Toxicity Of Three Species Of The Solanaceae Family Growing In Algeria Against Culiseta Longiareolata Mosquitos 4th Stage Larvae,
2024
Department of Natural and Life Sciences, Faculty of Sciences, Mohamed Boudiaf University of M'Sila, PO Box 166 Ichebilia, 28 000, M’sila, Algérie
Toxicity Of Three Species Of The Solanaceae Family Growing In Algeria Against Culiseta Longiareolata Mosquitos 4th Stage Larvae, Saliha Benhissen, Abdelmaddjid Yagoub Asloum, Nora Belkhiri, Zakaria Hedjouli, Siham Bounadji, Wafa Habbachi, Khellaf Rebbas
Journal of Bioresource Management
Mosquitoes have always been considered a source of harm to humans and animals mainly because they can be vectors of disease. This work represents a study on the effect of aqueous extract of three plants (Hyoscyamus albus, Solanum elaeagnifolium, Solanum nigrum) of the Solanaceae family on the mortality of 4th stage larvae of Culiseta longiareolata larvae. Extract of the high impact is of S. nigrum followed by H. albus and S. elaeagnifolium, respectivley of C. longiareolata larvae.
Pediatric Beta Blocker Therapy: A Comprehensive Review Of Development And Genetic Variation To Guide Precision-Based Therapy In Children, Adolescents, And Young Adults.,
2024
Children's Mercy Kansas City
Pediatric Beta Blocker Therapy: A Comprehensive Review Of Development And Genetic Variation To Guide Precision-Based Therapy In Children, Adolescents, And Young Adults., Mollie Walton, Jonathan B. Wagner
Manuscripts, Articles, Book Chapters and Other Papers
Beta adrenergic receptor antagonists, known as beta blockers, are one of the most prescribed medications in both pediatric and adult cardiology. Unfortunately, most of these agents utilized in the pediatric clinical setting are prescribed off-label. Despite regulatory efforts aimed at increasing pediatric drug labeling, a majority of pediatric cardiovascular drug agents continue to lack pediatric-specific data to inform precision dosing for children, adolescents, and young adults. Adding to this complexity is the contribution of development (ontogeny) and genetic variation towards the variability in drug disposition and response. In the absence of current prospective trials, the purpose of this comprehensive review …
An Acute Herb-Drug Interaction Of Magnoliae Officinalis Cortex With Methotrexate Via Inhibiting Multidrug Resistance-Associated Protein 2,
2024
School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan 406040, ROC.
An Acute Herb-Drug Interaction Of Magnoliae Officinalis Cortex With Methotrexate Via Inhibiting Multidrug Resistance-Associated Protein 2, Chung-Ping Yu, Pei-Ying Li, Szu-Yu Chen, Shiuan-Pey Lin, Ying-Chen Chen, Lu-Ching Ho, Yow-Wen Hsieh, Yu-Chi Hou
Journal of Food and Drug Analysis
Magnoliae Officinalis Cortex (MOC), an herbal drug, contains polyphenolic lignans mainly magnolol (MN) and honokiol (HK). Methotrexate (MTX), a critical drug for cancers and autoimmune deseases, is a substrate of multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP). This study investigated the effect of coadministration of MOC on the pharmacokinetics of MTX and relevant mechanisms. Sprague-Dawley rats were orally administered MTX alone and with single dose (2.0 and 4.0 g/kg) and repeated seven doses of MOC (2.0 g/kg thrice daily for 2 days, the 7th dose given at 0.5 h before MTX). The serum concentrations of MTX …
An Auxiliary Strategy Of Partial Least Squares Regression In Pharmacokinetic/Pharmacodynamic Studies: A Case Of Application Of Guhong Injection In Myocardial Ischemia/Reperfusion Rats,
2024
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053 Zhejiang, China
An Auxiliary Strategy Of Partial Least Squares Regression In Pharmacokinetic/Pharmacodynamic Studies: A Case Of Application Of Guhong Injection In Myocardial Ischemia/Reperfusion Rats, Hai-Yang Chen, Chang Li, Chong-Yu Shao, Yu-Jia Wu, Hai-Tong Wan, Yu He
Journal of Food and Drug Analysis
Guhong injection (GHI) has been applied in the therapy of cardio-cerebrovascular disease in clinic, but there is no report about the pharmacokinetic/pharmacodynamic (PK/PD) research on GHI treating myocardial ischemia/reperfusion (MI/R) injury in rats. In this study, eight compounds of GHI in plasma, including N-acetyl-L-glutamine (NAG), chlorogenic acid (CGA), hydroxysafflor yellow A (HSYA), p-coumaric acid (pCA), rutin, hyperoside, kaempferol-3-O-rutinoside, and kaempferol-3-O-glucoside, were quantified by LC-MS/MS. We discovered that the values of t1/2β, k12, V2, and CL2 were larger than those of t1/2α, k21, V1, and …
Ionizable Copolymer Functionalized Magnetic Nanocomposite As An Adsorbent For Boosting The Extraction Selectivity Of Aristolochic Acids,
2024
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China
Ionizable Copolymer Functionalized Magnetic Nanocomposite As An Adsorbent For Boosting The Extraction Selectivity Of Aristolochic Acids, Qi-Yue Xie, Yang Chen, Chang-Jun Li, Jia-Bin Zhang, Xiu-Jun Cao, Jun Lu
Journal of Food and Drug Analysis
Aristolochic acid nephropathy (AAN) has drawn increasing public attention. Organic anion transporters (OATs) are considered to be responsible for mediating nephrotoxicity of aristolochic acids (AAs), as AAs are typical OAT1 substrates that exhibit anionic properties and contain one hydrophobic domain. Inspired by the OAT1 three-dimensional structure or substrate/protein interactions involved in transport, we designed a magnetic polymeric hybrid, mimicking the effect of basic and aromatic residues of OAT1, for efficient enriching aristolochic acid I (AA I) and aristolochic acid II (AA II) in Traditional Chinese patent medicines (TCPM). N, N-dimethylaminopropyl acrylamide (DMAPAm) was used as a cationic monomer and copolymerized …
Effect Of Indian Gooseberry Extract On Improving Methylglyoxal-Associated Leptin Resistance In Peripheral Tissues Of High-Fat Diet-Fed Rats,
2024
Department of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan
Effect Of Indian Gooseberry Extract On Improving Methylglyoxal-Associated Leptin Resistance In Peripheral Tissues Of High-Fat Diet-Fed Rats, Sheng-Yi Chen, Yue-Ning Huang, Jer-An Lin, Gow-Chin Yen
Journal of Food and Drug Analysis
Increased leptin resistance and methylglyoxal (MG) levels are observed in obese patients. However, whether MG deposits contribute to leptin resistance, oxidative stress, and inflammation in peripheral tissues remains unclear. In addition, the edible fruit of Indian gooseberry (Phyllanthus emblica L.) contains abundant bioactive components such asvitamin C, β-glucogallin (β-glu), gallic acid (GA), and ellagic acid (EA). Water extract of Indian gooseberry fruit (WEIG) and GA has been shown to improve cognitive decline by suppressing brain MG-induced insulin resistance in rats administered a high-fat diet (HFD). Accordingly, this study investigated the functions of WEIG and GA in inhibiting MG-induced leptin …
Pomelo (Citrus Grandis (L.) Osbeck) Sponge Layers As A Potential Source Of Soluble Dietary Fiber: Evaluation Of Its Physicochemical, Structural And Functional Properties,
2024
Sericultural & Argi-Food Research Institute, Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, No.133 Yiheng Street, Dongguanzhuang road, Tianhe District, Guangzhou 510610, China
Pomelo (Citrus Grandis (L.) Osbeck) Sponge Layers As A Potential Source Of Soluble Dietary Fiber: Evaluation Of Its Physicochemical, Structural And Functional Properties, Xiaowei Chen, Jiajia Chen, Jian Peng, Yuanshan Yu, Jijun Wu, Jing Wen, Zhiying Kang, Yanhui Wang, Yujuan Xu, Lu Li
Journal of Food and Drug Analysis
Pomelo sponge layer (PSL) had been considered as a potential source of soluble dietary fiber (SDF), while they were mostly disposed of as waste. To promote high-value utilization of pomelo wastes, this study extracted SDF from PSL of six varieties of pomelo, and their physicochemical, structural and functional properties were investigated. Results indicated that all PSL-SDFs showed good physicochemical and functional properties. Among them, PSL-SDF from grapefruit (GRSDF) showed better water holding capacity and swelling capacity, whereas Shatian pomelo PSL-SDF and Guanxi pomelo PSL-SDF had the highest thermal stability and oil holding capacity, respectively. Furthermore, compared with other PSL-SDFs, GRSDF …
Trans-2-Nonadecyl-4-(Hydroxymethyl)-1,3-Dioxolane (Tnhd) Purified From Freshwater Clams Markedly Alleviates Dimethylnitrosamine-Induced Hepatic Fibrosis,
2024
Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan
Trans-2-Nonadecyl-4-(Hydroxymethyl)-1,3-Dioxolane (Tnhd) Purified From Freshwater Clams Markedly Alleviates Dimethylnitrosamine-Induced Hepatic Fibrosis, Ya-Ru Kuo, Chen-Yu Tsai, Wei-Sheng Lin, Chi-I Chang, Ching-Shu Lai, Min-Hsiung Pan
Journal of Food and Drug Analysis
Liver fibrosis occurs due to injury or inflammation, which results in the excessive production of collagen and the formation of fibrotic scar tissue that impairs liver function. Despite the limited treatment options available, freshwater clams may hold promise in the treatment of liver fibrosis. In this study, we demonstrated the effects of ethanol extract of freshwater clam (FCE), ethyl acetate extract of FCE (EA-FCE), and trans-2-nonadecyl-4-(hydroxymethyl)-1,3-dioxolane (TNHD) on liver fibrosis induced by dimethylnitrosamine (DMN). Administration of FCE and TNHD alleviated liver injury, including tissue damage, necrosis, inflammation scores, fibrosis scores, serum enzymes, and triglyceride levels. Furthermore, we analyzed the expression …
Environmental Health Assessments For Foodborne Illness Outbreaks In The United States From 2017- 2019,
2024
Walden University
Environmental Health Assessments For Foodborne Illness Outbreaks In The United States From 2017- 2019, Alyssa Shontel Woods
Walden Dissertations and Doctoral Studies
Individual cases of foodborne illness can lead to outbreaks that result in severe morbidity and fatality. As the United States’ food scene continues to evolve and diversify, there is a need to consider cultural variations and how they may affect food safety practices. This quantitative study, based on the National Environmental Assessment Reporting System (NEARS) data, grounded in the socio-ecological model, examined the prevalence and factors associated with salmonella outbreaks in ethnic versus non-ethnic food service establishments (FSEs) in the U.S. from 2017 to 2019. The research questions involved understanding the relationship between the primary language spoken, food safety training, …
Co-Crystallization Of Urea Granules For Slower Dissolution,
2024
Purdue University
Co-Crystallization Of Urea Granules For Slower Dissolution, Vidya Nagaraju, Carl Wassgren, Kingsly Ambrose
Graduate Industrial Research Symposium
Co-crystals are multicomponent crystals formed through hydrogen bond interactions. Co-crystallization, the process of developing cocrystals, serves as a versatile approach for discovering new solid forms of active ingredients (AIs) that can alter physical properties such as solubility, dissolution rates, and stability. These co-crystals can be produced through three main methods: solid-state methods, solution-based methods, and supercritical fluid methods. Recently, the solid-state (mechanochemical) method of developing cocrystals has gained more attention from researchers in the development of slow-release urea fertilizers. This technique can also be applied to the development of urease inhibitors. These multicomponent crystals present a potential solution to the …
Facile One-Pot Synthesis And Anti-Microbial Activity Of Novel 1,4-Dihydropyridine Derivatives In Aqueous Micellar Solution Under Microwave Irradiation,
2024
Chandigarh University
Facile One-Pot Synthesis And Anti-Microbial Activity Of Novel 1,4-Dihydropyridine Derivatives In Aqueous Micellar Solution Under Microwave Irradiation, Asmita Goswami, Navneet Kaur, Manvinder Kaur, Kishanpal Singh, Harvinder Singh Sohal, Haesook Han, Pradip K. Bhowmik
Chemistry and Biochemistry Faculty Research
The current study describes a novel and eco-conscious method to synthesize 1,4-dihydropyridine derivatives utilizing an aqueous micellar solution containing aluminum dodecyl sulfate, Al(DS)3, using readily available starting material. The final products were synthesized with excellent yields within remarkably quick reaction durations, promoting remarkable atom economy and minimizing environmental impacts. The present protocol has several advantages over other methodologies in terms of high yield (up to 97%) with excellent purity. Further, the synthesized 1,4-DHPs exhibit favorable to excellent resistance against examined bacterial and fungal species. Intriguingly, polar groups on the phenyl ring (5b, 5c, 5i and 5j) make the 1,4-DHPs equally …
Microplastics In Atlantic Ribbed Mussels (Geukensia Demissa) From The Delaware Inland Bays, Usa,
2024
Thomas Jefferson University
Microplastics In Atlantic Ribbed Mussels (Geukensia Demissa) From The Delaware Inland Bays, Usa, Jeffrey Ashley, Amanda Pilat, Ariana Ohlweiler, Connor Ogden, Priya Modi, Spencer Talbot, Caya Smith, Justin O'Pella, Gulnihal Ozbay
Student Papers, Posters & Projects
Due to the prevalence of plastic pollution in coastal ecosystems, aquatic organisms are at high risk for accumulating microplastics (MPs). Filter-feeding bivalves, such as mussels and oysters, may be exposed to, and subsequently accumulate, MPs due to the high volume of water they pass through their bodies. This study assessed the levels of MPs within Atlantic ribbed mussels (Geukensia demissa), a common filter feeder found along the United States Atlantic Coast, from 12 sites within Rehoboth Bay, Indian River Bay, and Little Assawoman Bay, collectively known as the Delaware Inland Bays. Composited mussels from each site were digested using potassium …
Assessment Of The Impact Of Humic Acids On Intestinal Microbiota, Gut Integrity, Ileum Morphometry, And Cellular Immunity Of Turkey Poults Fed An Aflatoxin B1-Contaminated Diet,
2024
University of Arkansas, Fayetteville
Assessment Of The Impact Of Humic Acids On Intestinal Microbiota, Gut Integrity, Ileum Morphometry, And Cellular Immunity Of Turkey Poults Fed An Aflatoxin B1-Contaminated Diet, Jesus A. Maguey-Gonzalez, Jing Liu, Guolong Zhang, Juan D. Latorre, Juan O. Hernandez-Ramirez, Maria De Jesus Nava-Ramirez, Roberto Señas-Cuesta, Sergio Gomez-Rosales, Maria De Lourdes Angeles, Andressa Stein, Bruno Solis-Cruz, Daniel Hernandez-Patlan, Ruben Merino-Guzman, Xochitl Hernandez-Velasco, Inkar Castellanos-Huerta, Santiago Uribe-Diaz, Alma Vazquez-Duran, Abraham Mendez-Albores, Victor Petrone-Garcia, Guillermo Tellez Jr., Billy M. Hargis, Guillermo Tellez-Isaias
Poultry Science Faculty Publications and Presentations
A recent study published data on the growth performance, relative weights of the organs of the gastrointestinal tract, liver histology, serum biochemistry, and hematological parameters for turkey poults fed an experimental diet contaminated with aflatoxin B1 (AFB1) and humic acids (HA) extracted from vermicompost. The negative effects of AFB1 (250 ng AFB1/g of feed) were significantly reduced by HA supplementation (0.25% w/w), suggesting that HA might be utilized to ameliorate the negative impact of AFB1 from contaminated diets. The present study shows the results of the remaining variables, as an extension of …
Human Mitragynine And 7-Hydroxymitragynine Pharmacokinetics After Single And Multiple Daily Doses Of Oral Encapsulated Dried Kratom Leaf Powder,
2024
Thomas Jefferson University
Human Mitragynine And 7-Hydroxymitragynine Pharmacokinetics After Single And Multiple Daily Doses Of Oral Encapsulated Dried Kratom Leaf Powder, Marilyn A. Huestis, Martin A. Brett, John Bothmer, Ramsey Atallah
Institute of Emerging Health Professions Faculty Papers
Kratom leaves, consumed by millions worldwide as tea or ground leaf powder, contain multiple alkaloids, with mitragynine being the most abundant and responsible for most effects. Mitragynine is a partial µ-opioid receptor agonist and competitive antagonist at κ- and δ-opioid receptors; however, unlike morphine, it does not activate the β-arrestin-2 respiratory depression pathway. Due to few human mitragynine data, the largest randomized, between-subject, double-blind, placebo-controlled, dose-escalation study of 500–4000 mg dried kratom leaf powder (6.65–53.2 mg mitragynine) was conducted. LC-MS/MS mitragynine and 7-hydroxymitragynine plasma concentrations were obtained after single and 15 daily doses. Mitragynine and 7-hydroxymitragynine Cmax increased dose …
Aloe Vera Assisted Green Synthesis Of Ag And Cu Co-Doped Zno Nanoparticles And A Comprehensive Analysis Of Their Structural, Morphological, Optical, Electrical And Antibacterial Properties,
2024
The Texas Medical Center Library
Aloe Vera Assisted Green Synthesis Of Ag And Cu Co-Doped Zno Nanoparticles And A Comprehensive Analysis Of Their Structural, Morphological, Optical, Electrical And Antibacterial Properties, Md Hasnat Rashid, Saiful Islam Sujoy, Md Saifur Rahman, Md Jahidul Haque
Faculty, Staff and Student Publications
This study investigates the potential of utilizing Aloe vera-assisted green synthesis with transition metal dopants of Ag and Cu for greater efficiency and sustainability in advanced scientific applications utilizing ZnO nanoparticles. Samples were prepared using the co-precipitation method, maintaining a basic pH media of 10. Aloe vera gel extract was chosen for its acclaimed role as a stabilizing and reducing agent and its proven antioxidant, antibacterial, and anticancer properties. The XRD report revealed the hexagonal Wurtzite crystal structure of nanoparticles, exhibiting a crystallite size range of 17-23 nm with substantial alterations in lattice parameters, dislocation density, and bond lengths when …
Evaluation Of Novel Therapeutic Agents For The Treatment Of Chronic Dry Eyes,
2024
Roseman University of Health Sciences
Evaluation Of Novel Therapeutic Agents For The Treatment Of Chronic Dry Eyes, Lilian Huynh, Evonie Villarete, Surajit Dey
Annual Research Symposium
Dry eye disease (DED) is a multifactorial ocular condition, where disrupted tear film stability and ocular surface inflammation affected between 5% to 34% of the worldwide population in 2015 and posed a challenge to conventional ophthalmic treatments. Recent advances have led to potential novel therapeutics aiming to alleviate symptoms and improve patient outcomes.
Protecting Human And Animal Health: The Road From Animal Models To New Approach Methods,
2024
The Texas Medical Center Library
Protecting Human And Animal Health: The Road From Animal Models To New Approach Methods, Barbara L F Kaplan, Alan M Hoberman, William Slikker, Mary Alice Smith, Emanuela Corsini, Thomas B Knudsen, M Sue Marty, Sonya K Sobrian, Suzanne C Fitzpatrick, Marcia H Ratner, Donna L Mendrick
Faculty, Staff and Student Publications
Animals and animal models have been invaluable for our current understanding of human and animal biology, including physiology, pharmacology, biochemistry, and disease pathology. However, there are increasing concerns with continued use of animals in basic biomedical, pharmacological, and regulatory research to provide safety assessments for drugs and chemicals. There are concerns that animals do not provide sufficient information on toxicity and/or efficacy to protect the target population, so scientists are utilizing the principles of replacement, reduction, and refinement (the 3Rs) and increasing the development and application of new approach methods (NAMs). NAMs are any technology, methodology, approach, or assay used …
Metabolic Stability And Metabolite Identification Of N-Ethyl Pentedrone Using Rat, Mouse And Human Liver Microsomes,
2024
Thomas Jefferson University
Metabolic Stability And Metabolite Identification Of N-Ethyl Pentedrone Using Rat, Mouse And Human Liver Microsomes, Alexandre Barcia Godoi, Natalícia De Jesus Antunes, Kelly Francisco Cunha, Aline Franco Martins, Marilyn A. Huestis, Jose Luiz Costa
Institute of Emerging Health Professions Faculty Papers
New Psychoactive Substances (NPSs) are defined as a group of substances produced from molecular modifications of traditional drugs. These molecules represent a public health problem since information about their metabolites and toxicity is poorly understood. N-ethyl pentedrone (NEP) is an NPS that was identified in the illicit market for the first time in the mid-2010s, with four intoxication cases later described in the literature. This study aims to evaluate the metabolic stability of NEP as well as to identify its metabolites using three liver microsomes models. To investigate metabolic stability, NEP was incubated with rat (RLM), mouse (MLM) and human …
Nanoparticles For Applications In Specific Diagnostics And Precision Medicine,
2024
CUNY Graduate Center
Nanoparticles For Applications In Specific Diagnostics And Precision Medicine, Naxhije Berisha
Dissertations, Theses, and Capstone Projects
Heterogeneity is common in the expression of cancer and treatment response. Precision medicine enables healthcare providers to tailor medical care to an individual's distinct genetic and environmental makeup. This customization has the potential to result in more efficient treatments while minimizing side effects. We believe that by studying the interface of nanotechnology and cancer medicine we can elucidate innovative solutions that address the challenges of disease heterogeneity. This includes advancements in drug delivery, formulations development, and diagnostic sensing. We highlight three studies that use nanotechnology for applications in precision medicine. In Chapter 2, we highlight design optimization of drug formulations …
The Effect Of Caffeine On Bee Behavior: A Progressive Ratio Study,
2024
University of Missouri-St. Louis
The Effect Of Caffeine On Bee Behavior: A Progressive Ratio Study, Kayle Cohen, Becky Hansis-O'Neill, Aimee Dunlap Dr
Undergraduate Research Symposium
This presentation focuses on the effect of caffeine on bee behavior using behavioral pharmacology methodologies. Researchers trained bumblebees to drink out of artificial flowers, then administered sucrose nectar or caffeinated sucrose nectar during a schedule of progressive and fixed ratios. The finding suggests that caffeine did increase the number of rewards during the fixed ratio, but not in the progressive ratio. However, research is still ongoing as bees continue to be tested..
