Pharmacology, Toxicology and Environmental Health Commons^™

When Substance Abuse And Mental Illness Combine, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

Solubility And Dissolution Enhancement Of Quercetin Via Preparation Of Spray Dried Microstructured Solid Dispersions, Ahmed Shawky Mohamed Ghanem, Hany Saleh, Sohair Mostafa El-Shanawany, El-Sayed Ali Ibrahim

The Thai Journal of Pharmaceutical Sciences

Quercetin (QC) is a bioflavonoid characterized with poor water solubility that limits its oral bioavailability and hence its therapeutic applications. เท an attempt to enhance its solubility and dissolution rate, both binary and ternary microstructur...

Bioequivalence Study Of 300 Mg Irbesartan Film-Coated Tablets Preparations In Healthy Thai Volunteers, Porranee Puranajoti, Peerawong Werarak, Burapat Intawong, Jarunee Hongrapipat, Rungrudee Talubsri, Soravee Sangsuriyawong, Temsiri Kuamsuk

The Thai Journal of Pharmaceutical Sciences

Irbesartan, an angiotensin II receptor antagonist, is indicated for the treatment of essential hypertension alone or in combination with other antihypertensive agents. The purpose of this study was to compare the bioavailability of two formulations of ir...

Quantitative Analysis Of Epigallocatechin Gallate In Young And Mature Assam Tea Leaf Extracts, Pattra Ahmadi Pirshahid, Thongchai Hemthanon, Yaowaluk Khamphan, Phatsuda Chueboonmee, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Pilot Study Of Antibacterial And Antiinflammatory Activities Of Indian Gooseberry (Phyllanthus Emblica L. Extract) Against Bacteria Associated With Pitted Keratolysis, Rattanasiri Giwanon., Krittiva Thisayakom, Pongsatom Limsiriwong, Saowaluck Ruengsri, Vichein Kheuynok, Kanchana Sriyam, Marudech Srisom, Darunee Pahusee, Sawai Nakakaew, Natthachest Ketmanee, Sontaya Peungsumrong, Chulerattana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Radical-Scavenging And Cellular Dna Protective Activities Of Active Fractions From Lansivm Domesticum Corr. Fruit, Prapaipat Klungsupya, Nava Suthepakul, Sarunya Laovitthayanggoon, Jeerayu Thongdon-A, Srisak Trangwacharakul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Cytotoxic Evaluation Of A Fruit Extract From Zanthoxylum Limonella In Human Dermal Fibroblast Cell Line Using Mtt Assay, Sarunva Laovitthayanggoon., Buppachart Potduang, Natthachest Ketmanee, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Fabrication Of Meloxicam Taste-Masked Oral Fast Disintegrating Tablet By Ion Exchange Resin And Cyclodextrin, Wipada Samprasit, Theerasak Rojanarata, Prasert Akkaramongkolpom, Tanasait Ngawhirunpat, Praneet Opanasopit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development Of Garcinia Mangostana Extract In Liquid Crystal Cream For Topical Delivery System, Napa Bunma, Jirapan Moungjaroen, Prasan Tanguenyongwatana

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Formulation Of Ketoprofen Matrix Membrane For Transdermal Delivery Systems, Jirapomehai Suksaeree, Wiwat Pichayakorn, Chaowalit Monton, Apirak Sakunpak, Tun Chusut, Worawan Saingam, Fameera Madaka

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Cosmeceutical Development Of Oxyresveratrol From Mahad (Artocarpus Lakoocha Roxb.), Surapol Natakankitkul, Nicha Chareonmuang, Tawan Panyakhong, Worrapon Wangkananon

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Time Kill Study Of The In Vitro Activity Of Tigecycline Against Carbapenem-Resistant Klebsiella Pneumoniae, Maimun Halee, Wanchai Treyaprasert, Pompan Koomanachai, Duangdao Waywa

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Does Nicotine Replacement Therapy Reduce The Withdrawal Symptom Of Craving, Or Urge To Smoke, In Dependent Adult Smokers During Smoking Cessation?, Theresa Dijoseph

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not nicotine replacement therapy reduces the withdrawal symptom of craving, or urge to smoke, in dependent adult smokers during smoking cessation.

STUDY DESIGN: Systematic review of three English language and peer-reviewed randomized-controlled trials published in 2009, 2010, and 2011.

DATA SOURCES: One single-blinded randomized-controlled crossover trial, one double-blinded, placebo controlled, randomized-controlled crossover trial, and one single-blinded, placebo controlled, randomized-controlled crossover trial

OUTCOMES MEASURED: Withdrawal symptoms of craving, irritability, difficulty concentrating, and restlessness were measured on a 100mm visual analog scale (VAS). Adverse effects (AEs) of mouth and …

Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma, Jennifer M. Rothberg

Wayne State University Dissertations

Among the non-cellular microenvironmental factors that contribute to malignancy of solid tumors is an acidic peritumoral pH. The first objective was to determine if an acidic extracellular pH observed in vivo (i.e., pHe 6.8) affects the activity of proteases, such as cathepsin B, that contribute to degradation of collagen IV by tumor cells when grown in biologically relevant three-dimensional cultures. At pHe 6.8 there were increases in pericellular active cysteine cathepsins and in degradation of DQ-collagen IV, which was partially blocked by a cathepsin B inhibitor. Imaging probes for active cysteine cathepsins localized to tumors in vivo. The amount of …

Progress Towards Development Of Multifunctional, Dopamine D2/D3 Receptor Agonists As Symptomatic And Disease-Modifying Therapeutic Agents For Parkinson's Disease, Mark Andrew Johnson

Wayne State University Dissertations

Parkinson¡¯s disease (PD) is a progressive, neurodegenerative disorder that arises primarily through the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), resulting in a diminished level of the neurotransmitter dopamine in the nigrostriatal pathway and ensuing loss of motor function. Common symptoms of PD include resting tremor, muscular rigidity, bradykinesia (slowness and decreased amplitude of movement), along with postural instability and cognitive psychiatric complications. PD affects 1% of the population ¡Ý 65 and is the second most prevalent neurodegenerative disorder next to Alzheimer¡¯s disease (AD). Although the etiology of PD is not yet clear and may be …

Mitochondrial Dna Instability In Cells Lacking Aconitase Correlates With Iron Citrate Toxicity, Muhammad A. Farooq, Tammy M. Pracheil, Zhejun Dong, Fei Xiao, Zhengchang Liu

Biological Sciences Faculty Publications

Aconitase, the second enzyme of the tricarboxylic acid cycle encoded by ACO1 in the budding yeast Saccharomyces cerevisiae, catalyzes the conversion of citrate to isocitrate. aco1 Delta results in mitochondrial DNA (mtDNA) instability. It has been proposed that Aco1 binds to mtDNA and mediates its maintenance. Here we propose an alternative mechanism to account for mtDNA loss in aco1 Delta mutant cells. We found that aco1 Delta activated the RTG pathway, resulting in increased expression of genes encoding citrate synthase. By deleting RTG1, RTG3, or genes encoding citrate synthase, mtDNA instability was prevented in aco1 Delta mutant …

Progress Towards Understanding Of Mechanisms Of Action Of Potent Multifunctional Disease Modifying Therapeutics For Parkinson's Disease & Investigating The Methamphetamine-Induced Striatal Microglia Activation., Mrudang M. Shah

Wayne State University Dissertations

PROGRESS TOWARDS UNDERSTANDING OF MECHANISMS OF ACTION OF POTENT MULTIFUNCTIONAL DISEASE MODIFYING

THERAPEUTICS FOR PARKINSON'S DISEASE.

by

MRUDANG MANOJKUMAR SHAH

December 2013

Advisor: Dr. Aloke Dutta

Major: Pharmaceutical Sciences

Degree: Doctor of Philosophy

Our long term goal is to design and develop potent multifunctional disease modifying therapeutics for Parkinson's disease. The objective of my dissertation was to understand the mechanisms of action of some potent small molecules (synthesized in our lab) as a disease modifying Parkinson's disease therapeutic. The objective was achieved by pursuing the following two specific aims:

1. Investigating anti-oxidant and neuroprotective effects of a lead molecule (D-512) …

Design, Synthesis, Biological Evaluation And Molecular Modeling Studies Of Novel Multifunctional Neuroprotective Drugs For The Treatment Of Parkinson's Disease: An Effort Towards The Improvement Of In Vivo Efficacy And Modulation Of Alpha Synuclein Aggregation Property Of The Neuroprotective Parent, Gyan Prakash Modi

Wayne State University Dissertations

DESIGN, SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR MODELING STUDIES OF NOVEL MULTIFUNCTIONAL NEUROPROTECTIVE DRUGS FOR THE TREATMENT OF PARKINSON'S DISEASE: AN EFFORT TOWARDS THE IMPROVEMENT OF IN VIVO EFFICACY AND MODULATION OF ALPHA SYNUCLEIN AGGREGATION PROPERTY OF THE NEUROPROTECTIVE PARENT MOLECULE (D-264)

by

GYAN PRAKASH MODI

May 2014

Advisor: Dr. Aloke K. Dutta

Major: Pharmaceutical Sciences

Degree: Doctor of Philosophy

Parkinson's disease (PD) is a progressive age-related neurodegenerative disorder of the central nervous system that is characterized by gradual loss of dopaminergic neurons in the substantia nigra region of the brain. The research from the past two decades in PD area …

The Bio-Nano-Interface In Predicting Nanoparticle Fate And Behaviour In Living Organisms: Towards Grouping And Categorising Nanomaterials And Ensuring Nanosafety By Design, Hugh Byrne, Arti Ahluwalia, Diana Boraschi,, Bengt Fadeel, Peter Gehr, Arno C. Gutleb, Michaela Kendall, Manthos Papadopoulos, Iseult Lynch

Articles

In biological media, nanoparticles acquire a coating of biomolecules (proteins, lipids, polysaccharides) from their surroundings, which reduces their surface energy and confers a biological identity to the particles. This adsorbed layer is the interface between the nanomaterial and living systems and therefore plays a significant role in determining the fate and behaviour of the nanoparticles. This review summarises the state of the art in terms of understanding the bio-nano interface and provides direction for potential future research directions and some recommendations for future priorities and strategies to support the safe implementation of nanotechnologies. The central premise is that nanomaterials must …

Insulin Treatment Attenuates Renal Adam17 And Ace2 Shedding In Akita Diabetic Mice, Esam Said Busah Salem

Browse all Theses and Dissertations

Diabetic patients have a 40%-50% lifetime chance of developing chronic kidney disease, which remains one of the leading causes of morbidity and mortality. Alterations within renin angiotensin system balance contribute to the pathogenesis of diabetic kidney disease. Angiotensin converting enzyme 2 (ACE2) has an endogenous renoprotective role due to its ability to form angiotensin (1-7) (Ang 1-7) by degrading angiotensin II (Ang II). We have shown previously that hyperglycemia increases urinary ACE2 and albumin excretion in db/db diabetic mice. The protease, disintegrin and metalloprotease (ADAM) 17, is involved in the shedding of several transmembrane proteins, including ACE2 in vitro. Tissue …