Pharmacology, Toxicology and Environmental Health Commons^™

Evaluation Of Anti-Anxiety Activity Of Melissa Parviflora (Benth.) In Rats, Kundan Singh Bora, Aruna Dubey

The Thai Journal of Pharmaceutical Sciences

Melissa parviflora Benth. (Family: Lamiaceae) has been traditionally used as a tranquillizer, relaxants, nervine and sleeping aids throughout the world. The plant is reported to relieve tension and stress reactions, and widely valued for its calming prop...

In Vitro Biological Activities Of Black Pepper Essential Oil And Its Major Components Relevant To The Prevention Of Alzheimer’S Disease, Pattamapan Lomarat, Kittisak Sripha, Phanida Phanthong, Worawan Kitphati, Krit Thirapanmethee, Nuntavan Bunyapraphatsara

The Thai Journal of Pharmaceutical Sciences

Black pepper oil and its major components were investigated for the biological activities related to the prevention of AD. The inhibition of acetylcholinesterase (AChE) and β-amyloid aggregation, anti-inflammatory and antioxidant activities were examine...

Phytofabrication Of Silver Nanoparticles Using Horse Gram (Dolichos Biflorus L.) Seed Extract And Assessment Of Its Bactericidal And Antioxidant Activities, Mahadevan Vijayalakshmi, Thangavel Rajagopal, Jeyachandran Vijayakumar, Ponnirul Ponmanickam

The Thai Journal of Pharmaceutical Sciences

The silver nanoparticles synthesized by phytofabrication method receive bigger attention due to their fascinating properties. This study deals with the green mediated synthesis of silver nanoparticles using seed extract of horse gram (Dolichos biflorus L...

Screening Of Patients Receiving Selegiline From Methamphetamine Abusers Using The Urinary Amphetamine/Methamphetamine Ratio, Nunthika Kaewpunya, Wichian Tungtananuwat, Akravudh Viriyavejakul, Patramon Yongpanich, Nantana Thong-Ra-Ar, Chanchai Hosanguan, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

Methamphetamine (MA), the major metabolite of selegiline excreted in urine, can cause false positive interpretation of patient receiving selegiline as a MA user based on the routine non-chiral separation method. This study aims to compare the ratio of am...

Protein-Protein Docking And Molecular Dynamics Simulations Elucidated Binding Modes Of Fubi-P62 Uba Complex, Sumet Chongruchiroj, Panida Kongsawadworakul, Veena Nukoolkarn, Montree Jaturanpinyo, Wichit Nosoong-Noen, Jiraporn Chingunpitak, Jaturong Pratuangdejkul

The Thai Journal of Pharmaceutical Sciences

The cytosolic Fau protein, a precursor of antimicrobial peptide, composes of ubiquitin-like domain FUBI at Nterminus and ribosomal protein rpS30 at C-terminus. Fau has been important in killing of intracellular Mycobacterium tuberculosis infection throug...

In Silico Docking And Pharmacophoric Analysis Of 3-Indolyl Pyridine Derivatives Toward Cyclooxygenase-2, Sukumar Bepary, Ge Hyeong Lee, Hee Jong Lim, In Kwon Youn

The Thai Journal of Pharmaceutical Sciences

A series of 3-indolyl pyridine derivatives having anti-inflammatory activities were docked into the indomethacin binding pocket of cyclooxygenase-2 enzyme. In this in silico study, the possible orientations of the molecules in the binding site of the rec...

Integration Of Thai Traditional Medicine Into Physicians' Practice Part 1: Conditions Facilitating The Integration, Katekaew Jehso, Sanguan Lerkiatbundit, Wantanee Wiroonpanich

The Thai Journal of Pharmaceutical Sciences

The purpose of this study was to gain a greater understanding of the physicians’ experiences in the conditions facilitating physicians to integrate Thai traditional medicine (TTM) into their current practice. A qualitative grounded theory method was de...

Integration Of Thai Traditional Medicine Into Physicians' Practice Part 2: Raising Consciousness, The Process Of Integration From Physicians' Experiences, Katekaew Jehso, Sanguan Lerkiatbundit, Wantanee Wiroonpanich

The Thai Journal of Pharmaceutical Sciences

The main purpose of the study was to gain deeper insight on physicians’ experiences in the integration process of Thai traditional medicine (TTM) into their practice. A grounded theory method was used to gain an understanding of the core process from p...

Hptlc Method For Simultaneous Estimation Of Ramipril And Losartan Potassium In Pharmaceutical Dosage Form: Development And Validation Consideration, Darshana A. Parmar, Dinesh V. Thakkar, Rashmin B. Patel, Mrunali R. Patel

The Thai Journal of Pharmaceutical Sciences

This paper describes validated high-performance thin-layer chromatography (HPTLC) methods for simultaneous estimation of ramipril (RAM) and losartan potassium (LOS) in pure powder and formulation. The HPTLC separation was achieved on an aluminum-backed l...

Anti-Platelet Aggregation Activity And Chemical Analysis Of Raw And Wine Stir-Fried Chuanxiong Rhizoma (Kot-Hua-Bua), Uthai Sotanaphun, Rataya Luechapudiporn, Prinyaporn Pradmeeteekul, Jankana Burana-Osot, Panadda Phattanawasin, Noppamas Soonthornchareonnon, Yenchit Techadamrongsin

The Thai Journal of Pharmaceutical Sciences

Chuanxiong Rhizoma (CR) is the dried rhizome of Ligusticum chuanxiong Hort. It is known as Kot-HuaBua in Thai traditional medicine. Two types of CR, raw CR and wine stir-fried CR, were commercially available in traditional drugstores in Thailand. Raw CR ...

Development Thai Herbal Medicine Knowledge Base Using Ontology Technique, Wachana Tungkwampian, Anuchai Theerarungchaisri, Marut Buranarach

The Thai Journal of Pharmaceutical Sciences

This study proposes a method for developing a knowledge base of Thai herbal medicine by using ontology techniques and developing its application as a semantic search system. Since knowledge of Thai herbal medicine is often presented in flat knowledge and...

Economic Impact Assessment On Good Pharmacy Practice Regulation In Thai Community Pharmacy, Thatjuta Wuttipanich, Tanattha Kitisopee

The Thai Journal of Pharmaceutical Sciences

Good Pharmacy Practice (GPP) in community and hospital pharmacy setting is a crucial standard for pharmacy services. The Thai Food and Drug Administration (Thai-FDA) realized the benefit of GPP and tried to implement this concept as a regulation for ever...

Preference On Medication Therapy Management (Mtm) Service: Results From Discrete Choice Experiment, Sutthawan Chancheochai, Rungpetch Sakulbumrungsil, Surachat Ngorsurachet

The Thai Journal of Pharmaceutical Sciences

Objectives: To assess preference and estimate willingness to pay (WTP) for medication therapy management (MTM) service. Method: A discrete choice experiment (DCE) was conducted in general population. The five relevant MTM service attributes (service sett...

Development And Validation Of A Stability-Indicating Hplc Method For Determination Of Clorazepate Dipotassium And Its Main Impurities In Bulk Drug And Capsules, Jankana Burana-Osot, Chanokporn Sukonpan, Sooksri Ungboriboonpisal

The Thai Journal of Pharmaceutical Sciences

A simple isocratic stability-indicating HPLC method was developed and validated for the simultaneous determination of clorazepate dipotassium in the presence of its main impurities; nordiazepam and 2-amino-5- chlorobenzophenone, in bulk drug and capsul...

Cocrystallization Of Artemisinin And Amodiaquine Hydrochloride, Wiriyaporn Sirikun, Jittima Chatchawalsaisin, Narueporn Sutanthavibul

The Thai Journal of Pharmaceutical Sciences

Artemisinin (ART) and amodiaquinedihydrochloride dihydrate (AQD) was selected as model host and guest molecules in the study. Cocrystallization of ART and AQD at mole ratio of 1:1 by temperature change technique using ethanol, new structure was found, ...

Approximation Of Fire-Return Intervals With Point Samples In The Southern Range Of The Coast Redwood Forest, California, Usa, Gregory Jones, Will Russell

Faculty Publications, Environmental Studies

A legacy of past fires is evident in the form of blackened basal hollows found throughout the southern range of the coast redwood (Sequoia sempervirens [D. Don] Endl.) forest.  A deeper look reveals cambial scars dating back centuries, telling a story of low- to moderate-intensity fires that burned periodically across California’s Central Coast bioregion.  While attempts have been made to reconstruct the fire history of this forest type, estimates of the fire-return interval vary widely, and the relationship of the fire-return interval to varying cultural influences is not fully understood.  We analyzed 373 fire scars from 70 cross-sections removed from …

Xlf-Dependent Nonhomologous End Joining Of Complex Dna Double-Strand Breaks With Proximal Thymine Glycol And Screening For Xrcc4-Xlf Interaction Inhibitors, Mohammed Al Mohaini

Theses and Dissertations

DNA double-strand breaks induced by ionizing radiation are often accompanied by ancillary oxidative base damage that may prevent or delay their repair. In order to better define the features that make some DSBs repair-resistant, XLF-dependent nonhomologous end joining of blunt-ended DSB substrates having the oxidatively modified nonplanar base thymine glycol (Tg) at the first (Tg1) , second (Tg2), third (Tg3) or fifth (Tg5) positions from one 3’ terminus was examined in human whole-cell extracts. Tg at the third position had little effect on end-joining even when present on both ends of the break. However, Tg as the terminal or penultimate …

Expression And Pharmacological Modulation Of Pain-Depressed Behavior In Rats, Michael D. Leitl

Theses and Dissertations

Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treatment. This goal of this dissertation was to conduct preclinical research experiments designed to address a set of three inter-related aims that examine the expression, mechanisms and treatment of pain-related depression of Intracranial Self-Stimulation (ICSS) in rats. First, studies evaluated the hypothesis that acute acid-induced depression of ICSS was mediated by a kappa opioid receptor mediated decrease in mesolimbic dopamine release in the nucleus accumbens. Results support a role for depressed mesolimbic dopamine release in pain-related depression of ICSS; however, …

Pemetrexed, A Modulator Of Amp-Activated Kinase Signaling And An Inhibitor Of Wild Type And Mutant P53, Stuti Agarwal

Theses and Dissertations

New drug discoveries and new approaches towards diagnosis and treatment have improved cancer therapeutics remarkably. One of the most influential and effective discoveries in the field of cancer therapeutics was antimetabolites, such as the antifolates. The interest in antifolates increased as some of the antifolates showed responses in cancers, such as mesothelioma, leukemia, and breast cancers. When pemetrexed (PTX) was discovered, our laboratory had established that the primary mechanism of action of pemetrexed is to inhibit thymidylate 22 synthase (TS) (E. Taylor et al., 1992). Preclinical studies have shown that PTX has a broad range of antitumor activity in human …

Integrated Nanoscale Imaging And Spatial Recognition Of Biomolecules On Surfaces, Congzhou Wang

Theses and Dissertations

Biomolecules on cell surfaces play critical roles in diverse biological and physiological processes. However, conventional bulk scale techniques are unable to clarify the density and distribution of specific biomolecules in situ on single, living cell surfaces at the micro or nanoscale. In this work, a single cell analysis technique based on Atomic Force Microscopy (AFM) is developed to spatially identify biomolecules and characterize nanomechanical properties on single cell surfaces. The unique advantage of these AFM-based techniques lies in the ability to operate in situ (in a non-destructive fashion) and in real time, under physiological conditions or controlled micro-environments.

First, AFM-based …