Untargeted Safety Pharmacology Screen Of Blood-Activating And Stasis-Removing Patent Chinese Herbal Medicines Identified Nonherbal Ingredients As A Cause Of Organ Damage In Experimental Models,
2019
Tianjin University of Traditional Chinese Medicine
Untargeted Safety Pharmacology Screen Of Blood-Activating And Stasis-Removing Patent Chinese Herbal Medicines Identified Nonherbal Ingredients As A Cause Of Organ Damage In Experimental Models, Xinyan Liu, Rui Shao, Xinyue Yang, Guangxu Xiao, Shuang He, Benjamin Feng, Yan Zhu
Peer Reviewed Articles
Blood activation and stasis removal from circulation is a central principle for treatment of syndromes related to cerebral and cardiovascular diseases in Chinese herbal medicine. However, blood-activating and stasis-removing patent Chinese herbal medicine (BASR-pCHM) widely used with or without prescription in China and elsewhere are highly variable in composition and manufacture standard, making their safety assessment a challenging task. We proposed that an integrated evaluation of multiple toxicity parameters of BASR-pCHM would provide critical reference and guidelines for their safe clinical application. Examination of standardized extracts from 58 compound BASR-pCHM in vivo in VEGFR2-luc mice and in vitro in cardiac, …
Zero Waste, Spring/Summer 2017, Issue 36,
2019
University of Louisville
Consent Decrees, Fall/Winter 2017, Issue 35,
2019
University of Louisville
Human Ecology, Spring/Summer 2016, Issue 34,
2019
University of Louisville
Citizen Science, Fall/Winter 2016, Issue 33,
2019
University of Louisville
Urban Streams, Spring/Summer 2015, Issue 32,
2019
University of Louisville
Unconventional Energy, Fall/Winter 2015, Issue 31,
2019
University of Louisville
Unconventional Energy, Fall/Winter 2015, Issue 31
Sustain Magazine
No abstract provided.
Carbon Neutral, Spring/Summer 2018, Issue 38,
2019
University of Louisville
Political Will, Fall/Winter 2018, Issue 37,
2019
University of Louisville
Adminstration Of Micronized Caffeine Using A Novel Oral Delivery Film Results In Rapid Absorption And Electroencephalogram Suppression,
2019
University of Nevada, Las Vegas
Adminstration Of Micronized Caffeine Using A Novel Oral Delivery Film Results In Rapid Absorption And Electroencephalogram Suppression, Rochelle M. Hines, Matthew Khumnark, Ben Macphail, Dustine J. Hines
Psychology Faculty Research
Route of administration is well-known to impact factors ranging from absorption and distribution, up through the subjective effects of active ingredients. Different routes of administration confer specific advantages, such as more rapid absorption resulting from intravenous injection, or increased convenience with oral administration, but a combination of both rapid and convenient delivery is highly desirable. QuickStrip™ was designed as a rapidly dissolving thin film matrix that contains active ingredients, which may be promising for rapid and convenient delivery via the oral mucosa. To assess the delivery of QuickStrip™, we administered the well-characterized active ingredient caffeine to mice and compared QuickStrip™ …
Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells,
2019
Technological University Dublin
Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells, Gillian Conway, Zhonglei He, Ana L. Hutanu, George P. Cribaro, Eline Manaloto, Alan Casey, Damien Traynor, Vladimir Milosavljevic, Orla Howe, Carlos Barcia, James T. Murray, Patrick J. Cullen, James Curtin
Articles
Room temperature Cold Atmospheric Plasma (CAP) has shown promising efficacy for the treatment of cancer but the exact mechanisms of action remain unclear. Both apoptosis and necrosis have been implicated as the mode of cell death in various cancer cells. We have previously demonstrated a caspase-independent mechanism of cell death in p53-mutated glioblastoma multiforme (GBM) cells exposed to plasma. The purpose of this study was to elucidate the molecular mechanisms involved in caspase-independent cell death induced by plasma treatment. We demonstrate that plasma induces rapid cell death in GBM cells, independent of caspases. Accumulation of vesicles was observed in plasma …
Pm25 Metal Constituent Exposure And Stillbirth Risk In Harris County, Texas,
2019
The Texas Medical Center Library
Pm25 Metal Constituent Exposure And Stillbirth Risk In Harris County, Texas, Amal Rammah, Kristina W Whitworth, Inkyu Han, Wenyaw Chan, Elaine Symanski
Faculty, Staff and Student Publications
There is limited evidence on the role of exposure to chemical constituents of fine particulate matter (PM
Food Safety Policies And Practices In Public Spaces: The Urban Water, Sanitation, And Hygiene Environment For Fresh Fish Sold From Individual Vendors In Mzuzu, Malawi.,
2019
Mzuzu University
Food Safety Policies And Practices In Public Spaces: The Urban Water, Sanitation, And Hygiene Environment For Fresh Fish Sold From Individual Vendors In Mzuzu, Malawi., Jazimoni Lazaro, Fanuel Kapute, Rochelle H. Holm
Faculty and Staff Scholarship
In sub-Saharan Africa, informal markets account for more than 80% of the total food selling. Fish is a major protein source for households in Malawi and is commonly purchased from individual vendors. The aim of this study was to review national acts and policies and local regulations focused on fresh fish sold at open-air markets or by mobile vendors and to further examine the water, sanitation, and hygiene environment that may impact food safety in Mzuzu City, Malawi. The study used interviews, an observational checklist, and sampling of water and fish skin. In general, there was limited oversight of food …
Developing A Dissociative Nanocontainer For Peptide Drug Delivery,
2019
CUNY Graduate Center
Developing A Dissociative Nanocontainer For Peptide Drug Delivery, Michael Patrick Kelly
Dissertations, Theses, and Capstone Projects
The potency and specificity of bioactive peptides have propelled these agents to the forefront of pharmacological research. However, delivery of peptides to their molecular target in cells is a major obstacle to their widespread application. A Trojan Horse strategy of packaging a bioactive peptide within a modified protein cage to protect it during transport, and releasing it at the target site, is a promising delivery method. Recent work has demonstrated that the viral capsid of the P22 bacteriophage can be loaded with an arbitrary, genetically-encoded peptide, and externally decorated with a cell-penetrating peptide, such as HIV-Tat, to translocate across in …
Socio-Ecological Wellness Wheel: Applied To Community Gardens To Measure Green Gentrification,
2019
University of Nevada, Las Vegas
Socio-Ecological Wellness Wheel: Applied To Community Gardens To Measure Green Gentrification, Micajah Daniels, Courtney Coughenour
McNair Poster Presentations
This project is intended to use Black Feminist Health Studies as an interdisciplinary approach to analyze the holisitc impacts of community gardens on nutrition behaviors. The implementation of green spaces such as community gardens have been correlated to both benefits and unintended consequences which this study demonstrates through the Socio-Ecological Wellness Wheel. An empirical and systematic way of measuring garden quality through an audit tool using Black Feminist Health Studies could help measure the nutrition environment of the community gardens and how they may influence fruit and vegetable consumption of food insecure populations. The need for this study is highlighted …
Mechanisms Of Simvastatin Myotoxicity: The Role Of Autophagy Flux Inhibition.,
2019
University of Manitoba
Mechanisms Of Simvastatin Myotoxicity: The Role Of Autophagy Flux Inhibition., Arya Emami, Shahla Shojaei, Simone C. Da Silva Rosa, Mahmoud Aghaei, Ehsan Samiei, Amir Reza Vosoughi, Forouh Kalantari, Philip Kawalec, James Thliveris, Pawan Sharma, Amir A. Zeki, Mohsen Akbari, Joseph W. Gordon, Saeid Ghavami
Center for Translational Medicine Faculty Papers
Statins are some of the most widely used drugs worldwide, but one of their major side effects is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell lines (RH30) in both 2-dimensional (2D) and 3-dimensional (3D) cell culture, we investigated the mechanisms of simvastatin's myotoxicity. We found that simvastatin significantly reduced cell viability in C2C12 cells compared to RH30 cells. However, simvastatin induced greater apoptosis in RH30 compared to C2C12 cells. Simvastatin-induced cell death is dependent on geranylgeranyl pyrophosphate (GGPP) in C2C12 cells, while in RH30 cells it is dependent on both farnesyl pyrophosphate (FPP) and GGPP. Simvastatin inhibited …
Our Envirome, Spring/Summer 2019, Issue 40,
2019
University of Louisville
Plastic Pollution, Fall/Winter 2019, Issue 39.3,
2019
University of Louisville
Plastic Pollution, Fall/Winter 2019, Issue 39.3
Sustain Magazine
No abstract provided.
Plastic Pollution, Fall/Winter 2019, Issue 39.2,
2019
University of Louisville
Plastic Pollution, Fall/Winter 2019, Issue 39.2
Sustain Magazine
No abstract provided.
Plastic Pollution, Fall/Winter 2019, Issue 39,
2019
University of Louisville
