Population Pharmacokinetics Analysis Of Vancomycin In Critically Ill Patients,
2018
Chulalongkorn University
Population Pharmacokinetics Analysis Of Vancomycin In Critically Ill Patients, Wanchai Treyaprasert
The Thai Journal of Pharmaceutical Sciences
Objectives: The aim of this study was to determine population pharmacokinetic parameters of vancomycin in adult critically ill patients and to investigate the covariates affecting population pharmacokinetic parameters. Methods: Plasma concentration data..
Effect Of Temperature And Time On Free Amino Acid Profile In Thai Chicken Bone Soup Stock Preparation,
2018
Chulalongkorn University
Effect Of Temperature And Time On Free Amino Acid Profile In Thai Chicken Bone Soup Stock Preparation, Nattida Chotechuang, Matichon Lokkhumlue, Pawinee Deetae
The Thai Journal of Pharmaceutical Sciences
Soup stock is the basic material for cooking various types of food, including Thai food. General practice to prepare Thai soup stock is to gentle boil chicken bone soup stock between 85-95°C for 1-3 hours to get good quality soup stock. Free amino aci..
Apigenin And Baicalin, Each Alone Or In Low Dose Combination, Attenuated Chloroquine Induced Male Infertility In Adult Rats,
2018
Chulalongkorn University
Apigenin And Baicalin, Each Alone Or In Low Dose Combination, Attenuated Chloroquine Induced Male Infertility In Adult Rats, Amira Akilah, Mohamed Balaha, Mohamed-Nabeih Abd-El Rahman, Sabiha Hedya
The Thai Journal of Pharmaceutical Sciences
Male infertility is a worldwide health problem, which accounts for about 50% of all cases of infertility and considered as the commonest single defined cause of infertility. Recently, apigenin and baicalin exhibited a powerful antioxidant and antiapoptot.
The Protective Effect Of Lycopene-Rich Products On Skin Photodamage: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials,
2018
Chulalongkorn University
The Protective Effect Of Lycopene-Rich Products On Skin Photodamage: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Witoo Dilokthornsakul, Teerapon Dhippayom, Piyameth Dilokthornsakul
The Thai Journal of Pharmaceutical Sciences
Background: Ultraviolet (UV) radiation has known as a major cause of photodamage, photoaging and skin cancer as it involves in reactive oxygen species generation. Several natural antioxidants including lycopene has been suggested for photoprotection. How.
Suitability Of Alternative Atp Potency Assay For Lot Release Of Tokyo Bcg- 172-1 Vaccines In Thailand,
2018
Chulalongkorn University
Suitability Of Alternative Atp Potency Assay For Lot Release Of Tokyo Bcg- 172-1 Vaccines In Thailand, Supaporn Phumiamorn
The Thai Journal of Pharmaceutical Sciences
The potency assay of the BCG vaccine is routinely performed by a conventional viable count on a solid medium. This assay method is not only time-consuming, but can give variable results because of the tendency to clump of mycobacterium. The intracellular.
A Simple High-Performance Liquid Chromatographic Method For Quantitative Analysis Of Brazilin In Caesalpinia Sappan L. Extracts,
2018
Chulalongkorn University
A Simple High-Performance Liquid Chromatographic Method For Quantitative Analysis Of Brazilin In Caesalpinia Sappan L. Extracts, Sakan Warinhomhaun, Boonchoo Sritularak, Dusadee Charnvanich
The Thai Journal of Pharmaceutical Sciences
The specific aim of the study was to develop and validate a simple reversed-phase high-performance liquid chromatographic (HPLC) method for assay of brazilin in Caesalpinia sappan L. (sappanwood) extracts. Validation of the HPLC method was conducted unde.
Access To Medicines For Breast, Colorectal, And Lung Cancer In Thailand,
2018
Chulalongkorn University
Access To Medicines For Breast, Colorectal, And Lung Cancer In Thailand, Pornsroung Saerekul, Tharin Limsakun, Puree Anantachoti, Rungpetch Sakulbumrungsil
The Thai Journal of Pharmaceutical Sciences
Cancer drugs have become prohibitive, and consequently their accessibility has increasingly been of great concern in many countries. Particularly, the information about cancer drug access in Thailand has been sporadic. Therefore, the goal of the study wa.
Anti-Inflammatory Effect Of Centella Asiatica Extract On Prevented Aortic Intima-Media Thickening In Diabetic Rats,
2018
Chulalongkorn University
Anti-Inflammatory Effect Of Centella Asiatica Extract On Prevented Aortic Intima-Media Thickening In Diabetic Rats, Amalia Anita Hawas, Dwi Aris Agung Nugrahaningsih, Eti Nurwening Sholikhah, Sadli Syarifuddin, Rahmi Ayu Wijayaningsih, Ngatidjan
The Thai Journal of Pharmaceutical Sciences
Objectives: To explore the effect of C. asiatica extract on intima-media thickness, eNOS expression, and macrophage M1/M2 ratio in diabetic rats aorta. Materials and Methods: Wistar rats consisted of normal group and diabetic group which divided into neg.
Effect Of Ipomoea Hederacea Jacq. Methanolic Extract On Blood Pressure And Relaxation Of Rat Thoracic Aorta: Evidence Indicated The Release Of No And H2s,
2018
Chulalongkorn University
Effect Of Ipomoea Hederacea Jacq. Methanolic Extract On Blood Pressure And Relaxation Of Rat Thoracic Aorta: Evidence Indicated The Release Of No And H2s, Chaweewan Jansakul
The Thai Journal of Pharmaceutical Sciences
Seeds of Ipomoeahederacea Jacq. (IH) are used in traditional medicine to manage ailments pertaining to the vasculature, circulatory system and related disorders. However no study exists to validate their usage for said ailments. The present study was con.
Solubilization Of Fluocinolone Acetonide By Cosolvents And Surfactants For Buccal Solution Preparation,
2018
Chulalongkorn University
Solubilization Of Fluocinolone Acetonide By Cosolvents And Surfactants For Buccal Solution Preparation, Pornpen Werawatganone, Walaisiri Muangsiri, Tipanan Chaivanon, Pavinee Kungwanpongpun, Paricha Rattanawong
The Thai Journal of Pharmaceutical Sciences
Fluocinolone acetonide (FA) buccal solution was prepared for treatment of oral lichen planus using cosolvents and surfactant to enhance FA solubility. Based on solubility power (s), cosolvents enhanced FA solubility in the order; polyethylene glycol 400 .
Antioxidant Potential Of Wild Lagenaria Siceraria (Molina) Standl,
2018
Chulalongkorn University
Antioxidant Potential Of Wild Lagenaria Siceraria (Molina) Standl, Suraj B. Patel, Usmangani A. Attar, S G. Ghane
The Thai Journal of Pharmaceutical Sciences
Objective: The aim of the present study was to evaluate the phytochemicals and antioxidant activity of leaf and fruit of wild Bottle gourd. Methods: Successive extraction of dried material was done by soxhlet apparatus and phytochemicals such as total p..
Study Of Antioxidant, Antimicrobial, Tyrosinase Inhibitory, Alcohol Dehydrogenase, And Acetaldehyde Dehydrogenase Activity Of Roasted Dendropanax Morbifera Lev. Leaves With Different Ethanol Concentrations,
2018
Chulalongkorn University
Study Of Antioxidant, Antimicrobial, Tyrosinase Inhibitory, Alcohol Dehydrogenase, And Acetaldehyde Dehydrogenase Activity Of Roasted Dendropanax Morbifera Lev. Leaves With Different Ethanol Concentrations, Masaya Nakamura, Ra Jong-Hwan, Kim Ju-Sung
The Thai Journal of Pharmaceutical Sciences
Introduction: The history of Dendropanax morbifera LEV., which is indigenous plant in Korea, is quit old and simultaneously, known for locals as remedy of various diseases such as migraine and inflammation. The aim of this study is evaluating the antioxi.
Quick-Fat Diet Inhibits The Development Of Diabetes In Spontaneously Diabetic Torii (Sdt) Rats,
2018
Chulalongkorn University
Quick-Fat Diet Inhibits The Development Of Diabetes In Spontaneously Diabetic Torii (Sdt) Rats, Takeshi Ohta, Takahisa Yamada, Taiichiro Kamiya, Takayuki Gotoh, Masataka Tsubaki, Masami Shinohara
The Thai Journal of Pharmaceutical Sciences
The diabetic animal model is very useful for developing functional foods and medicinal drugs. Spontaneously Diabetic Torii (SDT) rat, a non-obese type 2 diabetic model, is one of the hopeful models to play an important role for research and development o.
Hepatoprotective Activity Of Curcuma Xanthorrhiza Roxb. Paracetamol-Induced Liver Damage In Rats And Correlation With Their Chemical Compounds,
2018
Chulalongkorn University
Hepatoprotective Activity Of Curcuma Xanthorrhiza Roxb. Paracetamol-Induced Liver Damage In Rats And Correlation With Their Chemical Compounds, Suwijiyo Pramono, Fitriana Hayyu Arifah, Fitrawan Hernuza Pribadi, Agung Endro Nugroho
The Thai Journal of Pharmaceutical Sciences
Paracetamol is a widely used drug, but at high dose, it can produce undesirable side effects such as hepatotoxicity. Curcuma xanthorrhiza Roxb. is the one of Indonesian medicinal plants that traditionally used to treat liver disorders. The present study .
Effects Of Unweathered Or Soil Weathered Copper-Based Nanoparticles And Compounds On Soil Grown Bell Pepper (Capsicum Annuum) And Spinach (Spinacia Oleracea) Plants,
2018
University of Texas at El Paso
Effects Of Unweathered Or Soil Weathered Copper-Based Nanoparticles And Compounds On Soil Grown Bell Pepper (Capsicum Annuum) And Spinach (Spinacia Oleracea) Plants, Swati Rawat
Open Access Theses & Dissertations
Engineered nanoparticles (ENPs) find large scale industrial application because of their promising chemical, physical, electrical, magnetic, optical, and electronic properties. Copper-based ENP are used as gas sensors, in catalysts, electronics, semi-conductors, and in agriculture. They have been useful as agricultural amendments in the form of pesticides, herbicides, and fertilizers because of their antifungal and antibacterial properties. They also find application in electronics and sensors used in precision agriculture. Due to their massive production and use, ENPs are likely to be ubiquitous in the environment around us in the near future. Application of biosolids for fertilization and water from wastewater treatment …
Insulin Modulates The Strong Reinforcing Effects Of Nicotine And Changes In Insulin Biomarkers In A Rodent Model Of Diabetes,
2018
University of Texas at El Paso
Insulin Modulates The Strong Reinforcing Effects Of Nicotine And Changes In Insulin Biomarkers In A Rodent Model Of Diabetes, Bryan Cruz
Open Access Theses & Dissertations
This study examined whether the strong reinforcing effects of nicotine and changes in insulin biomarkers observed in diabetic rats are modulated via insulin. A model of diabetes was employed involving administration of streptozotocin (STZ), which produces hypoinsulinemia in rats. The present study included vehicle- or STZ-treated rats that received sham surgery or an insulin pellet. Two-weeks later, the rats were given extended access to intravenous self-administration (IVSA) of saline or nicotine. Concomitant changes in food intake, water responses, and body weight were assessed during 12 days of IVSA. After the last session, plasma levels of insulin, leptin, amylin, and glucagon-like …
Potential Candidates For Treating Deficits Associated With Developmental Ethanol Exposure In A Rodent Model: Solidago Nemoralis & Dimethoxybenzylidene-Anabasine,
2018
University of Kentucky
Potential Candidates For Treating Deficits Associated With Developmental Ethanol Exposure In A Rodent Model: Solidago Nemoralis & Dimethoxybenzylidene-Anabasine, Logan James Fields
Theses and Dissertations--Psychology
Prenatal alcohol exposure (Fetal Alcohol Syndrome [FAS] and Fetal Alcohol Spectrum Disorders [FASD’s]) represents the leading preventable cause of intellectual disabilities in the western world, with FASDs estimated to affect approximately 2-5% of live births in the United States at an approximate annual cost of $3.6 billion (CDC, 2015; May et al., 2009). Ethanol (ETOH) exposure during development can lead to a variety of long-term behavioral impairments including problems with executive functioning, motor coordination, spatial learning, attention, and hyperactivity (Jones, 2011; Mattson & Riley, 1998). Much research has been conducted to develop pharmacological and/or environmental interventions to reduce these deficits, …
Effect Of Environmental Factors On The Aggregation Behavior Of Silver Nanoparticles In The Aquatic Environment,
2018
University of South Carolina
Effect Of Environmental Factors On The Aggregation Behavior Of Silver Nanoparticles In The Aquatic Environment, Kamelia Afshinnia
Theses and Dissertations
Understanding the environmental factors that affect the fate and effects of engineered nanoparticles (ENPs) in the environment is crucial for NP risk assessment. Silver nanoparticles (Ag NPs) readily transform in the environment, which alters their properties and subsequently their transport, fate, and toxicity. The overall aim of this dissertation was to evaluate the effects of Ag NPs physicochemical properties (e.g., size, surface charge, surface coating) and water chemistry (e.g., buffer concentration, organic ligands, natural organic matter) in controlling Ag NPs colloidal stability. This aim was achieved by systematically 1) review and rationalize many studies that investigated the aggregation kinetics of …
Decoding The Signaling Of The D2r-2ar Heteromer: Relevance To Schizophrenia,
2018
Virginia Commonwealth University
Decoding The Signaling Of The D2r-2ar Heteromer: Relevance To Schizophrenia, Miao Huang
Theses and Dissertations
Schizophrenia is a severe mental disorder affecting ~1% of world population. Two G protein coupled receptors (GPCRs): Gi-coupled dopamine D2 receptor (D2R), and Gq-coupled serotonin 2A receptor (2AR), are targeted by the typical and atypical antipsychotic drugs to treat schizophrenia. These two receptors have been shown to co-localize in brain regions relevant to schizophrenia, including the ventral tegmental area (VTA), striatum, and prefrontal cortex (PFC). Studies in our lab characterized the integrated signaling of the D2R-2AR heteromer and found that both the Gi activity of D2R and the Gq activity of 2AR were potentiated …
Targeting Monoacylglycerol Lipase For The Reversal And Prevention Of Paclitaxel-Induced Allodynia In Mice,
2018
Virginia Commonwealth University
Targeting Monoacylglycerol Lipase For The Reversal And Prevention Of Paclitaxel-Induced Allodynia In Mice, Zachary Curry
Theses and Dissertations
Chemotherapy-induced peripheral neuropathy (CIPN) is a side-effect of chemotherapy causing pain in the hands and feet. In particular, paclitaxel causes CIPN lasting for years without effective treatment. There is a strong need for analgesics to both treat and prevent CIPN. One system containing multiple targets to treat CIPN is the endogenous cannabinoid system. This system consists of cannabinoid type 1 (CB1) and type 2 (CB2) receptors primarily expressed on presynaptic neurons and cells of the immune system, respectively. Inhibition of monoacylglycerol lipase (MAGL), which hydrolyzes the endogenous cannabinoid 2- arachidonoylglycerol (2-AG), with JZL184 or MJN110 produces …
