Nutrition Commons^™

The Effect Of Cocoa Flavanols On Β-Cell Mass And Function, Thomas John Rowley

Theses and Dissertations

A hallmark of type 2 diabetes (T2D) is β-cell dysfunction and the eventual loss of functional β-cell mass. Therefore, mechanisms that improve or preserve β-cell function could be used to improve the quality of life of individuals with T2D. Studies have shown that monomeric, oligomeric and polymeric cocoa flavanols have different effects on obesity, insulin resistance and glucose tolerance. We hypothesized that these cocoa flavanols may have beneficial effects on β-cell function. INS-1 832/13 derived β-cells and primary rat islets cultured with a monomeric catechin-rich cocoa flavanol fraction demonstrated enhanced glucose-stimulated insulin secretion, while cells cultured with total cocoa extract, …

Clinical And Therapeutic Significance Of Obesity In Melanoma, Jennifer L. Mcquade

Dissertations and Theses (Open Access)

While the FDA approval of targeted and immune therapies in metastatic melanoma (MM) have dramatically improved outcomes in this disease, de novo and/or acquired resistance can limit the clinical benefit of these agents. The IGF-1/PI3K/AKT pathway has been implicated in resistance to both targeted and immune therapy. The IGF-1/PI3K/AKT pathway has also been shown to play a key role in the pathogenesis of obesity in other malignancies. To date, the impact of energy balance on clinical outcomes and therapeutic response in MM has not been studied. I hypothesized that energy balance would impact the molecular biology, behavior, and drug sensitivity …

Teacher Perceptions Of School Breakfast Programs In Utah, Emily Breanne Krueger

Theses and Dissertations

The objective of this study was to identify differences in teacher perceptions of benefits, challenges, and preferences to different School Breakfast Program (SBP) service models. A survey instrument was developed, pilot tested, and then distributed electronically to K-12 teachers throughout the state of Utah, who were part of the Utah Education Association. Demographics and factors influencing SBP models in Utah were gathered. Frequencies and ANOVA tests were performed and a significance level of <0.01 was chosen to protect for multiple comparisons. Results indicated that traditional breakfast was the most preferred model with a mean score of 2.80 and breakfast in the classroom was the least preferred model by teachers with a mean of -1.32. Children not going hungry was identified as the greatest benefit (95.4%, n=352) to SBP and food waste was identified as the greatest challenge (45.8%, n=168). This study concluded that increased awareness and education amongst teachers regarding different models of SBP service could lead to increased efficiency, increased participation in SBP, decreased costs, decreased food waste, and increased academic performance and health benefits for students.

Starch-Entrapped Microsphere Fibers Improve Bowel Habit But Do Not Exhibit Prebiotic Capacity In Those With Unsatisfactory Bowel Habits: A Phase I, Randomized, Double-Blind, Controlled Human Trial, Heather E. Rasmussen, Bruce Hamaker, Kumar B. Rajan, Ece Mutlu, Stefan J. Green, Michael Brown, Amandeep Kaur, Ali Keshavarzian

Department of Nutrition and Health Sciences: Faculty Publications

Approximately one-third of individuals in the United States experience unsatisfactory bowel habits, and dietary intake, especially one low in fiber, could be partly responsible. We hypothesized that intake of a fermentable fiber (starch-entrapped microspheres, SM) that has a delayed, slow fermentation profile in vitro would improve bowel habit while exhibiting prebiotic capacity in those with self-described unsatisfactory bowel habits, all with minimal adverse effects. A total of 43 healthy volunteers completed a 3-month,double-blind, parallel-arm randomized clinical trial to assess the ability of a daily dose (9 or 12 g) of SM vs. psyllium (12 g) to improve bowel habit, including …

Integration Of Mirna And Mrna Expression Profles Reveals Microrna-Regulated Networks During Muscle Wasting In Cardiac Cachexia, Leonardo N. Moraes, Geysson J. Fernandez, Ivan Jose Vechetti Jr, Paula P. Freire, Rodrigo W. A. Souza, Rolando A.R. Villacis, Silvia R. Rogatto, Patricia P. Reis, Maeli Dal-Pai-Silvia, Robson F. Carvalho

Department of Nutrition and Health Sciences: Faculty Publications

Cardiac cachexia (CC) is a common complication of heart failure (HF) associated with muscle wasting and poor patient prognosis. Although different mechanisms have been proposed to explain muscle wasting during CC, its pathogenesis is still not understood. Here, we described an integrative analysis between miRNA and mRNA expression profiles of muscle wasting during CC. Global gene expression profiling identified 1,281 genes and 19 miRNAs differentially expressed in muscle wasting during CC. Several of these deregulated genes are known or putative targets of the altered miRNAs, including miR-29a-3p, miR-29b-3p, miR-210-5p, miR-214, and miR-489. Gene ontology analysis on integrative mRNA/miRNA expression profiling …

The Effects Of Calorie Information Disclosures On Food Choice And Retailer-Related Outcomes, Christopher Berry

Graduate Theses and Dissertations

Federal legislation will begin requiring the provision of calorie information on the menus and menu boards of restaurants and other retail food establishments with 20 or more locations in May 2018. Food retailers not included in this mandate can choose to voluntarily provide calorie information to consumers. However, there are concerns that this major policy change will not have the desired widespread positive effects on consumer choice behavior. Further, although proponents of calorie labeling argue that consumers have the right to know the calorie content of their food orders, many food retailers have argued that calorie labeling is too expensive …

The Effect Of Blinded Hydration State On Thermoregulation And Performance In Male Cyclists, Jon David Adams

Graduate Theses and Dissertations

Purpose: The purpose of these studies was to observe the effect of dehydration on exercise performance while subjects were blinded to their hydration status. Methods: Study 1: Seven male cyclists (weight: 71±8 kg, body fat: 14±6%, VO2peak: 59.4±6 ml∙kg-1·min-1) exercised for 2 hours on a cycle ergometer at 55% VO2peak, in a hot-dry environment (35°C, 30% rh), with a nasogastric (NG) tube under euhydrated (EUH-NT) and hypohydrated (DEH-NT) conditions. In both trials, thirst was matched by drinking 25 mL every 5 min. In the EUH-NT trial sweat losses were fully replaced via the NG tube. Following the 2 hours of …

Determinant Of Timely First-Shot Hepatitis B Immunization In East Lombok, West Nusa Tenggara, Indonesia, Putri Bungsu Machmud, Dwi Gayatri, Tri Yunis Miko Wahyono

Jurnal Epidemiologi Kesehatan Indonesia

Hepatitis B remains as one of health problems in the world. The results of several studies related to factors in predicting of the timely first-shot hepatitis B immunization were still inconsistent. Aim of this study is to identify determinant factors of the timely first-shot hepatitis B immunization in East Lombok, Indonesia. We used a cross sectional design study, and data derived from immunization coverage survey at six districts/ cities in 2013. A Total of 227 children aged 12 to 23 months who already got immunization of a first-shot hepatitis B vaccineand well documented were included as samples in this study. …

Feeding Problems Sebagai Prediktor Kejadian Obestitas Pada Anak Autis, Qisty Afifah Noviyanti

Jurnal Epidemiologi Kesehatan Indonesia

Latar belakang: Obesitas merupakan masalah yang dapat terjadi pada anak autis. Hal ini disebabkan adanya perubahan perilaku dan pola makan akibat kondisi autisme. Akan tetapi, belum banyak studi yang menjelaskan hubungan perilaku makan bermasalah (feeding problems) dengan kejadian obesitas pada anak autis. Tujuan: Penelitian ini untuk melihat hubungan antara masalah perilaku makan (feeding problem) dengan kejadian obesitas anak autis. Metode: Peninjauan artikel dilakukan dengan kata kunci autism OR autism spectrum disorder AND feeding problem OR food selectivity dan autism AND childhood obesity. Dua studi ditemukan sesuai dengan kriteria inklusi yang dibuat Anak autis memiliki perilaku makan bermasalah yang lebih tinggi …

Pengaruh Konsumsi Fruktosa Pada Minuman Kemasan Terhadap Toleransi Glukosa Terganggu Pada Kelompok Usia Muda Di Perkotaan Di Indonesia, Nicolaski Lumbuun, Nasrin Kodim

Jurnal Epidemiologi Kesehatan Indonesia

Peningkatan konsumsi minuman kemasan (soft drinks/ bevereges) tampak nyata di dunia, termasuk Indonesia. Peningkatan ini terutama terjadi di kelompok usia muda. Konsumsi minuman tersebut berkaitan dengan gangguan metabolik, antara lain obesitas, toleransi glukosa terganggu (TGT) dan diabetes melitus. Hal ini disebabkan penggunaan pemanis tinggi fruktosa (high fructose corn syrup, HFCS). TGT terutama menjadi masalah kesehatan serius karena umumnya tidak menunjukkan gejala dan terlambat untuk dideteksi sehingga sering kali telah berprogresi menjadi diabetes mellitus. Penelitian ini bertujuan untuk melihat hubungan konsumsi tinggi fruktosa dengan kejadian TGT pada usia muda, serta prevalensi kekerapan mengkonsumsi minuman tinggi fruktosa, baik secara nasional maupun pada …

Prediktor Kejadian Tb Pada Odha Di Salah Satu Rs Pemerintah Bogor, Tahun 2014-2016, Ulya Qoulan Karima, Mondastri Korib Sudaryo, Nuning Maria Kiptiyah

Jurnal Epidemiologi Kesehatan Indonesia

TB merupakan tantangan bagi pengendalian Acquired Immunodeficiency Syndrome (AIDS) karena merupakan infeksi oportunistik terbanyak pada orang dengan HIV/AIDS (ODHA). TB dapat meningkatkan progresivitas HIV dan meningkatkan risiko kematian bagi penderita HIV. Tujuan penelitian ini adalah untuk mengetahui prediktor yang berhubungan dengan kejadian TB pada ODHA di salah satu RS tahun 2014-2016. Desain studi yang digunakan adalah cross sectional dengan menggunakan data register ART dan Rekam Medis. Sampel berjumlah 817 pasien HIV. Analisis data dilakukan dengan menggunakan multiple cox regression. Hasil analisis multivariat menunjukkan adanya peningkatan risiko TB pada kelompok dengan anemia (PR=1,54, 95% CI: 1,17-2,03) dibandingkan kelompok tanpa anemia, adanya …

Hubungan Pengetahuan Hiv/Aids Dengan Stigma Terhadap Orang Dengan Hiv/Aids Di Kalangan Remaja 15-19 Tahun Di Indonesia (Analisis Data Sdki Tahun 2012), Berliana Situmeang, Syahrizal Syarif, Renti Mahkota

Jurnal Epidemiologi Kesehatan Indonesia

Stigma terhadap ODHA menjadi salah satu hambatan paling besar dalam pencegahan, perawatan, pengobatan, dan dukungan HIV/AIDS. Pengetahuan tentang HIV/AIDS mempengaruhi terjadinya stigma terhadap ODHA. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan tentang HIV/AIDS dengan stigma terhadap ODHA di kalangan remaja usia 15-19 tahun di Indonesia. Penelitian ini menggunakan data Survei Demografi dan Kesehatan Indonesia (SDKI) Tahun 2012 dengan disain cross-sectional. Sampel penelitian sebanyak 8.316 orang. Hasil studi menunjukkan 71,63% remaja mempunyai stigma terhadap ODHA, 49,10% remaja mempunyai pengetahuan yang kurang tentang HIV. Pengetahuan yang kurang tentang HIV/AIDS berhubungan dengan stigma terhadap ODHA (PR= 1,210 95% CI: 1,149-1,273) setelah dikontrol oleh …

Hubungan Obesitas Dengan Kejadian Hipertensi Derajat 1 Di Pos Pembinaan Terpadu Penyakit Tidak Menular (Posbindu Ptm) Kantor Kesehatan Pelabuhan Bandung Tahun 2016, Teguh Dhika Rohkuswara, Syahrizal Syarif

Jurnal Epidemiologi Kesehatan Indonesia

Hipertensi sampai saat ini masih menjadi masalah kesehatan di dunia termasuk Indonesia. Prevalensi hipertensi di Indonesia, cukup tinggi yaitu sebesar 25,8% (Riskesdas, 2013). Sebagian besar penderita hipertensi termasuk dalam kelompok hipertensi derajat 1 dan separuhnya tidak menyadari sebagai penderita. Hipertensi bukan penyakit kausal tunggal, ada berbagai faktor yang berkontribusi terhadap munculnya hipertensi, salah satunya yang sering ditemukan adalah obesitas. Penelitian ini bertujuan untuk mengetahui besarnya hubungan antara obesitas dengan kejadian hipertensi derajat 1 di Posbindu PTM Kantor Kesehatan Pelabuhan Bandung. Desain penelitian adalah cross sectional, menggunakan data sekunder kegiatan Posbindu PTM KKP Bandung tahun 2016. Subjek penelitian adalah pegawai instansi …

Pengaruh Jarak Kelahiran Terhadap Kematian Bayi Di Indonesia, Filipina, Dan Kamboja (Analisis Data Survei Demografi Kesehatan), Adelina Fitri, Asri Adisasmita, Renti Mahkota

Jurnal Epidemiologi Kesehatan Indonesia

Kematian bayi didefinisikan sebagai kematian yang terjadi pada tahun pertama kehidupan. Angka kematian bayi di Indonesia dan Kamboja sendiri masih berada diatas AKB Asia Tenggara, sedangkan Filipina sudah sama dengan AKB Asia Tenggara. Jarak kelahiran merupakan salah satu faktor yang memegang peran penting pada kematian bayi. Tujuan penelitian ini adalah untuk mengetahui pengaruh jarak kelahiran terhadap kematian bayi di Indonesia, Filipina dan Kamboja. Penelitian menggunakan data dari Demographic Health Survey (DHS). Desain penelitian adalah cross sectional dan sampel pada masing-masing negara berjumlah 10.162, 4.741 dan 4.330 bayi. Hasil penelitian memperlihatkan, jarak kelahiran < 18 bulan memiliki risiko paling besar terhadap kematian bayi di Indonesia (OR = 2,43: 95% CI 1,26 - 4,70), Kamboja (OR = 4,39: 95% CI 1,76 - 10,94) dibandingkan jarak kelahiran 18 - 23 bulan, 24 - 35 bulan dan > 36 bulan. Sedangkan di Filipina jarak kelahiran 18 …

Enzymatic Synthesis Of Chlorogenic Acid Glucoside Using Dextransucrase And Its Physical And Functional Properties, Seung-Hee Nam, Jin-A Ko, Young-Jung Wee, M. K. Walsh, Kwang-Yeol Yang, Sun-Hee Yim, Jon-Bang Eun, Woojin Jun, Jang-Hyun Park, Young-Min Kim, Songhee Han, Thi Thanh Hanh Nguyen, Nahyun M. Kim

Nutrition, Dietetics, and Food Sciences Faculty Publications

Chlorogenic acid, a major polyphenol in edible plants, possesses strong antioxidant activity, anti-lipid peroxidation and anticancer effects. It used for industrial applications; however, this is limited by its instability to heat or light. In this study, we, for the first time synthesized chlorogenic acid glucoside (CHG) via transglycosylation using dextransucrase from Leuconostoc mesenteroides and sucrose. CHG was purified and its structure determined by nuclear magnetic resonance and matrix-associated laser desorption ionization–time-of-flight mass spectroscopy. The production yield of CHG was 44.0% or 141 mM, as determined by response surface methodology. CHG possessed a 65% increase in water solubility and a 2-fold …

Maternal Choline Supplementation Alters Fetal Growth Patterns In A Mouse Model Of Placental Insufficiency, Julia H. King, Sze Ting (Cecilia) Kwan, Jian Yan, Kevin C. Klatt, Xinyin Jiang, Mark S. Roberson, Marie A. Caudill

Publications and Research

Impairments in placental development can adversely affect pregnancy outcomes. The bioactive nutrient choline may mitigate some of these impairments, as suggested by data in humans, animals, and human trophoblasts. Herein, we investigated the effects of maternal choline supplementation (MCS) on parameters of fetal growth in a Dlx3+/− (distal-less homeobox 3) mouse model of placental insufficiency. Dlx3+/− female mice were assigned to 1X (control), 2X, or 4X choline intake levels during gestation. Dams were sacrificed at embryonic days E10.5, 12.5, 15.5, and 18.5. At E10.5, placental weight, embryo weight, and placental efficiency were higher in 4X versus 1X choline. Higher concentrations …

Effects Of A Multidisciplinary Weight Loss Intervention In Overweight And Obese Children And Adolescents: 11 Years Of Experience, Chiara Mameli, Jesse C. Krakauer, Nir Y. Krakauer, Alessandra Bosetti, Chiara Matilde Ferrari, Laura Schneider, Barbara Borsani, Sara Arrigoni, Erica Pendezza, Gian Vincenzo Zuccotti

Publications and Research

Aims To evaluate the effects of an outpatient multidisciplinary weight loss intervention in reducing body mass index (BMI) in children and adolescents suffering overweight and obesity, changes in A Body Shape Index (ABSI, waist circumference normalized to height and weight) and Hip Index (HI, normalized hip circumference) during treatment and correlation between the ABSI and HI with change in BMI z score.

Methods We analyze anthropometric data from pediatric patients affected by overweight and obesity aged 2 to 18 years old who entered our multidisciplinary weight loss intervention, which included medical, psychological and nutritional sessions, from January 1st 2006 to …

Investigation Of The Cultural Context Of Sugars Consumption Behavior In Low-Income Mexican-American Women, Tanya J. Benitez, Colleen Keller, Kathryn Coe, Natasha Tasevska

Journal of Health Disparities Research and Practice

Despite the recent federal dietary recommendations to limit consumption of added sugars to less than ten percent of daily caloric intake, there is a gap in published literature examining the influence of food preparation behaviors on sugars consumption among low-income Mexican-American women. The purpose of the study was to describe the cultural context of Mexican-American women in procuring, preparing and presenting added sugars in their families’ diets.

Five focus groups were conducted to examine sugars consumption behavior in thirteen overweight/obese low-income Mexican-American women ages 27-40 years. Themes that emerged during the sessions included: changes in food procurement to include high-sugar …

The Role Of Nr4a1 In Maternal Obesity Induced Beta Cell Expansion, Jeffery S. Tessem

Journal of Undergraduate Research

The academic objectives of this Mentoring Environment Grant (MEG) were to 1) train undergraduate students in the scientific process to prepare them in careers as physicians and scientists, and 2) to examine the relationship between in utero Nr4a1 beta cell specific deletion during maternal overnutrition and obesity on beta cell mass at birth and diabetic onset. We were successful in accomplishing these objectives, as evidenced by the training of four undergraduate students, presentation of research and local and national meetings, and initial preparation of a manuscript reporting our findings.

College Students' Health Behavior Clusters: Differences By Sex., Sarah E. Colby, Wenjun Zhou, Morgan F F. Sowers, Karla Shelnutt, Melissa D. Olfert, Jesse Morrell, Mallory Koenings, Tandalayo Kidd, Tanya M. Horacek, Geoffrey W. Greene, Melissa D. Olfert, Adrienne A. White, Sharon L Hoerr, Carol Byrd-Bredbenner, Kendra Kattelmann

Health and Nutritional Sciences Faculty Publications

OBJECTIVE: The study purpose was to identify clusters of weight-related behaviors by sex in a college student populations.

METHODS: We conducted secondary data analysis from online surveys and physical assessments collected in Project Young Adults Eating and Active for Health (YEAH) with a convenience sample of students on 13 college campuses in the United States. We performed 2-step cluster analysis by sex to identify subgroups with homogeneous characteristics and behaviors. We used 8 derivation variables: healthy eating; eating restraints; external cues; stress; fruit/vegetable intake; calories from fat; calories from sugar-sweetened beverages; and physical activity. Contribution of derivation variables to clusters …