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Characterizing Pm2.5 Air Samples Of Northeast Mississippi, Harley Nabors 2021 University of Mississippi

Characterizing Pm2.5 Air Samples Of Northeast Mississippi, Harley Nabors

Honors Theses

Ambient air pollution has been associated with adverse health effects throughout the entire world. Although epidemiologists study air pollution extensively, rural areas are often the least understood. In 2020, the Mississippi Department of Environmental Quality used less than 10 air sampling locations across the state leaving a large gap in air quality knowledge. In this study, fine particulate matter (PM2.5) air samples were collected from three different rural Mississippi cities–Ackerman, Eupora, and Houston, in the summer of 2020. Following collection onto filters, elemental black carbon analysis and an oxidative potential assay were both used to characterize the samples ...


Surface-Eroding Drug Delivery Films For Sequential And/Or Intermittent Release Of Psychoactive Drugs, Jason Price 2021 University of Mississippi

Surface-Eroding Drug Delivery Films For Sequential And/Or Intermittent Release Of Psychoactive Drugs, Jason Price

Honors Theses

ABSTRACT JASON BLAKE PRICE: Surface-Eroding Drug Delivery Films for Sequential and/or

Intermittent Release of Psychoactive Drugs For patients with psychiatric diseases, adherence to medication schedules, medication

errors, and abuse are common issues. Promising new forms of therapy for these patients, such as micro-dosed lysergic acid diethylamide (LSD), where patients receive 10-20% of a full dose every third day, present further drug delivery challenges. Sequential or intermittent release of drugs from an implanted device could ensure long-term drug compliance, automate drug dosing during the life of the implant, and eliminate potential for abuse and medication errors. To this end, we ...


N-Nitrosodimethylamine (Ndma) Contamination Of Ranitidine Products: A Review Of Recent Findings, Fahad S. Aldawsari, Yahya M. Alshehri, Thamer S. Alghamdi 2021 Drug Reference Laboratory, Saudi Food and Drug Authority

N-Nitrosodimethylamine (Ndma) Contamination Of Ranitidine Products: A Review Of Recent Findings, Fahad S. Aldawsari, Yahya M. Alshehri, Thamer S. Alghamdi

Journal of Food and Drug Analysis

Ranitidine is a medication that has been used to alleviate heartburn and other disorders for over 40 years. Following reports of N-nitrosodimethylamine (NDMA) contamination in ranitidine products, there have been many recalls and registration suspensions. Here, we revise the literature information confirming ranitidine association with NDMA. Then, we highlight the documented mechanisms for NDMA release from ranitidine. In addition, the stability issue for this medicine is discussed. After that, we review and discuss the results of the United States Food and Drug Administration and the Australian Therapeutic Goods Administration laboratory testing of ranitidine products and the detected NDMA levels. Finally ...


Simultaneous Chemical And Sensory Analysis Of Domestic Cat Urine And Feces With Headspace Solid-Phase Microextraction And Gc-Ms-Olfactometry, Chumki Banik, Jacek A. Koziel, James Z. Li 2021 Iowa State University

Simultaneous Chemical And Sensory Analysis Of Domestic Cat Urine And Feces With Headspace Solid-Phase Microextraction And Gc-Ms-Olfactometry, Chumki Banik, Jacek A. Koziel, James Z. Li

Agricultural and Biosystems Engineering Publications

The association between humans and cats (Felis catus) is well known. This domestic animal is also known for its malodorous urine and feces. The complexity of the odorous urine and feces impacts human life by triggering the human sensory organ in a negative way. The objective of this research was to identify the volatile organic chemicals (VOCs) and associated odors in cat urine and feces using gas chromatography–mass spectrometry and simultaneous sensory analysis of fresh and aged samples. The solid-phase microextraction (SPME) technique was used to preconcentrate the VOCs emitted from urine or feces samples. Twenty-one compounds were identified ...


Achieving Better Care In Pennsylvania By Allowing Pharmacists To Practice Pharmacy, Travis Murray 2021 Penn State Dickinson Law

Achieving Better Care In Pennsylvania By Allowing Pharmacists To Practice Pharmacy, Travis Murray

Dickinson Law Review

Traditionally, state legislatures implemented Prescription Drug Monitoring Programs (“PDMPs”) to assist prescribers, pharmacists, and law enforcement in identifying patients likely to misuse, abuse, or divert controlled substances. PDMP databases contain a catalog of a patient’s recent controlled substances that pharmacies have filled, including the date, location, the quantity of medication filled, and the prescribing health care provider. Prescribers in Pennsylvania have a duty to query the PDMP before prescribing controlled substances in most clinical settings. Pharmacists have a similar duty in Pennsylvania to dispense safe and effective medication therapy to patients and to screen patients for potential signs of ...


Opioid Use Disorder: The Timeline For Medication Assisted Therapy, Alexander Cristofori 2021 Arcadia University

Opioid Use Disorder: The Timeline For Medication Assisted Therapy, Alexander Cristofori

Capstone Showcase

Opioid Use Disorder is patterns of opioid use leading to withdrawal, giving up important life events in order to use opioids, and excessive time spent using opioids, to name a few diagnostic criteria. The clinical progression of the disorder involves periods of acute exacerbation and remission that are cyclic in nature. Treatment is most effective when it includes both pharmacological and psychosocial modalities, referred to as medication assisted therapy (MAT). Three drugs used commonly in MAT-based treatment for OUD from oldest to newest include Methadone, Buprenorphine-naloxone, and Naltrexone. Treatment program models that prioritize total abstinence from the addictive substance attached ...


Chemically Induced Phytoextraction Of Lead (Pb) Contaminated Soil By Switchgrass (Panicum Virgatum L.), Austin Gilly 2020 Kennesaw State University

Chemically Induced Phytoextraction Of Lead (Pb) Contaminated Soil By Switchgrass (Panicum Virgatum L.), Austin Gilly

Master of Science in Integrative Biology Theses

Soils contaminated with lead (Pb) from human activities including industrial byproducts create an environmental and human health risk. Phytoextraction through chemical acquisition of Pb in soils offer a potentially cost effective and ecologically driven approach to remediation. Switchgrass (Panicum virgatum L.) is known to have a tolerance for a wide range of heavy metals including Pb. Switchgrass is also able to grow in a wide range of climates. Soil chemistry manipulation, using chelates and plant growth promoters could provide an effective field method for phytoremediation using switchgrass. In this study chemically enhanced phytoextraction using the soil-fungicide Infuse (active ingredient propiconazole ...


Prevalence Of Tuberculosis In District Haveli, Azad Jammu And Kashmir, Abu ul Hassan Faiz, Ghazal Tariq, Ayesha Faiz, Lariab Zahra Faiz 2020 Department of Zoology, Women University of Azad Jammu and Kashmir, Bagh, Pakistan

Prevalence Of Tuberculosis In District Haveli, Azad Jammu And Kashmir, Abu Ul Hassan Faiz, Ghazal Tariq, Ayesha Faiz, Lariab Zahra Faiz

Journal of Bioresource Management

Tuberculosis is an infectious disease with a common occurrence in population of Azad Jammu and Kashmir. The current study was designed to find out the prevalence of TB among the general population of a less developed District Haveli. Samples were collected from different hospitals and TB centers located in district Haveli and tested through sputum smear microscopy for conformation of positive for TB. The three-year (2015 to 2018) study was conducted to record prevalence of tuberculosis in selected area of Azad Jammu and Kashmir. The trend line of prevalence was made by using (SPSS software). Results produced linear trends yearly ...


Understanding Neonicotinoid Related Immunosuppression: A Potential For Beneficial Bacterial Intervention, John A. Chmiel 2020 The University of Western Ontario

Understanding Neonicotinoid Related Immunosuppression: A Potential For Beneficial Bacterial Intervention, John A. Chmiel

Electronic Thesis and Dissertation Repository

The use of neonicotinoid pesticides has been implicated in the recent decrease of honey bee (Apis mellifera) populations. In this thesis, a Drosophila melanogaster model was used to characterize immune impairment associated with imidacloprid (neonicotinoid) exposure and test the ability of beneficial bacteria (lactobacilli) to alleviate these harmful effects. The experiments outlined in chapters 2 and 3 demonstrate that imidacloprid alters the gut microbiota by exploiting the cooperation between gut immune pathways. The pesticide reduces expression of Duox via dysregulation of the immune deficiency pathway resulting in decreased hydrogen peroxide production. This contributes to the microbiota changes but also depletes ...


Optimization Of Dna Extraction From Human Milk, Cassandra Z. Rutherford 2020 Winthrop University

Optimization Of Dna Extraction From Human Milk, Cassandra Z. Rutherford

Graduate Theses

Background: Techniques are emerging for determining the best and most cost-effective way to test for human milk adulteration. Currently, the literature is focused on the use of qPCR testing, a technique used to isolate and amplify pieces of DNA for analysis. However, no recommendation currently exists on the best DNA extraction kit to use to achieve optimal DNA yield or purity from human milk samples for downstream qPCR use. Thus, the objective of this study is to assess and compare two DNA extraction kits for use with human milk samples for future DNA-based analysis in the testing for bovine milk ...


Volatile Organic Compound Exposure And Cardiometabolic Syndrome Risk In A Nationally Representative Cohort., Stacey Lane Konkle 2020 University of Louisville

Volatile Organic Compound Exposure And Cardiometabolic Syndrome Risk In A Nationally Representative Cohort., Stacey Lane Konkle

Electronic Theses and Dissertations

BACKGROUND: The relative importance of environmental exposures such as volatile organic compounds (VOCs) is one of the paramount public health priorities of our time, yet is presently unstudied. VOCs are ubiquitous in the environment and have been associated with numerous adverse health effects, including a number of cardiovascular and metabolic effects that are components of Cardiometabolic Syndrome (CMS). OBJECTIVES: To examine the relationship between CMS and individual-level exposures to VOCs, measured as urinary metabolites of VOCs (UM-VOCs), in a nationally representative sample. METHODS: Associations between urinary biomarkers of exposure to 19 parent VOCs and CMS were assessed using the National ...


The Influence Of Acidification And Copper Exposure On Copper Accumulation And Anti-Oxidant Enzyme Responses In The Pond Snail, Lymnaea Stagnalis, Gretchen K. Bielmyer-Fraser, Francis Alip, Ruth Adeyemi, Nolan Carney, Fasinia Santiago, Kyla Siemen, Kiley Donaghy 2020 Jacksonville University

The Influence Of Acidification And Copper Exposure On Copper Accumulation And Anti-Oxidant Enzyme Responses In The Pond Snail, Lymnaea Stagnalis, Gretchen K. Bielmyer-Fraser, Francis Alip, Ruth Adeyemi, Nolan Carney, Fasinia Santiago, Kyla Siemen, Kiley Donaghy

Georgia Journal of Science

Atmospheric carbon dioxide is rising at an accelerated rated due to increased anthropogenic activities. Metals have also been a noted problem; however, little research has addressed combined exposure of both pollutants to sensitive, calcifying organisms in freshwater habitats. This study examined copper accumulation (over 7 d) and activity of the antioxidant enzymes, catalase and glutathione peroxidase (over 2 d), in the freshwater common pond snail, Lymnaea stagnalis, after exposure to ambient and increased (2000 µatm) CO2 and copper (control, 5, and 20 µg/L). Results demonstrated increased copper accumulation in soft tissue of snails exposed to copper; however, exposure ...


It’S Not Cuul To Juul: Nicotine Addiction, The Rise Of E-Cigarette Usage, And How Zebrafish Can Help, Anna Pearson 2020 DePauw University

It’S Not Cuul To Juul: Nicotine Addiction, The Rise Of E-Cigarette Usage, And How Zebrafish Can Help, Anna Pearson

Honor Scholar Theses

No abstract provided.


The Diffusion Of Artificial Intelligence/Machine Learning Methods And Data Analytics Into An Undergraduate Nursing Research Course, Mary Anne Schultz 2020 California State University, San Bernardino

The Diffusion Of Artificial Intelligence/Machine Learning Methods And Data Analytics Into An Undergraduate Nursing Research Course, Mary Anne Schultz

Q2S Enhancing Pedagogy

The project is the adoption of principles of Artificial Intelligence (AI)/Machine Learning and Data Analytics into a traditional nursing research (hypothesis testing) course. Necessitated by the recent entrance of “Big Data” use in health care, there is an urgent need to inject an understanding of the AI/ML techniques necessary to extract, organize and derive meaning from this huge amount of evidence in clinical decision-making. In fact, our department recently approved the adoption of Precision Health (PH) (the clinical use of the plethora of highly-individualized data in health & medical decisions) principles into six undergraduate courses, NURS 4222 (Nursing Research ...


The Effect Of Seasonality On Yellow Perch Ecology And Ecotoxicology Within Lake Manganese, Bailey Duxbury 2020 Michigan Technological University

The Effect Of Seasonality On Yellow Perch Ecology And Ecotoxicology Within Lake Manganese, Bailey Duxbury

Dissertations, Master's Theses and Master's Reports

Seasonality is a consistent component of aquatic ecosystems yet most fish biological and ecotoxicological studies commonly employ field sampling protocols focused during the warm open water season with minimal emphasis placed on winter sampling, especially for north-temperate latitude ecosystems. Such strategies limit our understanding of poikilotherm biology and ecology during the overwintering seasons. Here, I investigated seasonal changes in yellow perch (Perca flavescens) biology, ecology and ecotoxicology over a one-year period in Lake Manganese. Significant seasonality was observed for metrics including fish energy densities (kJ/g), gonadosomatic indices, whole-body lipid contents, and carbon stable isotope values (δ13C). Mercury ...


Hear Me Roar, Abigail R. Seethoff 2020 University of Montana, Missoula

Hear Me Roar, Abigail R. Seethoff

Graduate Student Theses, Dissertations, & Professional Papers

Hear Me Roar, a compilation of personal essays interspersed with short forms, grapples with the nuances of compliance versus autonomy in the context of the male gaze, beauty standards, and pop culture. The collection also explores what it means to treasure something—another person, an object—and how to express and deepen that affection.


The Exploration Of Nanotoxicological Copper And Interspecific Saccharomyces Hybrids, Matthew Joseph Winans PhD 2020 West Virginia University

The Exploration Of Nanotoxicological Copper And Interspecific Saccharomyces Hybrids, Matthew Joseph Winans Phd

Graduate Theses, Dissertations, and Problem Reports

Nanotechnology takes advantage of cellular biology’s natural nanoscale operations by interacting with biomolecules differently than soluble or bulk materials, often altering normal cellular processes such as metabolism or growth. To gain a better understanding of how copper nanoparticles hybridized on cellulose fibers called carboxymethyl cellulose (CMC) affected growth of Saccharomyces cerevisiae, the mechanisms of toxicity were explored. Multiple methodologies covering genetics, proteomics, metallomics, and metabolomics were used during this investigation. The work that lead to this dissertation discovered that these cellulosic copper nanoparticles had a unique toxicity compared to copper. Further investigation suggested a possible ionic or molecular mimicry ...


Antifungal Defense Molecules From Bacterial Symbionts Of North American Trachymyrmex Ants, Georgia Scherer 2020 Claremont Colleges

Antifungal Defense Molecules From Bacterial Symbionts Of North American Trachymyrmex Ants, Georgia Scherer

CMC Senior Theses

Defensive symbioses, in which microbes provide molecular defenses for an animal host, hold great potential as untapped sources of therapeutically useful antibiotics. Fungus-growing ants use antifungal defenses from bacterial symbionts to suppress pathogenic fungi in their nests. Preliminary chemical investigations of symbiotic bacteria from this large family of ants have uncovered novel antifungal molecules with therapeutic potential, such as dentigerumycin and selvamicin.

In this study, the bacterial symbionts of North American Trachymyrmex fungus-growing ants are investigated for antifungal molecules. Plate-based bioassays using ecologically-relevant fungal pathogens confirmed that these bacteria have antifungal activity. In order to purify and identify the antifungal ...


The Effect Of Prebiotics On Intestinal Digestion Of Carbohydrates In Lead Intoxicated Rats, Lubov S. Kuchkarova, Irodakhon I. Karimova, Gulchekhra T. Kudeshova, Khasan Yu. Kayumov 2019 National University of Uzbekistan

The Effect Of Prebiotics On Intestinal Digestion Of Carbohydrates In Lead Intoxicated Rats, Lubov S. Kuchkarova, Irodakhon I. Karimova, Gulchekhra T. Kudeshova, Khasan Yu. Kayumov

Bulletin of National University of Uzbekistan: Mathematics and Natural Sciences

It has been shown the lead intoxication of growing rats result in increase the cavity and membrane carbohydrate hydrolysis and glucose absorption from small intestine which leads to hyperglicemiya. The oral treatment of intoxicated rats with inulin or lactulose results in decrease of carbohydrate assimilation in small intestine and content glucose level in blood. The correcting effect of lactulose on normalization of carbohydrate assimilation is more expressed in compare with inulin. So, inulin and/or lactulose take part in improving of adaptation of the carbohydrate assimilation system in the small intestine during intoxication with lead ions in growing rats. This ...


#39 - Extended-Spectrum Beta (Β) Lactamase-Producing Enterobacteriaceae Isolates From Flat Creek Water Samples, Luis Vidals, Maria Mayorga-Gutierrez 2019 University of North Georgia

#39 - Extended-Spectrum Beta (Β) Lactamase-Producing Enterobacteriaceae Isolates From Flat Creek Water Samples, Luis Vidals, Maria Mayorga-Gutierrez

Georgia Undergraduate Research Conference (GURC)

Antibiotics have played a major role in containing bacterial infections. Extended spectrum beta (β) lactamases, better known as ESBLs, are enzymes produced by the bacterial family Enterobacteriaceae that inhibit the activity of many common antibiotics used today such as penicillin. The genes that encode for ESBLs are bla genes and are plasmid encoded. Thus, they can be easily transferred to different species of bacteria via horizontal transmission. In this study, freshwater samples were collected upstream and downstream of a water treatment plant and were tested for ESBL-producing bacteria. A total of 12 colonies were isolated and DNA extraction was performed ...


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