Integration Of Thai Traditional Medicine Into Physicians' Practice Part 1: Conditions Facilitating The Integration, 2015 Chulalongkorn University
Integration Of Thai Traditional Medicine Into Physicians' Practice Part 1: Conditions Facilitating The Integration, Katekaew Jehso, Sanguan Lerkiatbundit, Wantanee Wiroonpanich
The Thai Journal of Pharmaceutical Sciences
The purpose of this study was to gain a greater understanding of the physicians’ experiences in the conditions facilitating physicians to integrate Thai traditional medicine (TTM) into their current practice. A qualitative grounded theory method was de...
Anti-Platelet Aggregation Activity And Chemical Analysis Of Raw And Wine Stir-Fried Chuanxiong Rhizoma (Kot-Hua-Bua), 2015 Chulalongkorn University
Anti-Platelet Aggregation Activity And Chemical Analysis Of Raw And Wine Stir-Fried Chuanxiong Rhizoma (Kot-Hua-Bua), Uthai Sotanaphun, Rataya Luechapudiporn, Prinyaporn Pradmeeteekul, Jankana Burana-Osot, Panadda Phattanawasin, Noppamas Soonthornchareonnon, Yenchit Techadamrongsin
The Thai Journal of Pharmaceutical Sciences
Chuanxiong Rhizoma (CR) is the dried rhizome of Ligusticum chuanxiong Hort. It is known as Kot-HuaBua in Thai traditional medicine. Two types of CR, raw CR and wine stir-fried CR, were commercially available in traditional drugstores in Thailand. Raw CR ...
Relationship Between Carbamazepine Concentrations In Serum And Saliva Of Thai Epileptic Patients, 2015 Chulalongkorn University
Relationship Between Carbamazepine Concentrations In Serum And Saliva Of Thai Epileptic Patients, Piyaporn Kaewdoung, Chartchai Puripokai, Chartchai Puripokai, Mayuree H. Tantisira, Somsong Laanwprasert
The Thai Journal of Pharmaceutical Sciences
This study aims to examine and verify the correlation between serum and saliva carbamazepine concentrations in Thai epileptic patients. The subjects were patients aged 15-60 years old who were under treatment with carbamazepine. Carbamazepine concentrati...
Integration Of Thai Traditional Medicine Into Physicians' Practice Part 2: Raising Consciousness, The Process Of Integration From Physicians' Experiences, 2015 Chulalongkorn University
Integration Of Thai Traditional Medicine Into Physicians' Practice Part 2: Raising Consciousness, The Process Of Integration From Physicians' Experiences, Katekaew Jehso, Sanguan Lerkiatbundit, Wantanee Wiroonpanich
The Thai Journal of Pharmaceutical Sciences
The main purpose of the study was to gain deeper insight on physicians’ experiences in the integration process of Thai traditional medicine (TTM) into their practice. A grounded theory method was used to gain an understanding of the core process from p...
Economic Impact Assessment On Good Pharmacy Practice Regulation In Thai Community Pharmacy, 2015 Chulalongkorn University
Economic Impact Assessment On Good Pharmacy Practice Regulation In Thai Community Pharmacy, Thatjuta Wuttipanich, Tanattha Kitisopee
The Thai Journal of Pharmaceutical Sciences
Good Pharmacy Practice (GPP) in community and hospital pharmacy setting is a crucial standard for pharmacy services. The Thai Food and Drug Administration (Thai-FDA) realized the benefit of GPP and tried to implement this concept as a regulation for ever...
Bacterial Communication And Its Role As A Target For Nanoparticle-Based Antimicrobial Therapy, 2015 University of South Carolina - Columbia
Bacterial Communication And Its Role As A Target For Nanoparticle-Based Antimicrobial Therapy, Kristen Publicover Miller
Theses and Dissertations
The goal of this dissertation is to establish the environmental and public health importance of alternative forms of antimicrobial therapy, specifically those that utilize nanotechnology to combat quorum sensing-controlled bacterial infections. Quorum sensing (i.e. chemical communication) is an inherent characteristic that is essential to bacterial pathogenesis and biofilm formation (where most infections occur). A thorough review of the literature has been conducted to establish an understanding of the state of nanotechnology research as it relates to combatting bacterial infections. This synthesis, provided in Chapter 1, demonstrates how the chemical and structural designs of nanoparticles can be manipulated to specifically target …
High-Content Screening In Zebrafish Embryos Identifies Abamectin As A Potent Neurotoxicant, 2015 University of South Carolina - Columbia
High-Content Screening In Zebrafish Embryos Identifies Abamectin As A Potent Neurotoxicant, Tara Diane Raftery
Theses and Dissertations
During development, the nervous system is a sensitive target for chemical exposure in both humans and animal models, and early life-stage exposures can lead to long-term effects on motor activity, sensory function, and cognition. Currently, there are minimal to no developmental neurotoxicity (DNT) data available for thousands of chemicals used in commerce, and it is impractical to screen these chemicals in rodent models using the existing DNT test guideline, as this test is costly, time- and animalintensive, and low-throughput. Therefore, there is a recognized need to use alternative non-mammalian models to support screening and prioritization of chemicals for DNT testing, …
Polychlorinated Biphenyl Exposure Alters Oxytocin Receptor Gene Expression And Maternal Behavior In Rat, 2014 Bowling Green State University
Polychlorinated Biphenyl Exposure Alters Oxytocin Receptor Gene Expression And Maternal Behavior In Rat, Howard Cromwell
Howard Casey Cromwell
Polychlorinated biphenyl (PCB) is a persistent organic pollutant known to induce diverse molecular and behavioral alterations. Effects of PCB exposure could be transmitted to future generations via changes in behavior and gene expression. Previous work has shown that PCB-exposure can alter social behavior. The present study extends this work by examining a possible molecular mechanism for these changes. Pregnant rats (Sprague-Dawley) were exposed through diet to a combination of non-coplanar (PCB 47 - 2,20,4,40-tetrachlorobiphenyl) and coplanar (PCB 77 - 3,30,4,40- tetrachlorobiphenyl) congeners. Maternal care behaviors were examined by evaluating the rate and quality of nest building on the last 4 …
Microcystin Detected In Little Brown Bats (Myotis Lucifugus), 2014 Grand Valley State University
Microcystin Detected In Little Brown Bats (Myotis Lucifugus), Megan Woller-Skar, Devin N. Jones, Mark R. Luttenton, Amy L. Russell
Amy L. Russell
Acute Toxicity Assessment Of N,N-Diethyl-M-Toluamide (Deet) On The Photosynthetic Activity Of The Dinoflagellate Gymnodinium Instriatum, 2014 Virginia Commonwealth University
Acute Toxicity Assessment Of N,N-Diethyl-M-Toluamide (Deet) On The Photosynthetic Activity Of The Dinoflagellate Gymnodinium Instriatum, Eloy Martinez , Ph D., Sylvia M. Velez, Marietta M. Mayo, Miguel P. Sastre
Eloy Martinez
Use Of Geographical Information Systems To Identify Counties In Georgia With High Risk For Childhood Lead Poisoning, 2014 Georgia Department of Public Health
Use Of Geographical Information Systems To Identify Counties In Georgia With High Risk For Childhood Lead Poisoning, R. Christopher Rustin, Christy Kuriatnyk, Byron Lobsinger, Simone Charles
R. Christopher Rustin
No Waste: Nyc, 2014 City University of New York (CUNY)
No Waste: Nyc, Minda Smiley
Capstones
I produced three video pieces about people who are living zero-waste lifestyles or using zero-waste practices in their businesses. I also wrote a narrative piece about my experience living zero-waste for one week.
Examining The Regulatory Value Of Multi-Route Mammalian Acute Systemic Toxicity Studies, 2014 Humane Society International
Examining The Regulatory Value Of Multi-Route Mammalian Acute Systemic Toxicity Studies, Troy Seidle, Pilar Prieto, Anna Bulgheroni
Troy Seidle, PhD
Regulatory information requirements for pesticides call for submission of acute systemic toxicity data for up to three different exposure routes (oral, dermal, inhalation) for both active ingredients and formulated products. Similar multi-route testing is required in the European Union and elsewhere for industrial chemicals. To determine the value of acute toxicity testing by more than one route, oral-dermal and oralinhalation concordances among regulatory classifications were examined for large data sets of chemicals and pesticide active ingredients. Across all sectors examined, oral acute toxicity classifications for pure active substances were more severe than those derived from dermal data in more than …
Can Acute Dermal Systemic Toxicity Tests Be Replaced With Oral Tests? A Comparison Of Route-Specific Systemic Toxicity And Hazard Classifications Under The Globally Harmonized System Of Classification And Labelling Of Chemicals (Ghs), Nigel P. Moore, David J. Andrew, Donald L. Bjerke, Stuart Creton, David Dreher, Thomas Holmes, Pilar Prieto, Troy Seidle, Tim G. Rowan
Troy Seidle, PhD
Acute systemic toxicity data (LD50 values) and hazard classifications derived in the rat following oral administration and dermal application have been analysed to examine whether or not orally-derived hazard classification or LD50 values can be used to determine dermal hazard classification. Comparing the oral and dermal classifications for 335 substances derived from oral and dermal LD50 values respectively revealed 17% concordance, and indicated that 7% of substances would be classified less severely while 76% would be classified more severely if oral classifications were applied directly to the dermal route. In contrast, applying the oral LD50 values within the dermal classification …
An Evaluation Of The Us High Production Volume (Hpv) Chemical-Testing Programme: A Study In (Ir)Relevance, Redundancy And Retro Thinking, 2014 People for the Ethical Treatment of Animals
An Evaluation Of The Us High Production Volume (Hpv) Chemical-Testing Programme: A Study In (Ir)Relevance, Redundancy And Retro Thinking, Andrew Nicholson, Jessica Sandler, Troy Seidle
Troy Seidle, PhD
Under the US Environmental Protection Agency (EPA) High Production Volume (HPV) Challenge Programme, chemical companies have volunteered to conduct screening-level toxicity tests on approximately 2800 widely-used industrial chemicals. Participating companies are committed to providing available toxicity information to the EPA and presenting testing proposals for review by the EPA and posting on the EPA Web site as public information. People for the Ethical Treatment of Animals (PETA) and a coalition of animal protection organisations have reviewed all the test plans submitted by the participating chemical companies for compliance with the original HPV framework, as well as with animal welfare guidelines …
Cross-Sector Review Of Drivers And Available 3rs Approaches For Acute Systemic Toxicity Testing, 2014 Humane Society International
Cross-Sector Review Of Drivers And Available 3rs Approaches For Acute Systemic Toxicity Testing, Troy Seidle, Sally Robinson, Tom Holmes, Stuart Creton, Pilar Prieto, Julia Scheel, Magda Chlebus
Troy Seidle, PhD
Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industry led to a paradigm shift whereby in vivo acute toxicity data are no longer routinely required in advance of human clinical trials. Based on this experience, the following review was undertaken to identify (1) regulatory and scientific drivers for acute toxicity testing in other industrial sectors, (2) activities aimed at replacing, reducing, or …
The Development Of New Concepts For Assessing Reproductive Toxicity Applicable To Large Scale Toxicological Programmes, 2014 European Centre for the Validation of Alternative Methods
The Development Of New Concepts For Assessing Reproductive Toxicity Applicable To Large Scale Toxicological Programmes, S. Bremer, C. Pellizzer, S. Hoffmann, T. Seidle, T. Hartung
Troy Seidle, PhD
Large scale toxicological testing programmes which are currently ongoing such as the new European chemical legislation REACH require the development of new integrated testing strategies rather than applying traditional testing schemes to thousands of chemicals. The current practice of requiring in vivo testing for every possible adverse effect endanger the success of these programmes due (i) to limited testing facilities and sufficient capacity of scientific/technical knowledge for reproductive toxicity; (ii) an unacceptable number of laboratory animals involved (iii) an intolerable number of chemicals classified as false positive.
A key aspect of the implementation of new testing strategies is the determination …
Bringing Toxicology Into The 21st Century: A Global Call To Action, 2014 Humane Society International
Bringing Toxicology Into The 21st Century: A Global Call To Action, Troy Seidle, Martin Stephens
Troy Seidle, PhD
Conventional toxicological testing methods are often decades old, costly and low-throughput, with questionable relevance to the human condition. Several of these factors have contributed to a backlog of chemicals that have been inadequately assessed for toxicity. Some authorities have responded to this challenge by implementing large-scale testing programmes. Others have concluded that a paradigm shift in toxicology is warranted. One such call came in 2007 from the United States National Research Council (NRC), which articulated a vision of ‘‘21st century toxicology” based predominantly on non-animal techniques. Potential advantages of such an approach include the capacity to examine a far greater …
A Modular One-Generation Reproduction Study As A Flexible Testing System For Regulatory Safety Assessment, 2014 Humane Society International
A Modular One-Generation Reproduction Study As A Flexible Testing System For Regulatory Safety Assessment, Richard Vogel, Troy Seidle, Horst Spielmann
Troy Seidle, PhD
The European Union’s Registration, Evaluation and Authorisation of Chemicals (REACH) legislation mandates testing and evaluation of approximately 30,000 existing substances within a short period of time, beginning with the most widely used “high production volume” (HPV) chemicals. REACH testing requirements for the roughly 3000 HPV chemicals specify three separate tests for reproductive toxicity: two developmental toxicity studies on different animal species (OECD Test Guideline 414) and a two-generation reproduction toxicity study (OECD TG 416). These studies are highly costly in both economic and animal welfare terms. OECD TG 416 is a fertility study intended to evaluate reproductive performance of animals …
Biological And Physiological Condition Of Juvenile California Halibut (Paralichthys Californicus) Exposed To A Contamination Gradient In Mission Bay, Ca, 2014 University of San Diego
Biological And Physiological Condition Of Juvenile California Halibut (Paralichthys Californicus) Exposed To A Contamination Gradient In Mission Bay, Ca, Kevin Stolzenbach
Theses
Contaminated sediments in marine environments have been shown to be good indicators of ecological risk and a means to assess anthropogenic impacts on marine habitats and the animals that inhabit them (Long et al. 1995, Rattner 2009). Estuarine sediments are especially complex media with regard to physical, chemical, and biological characteristics that trap, store, modify and sometimes release contaminants to the biota (Long et al. 1995). Especially vulnerable are animals that are in constant contact with the sediments, such as flatfishes that partially bury themselves for camouflage (Costa et al. 2011). Impacts can be assessed in a number of ways, …