Gut Dna Virome Diversity And Its Association With Host Bacteria Regulate Inflammatory Phenotype And Neuronal Immunotoxicity In Experimental Gulf War Illness,
2019
University of South Carolina
Gut Dna Virome Diversity And Its Association With Host Bacteria Regulate Inflammatory Phenotype And Neuronal Immunotoxicity In Experimental Gulf War Illness, Ratanesh K. Seth, Rabia Maqsood, Ayan Mondal, Dipro Bose, Diana Kimono, Larinda A. Holland, Patricia Janulewicz Lloyd, Nancy Klimas, Ronnie Horner, Kimberly Sullivan, Efrem S. Lim, Saurabh Chatterjee
Faculty Publications
Gulf War illness (GWI) is characterized by the persistence of inflammatory bowel disease, chronic fatigue, neuroinflammation, headache, cognitive impairment, and other medically unexplained conditions. Results using a murine model show that enteric viral populations especially bacteriophages were altered in GWI. The increased viral richness and alpha diversity correlated positively with gut bacterial dysbiosis and proinflammatory cytokines. Altered virome signature in GWI mice also had a concomitant weakening of intestinal epithelial tight junctions with a significant increase in Claudin-2 protein expression and decrease in ZO1 and Occludin mRNA expression. The altered virome signature in GWI, decreased tight junction protein level was …
Changes In Pm2.5 Peat Combustion Source Profiles With Atmospheric Aging In An Oxidation Flow Reactor,
2019
Desert Research Institute
Changes In Pm2.5 Peat Combustion Source Profiles With Atmospheric Aging In An Oxidation Flow Reactor, Judith C. Chow, Junji Cao, Lung-Wen Anthony Chen, Xiaoliang Wang, Qiyuan Wang, Jie Tian, Steven Sai Hang Ho, Adam C. Watts, Tessa B. Carlson, Steven D. Kohl, John G. Watson
Environmental & Global Health Faculty Research
Smoke from laboratory chamber burning of peat fuels from Russia, Siberia, the USA (Alaska and Florida), and Malaysia representing boreal, temperate, subtropical, and tropical regions was sampled before and after passing through a potential-aerosol-mass oxidation flow reactor (PAM-OFR) to simulate intermediately aged (∼2 d) and well-aged (∼7 d) source profiles. Species abundances in PM2.5 between aged and fresh profiles varied by several orders of magnitude with two distinguishable clusters, centered around 0.1 % for reactive and ionic species and centered around 10 % for carbon. Organic carbon (OC) accounted for 58 %–85 % of PM2.5 mass in fresh profiles with …
Dysbiosis-Associated Enteric Glial Cell Immune-Activation And Redox Imbalance Modulate Tight Junction Protein Expression In Gulf War Illness Pathology,
2019
University of South Carolina
Dysbiosis-Associated Enteric Glial Cell Immune-Activation And Redox Imbalance Modulate Tight Junction Protein Expression In Gulf War Illness Pathology, Diana Kimono, Sutapa Sarkar, Muayad Albadrani, Ratanesh K. Seth, Dipro Bose, Ayan Mondal, Yuxi Li, Amar N. Kar, Mitzi Nagarkatti, Prakash Nagarkatti, Kimberly Sullivan, Patricia Janulewicz, Stephen Lasley, Ronnie Horner, Nancy Klimas, Saurabh Chatterjee
Faculty Publications
About 14% of veterans who suffer from Gulf war illness (GWI) complain of some form of gastrointestinal disorder but with no significant markers of clinical pathology. Our previous studies have shown that exposure to GW chemicals resulted in altered microbiome which was associated with damage associated molecular pattern (DAMP) release followed by neuro and gastrointestinal inflammation with loss of gut barrier integrity. Enteric glial cells (EGC) are emerging as important regulators of the gastrointestinal tract and have been observed to change to a reactive phenotype in several functional gastrointestinal disorders such as IBS and IBD. This study is aimed at …
Réduire L’Exposition Des Travailleurs Aux Gaz, Odeurs, Poussières Et Agents Pathogènes Humains Présents Dans Les Bâtiments Porcins,
2019
Institut de recherche et de développement en agroenvironnement
Réduire L’Exposition Des Travailleurs Aux Gaz, Odeurs, Poussières Et Agents Pathogènes Humains Présents Dans Les Bâtiments Porcins, Matthieu Girard, Caroline Duchaine, Stéphane Godbout, Ariane Lévesque, Valérie Létourneau, Stéphane P. Lemay
Rapports de recherche scientifique
Les éleveurs de porcs du Québec sont quotidiennement exposés à d’importantes quantités de gaz, d’odeurs, de poussières et de bioaérosols. Par conséquent, ils sont à risque de développer des problèmes respiratoires (ex. asthme) ainsi que des maladies infectieuses telles qu’une méningite à Streptococcus suis. Le risque de développer un problème de santé est lié au nombre d’heures passées à l’intérieur des bâtiments d’élevage ainsi qu’aux concentrations des différents contaminants. De plus, les travailleurs peuvent être en contact avec des bactéries résistantes aux antibiotiques soit des bactéries sélectionnées par l’emploi d’agents antimicrobiens utilisés lors de l’engraissement des animaux. Finalement, de …
Petri Nets As A Unifying Tool To Link Physiologically Based Toxicokinetic (Pbtk) Models To Adverse Outcome Pathways (Aops),
2019
Illinois State University
Petri Nets As A Unifying Tool To Link Physiologically Based Toxicokinetic (Pbtk) Models To Adverse Outcome Pathways (Aops), Ian Edhlund
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
The Gut-Microbiome In Gulf War Veterans: A Preliminary Report,
2019
Boston University School of Public Health
The Gut-Microbiome In Gulf War Veterans: A Preliminary Report, Patricia A. Janulewicz, Ratanesh K. Seth, Jeffrey M. Carlson, Joy Ajama, Emily Quinn, Timothy Heeren, Nancy Klimas, Steven M. Lasley, Ronnie Horner, Kimberly Sullivan, Saurabh Chatterjee
Faculty Publications
Gulf War Illness (GWI) is a chronic multi-symptom disorder affecting the central nervous system (CNS), immune and gastrointestinal (GI) systems of Gulf War veterans (GWV). We assessed the relationships between GWI, GI symptoms, gut microbiome and inflammatory markers in GWV from the Boston Gulf War Illness Consortium (GWIC). Three groups of GWIC veterans were recruited in this pilot study; GWV without GWI and no gastrointestinal symptoms (controls), GWV with GWI and no gastrointestinal symptoms (GWI-GI), GWV with GWI who reported gastrointestinal symptoms (GW+GI). Here we report on a subset of the first thirteen stool samples analyzed. Results showed significantly different …
Biophysical And Biomechanical Properties Of Neural Progenitor Cells As Indicators Of Developmental Neurotoxicity,
2019
Cleveland State University
Biophysical And Biomechanical Properties Of Neural Progenitor Cells As Indicators Of Developmental Neurotoxicity, Gautam Mahajan, Moo-Yeal Lee, Chandrasekhar R. Kothapalli
Chemical & Biomedical Engineering Faculty Publications
Conventional in vitro toxicity studies have focused on identifying IC50 and the underlying mechanisms, but how toxicants influence biophysical and biomechanical changes in human cells, especially during developmental stages, remain understudied. Here, using an atomic force microscope, we characterized changes in biophysical (cell area, actin organization) and biomechanical (Young's modulus, force of adhesion, tether force, membrane tension, tether radius) aspects of human fetal brain-derived neural progenitor cells (NPCs) induced by four classes of widely used toxic compounds, including rotenone, digoxin, N-arachidonoylethanolamide (AEA), and chlorpyrifos, under exposure up to 36 h. The sub-cellular mechanisms (apoptosis, mitochondria membrane potential, DNA damage, glutathione …
Acetaminophen Protein Adducts In Hospitalized Children Receiving Multiple Doses Of Acetaminophen.,
2019
Children's Mercy Hospital
Acetaminophen Protein Adducts In Hospitalized Children Receiving Multiple Doses Of Acetaminophen., Sibo Jiang, Valvanera Vozmediano, Susan M. Abdel-Rahman, Stephan Schmidt, Laura P. James
Manuscripts, Articles, Book Chapters and Other Papers
Previous reports have questioned the safety of multiple doses of acetaminophen administered to ill children. Acetaminophen protein adducts (adducts) are a biomarker of acetaminophen-induced liver injury and reflect the oxidative metabolism of acetaminophen, a known mechanism in acetaminophen toxicity. In this prospective observational study, we analyzed adduct concentrations in 1034 blood samples obtained from 181 hospitalized children (1 to 18 years inclusive) who received 2 or more doses of acetaminophen. Linear regression analysis showed that serum adduct concentrations increased as a function of the cumulative acetaminophen dose, which could be attributed, in part, to a long half-life of adducts (2.17 …
Microcystin Exposure And Liver Injury Outcomes In Nafld,
2019
University of South Carolina
Microcystin Exposure And Liver Injury Outcomes In Nafld, Muayad Albadrani
Theses and Dissertations
Non-alcoholic fatty liver disease (NAFLD) is an emerging worldwide pandemic which is highly prevalent among obese individuals including children and adults. In a NAFLD condition, exposure to environmental contaminants or toxins can act as a second/ multiple hit, which leads to the progression of simple steatosis to NASH and ultimately may result in liver cirrhosis. With climate change today, elevated levels of microcystins are an emerging problem in fresh water bodies, which are a source of drinking water. Individuals are therefore at risk of exposure to microcystin through consuming contaminated water. In the progression of NAFLD from one clinical stage …
Study Of The Inflammatory And Fibrotic Pathology In The Gut Following Microcystin Exposure Under Conditions Of Non-Alcoholic Fatty Liver Disease.,
2019
University of South Carolina
Study Of The Inflammatory And Fibrotic Pathology In The Gut Following Microcystin Exposure Under Conditions Of Non-Alcoholic Fatty Liver Disease., Sutapa Sarkar
Theses and Dissertations
Non-alcoholic fatty liver disease (NAFLD) has become a global pandemic with increased risks of chronic inflammation in obese and elderly population. It has become a major public health concern due to the unavailability of proper therapeutic approaches. NAFLD is a condition of the liver involving wide spectrum of events including accumulation of fat in the liver and inflammation, which can progress to a fibrotic and cirrhotic phenotype, often termed as non-alcoholic steatohepatitis (NASH). In this backdrop, exposure to environmental toxins from harmful algal blooms could prove detrimental to the overweight, obese or elderly population. NAFLD not only affects the liver …
Investigating The Relationship Of Copd, Lung Cancer, And Polycyclic Aromatic Hydrocarbons From Ambient Air Pollution,
2019
University of South Carolina
Investigating The Relationship Of Copd, Lung Cancer, And Polycyclic Aromatic Hydrocarbons From Ambient Air Pollution, Daniel John Kilpatrick
Theses and Dissertations
Polycylic aromatic hydrocarbons (PAHs) are a group of chemically-related compounds with a well-established body of evidence of adverse human health impacts. Additionally, there is a growing area of research on the health outcomes following PAH exposure via air pollution, specifically with chronic obstructive pulmonary disorder (COPD) and lung cancer. The purpose of this dissertation was to investigate the strength of associations among PAHs, COPD, and lung cancer from ambient (outdoor) air pollution. The first objective was to determine if there is a potential environmental link among PAHs, COPD, and lung cancer occurrence among nonsmokers using data from the National Health …
Revisiting The Standard Soil Test: The Potential Of Macro- And Microbiological Measures To Improve Agricultural Health And Productivity,
2019
University of South Carolina
Revisiting The Standard Soil Test: The Potential Of Macro- And Microbiological Measures To Improve Agricultural Health And Productivity, Gabriel Jacob Kenne
Theses and Dissertations
The agricultural ecosystem has become the largest non-ice-covered terrestrial ecosystem on the planet and has significant direct and indirect impacts on the global health of both the environment and humanity. Recent shifts in modern agriculture are beginning to focus on the health of soil versus a focus traditionally on crop health and yield at any cost. By managing farmland regeneratively, systems are able to reverse many of the problems created by conventional land management such as erosion and unwanted nutrient runoff, and simultaneously create opportunities to move C from the atmosphere back into the soil. While the ways in which …
Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22,
2019
University of Louisville
Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22
Sustain Magazine
No abstract provided.
Sustainable Communities, Fall/Winter 2010, Issue 21,
2019
University of Louisville
Sustainable Communities, Fall/Winter 2010, Issue 21
Sustain Magazine
No abstract provided.
Sustainable Building, Spring/Summer 2009, Issue 20,
2019
University of Louisville
Sustainable Building, Spring/Summer 2009, Issue 20
Sustain Magazine
No abstract provided.
Environmental History, Fall/Winter 2009, Issue 19,
2019
University of Louisville
Environmental History, Fall/Winter 2009, Issue 19
Sustain Magazine
No abstract provided.
Student Research, Spring/Summer 2008, Issue 18,
2019
University of Louisville
Evolving Pollution Prevention, Fall/Winter 2008, Issue 17,
2019
University of Louisville
Evolving Pollution Prevention, Fall/Winter 2008, Issue 17
Sustain Magazine
No abstract provided.
Climate Change, Spring/Summer 2007, Issue 16,
2019
University of Louisville
Our Energy Future, Fall/Winter 2007, Issue 15,
2019
University of Louisville
