Other Nutrition Commons^™

What Kigali’S Open‑Air Markets Reveal About Achieving Food And Nutrition Security: The Role Of African Indigenous Crops, Eugene Baraka, Mary S. Willis, Brice A. Ishimwe

Nutrition and Health Sciences -- Faculty Publications

Background: Household dietary diversity in Rwanda remains low and significantly contributes to the double burden of malnutrition. Rwanda has one of the highest under five stunting rates globally, and malnutrition remains one of the most pressing public health issues; therefore, factors that shape food and nutrition security are of utmost concern. Globally, the variety of foods available in open-air markets has been shown to affect dietary diversity. Furthermore, the consumption of indigenous foods can contribute to a diverse diet and improve nutrition status. At present, there are limited data on foods available for purchase in open-air markets in Africa. …

Potential Effectiveness Of Registered Dietitian Nutritionists In Healthy Behavior Interventions For Managing Type 2 Diabetes In Older Adults: A Systematic Review, Laurel Dobrow, Isabella Estrada, Nasira Burkholder-Cooley, John Miklavcic

Food Science Faculty Articles and Research

Purpose: A systematic review was conducted to assess how the involvement of a registered dietitian nutritionist (RDN) in healthy behavior interventions (HBIs) potentially affects outcomes in older adults with type 2 diabetes (T2D).

Methods: Literature was searched for primary research published between 2016 and 2020 on HBI involving a RDN affecting outcomes in older adults with T2D. Evaluations of hemoglobin A1c (HbA1c), blood glucose, blood pressure, cholesterol, anthropometry, body composition, medication usage, healthcare cost, and self-efficacy and/or adherence to healthy behaviors outcomes were selected for inclusion. All the literature included were summarized, evaluated for certainty of evidence criteria, and assessed …

Preliminary Evidence That Lectins In Infant Soy Formula Apparently Bind Bovine Milk Exosomes And Prevent Their Absorption In Healthy Adults, Ezra Mutai, Alice Kah Hui Ngu, Janos Zempleni

Nutrition and Health Sciences -- Faculty Publications

Background: Milk exosomes and their microRNA (miR) cargos are bioavailable. The content of exosomes and miRs is negligible in infant formulas compared to human milk, and dietary depletion of exosomes led to changes in bacterial communities and impaired gut health in juvenile mice. Adverse effects of formula feeding may be compounded by using soy formulas due to exosome binding by abundant lectins in that matrix. The purpose of this study was to assess the bioavailability of milk exosomes and their miR cargos added to soy formula in adults, as well as the potential role of soy lectins in exosome …

Omega-6 And Omega-3 Fatty Acid-Derived Oxylipins From The Lipoxygenase Pathway In Maternal And Umbilical Cord Plasma At Delivery And Their Relationship With Infant Growth, Maranda Thompson, Arzu Ulu, Ana G. Yuil-Valdes, Maheswari Mukherjee, Melissa K. Thoene, Matthew Van Ormer, Rebecca Slotkowski, Elizabeth Lyden, Ann Anderson-Berry, Corrine K. Hanson, Tara M. Nordgren, Sathish Kumar Natarajan

Nutrition and Health Sciences -- Faculty Publications

Omega-3 and omega-6 fatty acids are important for neonatal development and health. One mechanism by which omega-3 and omega-6 fatty acids exert their effects is through their metabolism into oxylipins and specialized pro-resolving mediators. However, the influence of oxylipins on fetal growth is not well understood. Therefore, the objective of this study was to identify oxylipins present in maternal and umbilical cord plasma and investigate their relationship with infant growth. Liquid chromatography–tandem mass spectrometry was used to quantify oxylipin levels in plasma collected at the time of delivery. Spearman’s correlations highlighted significant correlations between metabolite levels and infant growth. They …

Scavenger Receptors In Host Defense: From Functional Aspects To Mode Of Action, Qamar Taban, Peerzada Tajamul Mumtaz, Khalid Z. Masoodi, Ehtishamul Haq, Syed Mudasir Ahmad

Nutrition and Health Sciences -- Faculty Publications

Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous and encompass the miscellaneous group of transmembrane proteins and soluble secretory extracellular domain. They are functionally diverse as they are involved in various disorders and biological pathways and their major function in innate immunity and homeostasis. Numerous scavenger receptors have been discovered so far and are apportioned in various classes (A-L). Scavenger receptors are documented as pattern recognition receptors and known to act in coordination with other co-receptors such as Toll-like receptors in generating the immune responses against a repertoire of ligands such as microbial pathogens, non-self, intracellular …

Ephemeroptera Culturing Methods: Development Of Culturing And Rearing Methodology And High Sulfate Simulated Mine Effluent Toxicity Test Using Field Collected Water, Daniel Edward Brady

Theses, Dissertations and Capstones

Ephemeroptera taxa are not frequently used in toxicity testing; however, some mayfly taxa may be more sensitive to aquatic pollutants than standard test organisms used to determine anthropogenic effects on aquatic ecosystems. Additionally, some standard test organisms are not native to the Appalachian region and may not be truly reflective of the effects on native organisms. With mayflies not being the typical test organism, there is not a great deal of literature on culturing methods for this organism. For a standard acute toxicity test, there must be 80% survival within the control organisms for the test to be considered viable. …

Intracellular Fate Of Bovine Milk Exosomes In Murine Bone Marrow-Derived Macrophages, Afsana Khanam, Janos Zempleni

Nutrition and Health Sciences -- Faculty Publications

Milk exosomes (MEs) and their microRNA cargos constitute novel bioactive food compounds, and bovine MEs (BMEs) are being considered for use in drug delivery. The internalization of MEs by macrophages and degradation in lysosomes (in all cells) limit biological activities. Here, we determined whether BMEs internalized by murine bone marrow-derived macrophages (BMDMs) retrofuse with the intralumenal membrane in the multivesicular body (MVB) for subsequent release into the extracellular space or whether BMEs are destined for degradation in lysosomes.

Conclusions: The retrofusion of BME-derived intralumenal MVBs and secretion of BME into the extracellular space is quantitatively minor in BMDMs. The majority …

Genetically Altered Bovine Milk Exosomes (Bmes) Evade Elimination Bymurine Bone Marrow-Derived Macrophages (Bmdms), Alice Ngu, Janos Zempleni

Nutrition and Health Sciences -- Faculty Publications

Objectives: To develop BMEs that evade elimination by BMDMs.

Conclusions: The elimination of BMEs UNL1 and UNL2 is significantly reduced compared unmodified BMEs in BMDM cultures. This is of great importance when using BMEs for delivering therapeutics.

“Many People Have No Idea”: A Qualitative Analysis Of Healthcare Barriers Among Yazidi Refugees In The Midwestern United States, Falah N. Rashoka, Megan S. Kelley, Jeong‑Kyun Choi, Marc A. Garcia, Weiwen Chai, Hazim N. Rashawka

Nutrition and Health Sciences -- Faculty Publications

Background: The COVID-19 pandemic has shed new light on inequities in healthcare access faced by immigrant and refugee communities. To address ongoing disparities, there is an urgent need for ecological approaches to better understand the barriers that hinder and resources that facilitate access to healthcare. This study investigates barriers to healthcare system access faced by Yazidi refugees in the Midwestern United States.

Methods: Informed by the Interpretative Phenomenological Approach, three focus group meetings with a community advisory board were conducted between September 2019 and January 2020. The nine-member focus group included social workers, healthcare providers, and members of the Yazidi …

The Impact Of Covid-19 On Perceived Barriers And Facilitators To The Healthfulness Of Communities With Low-Income, Elder Varela, Jamie Zeldman, Alison Kuch, Yanli Wang, Mohammad Shushari, Elizabeth L. Hall, Jade Mcnamara, Jesse Stabile Morrell, Terezie Tolar-Peterson, Onikia Brown, Melissa D. Olfert, Lisa Franzen-Castle, Tandalayo Kidd, Sarah Colby, Geoffrey Greene, Karla P. Shelnutt

Nutrition and Health Sciences -- Faculty Publications

Background: The COVID-19 pandemic brought new challenges affecting the wellbeing of individuals in communities with low income. Understanding where people live and how those environments can facilitate or hinder living a healthy lifestyle is essential for developing interventions that target behavior change and health promotion. Objective: This study compares Extension Nutrition Educators’ (NEs) perceptions of the barriers and facilitators impacting the healthfulness of the environment of communities with low income in eleven states before and during the COVID-19 pandemic.

Association Of Diet Qualitymeasured By Three A Priori-Defined Dietary Patterns With Gut Microbiota And Intestinal Permeability Among Obese Individuals, Sarah Eaton, Heather Rasmussen, Weiwen Chai

Nutrition and Health Sciences -- Faculty Publications

Objectives: The human gastrointestinal tract (GI)may play a critical role in the prevention of obesity and metabolic diseases. Considering the importance of a healthy diet for optimal health, this study examined associations of diet quality assessed by three a priori-defined dietary patterns (Healthy Eating Index 2010 [HEI-2010],Mediterranean Eating Pattern for Americans [MEPA], and Dietary Approaches to Stop Hypertension [DASH] with gut microbiota, short-chain fatty acids (SCFA) and intestinal permeabilitymarkers in adult obese participants.

Conclusions: Blautia abundance and inversely associated with intestinal permeability markers such as urinary 24-h sucralose levels suggesting diet quality may have positive impact on the human GI …

Barriers To Summer Food Service Program (Sfsp) Implementation Before And After Covid-19: A Qualitative, Collective Case Study, Masoomeh Hajizadeh Oghaz, Falah N. Rashoka, Megan S. Kelley

Nutrition and Health Sciences -- Faculty Publications

Objectives: SFSP, as a federal food assistance program, could ensure that children have sufficient nutritious food during summer. According to a 2016 USDA report, only 0.4–0.6% of eligible children participated in this program in Nebraska, which makes for one of the lowest SFSP participation rates in the U.S. This study aims to better understand how the COVID-19 pandemic has impacted SFSP implementation in urban and rural settings across the state.

Conclusions: Insights from this study may inform the development of policies that expand food access to vulnerable families. On the organizational level, this includes providing participating kids and their parents …

Γ-Glutamyl Valine, Found In Dry Edible Beans, Is Anti-Diabetic In Db/Db Mice, Bikram Upadhyaya, Kaustav Majumder, Regis Moreau

Nutrition and Health Sciences -- Faculty Publications

Objectives: Dietary γ -glutamyl peptides (γ -GPs) found in dry edible beans exhibit biological activities (antioxidant, anti-inflammatory) with potential benefits against chronic metabolic disorders. γ -GPs are responsible for the desirable Kokumi flavor through allosteric activation of the Calcium Sensing Receptor (CaSR) present in multiple mammalian tissues. In this study, we investigated the metabolic effects of γ -glutamyl valine (γ -EV) in diabetic obese mice.

Conclusions: γ -EV improved the diabetic condition of db/db mice via modulation of glucose and lipid metabolism.

Never Satisfied, Sara Medeiros

The Graduate Review

A written work that pushes against the stigmas of weight loss journeys, non-fiction "Never Satisfied" shows the real struggles and mental toll that weight and appearance can have on any person, especially a woman. It includes common difficulties that not only occurred before weight loss, but after it as well, making it different from the typical success stories that are told. Written by an obsessive-compulsive twenty-two year old female student, it is extremely relatable to college students and young adults.

Mechanical Overload-Induced Muscle-Derived Extracellular Vesicles Promote Adipose Tissue Lipolysis, Ivan J. Vechetti Jr, Bailey D. Peck, Yuan Wen, R Grace Walton, Taylor R. Valentino, Alexander P. Alimov, Cory M. Dungan, Douglas W. Van Pelt, Ferdinand Von Walden, Bjorn Alkner, Charlotte A. Peterson, John J. Mccarthy

Nutrition and Health Sciences -- Faculty Publications

How regular physical activity is able to improve health remains poorly understood. The release of factors from skeletal muscle following exercise has been proposed as a possible mechanism mediating such systemic benefits. We describe a mechanism wherein skeletal muscle, in response to a hypertrophic stimulus induced by mechanical overload (MOV), released extracellular vesicles (EVs) containing muscle-specific miR-1 that were preferentially taken up by epidydimal white adipose tissue (eWAT). In eWAT, miR-1 promoted adrenergic signaling and lipolysis by targeting Tfap2α, a known repressor of Adrβ3 expression. Inhibiting EV release prevented the MOV-induced increase in eWAT miR-1 abundance and expression of …

Evaluation Of Essential Oil Products On Performance, Intestinal Permeability, Bone Mineralization, And Oxidative Stress Parameters On Broiler Chickens Under Heat Stress Conditions, Jared Ruff

Poultry Science Undergraduate Honors Theses

The goal of this study was to show how dietary supplementation of three different formulations of essential oils (EO) affected the performance of broiler chickens during heat stress (HS). Day-of-hatch Cobb 500 chicks (n = 500) were randomly divided into four groups: 1. HS control + control diets; 2. HS + control meals supplemented with 37 ppm EO of Lippia origanoides (LO); 3. HS + control diets supplemented with 45 ppm LO + 45 ppm EO of Rosmarinus officinalis (RO) + 300 ppm red beetroot; 4. HS + 45 ppm LO + 45 ppm RO + 300 ppm natural betaine. …

Effects Of Cashew Nut Shell Extract On Nutrient Digestibility And Ruminal Fermentation Under In Vitro Batch Culture And Continuous Culture Conditions, Chandler Compton

All Theses

The overall objective of this research was to determine the effects of cashew nut shell extract (CNSE; 59% anacardic acid and 18% cardol) on nutrient digestibility and rumen fermentation profile under in vitro batch culture (Chapter 2) and continuous culture conditions (Chapter 3). The second objective was to determine an optimal supplementation dosage for dairy cows. The batch culture study was organized as a randomized complete block design with 15 replicates per treatment incubated for 24 h during four incubation runs. Each incubation was inoculated with rumen contents collected from ruminally fistulated cows fed either a close-up ( …

Evidence Of Myomir Regulation Of The Pentose Phosphate Pathway During Mechanical Load-Induced Hypertrophy, Taylor Valentino, Vandre C. Figueiredo, C. Brooks Mobley, John J. Mccarthy, Ivan Jose Vechetti Jr

Nutrition and Health Sciences -- Faculty Publications

Many of the molecular and cellular mechanisms discovered to regulate skeletal muscle hypertrophy were first identified using the rodent synergist ablation model. This model reveals the intrinsic capability and necessary pathways of skeletal muscle growth in response to mechanical overload (MOV). Reminiscent of the rapid cellular growth observed with cancer, we hypothesized that in response to MOV, skeletal muscle would undergo metabolic programming to sustain increased demands to support hypertrophy. To test this hypothesis, we analyzed the gene expression of specific metabolic pathways taken from transcriptomic microarray data of a MOV time course. We found an upregulation of genes involved …

Qupath Digital Immunohistochemical Analysis Of Placental Tissue, Ashley L. Hein, Maheswari Mukherjee, Geoffrey A. Talmon, Sathish Kumar Natarajan, Tara M. Nordgren, Elizabeth Lyden, Corrine K. Hanson, Jesse L. Cox, Annelisse Santiago‑Pintado, Mariam A. Molani, Matthew Van Ormer, Maranda Thompson, Melissa K. Thoene, Aunum Akhter, Ann Anderson‑Berry, Ana G. Yuil-Valdes

Nutrition and Health Sciences -- Faculty Publications

Background: QuPath is an open‑source digital image analyzer notable for its user‑friendly design, cross‑platform compatibility, and customizable functionality. Since it was first released in 2016, at least 624 publications have reported its use, and it has been applied in a wide spectrum of settings. However, there are currently limited reports of its use in placental tissue. Here, we present the use of QuPath to quantify staining of G‑protein coupled receptor 18 (GPR18), the receptor for the pro‑resolving lipid mediator Resolvin D2, in placental tissue. Methods: Whole slide images of vascular smooth muscle (VSM) and extravillous trophoblast (EVT) cells stained …

A Review Of Mobile Apps For Chronic Kidney Disease Patients, Clarisse Zigan, Carl Russell Iii, Kirsten Wozniak, Kshaunish Soni

The Journal of Purdue Undergraduate Research

No abstract provided.