Kinesiology Commons^™

Morphology Of Human Myoblasts In Cultured Muscle Cells By The Novel Small Molecule Sgi, Ryan Matekel, Robert Hyldahl

Journal of Undergraduate Research

Muscle wasting is a symptom of cancer, AIDS, renal failure, heart failure, aging, prolonged bed rest, and has been seen in rodent models for burn, and kidney disease (Han, 2013). Muscle wasting negatively impacts quality of life by decreasing functional independence and increasing morbidity and mortality (Anker, 1997). Muscle wasting is an especially serious issue given that the body weight of an average human is 40-50 percent skeletal muscle (Han, 2013). Myostatin is a protein that negatively regulates muscle mass and is primarily expressed within skeletal muscle (Lee & McPherron, 2001). Genetic studies have shown that inhibition of myostatin signaling …

Effect Of Myostatin Pathway Inhibition On Fibroblast Activity Using A Novel Small Molecule, Seth Hampton, Dr. Robert Hyldahl

Journal of Undergraduate Research

Fibroblasts play a key role in repairing injured tissue by secreting collagen and growth factors into the tissue. In states of disease and overuse, fibroblast activity can become overly abundant and can lead to skeletal muscle fibrosis, decreasing strength and muscle elasticity. This fibrotic condition can lead to muscle wasting disorders, such as muscular dystrophies, that severely decrease the length and quality of life. Previous studies have shown that the TGF-beta signaling family directly increases fibroblast proliferation. It has also been shown that inhibition of myostatin, a member of the TGF-beta family, reduces symptoms of muscular dystrophies and decreases fibrosis. …

Evidence For Regulatory T Cell In Skeletal Muscle Repair, Amanda Gier, Robert Hyldahl

Journal of Undergraduate Research

Testing multiple immunohistochemistry protocols, I was unsuccessful at identifying Tregulatory cells in human skeletal muscle samples. A total of 5 months was dedicated to this original project before I was reassigned to look into the presence of CD8+ cells in skeletal muscle. The new project proved to be fruitful as I was able to confidently identify CD8+ cells and analyze their presence in the process of skeletal muscle repair. Furthermore, the data I collected has be incorporated into a paper Dr. Robert Hyldahl is currently working on titled “Skeletal muscle inflammation following repeated bouts of lengthening contractions in humans.”

Foot Strike Angle Changes During Shod, Minimalist, And Barefoot Running, And Correlation To Injury, Ani Henriksen, Dr. Sarah Ridge

Journal of Undergraduate Research

Running is a popular form of exercise. With high incidence of injury, runners are always looking for the next cure to stay injury free. Many webpages offer conflicting advice about shoes and foot strike. Although recommendations vary, barefoot running and use of minimalist shoes has increased. With the change in footwear, many runners have reported injuries from improper technique and repetitive loading. With the use of current technology we analyzed movements of the foot ignored by other studies. This project analyzed foot strike movement in the frontal plane to help us better understand the ideal foot strike technique for running …

Task-Oriented Ankle And Foot Training For Improving Gait, Balance, And Strength In Individuals With Multiple Sclerosis: A Pilot Study, Cizelle Rodriques, Kurt Jackson, Joaquin Alberto Barrios, Lloyd L. Laubach, Kimberly Edginton Bigelow

Physical Therapy Faculty Publications

The purpose of this pilot study was to investigate the effects and feasibility of a task-oriented ankle and foot exercise program on gait, balance, and strength in 6 adults with mild to moderate disability from multiple sclerosis (MS). The subjects participated in an 8-wk task-specific home-based ankle and foot exercise program. Outcome measures included stance phase ankle joint torque and power, limits of stability, isometric and isokinetic ankle strength, gait speed, and the 12-item Multiple Sclerosis Walking Scale (MSWS-12). Five subjects completed the 8- wk intervention. Following training, there were significant increases in ankle power during early (38.1%) and late …

Ultrasound Estimates Of Muscle Quality In Older Adults: Reliability And Comparison Of Photoshop And Imagej For The Grayscale Analysis Of Muscle Echogenicity, Michael O. Harris-Love, Bryant A. Seamon, Carla Teixeira, Catheeja Ismail

Exercise and Nutrition Sciences Faculty Publications

Background. Quantitative diagnostic ultrasound imaging has been proposed as a method of estimating muscle quality using measures of echogenicity. The Rectangular Marquee Tool (RMT) and the Free Hand Tool (FHT) are two types of editing features used in Photoshop and ImageJ for determining a region of interest (ROI) within an ultrasound image. The primary objective of this study is to determine the intrarater and interrater reliability of Photoshop and ImageJ for the estimate of muscle tissue echogenicity in older adults via grayscale histogram analysis. The secondary objective is to compare the mean grayscale values obtained using both the RMT and …

Pull From The Knee: Proper Technique And Application, Brad H. Deweese, Timothy J. Suchomel, Ambrose J. Serrano, Jarrod D. Burton, Steven K. Scruggs, Christopher B. Taber

Exercise Science Faculty Publications

The pull from the knee is a weightlifting movement derivative that can be used in the teaching progression of the clean and snatch exercises. This exercise emphasizes positional strength during the transition phase and the triple extension of the hip, knee, and ankle joints that is characteristic of weightlifting movements.

Volumetric Flow Imaging Reveals The Importance Of Vortex Ring Formation In Squid Swimming Tail-First And Arms-First, Ian K. Bartol, Paul S. Krueger, Rachel A. Jastrebsky, Sheila Williams, Joseph T. Thompson

Biological Sciences Faculty Publications

Squids use a pulsed jet and fin movements to swim both arms-first (forward) and tail-first (backward). Given the complexity of the squid multi-propulsor system, 3D velocimetry techniques are required for the comprehensive study of wake dynamics. Defocusing digital particle tracking velocimetry, a volumetric velocimetry technique, and high-speed videography were used to study arms-first and tail-first swimming of brief squid Lolliguncula brevis over a broad range of speeds [0-10 dorsal mantle lengths (DML) s^-1) in a swim tunnel. Although there was considerable complexity in the wakes of these multi-propulsor swimmers, 3D vortex rings and their derivatives were prominent reoccurring features …

Hpcnmf: A High-Performance Toolbox For Non-Negative Matrix Factorization, Karthik Devarajan, Guoli Wang

COBRA Preprint Series

Non-negative matrix factorization (NMF) is a widely used machine learning algorithm for dimension reduction of large-scale data. It has found successful applications in a variety of fields such as computational biology, neuroscience, natural language processing, information retrieval, image processing and speech recognition. In bioinformatics, for example, it has been used to extract patterns and profiles from genomic and text-mining data as well as in protein sequence and structure analysis. While the scientific performance of NMF is very promising in dealing with high dimensional data sets and complex data structures, its computational cost is high and sometimes could be critical for …

Strengthening The Springs: Improving Sprint Performance Via Strength Training, Brad H. Deweese, Christopher Bellon, Eric Magrum, Christopher Taber, Timothy J. Suchomel

All PTHMS Faculty Publications

How the inclusion of properly sequenced weightlifting derivatives into the strength-training program can improve sprint performance.

Mastoid Vibration Affects Dynamic Postural Control During Gait, Jung Chien, Mukul Mukherjee, Nicholas Stergiou

Journal Articles

Our objective was to investigate how manipulating sensory input through mastoid vibration (MV) could affect dynamic postural control during walking, with and without simultaneous manipulation of the visual and the somatosensory systems. We used three levels of MV (none, unilateral, and bilateral) via vibrating elements placed on the mastoid processes. We combined this with the six conditions of the Locomotor Sensory Organization Test (LSOT) paradigm to challenge the visual and somatosensory systems. We hypothesized that MV would affect both amount and temporal structure measures of sway variability during walking and that, in combination with manipulations of the visual and the …

A Randomized Controlled Trial Comparing Rehabilitation Efficacy In Chronic 1 Ankle Instability, Cynthia J. Wright, Shelley W. Linens, Mary Spencer Cain

Health Sciences Faculty Scholarship

There is minimal patient-oriented evidence regarding the effectiveness of interventions targeted to reduce symptoms associated with chronic ankle instability (CAI). Additionally, clinicians aiming to prioritize care by implementing only the most effective components of a rehabilitative program have very little evidence on comparative efficacy. The objective of this research report is to assess the comparative efficacy of two common ankle rehabilitation techniques [wobble board (WB) balance training and ankle strengthening using resistance tubing (RT)] using patient-oriented outcomes.

Ambulation Speed And Corresponding Mechanics Are Associated With Changes In Serum Cartilage Oligomeric Matrix Protein, W. Matt Denning, Michael Becker Pardo, Jason G. Winward, Iain Hunter, Sarah T. Ridge, J. Ty Hopkins, C. Shane Reese, Allen C. Parcell, Matthew K. Seeley

Faculty Publications

Because serum cartilage oligomeric matrix protein (COMP) has been used to reflect articular cartilage condition, we aimed to identify walking and running mechanics that are associated with changes in serum COMP. Eighteen subjects (9 male, 9 female; age = 23 ± 2 yrs.; mass = 68.3 ± 9.6 kg; height = 1.70 ± 0.08 m) completed 4000 steps on an instrumented treadmill on three separate days. Each day corresponded to a different ambulation speed: slow (preferred walking speed), medium (+50% of slow), and fast (+100% of slow). Synchronized ground reaction force and video data were collected to evaluate walking mechanics. …

Utilization Of The Clinical Laboratory For The Implementation Of Concussion Biomarkers In Collegiate Football And The Necessity Of Personalized And Predictive Athlete Specific Reference Intervals, Stefanie Podlog (Nee Schulte), Natalie N. Rasmussen, Joseph W. Mcbeth, Patrick Q. Richards, Eric Yochem, David J. Petron, Frederick G. Strathmann

Athletic Training Collection

Background: A continued interest in concussion biomarkers makes the eventual implementation of identified biomarkers into routine concussion assessment an eventual reality. We sought to develop and test an interdisciplinary approach that could be used to integrate blood-based biomarkers into the established concussion management program for a collegiate football team.

Methods: We used a CLIA-certified laboratory for all testing and chose biomarkers where clinically validated testing was available as would be required for results used in clinical decision making. We summarized the existing methods and results for concussion assessment across an entire season to identify and demonstrate the challenges with the …

Chapter 8: Autocorrelation Function, Mutual Information, And Correlation Dimension, Nathaniel Hunt

Journal Articles

In this chapter, we will discuss in greater detail the autocorrelation function and the mutual information we mentioned in Chapter 3 on the reconstruction of the state space. We will also cover a new measure called the correlation dimension, which quantifies the dimensionality of an attractor.

Chapter 5: Surrogation, Sara A. Myers

Journal Articles

One of the goals of time series analysis is to understand the underlying mechanisms that generate different dynamics for different time series. If a time series is not a product of random process, then we can assume that some kind of dynamics govern the time series. The question is what kinds of dynamics are controlling the time series. For nonlinear time series analysis, our focus is on nonlinear dynamics, and one of the goals is to characterize those dynamics by applying nonlinear tools. However, it is important to establish evidence of nonlinearity in a time series first in order to …

Chapter 2: Time Series, Sara A. Myers

Journal Articles

Time series is “simply a list of numbers assumed to measure some process sequentially in time” (Stergiou et al. 2004). Mathematicians have a more formal definition, that is, a set or a sequence of observations, with each one recorded at specific times, or at least sequentially (Brockwell and Davis 2002; Box et al. 2008). Time series are created from multiple sources for research purposes to understand various behaviors. For example, social scientists could collect graduation rates, physiologists record heart rates, economists study consumer spending, and climatologists examine weather patterns. Basically, any time observations are taken repeatedly over time, from any …

Utilization Of An Anti-Gravity Treadmill In A Physical Activity Program With Female Breast Cancer Survivors: A Pilot Study, Ciaran M. Fairman, Kristina L. Kendall, Brandonn S. Harris, Kenneth J. Crandall, Jim Mcmillan

International Journal of Exercise Science

International Journal of Exercise Science 9(1): 101- 109, 2016. Breast Cancer survivors can experience a myriad of physical and psychological benefits as a result of regular exercise. This study aimed to build on previous research using lower impact exercise programs by using an anti-gravity (Alter-G®) treadmill to administer cardiovascular training. The purpose of this study was to determine the effectiveness a physical activity program, including an Alter-G® treadmill, for improving physiological and psychosocial measures in female breast cancer survivors. A 14-week intervention using an AB-AB study design was employed. Six female breast cancer survivors were recruited to participate in the …

The Effect Of Cardiowaves Interval Training On Resting Blood Pressure, Resting Heart Rate, And Mind-Body Wellness, Camilla M. Nielson, Barbara D. Lockhart, Ronald L. Hager, James D. George, Dennis L. Eggett, Patrick R. Steffen, Ulrike H. Mitchell, Bruce W. Bailey

International Journal of Exercise Science

International Journal of Exercise Science 9(1): 89-100, 2016. An experimental study to examine the effects of CardioWaves interval training (CWIT) and continuous training (CT) on resting blood pressure, resting heart rate, and mind-body wellness. Fifty-two normotensive (blood pressure <120/80 mmHg), pre-hypertensive (120–139/80–89 mmHg), and hypertensive (>140/90 mmHg) participants were randomly assigned and equally divided between the CWIT and CT groups. Both groups participated in the assigned exercise protocol 30 minutes per day, four days per week for eight weeks. Resting blood pressure, resting heart rate, and mind-body wellness were measured pre- and post-intervention. A total of 47 participants (15 females and 32 males) were included in the …

Oxygen Consumption And Substrate Utilization During And After Resistance Exercises Performed With Different Muscle Mass, Paulo Farinatti, Antonio G. Castinheiras Neto, Paulo Rs Amorim

International Journal of Exercise Science

International Journal of Exercise Science 9(1): 77-88, 2016. This study investigated the energy expenditure (EE) and substrate utilization reflected by the respiratory-exchange ratio (RER) during and after resistance exercises performed with different muscle mass. Ten male volunteers (mean±SD; 26±4yr, 179±6cm, 77±8kg) performed multiple sets of the horizontal leg press (LP) and chest fly (CF) (5 sets of 10 repetitions with 15 repetition-maximum, 1-minute between-set intervals) in a counterbalanced design. Oxygen uptake and carbon dioxide production were measured during 40 minutes of resting; resistance exercise protocols (sets and intervals); 90 minutes of post-exercise recovery. Total fat and carbohydrate oxidation rates were …