The Antiinflammatory Action And Pharmacokinetics Of A Novel Glucosamine-Based Di-Peptide Aminosugar,
2013
University of Alberta
The Antiinflammatory Action And Pharmacokinetics Of A Novel Glucosamine-Based Di-Peptide Aminosugar, Mohammad H. Gilzad-Kohan, Kamaljit Kaur, Fakhreddin Jamali
Pharmacy Faculty Articles and Research
Purpose. We have previously shown favorable in vitro gut permeability for three novel dipeptide esters of glucosamine (GlcN) likely facilitated by the peptide transporter 1 (PepT1). Herein, we report the development of a novel assay for the determination of bioavailability of the peptide ester of interest, the anti-inflammatory properties of a glycine-valine ester derivative of GlcN (GVG) as well as its pharmacokinetics under healthy and inflammatory conditions.
Methods. A pre-column derivatization (with 9-fluorenylmethoxycarbonyl) HPLC assay was developed to study bioavailability of GVG, GlcN or cleaved GlcN in the rats that were cannulated in their right jugular vein for …
Computational Approaches For Structure Based Drug Design And Protein Structure-Function Prediction,
2013
University of South Florida
Computational Approaches For Structure Based Drug Design And Protein Structure-Function Prediction, Sai Lakshmana Kumar Vankayala
USF Tampa Graduate Theses and Dissertations
This dissertation thesis consists of a series of chapters that are interwoven by solving interesting biological problems, employing various computational methodologies. These techniques provide meaningful physical insights to promote the scientific fields of interest. Focus of chapter 1 concerns, the importance of computational tools like docking studies in advancing structure based drug design processes. This chapter also addresses the prime concerns like scoring functions, sampling algorithms and flexible docking studies that hamper the docking successes. Information about the different kinds of flexible dockings in terms of accuracy, time limitations and success studies are presented. Later the importance of Induced fit …
Evaluation Of Occupational Risk Factors For Nurses And Cnas: Analysis Of Florida Workers' Compensation Claims Database,
2013
University of South Florida
Evaluation Of Occupational Risk Factors For Nurses And Cnas: Analysis Of Florida Workers' Compensation Claims Database, Sheila Mohammed
USF Tampa Graduate Theses and Dissertations
Musculoskeletal injuries lead to most claims even though needlestick injuries receive the most attention. In 2010, health expenditures in the United States neared $2.6 trillion. CNAs, orderlies, and attendants had the highest rates of musculoskeletal disorders of all occupations with an incidence of 249 per 10,000 compared to 34 per 10,000 for all workers. The financial burden of back injuries in the healthcare industry is estimated to add up to $20 billion annually. Data was extracted for cause of injury, nature of injury and body part injured. Extracted data was analyzed both descriptively and by logistic and linear regression using …
The Assessment Of An In-Vitro Model For Evaluating The Role Of Parp In Ethanol-Mediated Hepatotoxicity,
2013
University of South Florida
The Assessment Of An In-Vitro Model For Evaluating The Role Of Parp In Ethanol-Mediated Hepatotoxicity, Jayme Coyle
USF Tampa Graduate Theses and Dissertations
This investigation assesses the role of poly(ADP-ribose) polymerase in ethanol-mediated hepatotoxicity using the untransfected HepG2 hepatocellular carcinoma line, an established, well-characterized toxicological model. HepG2 cells were treated with ethanol at concentrations between 100 mM and 800 mM, and assessed for markers of cytotoxicity. PARP-1 activity in total cell protein lysates was quantified as a proxy of apoptotic induction at six hours. Our results demonstrated a 1.43-fold AST activity increase in culture medium isolates of cells exposed to 800 mM without significant effect on cellular viability. PARP-1 activity varied greatly and results for enzyme activity remained inconclusive. The results suggest a …
Cd44 Containing Complexes As A Therapeutic Target In Multiple Myeloma,
2013
University of South Florida
Cd44 Containing Complexes As A Therapeutic Target In Multiple Myeloma, Anthony Gebhard
USF Tampa Graduate Theses and Dissertations
Our laboratory recently reported that treatment with the d-amino acid containing peptide HYD1 induces necrotic cell death in multiple myeloma (MM) cell lines. Due to the intriguing biological activity and promising in vivo activity of HYD1, we pursued strategies for increasing the therapeutic efficacy of the parent linear peptide. These efforts led to the development of a cyclized peptidomimetic, MTI-101, with increased in vitro activity and robust in vivo activity as a single agent using two myeloma models that consider the bone marrow microenvironment. MTI-101 treatment resulted in mechanistically similar hallmarks of HYD1 induced cell death, namely the generation of …
Development Of A Novel Method For Deriving Thresholds Of Toxicological Concern (Ttcs) For Vaccine Constituents,
2013
University of South Florida
Development Of A Novel Method For Deriving Thresholds Of Toxicological Concern (Ttcs) For Vaccine Constituents, Jennifer Jessica White
USF Tampa Graduate Theses and Dissertations
Abstract
Safety assessment relating to the presence of impurities, residual materials and contaminants in vaccines is a focus area of research at the United States Food and Drug Administration (FDA). Sponsors who submit Investigational New Drug (IND) applications for new vaccine products must report the results of safety assessments to the Division of Vaccines and Related Products Applications (DVRPA). Scientifically defining thresholds of toxicological concern (TTCs) as they apply to vaccine constituents will provide a useful aid to the sponsors and public regarding safety assessments of compounds for which there is little or no toxicity data. TTCs are mathematically modeled …
Asbestos Exposure In The Research Laboratory,
2013
University of South Florida
Asbestos Exposure In The Research Laboratory, Ediberto D. Garcia
USF Tampa Graduate Theses and Dissertations
Introduction: Asbestos has been employed in a myriad of industrial applications for more than a century. Of the 181 Mt of asbestos produced worldwide, over 31 Mt was consumed in the U.S. The production and consumption of this mineral eventually was found to cause asbestosis, lung cancer and mesothelioma. While the brunt of the human exposure to asbestos occurred in insulation work, many more workers in other jobs were expose to asbestos fibers. Very little is known about the potential exposure to asbestos in research labs.
Goal: In order to investigate potential research lab work exposures, we simulated lab work …
The Perception Of Emergency Department Physicians Regarding Economic And Regulatory Factors Impacting Management Of Drug Seeking Patients,
2013
University of South Florida
The Perception Of Emergency Department Physicians Regarding Economic And Regulatory Factors Impacting Management Of Drug Seeking Patients, Sharon Susanne Kelley
USF Tampa Graduate Theses and Dissertations
Abstract
Physicians in the emergency department (ED) are facing a number of unique challenges in the currently changing healthcare and economic climates. Dramatic increases in ED patient volumes have been noted nationwide with visits related to prescription opioid abuse and misuse alone having increased by 111% between 2004 and 2008.
Ironically, several challenges ED physicians are facing arise from regulatory and economic initiatives which were originally designed for the protection of patients. Regulatory requirements to address pain as the fifth vital sign, along with entities utilizing patient satisfaction based reimbursement, have inadvertently created an environment conducive to exploitation by the …
Full Issue: Volume 6, Number 2,
2013
Touro College and University System
Full Issue: Volume 6, Number 2
The Science Journal of the Lander College of Arts and Sciences
No abstract provided.
Full Issue: Volume 7, Number 1,
2013
Touro College and University System
Full Issue: Volume 7, Number 1
The Science Journal of the Lander College of Arts and Sciences
No abstract provided.
Anti-Lipase Activity Of Quercus Infectoria G.Olivier Extract,
2013
Chulalongkorn University
Anti-Lipase Activity Of Quercus Infectoria G.Olivier Extract, Sirinan Thubthimthed., Sarunya Laovitthayanggoon, Parkpoom Siriarchavatana, Konlawit Chaithongsri, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Antibacterial Activity Of A-Mangostin From The Pericarp Extract Of Garcinia Mangostana L. Against Drug Resistant Bacteria,
2013
Chulalongkorn University
Antibacterial Activity Of A-Mangostin From The Pericarp Extract Of Garcinia Mangostana L. Against Drug Resistant Bacteria, Griangsak Eumkeb, Sineewan Phitaktim
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Gene Cloning And Expression Of A Triterpene Synthase From Alangium Lamarckii,
2013
Chulalongkorn University
Gene Cloning And Expression Of A Triterpene Synthase From Alangium Lamarckii, Nattaon Tansakul, Pimpimon Tansakul, Wanchai De-Eknamkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Investigation On Phytochemical, Antioxidant And Cytotoxic Properties Of Momordica Cochinchinensis (Gac) Fruit Extracted By Supercritical Fluid Carbon Dioxide (Scf-Co2) Method,
2013
Chulalongkorn University
Investigation On Phytochemical, Antioxidant And Cytotoxic Properties Of Momordica Cochinchinensis (Gac) Fruit Extracted By Supercritical Fluid Carbon Dioxide (Scf-Co2) Method, Prapaipat Klungsupya., Worawan Tiatragoon, Thanchanok Muangman, Jirawat. Eiamwat, Sarunya Laovitthayanggoon, Jeerayu Thongdo-A, Srisak Trangwacharakul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Meloxicam-Loaded Ph Sensitive Polymeric Micelles: Solvents And Entrapment Methods,
2013
Chulalongkorn University
Meloxicam-Loaded Ph Sensitive Polymeric Micelles: Solvents And Entrapment Methods, Thisirak Woraphatphadung, Warayuth Sajomsang, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Stability Evaluation Of A Hair Conditioner Comprising A Mixed Extract From Fruits Of Phyllanthus Emblica And Zanthoxylum Limon Ella,
2013
Chulalongkorn University
Stability Evaluation Of A Hair Conditioner Comprising A Mixed Extract From Fruits Of Phyllanthus Emblica And Zanthoxylum Limon Ella, Sitthiphong Soradech, Buppachart Potduang, Itsara Keeta, Wanlapha Saisin, Suchipha Wannaphatchaiyong, Cholticha Niwaspragrit
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Pharmacokinetic And Bioequivalence Evaluation Of Two Formulations Of Levocetirizine 5 Mg In Healthy Thai Volunteers,
2013
Chulalongkorn University
Pharmacokinetic And Bioequivalence Evaluation Of Two Formulations Of Levocetirizine 5 Mg In Healthy Thai Volunteers, Chutima Jantarat, Thitima Keskanokwong
The Thai Journal of Pharmaceutical Sciences
Pharmacokinetics of levoceterizine have been studied, however, obtained information was only from the Western people. เท addition, the license of this drug formulation was expired few years ago. For approval of this new generic drug, the bioequivalen...
Compulsory Licensing Of Chronic Diseases Pharmaceuticals Thailand,
2013
Chulalongkorn University
Compulsory Licensing Of Chronic Diseases Pharmaceuticals Thailand, Sakda Thanicul, Matthew Lim Braslow
The Thai Journal of Pharmaceutical Sciences
For pharmaceutical companies, obtaining patent protection for the pharmaceuticals they develop is essential. Patent protection assures that the pharmaceutical company will have a reasonable opportunity to recoup their most likely quite heavy investment in the new drug and allow the company to control the wholesale market price of the drugs. These key intellectual property rights are truly at the heart of the internationally recognized intellectual property regime. For patent right holders in general merchandise, say an innovative paperclip or mousetrap, the absolute right of the patent holder as to the distribution and price is perfectly acceptable. Pharmaceutical patents however, with …
Detection Of Esterase Activity Converting Cytotoxic Renieramycin M To Jorunnamycin A In The Crude Enzyme Of The Nudibranch Jorunna Funebris,
2013
Chulalongkorn University
Detection Of Esterase Activity Converting Cytotoxic Renieramycin M To Jorunnamycin A In The Crude Enzyme Of The Nudibranch Jorunna Funebris, Dalad Waropastrakul., Khanit Suwanborirux, Wanchai De-Eknamkul, Taksina Chuanasa
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Use Of Three Thai Indigenous Vegetables As Potential Dietary Fiber Sources For Health Food Product,
2013
Chulalongkorn University
Use Of Three Thai Indigenous Vegetables As Potential Dietary Fiber Sources For Health Food Product, Jeeravu Thongdon-A., Prapaipat Klungsupya, Thanchanok Muangman, Arkachai Tantrawong, Srisak Trangvacharakul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
