwipa Suwannaprom, Siritree Suttajit
The Thai Journal of Pharmaceutical Sciences
Objective: Regardless of effective harm reduction services (HRS) in Thanyarak Hospital, difficulties exist while implementing them in community hospitals. This study aimed to investigate the complexities of HRS implementation in two community hospitals in Mae Hong Son. Methods: Phase 1, in-depth interviews were conducted with 21 participants to investigate the complexity of HRS dissemination. An interview guide was developed from the seven domains of the Nonadoption, Abandonment, Scale-up, Spread, and Sustainability framework, and thematic analysis was used. Phase 2 involved two rounds of a Delphi technique with 17 experts to evaluate the HRS’s complexity level (complex, complicated, and simple). Results: …
The Impact Of Pharmacists’ Interventions In Female Internal Medicine Ward At University-Based Hospital On Cost Savings And Cost Avoidance,
2022
Chulalongkorn University
The Impact Of Pharmacists’ Interventions In Female Internal Medicine Ward At University-Based Hospital On Cost Savings And Cost Avoidance, Tanatape Wanishayakorn, Orawan Sae-Lim, Onnicha Suntornlohanakul, Pastraporn Yiengkulchao, Prayut Muangming, Natayu Chuerdee
The Thai Journal of Pharmaceutical Sciences
Background: Several studies have been conducted regarding the role of clinical pharmacist in the reduction of medical costs, the impact of clinical pharmacists in internal medicine wards on cost saving had been rarely studied. Objective: The objective of this study was to define the characteristics of drug-related problem (DRPs) and evaluate the effect on cost savings and cost avoidance by clinical pharmacists in female internal medicine ward at Songklanagarind Hospital. Materials and Methods: A retrospective analysis of pharmacists’ interventions recorded for 6 months was conducted. DRPs were categorized based on Pharmaceutical Care Network Europe V9.00. The interventions that were accepted …
Plaque Reduction Neutralization Test As A Method For Detecting Functional Neutralizing Antibodies Against Live Sars-Cov-2 Virus,
2022
Chulalongkorn University
Plaque Reduction Neutralization Test As A Method For Detecting Functional Neutralizing Antibodies Against Live Sars-Cov-2 Virus, Supaporn Phumiamorn, Skalin Trisiriwanich, Kornnika Kulabutar, Asmah Usoo, Thitiporn Somporn, Wipawee Wongchana, Sompong Sapsutthipas
The Thai Journal of Pharmaceutical Sciences
Introduction and objective: Since 2020, little is known about neutralizing antibody (NAb) responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus emerging and causing COVID-19 in humans. Here, we established a plaque reduction neutralization test (PRNT) to use as a method for detecting functional NAbs to SARS-CoV-2. Materials and Method: Vero cells were used as target cells for infection with the new coronavirus and cytopathic effects were obviously exhibited. Results: The development of plaque reduction after neutralization of virus with diluted specific antiserum was assessed according to a dose-response effect and consistency of test results with pooled …
Pueraria Candollei Var. Mirifica: A
Precious Source Of Pharmaceuticals And
Cosmeceuticals,
2022
Chulalongkorn University
Pueraria Candollei Var. Mirifica: A Precious Source Of Pharmaceuticals And Cosmeceuticals, Dolly Rani, Khwanlada Kobtrakul, Sornkanok Vimolmangkang
The Thai Journal of Pharmaceutical Sciences
Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham (PM), popularly known as “Kwao Krua,” is a medicinal plant that has been used for centuries in Thailand. Phytochemical studies indicated the presence of several bioactive molecules such as miroestrol, deoxymiroestrol, puerarin, daidzein, daidzin, genistin, genistein, and kwakhurin. The pharmacological evaluation of PM indicated strong estrogenic, anti-osteoporosis effects, anti-aging and antioxidant activities, as well as the ability to relieve other climacteric-related symptoms. There is conflicting evidence on the safety and toxicity of PM. The active ingredients in PM make it an ideal candidate for large-scale pharmaceutical exploitation as a cosmeceutical. Further …
Study On Post Approval Source Change
Of Active Pharmaceutical Ingredient In
The Finished Product And Its Regulatory
Requirements In Eu And Us,
2022
Chulalongkorn University
Study On Post Approval Source Change Of Active Pharmaceutical Ingredient In The Finished Product And Its Regulatory Requirements In Eu And Us, Kalpana Kamnoore, M. P. Venkatesh, T.M. Pramod Kumar
The Thai Journal of Pharmaceutical Sciences
Post approval changes are changes to any characteristic of pharmaceutical product after approval. Certificate of suitability of European pharmacopoeia (CEP) and drug master file (DMF) are two mechanisms for active pharmaceutical ingredient (API) registration. Regulatory requirements vary for each mechanism. This study focused on regulatory requirements for post approval API source change in the European Union (EU) and USA; and to delve on the mechanism of post approval API source changes in the USA and EU. To improve quality of the API, the most of the pharmaceutical industries concentrate on CEP certified source instead of DMF as CEP assures compliance …
Cytotoxic Effect Of Crude Vitex Glabrata
Fruit Extracts On Human Cancer Cell Lines,
2022
Chulalongkorn University
Cytotoxic Effect Of Crude Vitex Glabrata Fruit Extracts On Human Cancer Cell Lines, Saraphorn Intarasam, Vorranuch Keerathinant, Mesayamas Kongsema, Kantimanee Pradermwong
The Thai Journal of Pharmaceutical Sciences
Vitex glabrata (VG) or Khai-noa fruit extracts were prepared from three methods; squeezing extract (SE), maceration extract (ME), and ethanol extraction (EE) to evaluate their effects in vitro. By the (1,1-diphenyl-2-picrylhydrazyl) scavenging assay, all extracts revealed very weak antioxidant. Results of (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide, a tetrazole) assay showed the increase in cell viability of SE at 100 and 500 μg/ml on TK6 cells after 24 and 48 h treatments (P < 0.01) without affecting Caco-2 cells. Conversely, a dose- and time-dependent cytotoxicity of all extracts revealed at 1000-2000 μg/ml on both cells (P < 0.01). SE showed cytotoxicity on PC-3 cells and anticancer activity when confirmed by clonogenic assay in a dose-dependent manner. SE also showed cytotoxicity on HT-29 cells after 24 h treatment but the cells could recurrent in the clonogenic assay. No effect was observed on MCF-7 cells after SE alone, SE co-treated with MMC treatment, and in the clonogenic assay. Moreover, HT-29 cells revealed a dose-dependent decrease in viability when treated with SE co-treated with MMC by 24 h. Hence, SE can selectively promote cell viability on TK6 and anticancer activity on PC-3. These results suggest that the different potential of SE depends on different cell lines.
In Situ Hyaluronic Acid-Based Hydrogel
Incorporated With Insulin-Like Growth Factor-1 For Three-Dimensional Encapsulation Of Keratinocytes,
2022
Chulalongkorn University
In Situ Hyaluronic Acid-Based Hydrogel Incorporated With Insulin-Like Growth Factor-1 For Three-Dimensional Encapsulation Of Keratinocytes, Pornsuda Lengwan, Pithi Chanvorachote
The Thai Journal of Pharmaceutical Sciences
Background/Aim: This work aimed to establish in situ hydrogel formation based on crosslinking of methacrylated hyaluronic acid (MeHA) and the polymer incorporated with insulin-like growth factor 1 (IGF-1) for keratinocyte three-dimension (3D) culture. Materials and Methods: The compatibility of human keratinocytes with developed hydrogel was determined by PrestoBlueTM cell viability assay. The live and dead cells were determined by Calcein AM, Propidium Iodide and Hoechst 33342 staining. The physical properties including gelation time, microstructure (porosity and interconnectivity), swelling ratio, and stability of the different concentration hydrogel were determined and correlated to cell viability. Results: Three percent w/v MeHA for in …
Formulation, Ex-Vivo And In-Vitro Characterization Of Liposomal Drug Delivery System Of Fexofenadine,
2022
Chulalongkorn University
Formulation, Ex-Vivo And In-Vitro Characterization Of Liposomal Drug Delivery System Of Fexofenadine, Safin Shrestha, Uttam Budhathoki
The Thai Journal of Pharmaceutical Sciences
In order to improve the low permeability associated with conventional or immediate release dosage forms such as nasal spray and oral solid dosage form, tablets, fexofenadine liposomes were prepared by using ethanol injection method by varying the concentration of surfactant, (Tween -80), along with crude lecithin and cholesterol. The optimized formulations was evaluated for size, shape, entrapment efficiency and in vitro drug release. In this study the optimized formulated liposomes appeared to be spherical in shape and particle size was found to be 4703.667±445 nm. There is 1.25 times more flux of liposome as compared with free drug. The entrapment …
Behavior Of Polymers And In-Vitro Evaluation On Gastroretentive Nifedipine Sustained Release Floating Tablets,
2022
Chulalongkorn University
Behavior Of Polymers And In-Vitro Evaluation On Gastroretentive Nifedipine Sustained Release Floating Tablets, H. K. Pradeep, Juturu Thimmasetty, P.R. Sathesh Babu, S. Gururaj, N. Sreeharsha
The Thai Journal of Pharmaceutical Sciences
Nifedipine is one of the calcium channel blockers widely employed in indications such as high blood pressure and angina pectoris. In the present study, a prompt attempt is done in the formulation of gastro retentive sustained-release tablets. The effect of polymers and their combination on release pattern, initial burst release, and floating behavior were studied. Out of four polymers, two polymers such as cellulose derivatives like highly viscous polymer Hydroxypropyl methylcellulose (HPMC) K100, low viscous HPMC K4M and their combinations, and other two polymers used were from natural sources like xantham gum, guar gum and their combinations were studied. The …
Acute And Sub-Acute Toxicity Profile Of Methanol Leaf Extract Of Geophila Obvallata On Renal And Hepatic Indices In Wistar Rats,
2022
Chulalongkorn University
Acute And Sub-Acute Toxicity Profile Of Methanol Leaf Extract Of Geophila Obvallata On Renal And Hepatic Indices In Wistar Rats, Osafanme Lucky Iserhienrhien, Paulinus Ngozi Okolie
The Thai Journal of Pharmaceutical Sciences
Introduction: Geophila obvallata (Rubiaceae) is a medicinal herb used for the treatment of diseases associated with oxidative damage. Objective: The study investigated the toxic effects of acute and sub-acute oral doses of methanol extracts of G. obvallata (GOE) in rats. Materials and Methods: In acute toxicity study, extract doses of 1600, 2900, and 5000 mg/kg were orally administered. The rats were observed for signs of toxicity for 2 weeks. In sub-acute toxicity study, the extract was administered to rats at doses of 100, 500, and 1000 mg/kg for 28 days, while control rats received only water. At the end of …
Efavirenz Listed In The World Health Organization Prequalification Program: A Successful Case Study Of A Public Private Collaboration For Technology Transfer In Pharmaceutical Production And Quality Control In Thailand,
2022
Chulalongkorn University
Efavirenz Listed In The World Health Organization Prequalification Program: A Successful Case Study Of A Public Private Collaboration For Technology Transfer In Pharmaceutical Production And Quality Control In Thailand, Yupadee Sirisinsuk, Mukdavan Prakobvaitayakit, Nusaraporn Kessomboon, Usawadee Sutapuk, Kannikar Kijtiwatchakul, Noppawan Angkulsansanee
The Thai Journal of Pharmaceutical Sciences
Pharmaceutical technology transfer is an important tool for enhancing production development and quality control. The Government Pharmaceutical Organization (GPO) is the state enterprises under the Ministry of Public Health, whose main mission is to produce high quality medicines with reasonable price to increase accessibility to the Thai people. GPO has received the technology transfer from an overseas pharmaceutical company for the successful production of the efavirenz 600 mg tablet that was certified by the WHO Prequalification Program. The research objective was to study how this success has been achieved with the support of technology transference as well as the relevant …
A Review On Ethnomedicinal And Phytopharmacological Potential Of Traditionally Wild And Endemic Plant Berberis Tinctoria Lesch.,
2022
Chulalongkorn University
A Review On Ethnomedicinal And Phytopharmacological Potential Of Traditionally Wild And Endemic Plant Berberis Tinctoria Lesch., Arumugam Vignesh, Ramamoorthy Sivalingam, Subramaniam Selvakumar, Krishnan Vasanth
The Thai Journal of Pharmaceutical Sciences
Introduction: Berberis tinctoria an evergreen shrub, endemic and predominantly found at a higher altitude of the Nilgiri Biosphere Reserve, India. This leaf and fruit are edible, which are also used in homeopathic remedies for countless illnesses. Objectives: B. tinctoria with diverse ethnomedicinal uses was focused in the prevailing study to detailed the phytochemical and pharmacological properties for further imminent research in this species. Materials and methods: Published data in this review were all gathered from the online bibliographical databases: PubMed, Elsevier, Scopus, Google Scholar, Web of Science, and local ethnic community peoples of Kurumba and Toda. Results: B. tinctoria was …
Gastroprotective Effect Of Phyllanthus
Reticulatus Poir. Against Pylorus Ligation-, Ethanol-Induced, And Stress-Induced Ulcer Models In Wistar Rats,
2022
Chulalongkorn University
Gastroprotective Effect Of Phyllanthus Reticulatus Poir. Against Pylorus Ligation-, Ethanol-Induced, And Stress-Induced Ulcer Models In Wistar Rats, Saravanan Jayaram, G. Thamotharan, N. Senthilkumar
The Thai Journal of Pharmaceutical Sciences
Objective: The objective of the present study is to evaluate the antiulcer property of ethanolic extract of Phyllanthus reticulatus Poir. against pylorus ligation-, ethanol-induced, and stress-induced ulcer models in Wistar albino rats. Materials and Methods: Three models – pylorus ligation-induced ulcer, ethanol-induced ulcer, and swim stress-induced ulcer – were used to induce ulcer in Wistar rats. The animals were treated with 200 mg/kg and 400 mg/kg p. o of the ethanolic extract of P. reticulatus Poir, to estimate the gastroprotective potential. The effect of P. reticulatus Poir. on pH of the gastric juice, volume of acid secretion, total and free …
Synthesis And Cytotoxic Activity Of N-(2,4-Dichloro)Benzoyl-N’-Phenylthiourea Against Human Breast Cancer Cell Line,
2022
Chulalongkorn University
Synthesis And Cytotoxic Activity Of N-(2,4-Dichloro)Benzoyl-N’-Phenylthiourea Against Human Breast Cancer Cell Line, Dini Kesuma, Anwar Medika, Tegar Achsendo Yuniarta
The Thai Journal of Pharmaceutical Sciences
Introduction: Urea- and thiourea-based compound has shown a potency to be further developed as anticancer compound. Objective: Another novel phenylthiourea analog (N-(2,4-dichloro)benzoyl-N’-phenylthiourea) was synthesized through Schotten-Baumann reaction followed by the assessment of its cytotoxic activity. Methods: N-(2,4-dichloro)benzoyl-N’-phenylthiourea was synthesized using N-Phenylthiourea and 2,4-dichlorobenzoyl chloride as starting materials. The reaction started at low temperature for 30 min followed by reflux for 8 h to yield target compound. Cytotoxicity assay was then performed against MCF-7, T47D, and Vero normal cell line. Results: The compound has been synthesized and its structure has been verified using infrared, 1H-nuclear magnetic resonance (NMR), 13C-NMR, various 2D …
