Bacterial Communication And Its Role As A Target For Nanoparticle-Based Antimicrobial Therapy,
2015
University of South Carolina - Columbia
Bacterial Communication And Its Role As A Target For Nanoparticle-Based Antimicrobial Therapy, Kristen Publicover Miller
Theses and Dissertations
The goal of this dissertation is to establish the environmental and public health importance of alternative forms of antimicrobial therapy, specifically those that utilize nanotechnology to combat quorum sensing-controlled bacterial infections. Quorum sensing (i.e. chemical communication) is an inherent characteristic that is essential to bacterial pathogenesis and biofilm formation (where most infections occur). A thorough review of the literature has been conducted to establish an understanding of the state of nanotechnology research as it relates to combatting bacterial infections. This synthesis, provided in Chapter 1, demonstrates how the chemical and structural designs of nanoparticles can be manipulated to specifically target …
High-Content Screening In Zebrafish Embryos Identifies Abamectin As A Potent Neurotoxicant,
2015
University of South Carolina - Columbia
High-Content Screening In Zebrafish Embryos Identifies Abamectin As A Potent Neurotoxicant, Tara Diane Raftery
Theses and Dissertations
During development, the nervous system is a sensitive target for chemical exposure in both humans and animal models, and early life-stage exposures can lead to long-term effects on motor activity, sensory function, and cognition. Currently, there are minimal to no developmental neurotoxicity (DNT) data available for thousands of chemicals used in commerce, and it is impractical to screen these chemicals in rodent models using the existing DNT test guideline, as this test is costly, time- and animalintensive, and low-throughput. Therefore, there is a recognized need to use alternative non-mammalian models to support screening and prioritization of chemicals for DNT testing, …
Effects Of Hiv-1 Tat On The Enteric Nervous,
2015
Virginia Commonwealth University
Effects Of Hiv-1 Tat On The Enteric Nervous, Joy Ngwainmbi
Theses and Dissertations
More than 1.2 million people are estimated to be currently living with the human immunodeficiency virus (HIV) in the United States of America. The gastrointestinal (GI) tract is both a major target and an important component of HIV pathogenesis. The GI processes that are dysregulated during HIV infection are controlled by the enteric nervous system (ENS). Indeed, both clinical and experimental studies have implicated the ENS in HIV and simian immunodeficiency virus (SIV) pathogenesis. In addition to direct viral effects, the HIV virus also indirectly affects the GI tract via cellular and/or viral toxins released by infected cells. Trans-activator of …
Relationship Between Autophagy, Senescence, And Dna Damage In Radiation Sensitization By Parp Inhibition,
2015
Virginia Commonwealth University
Relationship Between Autophagy, Senescence, And Dna Damage In Radiation Sensitization By Parp Inhibition, Moureq Alotaibi
Theses and Dissertations
Radiotherapy continues to be a primary modality in the treatment of cancer. DNA damage induced by radiation can promote apoptosis as well as both autophagy and senescence, where autophagy and senescence can theoretically function to prolong tumor survival. A primary aim of this work was to investigate the hypothesis that autophagy and/or senescence could be permissive for DNA repair, thereby facilitating tumor cell recovery from radiation-induced growth arrest and/or cell death. In addition, studies were designed to elucidate the involvement of autophagy and senescence in radiation sensitization by PARP inhibitors and the re-emergence of a proliferating tumor cell population. In …
Synthetic Cannabinoids Versus Delta-9-Tetrahydrocannabinol: Abuse-Related Consequences Of Enhanced Efficacy At The Cannabinoid 1 Receptor,
2015
Virginia Commonwealth University
Synthetic Cannabinoids Versus Delta-9-Tetrahydrocannabinol: Abuse-Related Consequences Of Enhanced Efficacy At The Cannabinoid 1 Receptor, Travis Grim
Theses and Dissertations
In the past ten years, synthetic cannabinoids (SC) have emerged as drugs of abuse. Unlike D9-tetrahydrocannabinol (THC), many SCs are associated with serious health complications and death. One way in which THC and SCs differ lies with their enhanced potency and efficacy at the CB1 receptor. No current methods exist to measure efficacy at the CB1 receptor in vivo, and the abuse-related properties of SC cannabinoids are not well explored. Here, we utilized CB1 wild type (WT), heterozygous (HET), and knockout (KO) mice. By employing CB1 ligands which differ in efficacy we have …
Detecting Diesel Particulate Matter Using Real Time Monitoring Under The Influence Of An Exhaust Fan System,
2015
Missouri University of Science and Technology
Detecting Diesel Particulate Matter Using Real Time Monitoring Under The Influence Of An Exhaust Fan System, Yasir Helal Alghamdi
Masters Theses
"Diesel Particulate Matter (DPM) is a complex mixture of diesel exhaust gas that consists of carbon, ash, metallic abrasion particles, sulfates and silicates. The diesel soot particle includes a solid core made of elemental carbon, and organic carbon compound attached to the surface of the soot particle. The main source of DPM is diesel exhaust gas. The National Institute for Occupational Safety and Health (NIOSH) and the Environmental Protection Agency (EPA) have determined that DPM is the source of most of the emissions of carbon monoxide, carbon dioxide, oxide of nitrogen, and hydrocarbons in underground coal, metal and non metal …
Effect Of Vitamin E Supplementation On Inflammatory Markers And Nutrition Status In Thalassemia Intermedia Patients,
2015
Chulalongkorn University
Effect Of Vitamin E Supplementation On Inflammatory Markers And Nutrition Status In Thalassemia Intermedia Patients, Watcharee Prapawatwech, Bunchoo Pongtanakul, Kulwara Meksawan
The Thai Journal of Pharmaceutical Sciences
Inflammation is a complication found in thalassemic patients. It may be diminished by supplementation of vitamin E. The purpose of this study was to investigate the effects of 12-week vitamin E supplementation on inflammatory markers in patients with tha...
Approximation Of Fire-Return Intervals With Point Samples In The Southern Range Of The Coast Redwood Forest, California, Usa,
2015
National Park Service
Approximation Of Fire-Return Intervals With Point Samples In The Southern Range Of The Coast Redwood Forest, California, Usa, Gregory Jones, Will Russell
Faculty Publications, Environmental Studies
A legacy of past fires is evident in the form of blackened basal hollows found throughout the southern range of the coast redwood (Sequoia sempervirens [D. Don] Endl.) forest. A deeper look reveals cambial scars dating back centuries, telling a story of low- to moderate-intensity fires that burned periodically across California’s Central Coast bioregion. While attempts have been made to reconstruct the fire history of this forest type, estimates of the fire-return interval vary widely, and the relationship of the fire-return interval to varying cultural influences is not fully understood. We analyzed 373 fire scars from 70 cross-sections removed from …
Xlf-Dependent Nonhomologous End Joining Of Complex Dna Double-Strand Breaks With Proximal Thymine Glycol And Screening For Xrcc4-Xlf Interaction Inhibitors,
2015
Virginia Commonwealth University
Xlf-Dependent Nonhomologous End Joining Of Complex Dna Double-Strand Breaks With Proximal Thymine Glycol And Screening For Xrcc4-Xlf Interaction Inhibitors, Mohammed Al Mohaini
Theses and Dissertations
DNA double-strand breaks induced by ionizing radiation are often accompanied by ancillary oxidative base damage that may prevent or delay their repair. In order to better define the features that make some DSBs repair-resistant, XLF-dependent nonhomologous end joining of blunt-ended DSB substrates having the oxidatively modified nonplanar base thymine glycol (Tg) at the first (Tg1) , second (Tg2), third (Tg3) or fifth (Tg5) positions from one 3’ terminus was examined in human whole-cell extracts. Tg at the third position had little effect on end-joining even when present on both ends of the break. However, Tg as the terminal or penultimate …
Expression And Pharmacological Modulation Of Pain-Depressed Behavior In Rats,
2015
Virginia Commonwealth University
Expression And Pharmacological Modulation Of Pain-Depressed Behavior In Rats, Michael D. Leitl
Theses and Dissertations
Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treatment. This goal of this dissertation was to conduct preclinical research experiments designed to address a set of three inter-related aims that examine the expression, mechanisms and treatment of pain-related depression of Intracranial Self-Stimulation (ICSS) in rats. First, studies evaluated the hypothesis that acute acid-induced depression of ICSS was mediated by a kappa opioid receptor mediated decrease in mesolimbic dopamine release in the nucleus accumbens. Results support a role for depressed mesolimbic dopamine release in pain-related depression of ICSS; however, …
Structural Determinants Of Abuse-Related Neurochemical And Behavioral Effects Of Para-Substituted Methcathinone Analogs In Rats,
2015
Virginia Commonwealth University
Structural Determinants Of Abuse-Related Neurochemical And Behavioral Effects Of Para-Substituted Methcathinone Analogs In Rats, Julie S. Bonano
Theses and Dissertations
Methcathinone (MCAT) is the β-ketone analog of methamphetamine, and like its amphetamine analog, MCAT functions as a monoamine releaser that selectively promotes the release of dopamine (DA) and norepinephrine (NE) over serotonin (5-HT). MCAT produces amphetamine-like psychostimulant effects and is classified as a Schedule I drug of abuse by the United States Drug Enforcement Administration (DEA). Recently, synthetic MCAT analogs have emerged as designer drugs of abuse in Europe and the United States and have been marketed under deceptively benign names like “bath salts” in an attempt to evade legal restriction. These dangerous, recently emergent and novel drugs of abuse …
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix F. Gene Ontology Maps,
2015
Utah State University
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix F. Gene Ontology Maps, Trevor Fish, Abby Benninghoff
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This archive includes 10 individual image files, each of which depicts a Gene Ontolgoy map for GO terms representing hypermethylated gene promoters unique for the indicated tissue(s) (listed first in file name) compared to other tissues (listed in parentheses in file name).
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix D. Gene Lists For Ontology Analysis,
2015
Utah State University
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix D. Gene Lists For Ontology Analysis, Trevor Fish, Abby Benninghoff
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No abstract provided.
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix B. Nimblegen Processed Data Report For Nearest Methylated Peaks,
2015
Utah State University
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix B. Nimblegen Processed Data Report For Nearest Methylated Peaks, Trevor Fish, Abby Benninghoff
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No abstract provided.
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix C. Peak Scores Summary Table For All Methylated Genes In Any Data Set,
2015
Utah State University
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix C. Peak Scores Summary Table For All Methylated Genes In Any Data Set, Trevor Fish, Abby Benninghoff
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No abstract provided.
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix A. Nimblegen Processed Data Report For All Methylated Peaks,
2015
Utah State University
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix A. Nimblegen Processed Data Report For All Methylated Peaks, Trevor Fish, Abby Benninghoff
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No abstract provided.
Sigma Receptor Activation Mitigates Toxicity Evoked By The Convergence Of Ischemia, Acidosis And Amyloid-Beta,
2015
University of South Florida
Sigma Receptor Activation Mitigates Toxicity Evoked By The Convergence Of Ischemia, Acidosis And Amyloid-Beta, Adam Alexander Behensky
USF Tampa Graduate Theses and Dissertations
Stroke is the fifth leading cause of death in the United States and a major cause of long-term disability in industrialized countries. The core region of an ischemic stroke dies within minutes due to activation of necrotic pathways. Outside of this core region is the penumbral zone, where some perfusion is maintained via collateral arteries. Delayed cell death occurs in this area due to the triggering of apoptotic mechanisms, which expands the ischemic injury over time. The cellular and molecular events that produce the expansion of the ischemic core continue to be poorly understood. The increases in the amyloid precursor …
Utilization Of Placebo Response In Double-Blind Psychopharmacological Studies, Contextual Perspective,
2015
Antioch University - Seattle
Utilization Of Placebo Response In Double-Blind Psychopharmacological Studies, Contextual Perspective, Margarita Olegovna Ashirova
Antioch University Dissertations & Theses
Placebo response has been an elusive phenomenon in the fields of medicine, medical research, and psychology. Even though it has been heavily utilized as a comparator treatment in double-blind psychopharmacological studies, the reliable definition and consistent understanding of placebo response are missing. In this contextual exploration, I outlined the state of current placebo response research and variable rates of placebo response reported in double-blind studies. I identified the gap in the literature—lack of consistent understanding of placebo response—that has led to a waste of resources by the psychopharmacological research industry. Further, I compared and contrasted the current inconsistent Western medical …
Ramapough/Ford The Impact And Survival Of An Indigenous Community In The Shadow Of Ford Motor Company’S Toxic Legacy,
2015
Antioch University - New England
Ramapough/Ford The Impact And Survival Of An Indigenous Community In The Shadow Of Ford Motor Company’S Toxic Legacy, Chuck Stead
Antioch University Dissertations & Theses
The purpose of this study was to examine the history of the Ford Motor Company’s impact upon the Ramapo Watershed of New York and New Jersey, as well as upon the Ramapough Munsi Nation, an indigenous population living there. In a 25 year span the automaker produced a record number of vehicles and dumped a massive amount of lead paint, leaving behind a toxic legacy that continues to plaque the area and its residents. The Ramapough people are not unlike many native nations living in the United States who have experienced industrial excess. This study examines the mindset that allows …
Challenges Posed By Tick-Borne Rickettsiae: Eco- Epidemiology And Public Health Implications,
2015
Georgia Southern University
Challenges Posed By Tick-Borne Rickettsiae: Eco- Epidemiology And Public Health Implications, Marina E. Eremeeva, Gregory A. Dasch
Environmental Health Sciences: Faculty Publications
Rickettsiae are obligately intracellular bacteria that are transmitted to vertebrates by a variety of arthropod vectors, primarily by fleas and ticks. Once transmitted or experimentally inoculated into susceptible mammals, some rickettsiae may cause febrile illness of different morbidity and mortality, and which can manifest with different types of exhanthems in humans. However, most rickettsiae circulate in diverse sylvatic or peridomestic reservoirs without having obvious impacts on their vertebrate hosts or affecting humans. We have analyzed the key features of tick-borne maintenance of rickettsiae, which may provide a deeper basis for understanding those complex invertebrate interactions and strategies that have permitted …
